APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Chengfu Deng,Zhibing He,Jinglin Huang,Lei Liu,Yansong Liu,Tao Wang,Guo Chen,Yong Yi,Kai Du
Aqueous asymmetric sodium-ion supercapacitors (ASSCs) with high energy density assembled from all-inorganic materials are expected to provide high-efficiency power sources for intelligent electric vehicles and off-grid systems. However, it is still challenging to fabricate high-performance positive materials by a simple method and rationally assemble ASSCs to meet the demand of ultralong cycle life and high energy/power density. Here, a simple pre-activation strategy was introduced into the α-MnO 2 electrode with a microcrystalline nanosheet structure to improve the Na-storage performance. The sodium-ions concentration was optimized by tuning charge-discharge parameters. Impressively, the pre-activated electrode achieved superior capacitance retention after 10,000 cycles, high volumetric capacitance of 377 F cm −3 and low charge transfer resistance of 5.9 Ω. Based on the facile operability of the proposed pre-activation strategy, it can be expected to be easily ported to other Li/K/Zn-storage, providing a novel avenue for the exploration of positive electrode materials with outstanding electrochemical behaviors. A novel ASSC was fabricated by matching α-MnO 2 //WO 3 electrodes, exhibiting wide voltage of 2.0 V, high energy/power density (0.965 W h cm −3 /65.2 W cm −3 ) and ultralong cycle life. This work proposes a simple strategy to develop high-performance positive materials and assemble ASSC with high energy/power density and long-term stable operation.
研究领域:
电化学
·
材料科学
·
能源存储
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DOI
高影响因子
Physica Status Solidi-Rapid Research Letters
·
2023
·Vol. 18
·期 7
·2300102
·
IF 2.8
Wenlong Chu,Ruifeng Xin,Luwei Zou,Xiulian Fan,Xilong Zhou,Cheng Li,Yu Zhou
2D nonlayered materials have attracted more and more attention due to their novel properties and special surface structures. However, due to isotropic chemical bonds within the crystal, the synthesis of ultrathin 2D nonlayered materials is an urgent challenge. Herein, α -Fe 2 O 3 2D nanosheets as thin as ≈8.2 nm on different substrates using self-designed ultralow concentration precursors combined with Gibbs free energy and Se catalysts design are successfully synthesized. The thickness-dependent growth mechanism is systematically studied, demonstrating the thermodynamic and kinetic controlling factors. The as-grown α -Fe 2 O 3 nanosheets are demonstrated with single-crystal structures without any other elements doping. The α -Fe 2 O 3 nanosheets photodetectors show the reasonable response performance with the positive photoconductive mechanism. This improved chemical vapor deposition method provides a promising idea for the synthesis of ultrathin 2D nonlayered materials.
研究领域:
材料科学
·
纳米科技
·
表面科学
·
凝聚态物理
·
光电子学
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DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 35
·期 2
·394-408
·
IF 2.007
Lv Xiao,Xiao Jun,Sun Tingting,Huo Xiaodong,Song Min,Shen Laihong
Tar is a barrier to limit the development of biomass gasification. Catalytic steam reforming experiments using α -methylnaphthalene (MNP) as a model tar compound were carried out in the two-stage reactor system (TSR). Based on response surface methodology, the effects of TSR temperatures and the molar ratio of steam to carbon (S/C) on MNP reforming performances were analyzed using the Li-modified Ni-based catalyst (NBC). The results show that the proper introduction of H 2 is able to improve significantly the MNP conversion, specially at lower temperatures. Furthermore, it is more appropriate for the modified catalysts by Li and Mg to be loaded in the first reactor due to their significant promotion to hydrocracking reactions, and it is favorable to place the Ni/Al catalyst in the second reactor for H 2 -rich gas. Additionally, the carbon deposition resistance of the NBC modified by Li exhibits better than that of the NBC modified by Mg.
研究领域:
能源化学
·
催化化学
·
可再生能源
·
生物质转化
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气体化技术
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2016
·Vol. 27
·期 3
·1605011
·
IF 11.382
Yaxiong Yang,Yongfeng Liu,Kaichao Pu,Xing Chen,He Tian,Mingxia Gao,Min Zhu,Hongge Pan
In this study, an amorphous Li 2 CO 3 -coated nanocrystalline α-Fe 2 O 3 hierarchical structure is synthesized for the first time using a facile one-step mechanochemical process at room temperature, taking advantage of the concurrence of repeated fracture-cold welding of material's particles and a gas-solid redox reaction. The conformal coating and hierarchical structure significantly increase the cycling durability and rate capability. Typically, a 1–3 nm thick amorphous Li 2 CO 3 layer is conformally coated on Fe 2 O 3 nanocrystallines (≈10 nm in size) that form hierarchically aggregated particles 400–800 nm in size by ball milling α-Fe 2 O 3 with LiH in CO 2 . The prepared Li 2 CO 3 -coated nanocrystalline α-Fe 2 O 3 exhibits highly stable long-term cyclability as it delivers a reversible capacity of 975 mAh g −1 with 99% of retention after 400 cycles at 100 mA g −1 . At a high rate of 3000 mA g −1 , its reversible capacity still remains at 537 mAh g −1 , superior to the uncoated counterpart (311 mAh g −1 ). Moreover, amorphous Li 2 O and Li 2 CO 3 coatings are also similarly produced on Fe 2 O 3 and NiO nanocrystallines, respectively, representing the general applicability of this mechanochemical approach.
研究领域:
材料科学
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电化学
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纳米材料
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能源存储
·
固态化学
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DOI
高影响因子
Journal of the Mechanical Behavior of Biomedical Materials
·
2019
·
IF 3.485
Tao Feng,Junjie Niu,Bin Pi,Yingjie Lu,Jinning Wang,Wen Zhang,Bin Li,Huilin Yang,Xuesong Zhu
High brittleness and lack osteogenesis are two major limitations of calcium phosphate cement (CPC) in application in bone defect reconstruction. Here we prepared a composite calcium phosphate cement by mixing N-acetyl cysteine loaded silk fibroin solution with α-tricalcium phosphate. In vitro cytology experiment revealed that SF-NAC/α-TCP could significantly increase the activity of exocrine ALP and up-regulated expression of bone-related genes. However, NAC up-regulated gene expression could be significantly suppressed by DKK1. We propose that NAC functioning as osteogenic factor by activating the Wnt/β-catenin signaling pathway may be the possible mechanism of up-regulation of osteogenic genes. Bone regeneration in vivo shown in a rat femur defect was enhanced by the addition of NAC in SF/α-TCP. In addition, the combination intensity of cement-bone interface was improved. The combination SF-NAC/α-TCP might be developed into a promising tool for bone tissue repair in the clinic.
研究领域:
生物材料学
·
骨组织工程
·
分子生物学
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DOI
PubMed
高影响因子
ACS Pharmacology & Translational Science
·
2024
·
IF 4.9
Jing-Jing Du,Shi-Hao Zhou,Jin Liu,Xing-Yuan Zhong,Ru-Yan Zhang,Wen-Xiang Zhao,Yu Wen,Zhen-Hong Su,Zheng Lu,Jun Guo
The tumor-associated antigen MUC1 is an attractive target for immunotherapy, however, its weak immunogenicity limits the induction of antitumor immune responses. To overcome this limitation, in this study, MUC1 glycopeptide was covalently linked with a diphtheria toxin-derived T-helper epitope (DT331–345). Subsequently, the resulting DT-MUC1 glycopeptide was physically mixed with natural killer T cell agonist αGalCer to explore their immunomodulatory synergy. Biological results demonstrated that compared to MUC1+αGalCer and DT-MUC1 groups, the specific IgG antibody titer of DT-MUC1+αGalCer group increased by 189- and 3-fold, respectively, indicating that the diphtheria toxin-derived T-helper epitope synergistically enhanced MUC1 immunogenicity with αGalCer. Moreover, the DT-MUC1+αGalCer vaccine induced potent cellular immune responses and significantly inhibited the growth of B16-MUC1 tumors in vivo. Furthermore, it was found that the anti-MUC1 IgG antibody titer induced by DT-MUC1+αGalCer was equivalent to that induced by palmitoylated DT-MUC1+αGalCer (P1-DT-MUC1+αGalCer) and significantly higher than that induced by doubly palmitoylated DT-MUC1+αGalCer (P2-DT-MUC1+αGalCer), suggesting that the easily synthesized DT-MUC1 may not require lipid chain modification and already possess good amphiphilicity. This is the first time that a diphtheria toxin-derived helper T-helper epitope was covalently linked to a glycopeptide antigen to enhance its immunogenicity, and this study may provide an effective vaccine design strategy for MUC1-targeted antitumor vaccines and offer novel insights into the design of fully synthetic peptide vaccines.
研究领域:
免疫学
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肿瘤学
·
疫苗开发
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DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 24
·4267
·
IF 5.1
Jing Xu,Wen-Zhao Wen,Jun-Hui Zhao,Jun-Rong Guo,Zhuo-Ya Zhang,Ping Xiong
Citri grandis exocarpium ( Citri grandis ) has been consumed by human beings for fifteen hundred years. It is commonly consumed as a health drink and dietary supplement in China. However, its nutritional and healthcare functions are still not fully understood. Objective: Our previous study found that oral administration of Citri grandis extract can significantly decrease the blood lipid levels of hyperlipidemic mice fed a high-fat diet. The aim of this study was to confirm the preventative effects of Citri grandis extract against atherosclerosis. Methods: Atherosclerotic lesion models were induced in HUVECs and apoE −/− C57BL/6J mice. ApoE −/− mice fed a high-fat diet were orally administered Citri grandis extract (0.4, 0.8, and 1.6 g/kg/d BW) and Simvastatin (1 mg/kg/d BW) on the first day of model establishment. After a 16-week treatment, serum samples and aorta and liver tissues were collected. Observation of pathological changes in aortic and liver tissues was performed using a light microscope with oil red O, H&E, Masson’s trichrome staining, and TEM. Biochemical detection was employed to determine the serum levels of TC, TG, LDL-C, and HDL-C as well as the activities of AST and ALT. In addition, expression studies of TGF-β, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1 were performed via qPCR and Western blot analysis. Results: Compared with cholesterol-induced HUVECs, Citri grandis extract significantly enhanced cell viability, attenuated the morphological changes in HUVECs, and reduced LDH release. Furthermore, after treatment with Citri grandis extract, the levels of TC, TG, and LDL-C significantly decreased in the atherosclerosis model apoE −/− mice after 16 weeks, and aortic plaque, lipid deposition, and endothelial injury were obviously ameliorated. The mRNA and protein expression of TGF-β, PPAR-γ, LXR-α, and ABCA1 in aortic and liver of atherosclerosis apoE −/− mice were upregulated ( p < 0.05, p < 0.01), while those of PI3K and Akt1 were suppressed ( p < 0.05, p < 0.01). Conclusions: Citri grandis extract can significantly decrease the high circulating lipid levels and the liver lipid deposition of high-fat-diet-fed apoE −/− mice and reduce aorta lipid accumulation and atherosclerotic plaques by regulating the expression of TGF-β1, PI3K, AKT1, PPAR-γ, LXR-α, and ABCA1. Citri grandis extract can be used as a healthcare dietary supplement for the prevention of abnormal lipid metabolism and atherosclerosis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Wenjing Pan,Yong Zhang,Sujing Yu,Xiaohua Liu,Dongzhi Zhang
The metal-organic framework (MOF)-derived alpha-iron oxide hollow nanosphere/molybdenum diselenide nanoflower (α-Fe 2 O 3 /MoSe 2 ) composite is fabricated via simple hydrothermal route. Multiple characterization methods have proved the successful synthesis of α-Fe 2 O 3 /MoSe 2 composites. The nanocomposite with a mass ratio of α-Fe 2 O 3 and MoSe 2 of 4:1 shows high response to H 2 S gas sensing. Moreover, the gas sensitivity test of the system shows that the α-Fe 2 O 3 /MoSe 2 composite sensor exhibits a faster response/recovery rate, outstanding repeatability and anti-humidity interference toward H 2 S sensing at room temperature, which also shows excellent selectivity for H 2 S compared to various potentially interfering gases. Further studies have shown that α-Fe 2 O 3 /MoSe 2 nanocomposites have improved H 2 S gas sensing performance due to the increased active sites and specific surface area, and the formation of n-n heterojunctions at the interface between α-Fe 2 O 3 hollow nanospheres and MoSe 2 nanoflowers.
研究领域:
材料科学
·
化学传感器
·
纳米技术
✓ 已验证
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 21
·4655
·
IF 4.967
Hongyan Wu,Xinying Ao,Jianan Liu,Junya Zhu,Jingran Bi,Hongman Hou,Hongshun Hao,Gongliang Zhang
The 3-(Methylthio) propyl isothiocyanate (MTPITC)-loaded inclusion complex prepared by α-cyclodextrin (α-CD) was incorporated into chitosan (CS) film to fabricate a packaging material for fresh chicken meat preservation. Scanning electron microscope images indicated homogenous dispersion of the MTPITC-α-CD in CS polymer. Fourier-transform infrared and X-ray diffraction techniques revealed that MTPITC-α-CD was incorporated into the CS film matrix by the physical interactions. The introduction of MTPITC-α-CD improved the UV-vis light-blocking ability, with a slight loss of transparency. Although the water solubility and water vapor barrier capacity were not significantly influenced by the addition of MTPITC-α-CD, the antioxidant attribute was significantly enhanced. The CS-MTPITC-α-CD film displayed obvious and sustained suppressive effects againstSalmonella typhimurium, with the inhibition zone diameters of 14.7 mm at 12 h and 7.3 mm at 24 h, respectively. Moreover, the quality index analysis indicated that the CS-MTPITC-α-CD film-wrapped fresh chicken, during refrigerated storage, exhibited better preservative efficacy than the control groups, with the total viable counts of 6.5 Log CFU/g, total volatile base nitrogen of 8.4 mg/100 g, pH of 6.6, thiobarbituric acid-reactive substances of 0.2 mg/kg, and the sensory score of 5 at day 16. Collectively, these results suggest that CS-MTPITC-α-CD film is a prospective packaging candidate for delaying the quality deterioration of chicken meat.
研究领域:
食品科学
·
材料科学
·
生物技术
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2023
·
IF 1.4
Mingguang Zhang,Wenlong Wang,Cheng Guo,Chunhuan Jiang
Alkyl-substituted testosterone derivatives are promising platforms for new drug discovery in medicinal chemistry. This approach provides a simple and efficient method for introducing an alkyl substituent to steroids at the C-4 position. In this study, the novel compound 3α-hydroxy-3β-methyl-4,4-dimethyl-5α-21-bromo-19-nor-pregnan-20-one is synthesized from 19-nor-testosterone. The protocol involves methylation of the dienolate, reduction of the alkene, the Grignard reaction of the carbonyl group, a Wittig reaction, hydroboration with BH3, the oxidation and bromination with a 49% overall yield. For the methylation and reduction steps, the effects of the base, solvent, and reactant ratio on the conversion and yield are investigated. The structures of the synthesized compounds are determined by nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) (electrospray ionization (ESI)).
研究领域:
药物化学
·
有机化学
·
生物化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 19
·4507
·
IF 3.267
Zhen Li,Zongcai Tu,Hui Wang,Lu Zhang
Ceratophyllum demersumL. (CDL) is a traditional Chinese herb to treat many diseases, but research on its anti-diabetic activity is not available. In this research, the α-glucosidase inhibitory ability and phytochemical constituents of CDL extract were firstly studied. Optimal ultrasound-assisted extraction conditions for α-glucosidase inhibitors (AGIs) were optimized by single factor experiment and response surface methodology (RSM), which was confirmed as 70% methanol, liquid-to-solid ratio of 43 (mL/g), extraction time of 54 min, ultrasonic power of 350 W, and extraction temperature of 40 °C. The lowest IC50value for α-glucosidase inhibition was 0.15 mg dried material/mL (mg DM/mL), which was much lower than that of acarbose (IC50value of 0.64 mg DM/mL). In total, 80 compounds including 8 organic acids, 11 phenolic acids, 25 flavonoids, 21 fatty acids, and 15 others were identified or tentatively identified from CDL extract by HPLC-QTOF-MS/MS analysis. The results suggested that CDL could be a potential source of α-glucosidase inhibitors. It can also provide useful phytochemical information for research into other bioactivities.Keywords:Ceratophyllum demersumL.;response surface methodology;α-glucosidase inhibitors;phytochemical profile
研究领域:
药理学
·
植物化学
·
中药学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Cheng Zhang,Shuangling Zhang,Jingjun Ma,Xiaohui Wang,Min Chen,Liangtao Lv,Heping Liu,Guanyu Zhao,Junpeng Li,Nan Sun
BACKGROUND The limited water solubility and instability of myricetin (Myr) restrict its application in functional food. Peptides from colla corii asini (CCAP) have recognized potential for the design of hybrid nanoparticles due to their therapeutic bioactivity. In this study, a dual-protein (animal–plant hybrid) delivery system was developed by the integration of CCAP with Zein (Z), with the objective of enhancing the efficiency of Myr for diabetes management. RESULTS Size-exclusion chromatography combined with multi-angle light scattering and zeta potential revealed small- and medium-sized CCAP fragments (83.0–100.5 and 100.5–785.6 Da, 10.0% and 80.0%, respectively; degree of hydrolysis: 78.3%) enabling electrostatic interactions with Z. CCAP-Z-Myr nanoparticles (98.2 nm) exhibited enhanced encapsulation efficiency (91.4%) and thermal stability (endothermic peak shift from 71.8 °C (Z-Myr) to 138 °C (CCAP-Z-Myr)). Fourier transform infrared spectroscopy and X-ray diffraction confirmed Myr amorphization (disappearance of crystalline peaks at 5.8°, 11.4°, 14.1°, 16.6°, 26.3° and 28.4°) and electrostatic interactions between CCAP and Z (CO peak shift from 1657 cm −1 (Z) to 1633 cm −1 (CCAP-Z), amide II from 1542 cm −1 (Z) to 1536 cm −1 (CCAP-Z)). Antioxidant activity of CCAP-Z-Myr surpassed that of Z-Myr (ABTS: 60.4% versus 25.3%, DPPH: 57.6% versus 33.0%, FRAP: 0.65 versus 0.42, hydroxyl radicals: 50.4% versus 30.2%, superoxide anions: 50.9% versus 29.7%). α -Glucosidase inhibitory activity of CCAP-Z-Myr was notably improved compared with Z-Myr (78.5% versus 64.8%). CONCLUSION This study demonstrated a dual animal–plant protein strategy to enhance hydrophobic bioactive Myr delivery for diabetes management, offering novel insights for functional foods and therapeutic formulations. © 2025 Society of Chemical Industry.
研究领域:
食品科学
·
生物化学
·
药理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）