Science Bulletin
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2024
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IF 18.8
Gang Wang,Jingrui Li,Shumin Sun,Yuqi Yang,Zhihui Han,Zifan Pei,Liang Cheng
Excess intracellular H 2 S induces destructive mitochondrial toxicity, while overload of Zn 2+ results in cell pyroptosis and potentiates the tumor immunogenicity for immunotherapy. However, the precise delivery of both therapeutics remains a great challenge. Herein, an electrically activable ZnS nanochip for the controlled release of H 2 S and Zn 2+ was developed for enhanced gas-ionic-immunotherapy (GIIT). Under an electric field, a locality with particularly high concentrations of H 2 S and Zn 2+ was established by the voltage-controlled degradation of the ZnS nanoparticles (NPs). Consequently, the ZnS nanochip-mediated gas-ionic therapy (GIT) resulted in mitochondrial membrane potential depolarization, energy generation inhibition, and oxidative stress imbalance in tumor cells. Interestingly, the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway was activated due to the mitochondrial destruction. Moreover, the released Zn 2+ resulted in the increase of the intracellular Zn levels and cell pyroptosis, which enhanced the immunogenicity via the release of damage-associated molecular patterns (DAMPs). In vitro and in vivo studies revealed that the ZnS nanochip-based GIT effectively eliminated the tumors under an electric field and mobilized the cytotoxic T lymphocytes for immunotherapy. The combination with αCTLA-4 further promoted the adaptive immune response and inhibited tumor metastasis and long-term tumor recurrence. This work presented an electrically activable ZnS nanochip for combined immunotherapy, which might inspire the development of electric stimulation therapy.
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高影响因子
DALTON TRANSACTIONS
·
2017
·Vol. 46
·期 35
·11875-11883
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IF 4.029
Yi Ding,Ziyi Song,Qian Liu,Shaohua Wei,Lin Zhou,Jiahong Zhou,Jian Shen
Sonodynamic therapy (SDT) is a non-invasive therapeutic modality for cancer treatment. Finding new effective sonosensitizers has attracted great attention in the field of SDT. Mesoporous silica nanoparticles (MSN) have been extensively explored as a drug delivery system because of their good biocompatibility and satisfactory drug loading ability. However, there are relatively few studies devoted to using MSN as an efficient sonosensitizer. In this paper, we found that MSN could be used as an efficient sonosensitizer to induce cell apoptosis after ultrasound (US) treatment. To make the full use of MSN and increase its activity for cancer treatment, a chemotherapeutic drug was encapsulated inside MSN to achieve a chemotherapy-SDT synergistic function. Furthermore, photoinitiated polymerization cross-linked methacrylated hyaluronic acid (m-HA) gel was covered on the surface of DOX@MSN to improve its tumour targeting ability. In vitro and in vivo research studies indicated that the degradation of the m-HA shell by hyaluronidase (HAase) that is concentrated in the tumour environment results in the release of DOX@MSN. Importantly, subsequent US treatment could not only trigger SDT of MSN but also promote DOX release from MSN to show chemotherapeutic activity.
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MATERIALS LETTERS
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2016
·
IF 2.437
Xiaogang Guo,Xueming Li
This work firstly utilizes electrophoretic deposition (EPD) followed by perfluorodecyltriethoxysilane (FAS-17) modification as a novel and facile method to fabricate superhydrophobic ZnO and Bi 2 O 3 coatings with great potential application. The stable suspension consists of isopropyl alcohol and polyethyleneimine (PEI). The FESEM investigations show that the resulting two superhydrophobic oxide coatings with reticular-like structures uniformly distribute in nanoscale. The wettability results demonstrate that the water contact angle of all samples can reach to ca. 167° and remain almost unchange after exposure for nine weeks, resulting into an excellent stable superhydrophobicity. Most importantly, this paper provides an effective and low-cost strategy to fabricate to other functional superhydrophobic coatings for various applications.
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RSC Advances
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2016
·Vol. 6
·期 74
·70124-70132
·
IF 3.289
T. M. Chen,J. Xiao,G. W. Yang
Inorganic artificial enzymes have been developed as potential candidates to naturally occurring enzymes, and three inorganic enzyme mimics, noble metals, metal oxides and carbon materials, have been reported so far. Here, we reported the inorganic enzyme mimic of nitride-based materials. We demonstrated that cubic boron nitride (c-BN) as an enzyme mimic showed intrinsic peroxidase-like activity towards classical colorimetric substrates in the presence of hydrogen peroxide (H2O2). The Michaelis–Menten kinetics studies indicated that the catalytic efficiency of c-BN is superior to its natural peroxidase counterparts. We also established that the peroxidase-like activity of c-BN is induced by catalyzing the decomposition of H2O2 and generating hydroxyl radicals (˙OH). Based on the color reaction, a strategy was developed for H2O2 and glucose quantitative detection with high sensitivity. A reactor was constructed by entrapping c-BN in a porous platform and the peroxidase mimic immobilization for removal of organic pollutants was successfully conducted. Additionally, c-BN can be re-used up to 5 times and retain its catalytic activity after incubation at extremes of pH and temperature. These findings open the door for the application of c-BN as a catalyst and the development of nitride-based materials in the enzyme-mimics field.
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ELECTROCHIMICA ACTA
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2016
·
IF 4.803
Xiangli Zheng,Hongli Li,Fangquan Xia,Dong Tian,Xiaoxia Hua,Xueying Qiao,Changli Zhou
A new electrochemical sensor for ultrasensitive determination the polychlorinated biphenyls (PCBs) is presented here, exploiting the electrochemical route of sensing which has a distinct advantage over other conventional analysis. Chemically converted reduced graphene oxide modified with β-cyclodextrin polymer (β-CDP), being more soluble in water and the formation constants of target molecules with β-CDP are generally stronger and larger than that of β-CD, provides a platform for the electrochemical detection of PCBs using ferrocene as redox indicator. Ferrocene can form a host-guest complex with β-CDP. PCBs will replace the ferrocene in the cavity due to its higher affinity towards β-CDP, offering wide linear range and higher detection sensitivity via selective host-guest interaction. As ferrocene is a well known redox probe and hence can be easily detected using differential pulse voltammetery (DPV) technique. The new method exhibited excellent analytical performance toward PCBs with a low detection limit of 5.0 × 10 −13 M (S/N = 3). More importantly, the developed method was applied to the quantitative determination of PCBs level in sediment core collected from Lake Nansihu and displayed satisfactory results. These results indicate that the method offers considerable potential for trace PCBs monitoring. We believe that the method has a profound impact on the design of a convenient platform for rapid screening and determination of PCBs in environment.
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FOOD CHEMISTRY
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2012
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IF 3.655
Yali Wang,Yu Zhao,K. Andrae-Marobela,H. Okatch,Jianbo Xiao
The crude polysaccharides from tea leaves (TPS) looks like have good antioxidant activities. However, whether or not the antioxidant abilities of crude TPS depend on tea polyphenols in the crude TPS is not understand. Herein, TPS fractions were isolated from crude TPS and their antioxidant activities were compared. The crude TPS showed stronger antioxidant activities than that of TPS fractions. However, EGCG (6.15 μg/mL) significantly enhanced DPPH radical scavenging potential of TPS fractions for each dose. Moreover, EGCG (8.0 μg/mL) significantly improved the reducing power of TPS fractions. EGCG causes a synergistic increase in the antioxidant activities of TPS fractions. The antioxidant activities of dextrans in the absence and presence of EGCG were investigated to illustrate that the antioxidant activities of TPS is similar to dextrans. These results illustrated that TPS fractions hardly exhibited antioxidant activities and tea polyphenols are the major antioxidant in the crude TPS. TPS as food antioxidants is an old woman’s tale.
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ADVANCED FUNCTIONAL MATERIALS
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2024
·
IF 18.5
Bin Li,Ruiqing Ge,Wenwen Du,Zhenning Wang,Tao Peng,Ruojiang Wang,Yu Chang,Tingrui Pan
Woodwork is involved in a variety of interactions with humans through physical contact, which may reveal valuable information if the tactile data can be unnoticeably extracted. In this work, an intelligent iontronic wood (iWood) device, along with its seamlessly integrated architecture into the woodwork, enabled by the iontronic sensing principle, is implemented. Notably, the tactile sensing structure is generated at the iontronic interface between ionic and conductive woods. In particular, the ionic wood is established by infusing an ionic liquid into the wood, followed by immobilizing it via chemical bonding, presenting both prominent ionic conductivity and excellent stability under pressure. By formatting the woods into identical strips, the high-density tactile sensing array can be simply formed by a braiding process for a scalable interwoven structure. As a result, the iWood device has offered a high sensitivity over a broad detection of 0.5 MPa and an array of 40 × 90 units covering an area up to 3600 cm 2 . The iWood device is showcased as an interactive human interface, demonstrating its potential as a smart desktop capable of gesture and object recognition, a health-tracking chair for real-time ballistocardiograph monitoring, and an embedded intelligent floor for weight management and gait analysis.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Yang Zong,Minjie Xi,Yunqi Wang,Guohonghao Zeng,Dongliang Hu,Huihui Hu,Xiaoqi Hou,Kewang Nan,Xiangzhong Chen,Fan Xu,Oliver G. Schmidt,Yongfeng Mei,Jizhai Cui
Precisely capturing and manipulating microscale objects, such as individual cells and microorganisms, is fundamental to advancements in biomedical research and microrobotics. Photoactuators based on optical fibers serving as flexible, unobstructed waveguides are well-suited for these operations, particularly in confined locations where free-space illumination is impractical. However, integrating optical fibers with microscale actuators poses significant challenges due to size mismatch, resulting in slow responses inadequate for handling motile micro-objects. This study designs microactuators based on hydrogel/Au bilayer heterostructures that self-roll around a tapered optical fiber. This self-rolling mechanism enables the use of thin hydrogel layers only a few micrometers thick, which rapidly absorb and release water molecules during a phase transition. The resulting microactuators exhibit low bending stiffness and extremely fast responses, achieving large bending angles exceeding 800° within 0.55 s. Using this technique, this study successfully captures rapidly swimming Chlamydomonas and Paramecium, and demonstrates programmable non-reciprocal motion for effective non-contact manipulation of yeast cells. This approach provides a versatile platform for microscale manipulations and holds promise for advanced biomedical applications.
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ACS Omega
·
2024
·
IF 3.7
Xiaoru Hao,Zhihao Cheng,Yu Zhang,Jun Xie,Haikun Zheng,Chunxiao Yue,Wei Sheng
The operation of aerospace equipment is often affected by icing and frosting. In order to reduce the loss caused by icing in the industrial field, it is an effective method to prepare superhydrophobic coatings by modifying nanoparticles with low surface energy materials. In order to explore a method of preparing a superhydrophobic surface that can be popularized, a two-step spraying method was employed to create a superhydrophobic coating. The surface was characterized by Fourier transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (SEM). The optimal preparation process was obtained by analyzing the surface contact angle data. The results showed that stearic acid was grafted onto the surface of TiO2 by esterification reaction. The existence of long methyl and methylene hydrophobic groups in the tail of the stearic acid molecule made the modified TiO2 hydrophobic. It is verified that water molecules have strong adsorption on the surface of unmodified TiO2. Stearic acid molecules can reduce the interfacial energy in the system.
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ANTIOXIDANTS & REDOX SIGNALING
·
2024
·
IF 5.9
Siyu Lu,Yiming Zhou,Mincong Liu,Lijun Gong,Li Liu,Zhigui Duan,Keke Chen,Frank J. Gonzalez,Fang Wei,Rong Xiang,Guolin Li
Aims: Redox signaling plays a key role in skeletal muscle remodeling induced by exercise and prolonged inactivity, but it is unclear which oxidant triggers myofiber hypertrophy due to the lack of strategies to precisely regulate individual oxidants in vivo. In this study, we used tetrathiomolybdate (TM) to dissociate the link between superoxide (O2•−) and hydrogen peroxide and thereby to specifically explore the role of O2•− in muscle hypertrophy in C2C12 cells and mice.Results: TM can linearly regulate intracellular O2•− levels by inhibition of superoxide dismutase 1 (SOD1). A 70% increase in O2•− levels in C2C12 myoblast cells and mice is necessary and sufficient for triggering hypertrophy of differentiated myotubes and can enhance exercise performance by more than 50% in mice. SOD1 knockout blocks TM-induced O2•− increments and thereby prevents hypertrophy, whereas SOD1 restoration rescues all these effects. Scavenging O2•− with antioxidants abolishes TM-induced hypertrophy and the enhancement of exercise performance, whereas the restoration of O2•− levels with a O2•− generator promotes muscle hypertrophy independent of SOD1 activity.Innovation and Conclusion: These findings suggest that O2•− is an endogenous initiator of myofiber hypertrophy and that TM may be used to treat muscle wasting diseases. Our work not only suggests a novel druggable mechanism to increase muscle mass but also provides a tool for precisely regulating O2•− levels in vivo.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Fei Wang,Chao Jiang,Teng-Jie Wang,Xin Pan,Bin Che,Ding-Yi Zhang,Kai-Long Zhang,Ping Zhou,Ke-Feng Ren
Bacterial infections, aseptic loosening, and poor osseointegration remain challenges for orthopedic implants. In this study, we developed a dual-network polyelectrolyte antibacterial coating for orthopedic implants to prevent bacterial infections. The coating was prepared via UV-triggered in situ polymerization, composed of polyethyleneimine (PEI) and polyacrylic acid (PAA), with enhanced mechanical properties due to electrostatic interactions between them. The antimicrobial peptide ε-poly-L-lysine (EPL) was immobilized in the coating, providing efficient antibacterial functionality. The coating's substrate was made of hydroxyapatite (HA) and polylactic acid (PLA) composites to promote bone cell growth and tissue regeneration. In vitro experimental results demonstrated that the coating exhibited excellent antibacterial properties against both Gram-negative and Gram-positive bacteria, while enhancing the adhesion, proliferation, and differentiation of osteoblasts. In vivo experiments further confirmed the coating's capability to resist infection in an infected microenvironment. This study provides a practical strategy for developing orthopedic implant surface coatings with antibacterial functions.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2017
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IF 4.233
Ni Cheng,Qi Kang,Jianhong Xiao,Na Du,Li Yu
Studies on supramolecular gel aggregates via supramolecular interactions are very fascinating and impressive. The interactions of gelator with solvent and inorganic salt can functionalize, activate, or control the properties of supramolecular gels. A lot of work on this area has been done, but all these contributions are only at an early stage. In this work, we tuned the gel formation conditions and properties by using low-molecular-weight gelator (LMWGs), amide-functionalized imidazolium-based surfactant , viz., N-cetyl-N′-acetamido imidazolium bromide ([N-C 16 , N′-CONH 2 -Im]Br), in different solvents and with inorganic salt additives. Under chemical (Cu 2+ /H 2 O 2 ) and physical (temperature) stimuli, gel-sol phase transition occurred in the gel formed from 2 wt% [N-C 16 , N′-CONH 2 -Im]Br in the solvent formamide (FM). Accompanied with increased mechanical strength of the gels, morphology alternation from initial straight stripe-shaped structures to curly belt-like textures was observed in the addition of CuBr 2 . From Small-angle X-ray scattering (SAXS) measurements, bilayer units with interdigitated hydrocarbon tails of the gelator were testified to appear in the gels. Comparative experiments demonstrate that the π-π interaction, H-bonding, and hydrophobic interaction between the gelator molecules are the main driving forces for the gelation . The low-cost gelator, facile preparation, and coordination-driven assembly process make the robust gel a good candidate in various applications, such as material templates and drug deliveries.
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