JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2024
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IF 5.8
Yuan-Bin Chen,Siyi Xiong
This article explores the microwave dielectric properties of (La 1-x Nd x ) 2 (Zr 0.96 Ti 0.04 ) 3 (MoO 4 ) 9 (x=0.1,0.3,0.5, and 0.7) ceramics prepared by solid-state reaction. Utilizing the Rietveld refinement technique in XRD, the sample is identified as a trigonal crystal system belonging to the R 3 ¯ c space group. SEM analysis indicates that relative density has a significant impact on the ε r and Q×f of ceramics. The Q×f values of ceramics are closely related to the FWHM of the Raman spectra. At 750℃, (La 0.5 Nd 0.5 ) 2 (Zr 0.96 Ti 0.04 ) 3 (MoO 4 ) 9 ceramic exhibited excellent dielectric properties: ε r = 10.4 (±0.08), Q×f = 149,300 (±3211) GHz, τ f = −34.8 (±0.7) ppm/℃. To gain a deeper understanding of the intrinsic mechanisms governing the microwave dielectric properties of ceramics, analysis based on the P-V-L theory reveals that the La(Nd)-O bond and Mo-O bond contribute significantly to ε r and Q×f, respectively.
研究领域:
材料科学
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陶瓷学
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高影响因子
MATERIALS & DESIGN
·
2022
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IF 9.417
Yuqin Yang,Desheng Cai,Yisong Shu,Zhihua Yuan,Wenmin Pi,Yaozhi Zhang,Jihui Lu,Jingyi Jiao,Xuehao Cheng,Feifei Li,Penglong Wang,Haimin Lei
It is crucial to inhibit tumor growth and distant metastasis for breast cancer (BC) therapy. However, the treatment primarily dependent on surgery, chemotherapy, and radiotherapy is far from satisfactory. It had been demonstrated that the CXCL1/2-S100A8/9 axis played an essential role in BC therapy. Therefore, we constructed a natural product hydrogel for BC therapy by blocking CXCL1 signaling. The GK-GA (phytochemicals of Genkwa Flos -glycyrrhizic acid) hydrogel was designed in a one-step “green” approach. The pharmacodynamics study showed GK-GA exhibited significant anti-tumor and anti-lung metastasis activities, resulting in the inhibition rate of tumor growth (IRG) over 90 % at 6.25 mg·kg −1 , and did not display any obvious toxicity. In addition, the potent antitumor efficiency was also attributed to aggregation/assembly-induced retention (AIR) property. RNA sequencing analysis revealed the gene expression was significantly down-regulated in the GK-GA group, which were BCL2, CASP3, CXCL1, CXCL2, CXCR2, S100A8, S100A9, and confirmed further by western blot (WB). Our findings indicated natural product GK-GA hydrogel inhibited tumor growth and lung metastasis via the BCL2-CASP3 mitochondrial apoptosis pathway as well as the CXCL1/2-S100A8/9 pathway. This study provides inspiration for the fabrication of new excipients-free nano-dispersion in a one-step, no‐carrier‐added, organic solvent-free, “green” approach, particularly for small molecular antitumor agents.
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SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Weilu Liu,Fan Cui,Haifeng Li,Shuang Wang,Beibei Zhuo,Shuang Wang
A novel hybrid networks of molecularly imprinted poly(9-carbazoleacetic acid) and multi-walled carbon nanotubes (MWCNTs) was developed applying the electro-polymerization technique for the simultaneous voltammetric determination of dopamine and epinephrine. A carbazole derivative, 9-carbazoleacetic acid, was synthesized and used as a monomer for the first time. Owing to the introduction of carboxyl group, as well as the π-conjugated rigid plane structure of 9-carbazoleacetic acid, the molecularly imprinted poly(9-carbazoleacetic acid) afforded sufficient non-covalent interactions with the templates, enabled a good selectivity of the sensor. The MWCNTs acted as the supportive material for the molecularly imprinted poly(9-carbazoleacetic acid), resulted in the high specific surface area and high conductivity of the sensing interface. The as-prepared hybrid networks exhibited enhanced sensitivity and selectivity in the simultaneous voltammetric determination of dopamine and epinephrine. Experimental parameters involved in the sensor fabrication process were evaluated. A wide linear range of 0.04 ∼ 70 μM were obtained for the simultaneous detection of dopamine and epinephrine. The developed sensor, that requires only 100 μL samples for analysis, was applied to detect dopamine and epinephrine simultaneously in rat plasma sample. The recoveries were found in the range from 97.15 % to 105.5 %, indicating a promising potential in medical care and biological applications.
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Nanoscale
·
2020
·Vol. 12
·期 9
·5380-5396
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IF 6.895
Yalin Sun,Yan Liang,Na Hao,Xiaoheng Fu,Bin He,Shangcong Han,Jie Cao,Qingming Ma,Wen Xu,Yong Sun
9-Nitro-20(S)-camptothecin (9-NC) is a broad-spectrum antitumor drug used in tumor treatments, but its clinical applications and antitumor efficacy are limited by its structural instability, poor solubility, and extremely low drug utilization in tumor tissues. In this study, enzyme-sensitive nuclear-targeted dual-functional polymeric micelles were developed for 9-NC delivery with a high drug loading content (12.93 ± 0.88%), steady-state circulation, and a rapid attack at the “heart” of tumor cells. Briefly, chrysin (CHR) as a π-conjugated moiety was immobilized on the PCL terminal in the TAT–PCL amphiphiles and combined with the ALAL peptide as a linker on HA chains to yield the ultimate CHR–PCL–TAT–ALAL–HA (HATPC) amphiphiles. Spherical 9-NC-loaded micelles were obtained from the self-assembly of the dual-functional amphiphiles comprising HATPC and 9-NC with uniform nanosize (121.6 ± 5.79 nm), well-distributed morphology (PDI: 0.256), and negative surface charge (−23.2 ± 0.5 mV), yielding high stability during blood circulation. In this drug delivery system, HA acts as an active tumor-targeting instrument via CD44-receptor-mediated endocytosis; further, the ALAL peptide could be cutoff in the lysosomes of the tumor cells due to the high expression of cathepsin B, leading to lysosomal escape, while the secondary polymeric micelles targeted the tumor cell nucleus via the exposed TAT peptide. The enzyme sensitivity and nuclei targetability of the 9-NC/HATPC micelles were confirmed by dynamic light scattering and confocal laser scanning microscopy analyses. As compared to free 9-NC and traditional mPEG2k–PCL2k polymeric micelles, 9-NC/HATPC micelles were the most concentrated in the tumor cell nucleus; therefore, they exhibited the highest cytotoxicity against SKOV3 tumor cells both in vitro (IC50 = 0.03 μg mL−1) and in vivo. This enzyme-sensitive nuclear-targeted dual-functional drug delivery system involving HATPC provided a new and promising strategy for enhanced 9-NC delivery and antitumor efficacy.
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PubMed
高影响因子
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
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2021
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IF 1.312
Yan Du,Jinhua Hu,Zhixiong Hu,Weinong Zhang,Yutang Qi,Yanpeng Zhang,Xiaomin Li,Yi Liu
In this paper, a sensitive method for the determination of 3-chloro-1,2-propanediol (3-MCPD) by high performance liquid chromatography-fluorescence detection (HPLC-FLD) was established, in which 9-(2-Hydroxypropyl) adenine (HP-Ade) was selected as the fluorescent derivatization reagent because of its good water solubility and hydrophobicity. The principle of the method lies in the origination of chloroacetaldehyde with the periodate oxidation of 3-MCPD and its' fluorescence derivatization by HP-Ade to produce a strong fluorescent substance, name as 1-N6-vinylidene-9-(2-hydroxypropyl)adenine (ε-HP-Ade), used for quantitative determination of 3-MCPD by HPLC-FLD. Some mobile phase conditions and incubation parameters related with the method features were studied and optimized. Under the optimal conditions, the method shows high sensitivity, good linearity (r2 = 0.999) and good repeatability (RSD% between 1.04% and 2.55%), the detection limit (LOD) and quantification limit (LOQ) were 0.02 ng/mL and 0.06 ng/mL respectively. It has been successfully applied for the determination of various edible vegetable oil samples, the chromatogram shows symmetrical peak shape, perfect separation and very “clean” profiles. In comparison with gas chromatography-mass spectrum (GC-MS), the pretreatment process of the proposed method was totally operated in aqueous phase, the instrument requirements and cost are relatively lower, thus it will provide another choice for the routine analysis of 3-MCPD.
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JOURNAL OF SOLID STATE CHEMISTRY
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2012
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IF 2.159
Yan-Jing Gu,Bing Yan,Xiao-Fei Qiao
Novel rare earth complex-functionalized mesoporous SBA-16-type hybrid materials are synthesized by the co-condensation of modified 2-methyl-9-hydroxyphenalenone (MHPOSi), from modified 3-(triethoxysilyl)-propyl isocyanate (TEPIC), and tetraethoxysilane (TEOS) in the presence of Pluronic F127 as a template. These inorganic–organic mesoporous hybrids are characterized by FT-IR spectra, small-angle X-ray diffraction (SAXRD), N 2 adsorption–desorption measurements, thermal analysis and spectroscopy. Their photophysical properties, which show novel light conversion properties, are discussed in detail. The Eu 3+ hybrid system shows ultraviolet excitation and visible emission, and the Nd + and Yb 3+ hybrids exhibit visible excitation and NIR emission.
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NEW JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 24
·10873-10883
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IF 2.7
Yunxia Shi,Hui Duan,Meiyan Du,Xia Kong,Ke Xue,Guang Lu,Qingyun Liu
In this work, 2(3),9(10),16(17),23(24)-octamethoxyphthalocyanine (Pc(OH)8) was first used to modify Cu/CuFe2O4(Cu/CFO) nanospheres, and Pc(OH)8–Cu/CFO nanocomposites with enhanced peroxidase mimetic enzyme activity was obtained compared to the performance of Cu/CFO alone. SEM, XRD, and XPS were used to study the surface morphology, phase composition and elemental analysis of the newly synthesized Pc(OH)8–Cu/CFO. Using TMB as the chromogenic substrate, Pc(OH)8–Cu/CFO accelerate the oxidation process of chromogenic substrate 3,3′,5,5′- tetramethylbenzidine (TMB) by hydrogen peroxide in three minutes. The catalytic oxidation mechanism of Pc(OH)8–Cu/CFO on TMB was comprehensively investigated through free radical and fluorescence probe experiments. Based on the excellent catalytic performance of the composite materials, a simple and fast colorimetric sensing platform for the colorimetric detection of H2O2 and glutathione (GSH) was constructed in the range of 0.6–5 mM and 2–10 μM with detection limits (LODs) of 0.35 mM and 0.55 μM, respectively. In addition, using Pc(OH)8–Cu/CFO colorimetric detection for GSH has a lower detection limit, good selectivity and high sensitivity, which is expected to become an ideal material for GSH colorimetric detection.
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RSC Advances
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2026
·Vol. 16
·期 20
·18657-18665
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IF 6.1
Lu Li,Na Li,Wendan Niu,Aijing Guo,Ling Ma,Wei Zhao,Yawei Zhang,Ke Wang
β-Lactams (β-LAs) are a class of widely used antibiotics. However, their residues in food may pose a threat to human health. Therefore, it is of great necessity to develop a method that can sensitively and effectively detect β-LAs at trace levels in complex matrices. In this study, a novel functionalized magnetic covalent organic framework was synthesized based on biphenyl-3,3′,5,5′-tetracarbaldehyde and p-phenylenediamine. This material was used as an adsorbent for the effective extraction of 9 β-LAs in water and milk samples, which were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The experimental parameters were optimized, then the sensitive and accurate detection method was developed with excellent linearity (R2 ≥ 0.9990), low limits of detection (0.001–0.347 µg L−1) and limits of quantitation (0.002–1.051 µg L−1) for β-LAs. Meanwhile, good recoveries (71.7–118.8%) of 9 β-LAs in water and milk samples were obtained with the relative standard deviations (RSD) <10% (n = 5). In conclusion, Fe3O4@SiO2@Ap-COF can be regarded as an effective magnetic adsorbent, and the established method holds significant promise for rapid detection of 9 β-LAs in water and milk samples.
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Analytical Methods
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2023
·Vol. 15
·期 21
·2693-2699
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IF 3.1
Jianghua Chen,Yuanshuai Zang,Mengyi Chen,Chen Shi,Manlei Zhang,Bin Di,Cheng Jiang
As the dangers of cannabis abuse draw attention worldwide, it is necessary to assess the level of consumption in the community. The analysis of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THC-COOH) excreted in wastewater can provide information for a defined catchment area. Due to its hydrophobic nature and absence of ionizable groups, its detection is challenging. In this study, a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of THC-COOH in urban wastewater. The derivatization reagent 6-methylpyridine-3-sulfonyl chloride (MPS) with analyte-specific fragmentation was proven to be the most effective for improving sensitivity. Samples were extracted by solid-phase extraction (SPE) and satisfactory recovery was achieved (>79%) by adding acetonitrile to the samples for ultrasonic-assisted extraction before filtration. The limit of detection (LOD) and limit of quantification (LOQ) was 0.03 ng L−1 and 0.1 ng L−1, respectively, from a 40 mL sample. The established methodology was applied to profile the presence of THC-COOH in influent wastewater samples. It was shown that 20 out of the 252 samples contained THC-COOH and the concentrations were all below 1 ng L−1.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
·
IF 5.279
Xuejiao Zhang,Jiaxin Gu,Congying Zhao,Yaozhong Hu,Bowei Zhang,Jin Wang,Huan Lv,Xuemeng Ji,Shuo Wang
Non-nutritive sweeteners are the most widely used food additives designed to provide sweetness and reduce caloric intake. Studies have confirmed a link between sweeteners and colitis, yet supporting scientific data remain exiguous and controversial. In this study, three common sweeteners (Saccharin sodium, Stevioside, and Sucralose) in acceptable daily intake dosage were added to water in order to determine their effects on dextran sodium sulfate-induced colitis in mice. Our results show that the three sweeteners meliorate colitis to varying degrees─Saccharin exerts the most pronounced effect, followed by Stevioside and Sucralose. Intake of sweeteners alleviates colitis symptoms, alters gut microbiota, reshapes the TH17/Treg balance, protects the intestinal barrier, and reduces inflammation. Most significantly, sweeteners can enhance the abundance of Mucispirillum and Alistipes, which are conducive to colitis recovery, and upregulate the expression of E-cadherin through the miR-15b/RECK/MMP-9 axis to improve intestinal barrier integrity. Moreover, by inhibiting the MMP-9/AKT/NF-κB pathway, inflammation is relieved, as reflected in the restoration of the Th17/Treg balance. Our results link the consumption of sweeteners to the remission of colitis, which provides new scientific evidence for the safe use of sweeteners.
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Materials Today Bio
·
2026
·
IF 11
Chengbai Dai,Cheng Chen,Jun Zhu,Minghao Chao,Hanrong Yan,Pengjin Wei,Ming Guan,Bin Pan,Fenglei Gao,Rongze Tang
ZCM2 reprograms redox–inflammatory coupling by activating Nrf2/HO-1 signaling and suppressing NF-κB–driven responses in macrophages. • ZCM2 disrupts macrophage-mediated matrix degradation via downregulation of MMP-9, mitigating pathological bone resorption. • Calcium ion release from ZCM2 instructs osteogenic commitment through activation of the RUNX2-centered transcriptional network. • ZCM2 achieves immune modulation–coupled bone regeneration, enabling systemic restoration of bone homeostasis in osteoporosis. Osteoporosis is a systemic skeletal disorder characterized by bone loss and microstructural deterioration, and its pathogenesis is closely associated with dysregulation of the bone marrow immune microenvironment. In this study, bioinformatic analysis first revealed significant oxidative stress and mitochondrial metabolic dysfunction in macrophages within the osteoporotic microenvironment. Based on this, we constructed a biomimetic nanoplatform (ZCM2) composed of ZIF-8@CaCO 3 core–shell nanoparticles camouflaged with M2 macrophage membranes, designed to achieve comprehensive osteoporosis therapy through a triple synergistic mechanism: the ZIF-8 core scavenges reactive oxygen species to exert antioxidant and anti-inflammatory effects, inhibits MMP-9 secretion to reduce pathological bone resorption, and the CaCO 3 shell releases calcium ions to promote osteogenic differentiation. ZCM2 exhibited favorable biosafety, high cellular uptake efficiency, and excellent bone-targeting capability. Mechanistic studies demonstrated that ZCM2 upregulates the expression of Nrf2 and HO-1, downregulates the expression of NF-κB p65, and significantly reduces the secretion of matrix metalloproteinase-9 (MMP-9) by macrophages, thereby attenuating bone resorption. Meanwhile, calcium ions released from the CaCO 3 shell activate the RUNX2/OSX/OPN signaling axis, promoting osteogenic differentiation of bone marrow mesenchymal stem cells. In an ovariectomized mouse model of osteoporosis, ZCM2 markedly improved bone microarchitecture, promoted new bone formation, and effectively inhibited bone resorption activity. Collectively, this biomimetic nanoplatform integrates anti-inflammatory, anti-resorptive, and pro-osteogenic functions, offering a multifaceted synergistic therapeutic strategy for osteoporosis. M2 macrophage membrane–biomimetic nanoparticles activates the Nrf2/HO-1 antioxidant pathway in macrophages, thereby inhibiting NF-κB activation and MMP-9 secretion, which suppresses pathological bone resorption. Download: Download high-res image (327KB) Download: Download full-size image
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Xiangjuan Ma,Yan Yan,Qizhou Dai,Jianxian Gao,Shengjue Liu,Yijing Xia
This study focused on the electrochemical oxidation of Acid Blue 9 (AB 9) under direct and pulse current modes using a Ti/SnO 2 -Sb/α,β-Polytetrafluoroethylene-Fe-PbO 2 (PTFE-Fe-PbO 2 ) anode. The results showed that 99.0% of AB 9 and 68.9% of COD could be eliminated at initial pH of 5, initial AB 9 concentration of 100 mg L -1 , pulse frequency of 4000 Hz, current density of 20 mA cm −2 and pulse duty cycle of 50% after 120 min of electrolysis. The pulse electrochemical oxidation of AB 9 at the investigated conditions followed pseudo-first-order kinetics. Compared with the direct current mode, 76.0% of energy consumption could be saved at pulse current mode. The effect of mass transfer and electrode distance on the pulse electrochemical oxidation of AB 9 was also investigated in terms of mass transfer coefficient and effectiveness factor, the results showed that the reduced electrode distance was beneficial to improve the mass transfer and oxidation efficiency, as well as the energy efficiency. LC-MS analysis revealed that benzenesulfonate group, C-N and C-S bonds in AB 9 molecule were initially cleaved under the attack of ⋅OH, then some carboxylic acids were formed and eventually mineralized to CO 2 and H 2 O. Therefore, pulse electrochemical oxidation with a PTFE-Fe-PbO 2 electrode might be a promising alternative to enhance the practicability of electrochemical treatment for dye wastewater.
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