RSC Advances
·
2023
·Vol. 13
·期 35
·24385-24392
·
IF 3.9
Shiyu Cao,Yanhong Xiang,Qiuling Zou,Youliang Jiang,Hanzhang Zeng,Jian Li,Jianhua Wu,Xiangsi Wu,Xianwen Wu,Lizhi Xiong
To alleviate the depletion of lithium resources and improve battery capacity and rate capacity, the development of aqueous zinc-ion batteries (AZIBs) is crucial. The open channels monoclinic structure Li3V2(PO4)3 is conducive to the transfer and diffusion of guest ions, making it a promising cathode material for AZIBs. Therefore, in this study, nanoneedles and particles Li3V2(PO4)3 cathode materials for AZIBs were prepared by a hydrothermal assisted sol–gel method, and the effect of synthesized pH values was studied. XRD results show that all samples had the monoclinic structure, and the Li3V2(PO4)3 sample prepared at pH = 7 exhibits (LVP-pH7) the highest peak tips and narrowest peak widths. SEM images demonstrate that all samples have the morphology character of randomly oriented needles and irregular particles, with the LVP-pH7 sample having more needle-like particles that contribute to ion diffusion. EDS results show uniform distribution of P, V, and O elements in the LVP-pH7 sample, and no obvious aggregation phenomenon is observed. Electrochemical tests have shown that the LVP-pH7 sample exhibits excellent cycling performance (97.37% after 50 cycles at 200 mA g−1) and rate ability compared to other samples. The CV test results showed that compared with other samples, the LVP-pH7 sample had the most excellent ionic diffusion coefficient (2.44 × 10−12 cm2 s−1). Additionally, the Rct of LVP-pH7 is the lowest (319.83 Ω) according to the findings of EIS and Nyquist plot fitting, showing a decreased charge transfer resistance and raising the kinetics of the reaction.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 4
·047502
·
IF 3.3
Lanyue Wang,Beibei Wang,Kai Kang,Xueping Ji,Zhenzhen Zhao,Congwei Li,Yuping Wang
An electrochemical sensor utilizing Au-Ni@ etched metal-organic framework (etched MOF) on a glassy carbon electrode (GCE) was constructed for ultrasensitive detection of 3-nitrophenol (3-NP). The Au-Ni@etched MOF in situ nanocomposite was synthesized via a simple one-step process that combines the electrochemical etching of Ni-hemin MOF with the simultaneous electrodeposition of Au-Ni bimetallic nanoparticles. The etched MOF not only provides abundant active sites for adsorbing 3-NP, but also serves as a supporter for loading Au-Ni bimetallic nanoparticles. This innovative design endows the electrochemical sensor with exceptional electrocatalytic activity towards 3-NP, achieving a low detection limit of 0.015 μM over the ranges of 0.06 ∼ 10 μM and 10 ∼ 200 μM. Moreover, the electrochemical sensor also shows excellent sensitivity, repeatability, and stability in 3-NP detection. This method offers a highly sensitive electrochemical strategy for accurately assaying 3-NP in water samples and opens new avenues for the application of MOF derivatives in electrochemical platforms.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Gut Microbes
·
2024
·
IF 12.2
Jiyan Su,Xiaojie Lin,Dan Li,Chunmin Yang,Shumei Lv,Xiaohong Chen,Xiujuan Yang,Botao Pan,Rui Xu,Liping Ren,Yanfang Zhang,Yizhen Xie,Qianjun Chen,Chenglai Xia
Emerging evidence has revealed the novel role of gut microbiota in the development of cancer. The characteristics of function and composition in the gut microbiota of patients with breast cancer patients has been reported, however the detailed causation between gut microbiota and breast cancer remains uncertain. In the present study, 16S rRNA sequencing revealed that Prevotella, particularly the dominant species Prevotella copri, is significantly enriched and prevalent in gut microbiota of breast cancer patients. Prior-oral administration of P. copri could promote breast cancer growth in specific pathogen-free mice and germ-free mice, accompanied with sharp reduction of indole-3-pyruvic acid (IPyA). Mechanistically, the present of excessive P. copri consumed a large amount of tryptophan (Trp), thus hampering the physiological accumulation of IPyA in the host. Our results revealed that IPyA is an intrinsic anti-cancer reagent in the host at physiological level. Briefly, IPyA directly suppressed the transcription of UHRF1, following by the declined UHRF1 and PP2A C in nucleus, thus inhibiting the phosphorylation of AMPK, which is just opposite to the cancer promoting effect of P. copri. Therefore, the exhaustion of IPyA by excessive P. copri strengthens the UHRF1-mediated negative control to inactivated the energy-controlling AMPK signaling pathway to promote tumor growth, which was indicated by the alternation in pattern of protein expression and DNA methylation. Our findings, for the first time, highlighted P. copri as a risk factor for the progression of breast cancer.
研究领域:
癌症生物学
·
微生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Shijie Gu,Yingyue Cui,Kaihua Wen,Shimou Chen,Jianling Zhao
Layered lithium/manganese-rich oxides (LMR) receive much attention due to its high specific capacity (∼300 mAh g -1 ). However, the serious capacity degradation during cycling hinders the commercial application of the LMR. Herein, 3-cyano-5-fluorophenylboronic acid (CFBA) was applied as an electrolyte additive for enhancing the cycling stability of LMR at high voltage. Linear sweep voltammetry (LSV), density function theory (DFT) calculations and the initial charge d Q /d V profiles indicate that the preferential oxidation of CFBA can improve the oxidative stability of electrolyte. By adding 0.7 wt% CFBA into standard (STD) electrolyte (1 M LiPF 6 in EC :EMC:DMC = 1:1:1, by weight), the LMR/Li half-cell delivered a discharge capacity of 245 mAh g -1 with a capacity retention of 88.4% after 200 cycles at 0.5C, while only 68 mAh g -1 with 25.2% retention in STD electrolyte. Further characterizations and theoretical calculation illustrate that CFBA can effectively eliminate the harmful HF, which improve the electrochemical performance . More importantly, the CFBA participates in the formation of a thin and uniform protective cathode-electrolyte interface (CEI) film on the surface of LMR, which effectively suppresses electrolyte decomposition and protects the structural integrity of LMR.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
FASEB JOURNAL
·
2025
·Vol. 39
·期 8
·e70510
·
IF 4.2
Songlun Jiang,Xu Zhang,Fanfan Chen,Zifan Zhao,Chenglong Zhang,Yuchun Sun
Bone organoids offer potential for bone regeneration and in vitro organ models. Current limitations in bone organoid culture systems include low efficiency in construction and functionality, as well as increased apoptosis in prolonged cultures of larger sizes. The ketone body 3-hydroxybutyrate (3HB), synthesized in the liver, addresses these challenges effectively. Our findings suggest that 3HB increases intracellular calcium ion (Ca 2+ ) levels in human bone marrow-derived mesenchymal stem cells (hBMSCs) by activating the hydroxycarboxylic acid receptor 2 (HCAR2). This activation initiates the cAMP/PKA/CREB pathway, which elevates the expression of anti-apoptotic genes such as myeloid cell leukemia 1 (MCL1) and B cell lymphoma 2-related protein A1 (BCL2A1), thereby reducing apoptosis. Furthermore, this pathway boosts the expression of osteogenic proteins, including Runt-related transcription factor 2 (RUNX2) and bone morphogenetic protein 2 (BMP2), facilitating osteogenesis in bone organoids. Consequently, 3HB may enhance the construction of bone organoids that are more mature, larger, and have longer viability. Graphical Our study demonstrates that 3-Hydroxybutyrate (3HB) activates the HCAR2 receptor in hBMSCs, leading to an increase in intracellular calcium levels and subsequent activation of the cAMP/PKA/CREB signaling pathway. This pathway upregulates the expression of the anti-apoptotic molecule MCL1 and early osteogenic factors RUNX2 and BMP2. These dual effects of 3HB, promoting osteogenesis and inhibiting apoptosis, provide a promising strategy for constructing more viable and mature bone organoids with higher efficiency.
研究领域:
再生医学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MECHANISMS OF AGEING AND DEVELOPMENT
·
2022
·
IF 5.498
Wen Chen,Zhen Chen,Shuo Shan,Aibo Wu,Chao Zhao,Xiang Ye,Xiaodong Zheng,Ruiyu Zhu
Microplastic pollution has attracted growing attention due to its prevalent and persistent exposure to general population through the food chain, but few reports have focused on the toxicological prevention of polystyrene (PS). Using the wild-type and mutant strains, this study explored the impacts of PS and cyanidin-3-O-glucoside (C3G) on stress tolerance and lifespan of Caenorhabditis elegans ( C. elegans ). In N2 nematodes, PS exposure initiated the oxidative stress and subsequent lifespan reduction, while these adverse impacts could be positively improved by C3G treatment. Considering the pivotal role of DAF-16 pathway in stress tolerance and lifespan regulation, the expression of the daf-16 gene and its downstream antioxidant genes ( clt-2 , hsp-16.1 , sod-3 , sod-5 ) were examined, and found to be significantly enhanced by C3G. Since the sod-3 gene was up-regulated the most fold by C3G, the activity of SOD enzyme that encoded by the sod-3 was examined, and could be obviously enhanced upon C3G treatment. This explained the improved oxidative stress and delayed oxidation-associated aging after C3G intervention. Nevertheless, these positive effects of C3G were weakened in daf-16 (-) mutant strain (with deleted DAF-16 gene), for which the beneficial effects of C3G in promoting stress resistance and lifespan extension were inhibited. These findings suggested that the DAF-16 gene and its downstream antioxidant genes, have participated in C3G’s regulations on redox balance and lifespan that impacted by nano-polystyrene particles. This study highlighted the link between dietary components and environmentally driven disturbance.
研究领域:
环境科学
·
分子生物学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Shuang Zhao,Lulu Lou,Shuwen Yuan,Daoyun Zhu,Fugen Wu,Zhongfei Mu
The near-infrared phosphor converted light-emitting diodes (NIR pc-LEDs) have been broadly used in the fields of night vision, biomedicine, nondestructive testing and food analysis. Over the past few years, many Cr 3+ doped NIR phosphorus has been reported. However, the realization of ultra-broad band NIR emission with high quantum efficiency remains a great challenge. Here, we report an ultra-broadband NIR emitting phosphor Li 3 Sc 1.92 (PO 4 ) 3 :0.08Cr 3+ with a full width at half maximum (FWHM) of 240 nm. The reason for the ultra-broad emission band is that the host Li 3 Sc 2 (PO 4 ) 3 provides two different kinds of ScO6 octahedral sites for Cr 3+ ions to occupy. This FWHM is better than most NIR emitting phosphors reported so far. Our research indicates that Li 3 Sc 2 (PO 4 ) 3 :Cr 3+ phosphors have great potential in night vision and NIR spectroscopy .
研究领域:
材料科学
·
光电技术
·
光子学
·
光谱学
✓ 已验证
DOI
高影响因子
Cell Chemical Biology
·
2020
·
IF 7.739
Giorgia Croppi,Yueyang Zhou,Rong Yang,Yunfei Bian,Mingtao Zhao,Youtian Hu,Benfang Helen Ruan,Jing Yu,Fang Wu
Summary H 2 S-producing enzymes in bacteria have been shown to be closely engaged in the process of microbial survival and antibiotic resistance. However, no inhibitors have been discovered for these enzymes, e.g., 3-mercaptopyruvate sulfurtransferase (MST). In the present study, we identified several classes of inhibitors for Escherichia coli MST (eMST) through high-throughput screening of ∼26,000 compounds. The thiazolidinedione-type inhibitors were found to selectively bind to Arg178 and Ser239 residues of eMST but hardly affected human MST. Moreover, the pioglitazone of this class concentration dependently accumulates the 3-mercaptopyruvate substrate and suppresses the H 2 S and reactive sulfane sulfur products in bacteria. Importantly, pioglitazone could potentiate the level of reactive oxygen species in cellulo and consequently enhance the antimicrobial effects of gentamicin and macrophages in culture. This study has identified the bioactive inhibitor of eMST, paving the way for the pharmacological targeting of eMST to synergistically control the survival of E. coli .
研究领域:
微生物学
·
药理学
·
细菌致病机制
·
抗菌治疗
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2019
·
IF 4.027
Yu-Heng Hu,Jie Yang,Yun Zhang,Ke-Chun Liu,Teng Liu,Jie Sun,Xiao-Jing Wang
The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 ± 0.011 µM and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 ± 0.017 µM. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.
研究领域:
药理学
·
神经科学
·
药物设计
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 5
·1-9
·
IF 5.479
Chen Dan,Xu Hui
The exploration of monohydroxy polycyclic aromatic hydrocarbons and 8-hydroxy-2′-deoxyguanosine (8-OHdG) produced by oxidative stress and DNA damage is a powerful and non-invasive tool to study the health risk of exposure to polycyclic aromatic hydrocarbons (PAHs). A nanocomposite prepared from graphene oxide, poly(3,4-ethylenedioxythiophene) and polypyrrole was electrodeposited on the internal surface of a stainless-steel tube for online in-tube solid phase microextraction (IT-SPME) of 8-OHdG, 3-hydroxyphenanthrene and 1-hydroxypyrene from urine. The coating possesses excellent chemical and mechanical stability, high extraction efficiency, good resistance to matrix interference, and a long lifespan. An online IT-SPME-high performance liquid chromatography-mass spectrometry method was developed for the determination of these three metabolite biomarkers in human urine. Figures of merit include (a) enrichment factors of 30–48; (b) low limits of detection (4–41 pg·mL −1 at S/ N = 3); (c) wide linear ranges (0.05–50 ng·mL −1 ); (d) good recoveries from spiked samples (71.6–109.5%); and (e) acceptable repeatability (2.3–14.6%). The method offers the advantages of low cost, simplicity, sensitivity, rapidity and automation.
Schematic illustration of online in-tube solid phase microextraction using graphene oxide/poly(3,4-ethylenedioxythiophene)/polypyrrole composites as adsorbent in a stainless-steel (SS) tube for the enrichment and simultaneous determination of 8-hydroxy-2′-deoxyguanosine, 3-hydroxyphenanthrene and 1-hydroxypyrene prior to HPLC-MS analysis.
研究领域:
分析化学
·
环境健康
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Jinhong Song,Chen Zhang,Zejian Zheng,Shizhe Huo,Yihan Lin,Fei Yang,Lei Liu
SnO 2 layer between Li 1.5 Al 0.5 Ge 1.5 (PO 4 ) 3 (LAGP) and lithium anode was prepared through simple scratch-coating process to improve interface properties. The physical phase, morphology, and electrochemical properties of Li/SnO 2 /LAGP structure were characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and electrochemical analytical methods. It was found that SnO 2 layer effectively improved the interface stability of LAGP and lithium anode. The prepared Li/SnO 2 /LAGP/SnO 2 /Li symmetric cell exhibited a large critical current density of 1.8 mA cm −2 and demonstrated excellent cycling characteristics. The polarization voltages of symmetric cell were 0.1 V and 0.8 V after 1000 h of cycling at current densities of 0.04 mA cm −2 and 0.5 mA cm −2 , respectively. Li/SnO 2 @LAGP/LiFePO 4 solid-state full cells were also assembled, exhibiting a discharge specific capacity of 150 mAh g −1 after 200 cycles at 0.1C with capacity retention rate of 96 %. The good interface properties of Li/SnO 2 /LAGP structure are attributed to the transformation of SnO 2 layer into a buffer layer containing Li 2 O, Sn 0 , and Li x Sn y alloy during cycling process, which effectively inhibits the reduction reaction between LAGP and lithium anode.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Dongmei Wu,Jiaqi Zheng,Weiwei Hu,Xiaoliang Zheng,Qiaojun He,Robert J. Linhardt,Xingqian Ye,Shiguo Chen
Rhamnogalacturonan I (RG-I) pectin are regarded as strong galectin-3 (Gal-3) antagonist because of galactan sidechains. The present study focused on discussing the effects of more structural regions in pectin on the anti-Gal-3 activity. The water-soluble pectin (WSP) recovered from citrus canning processing water was categorized as RG-I pectin. The controlled enzymatic hydrolysis was employed to sequentially remove the α-1,5-arabinan, homogalaturonan and β-1,4-galactan in WSP. The Gal-3-binding affinity KD (kd/ka) of WSP and debranched pectins were calculated to be 0.32 μM, 0.48 μM, 0.56 μM and 1.93 μM. Moreover, based on the more sensitive cell line (MCF-7) model, the IC 30 value of WSP was lower than these of modified pectins, indicating decreased anti-Gal-3 activity. Our results suggested that the total amount of neutral sugar sidechains, the length of arabinan and cooperation between HG and RG-I played important roles in the anti-Gal-3 activity of WSP, not the Gal/Ara ratio or RG-I/HG ratio. These results provided a new insight into structure-activity relationship of citrus segment membrane RG-I as a galectin-3 antagonist and a new functional food.
研究领域:
食品科学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）