Materials Today Bio
·
2025
·
IF 10.2
Ziling Li,Huiling Lei,Jiannan Hu,Tong Zhou,Shuaiqi Yuan,Xinyue Ma,Yunfei Zhu,Chao Liu,Decai Wang,Yuzhou Wu,Shuyun Xu
The pneumonia induced by carbapenem resistant Klebsiella pneumoniae (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous administration of PMB has many problems, such as severe neurotoxicity and nephrotoxicity. In this study, a novel inhaled PMB-loaded albumin nanoparticles (PEG-pHSA@PMB) capable of penetrating airway mucus and responding to the infection microenvironment is constructed. An acid-responsive functional molecule (PEBA) and NH 2 -PEG-SH are linked to the surface of human serum albumin (HSA) via the conjugation reaction. Subsequently, PMB is loaded through electrostatic interactions to yield PEG-pHSA@PMB. The sulfhydryl groups of PEG-pHSA@PMB interact with mucins to help penetrate mucus after inhaled. In an acidic environment, the protonation of the tertiary amino groups within PEG-pHSA@PMB causes the charge alteration, which leads to the release of PMB. It demonstrated excellent mucus permeability, potent bactericidal activity, and superior bacteriostatic effects compared to sole PMB. Inhalation of PEG-pHSA@PMB significantly reduced the bacterial load in the lungs of mice with CRKP pneumonia, alleviating inflammatory response. Moreover, PEG-pHSA@PMB exhibited good cytocompatibility and biosafety. The novel strategy of the inhalation drug delivery system is promising for the treatment of pneumonia caused by drug-resistant bacteria.
研究领域:
医学
·
药剂学
·
感染病学
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产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2020
·
IF 4.419
Dan Wang,Pengkun Hou,Dietmar Stephan,Shifeng Huang,Lina Zhang,Ping Yang,Xin Cheng
For surface functionalization of cement-based materials with photocatalytic properties, weak adhesion between photocatalysis and matrix worsens these properties and results in poor weathering resistance in outdoor environments. To overcome these problems, in this study, two SiO 2 /TiO 2 composites, with different deposited densities of TiO 2 nanoparticles on a SiO 2 sphere, were prepared and used for surface coating of cement-based materials. The two composites show different efficiencies. The photocatalytic results show that the coated cement pastes exhibited excellent rhodamine B-removal efficiency before and after curing and accelerated weathering processes, indicating that SiO 2 in the system has a crucial effect as a ‘glue’ preventing the release of TiO 2 . The bonding mechanism was revealed by the reaction of the samples and main components and hydration products (such as CH, C-S-H and C 3 S).
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 18
·4614-4623
·
IF 7.779
Feixiang Wang,Yun Yang,Congcong Jin,Shilie Pan
A new borate, Li6.58Na7.43Sr4(B9O18)(B12O24)Cl (LNSBOC), was successfully obtained via a spontaneous crystallization method in an open system. LNSBOC crystallizes in a hexagonal crystal system with the centrosymmetric space group of P63/m, with a = 9.3046(2) Å, c = 24.3239(7) Å and Z = 2. According to the statistics, the structure of LNSBOC is extraordinary not only because of the discovery of the novel fan-like fundamental building block B9O18, but also for the unprecedented coexistence of the largest two highly polymerized (number of B atoms more than six) isolated B–O clusters in the structure. A discussion about the cause of the rareness of borates containing two polymerized isolated B–O clusters was carried out by investigating previous research and extant compounds. Even more significantly, a strategy to design compounds/crystal structures containing two polymerized isolated B–O clusters is put forward in this work from the viewpoint of structures and elements. In addition, thermal analysis and infrared and UV–Vis–NIR diffuse reflectance spectroscopy were performed for the title compound.
研究领域:
材料科学
·
无机化学
·
晶体学
·
功能材料
·
结构化学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Liang Zeng,Ling Xiao,Xiaowen Shi,Mingyu Wei,Jinying Cao,Yangke Long
Herein, Prussian blue analogues@poly(m-phenylenediamine) nanoparticles (PBA@PmPDs) with well-defined core-shell structure were synthesized. The successful coating of poly(m-phenylenediamine) (PmPD) on the surface of Fe y Co 3-y [Co(CN) 6 ] 2 (Fe-Co-Co PBA) was confirmed by SEM, TEM , XRD , TGA , FT-IR and XPS . The catalytic performance of Fe-Co-Co PBA@PmPDs was evaluated by activation of peroxymonosulfate (PMS) for degradation of Rhodamine B (RhB), the effects of different influence factors on the RhB degradation efficiency were investigated, including PMS concentration, temperature, initial solution pH, and co-existing inorganic salts. Cobalt ions leaching and stability of the catalysts were studied, Co ions concentration dissolved into the solution from the solid catalysts at 60 min is reduced by half after the Fe-Co-Co PBA is coated with PmPDs. The RhB removal efficiency is higher than 90% even after four cycles and the nanoparticles still maintain the core-shell structure, indicating that Fe-Co-Co PBA@PmPDs is stabile and reusable. Radical quenching experiments and electron paramagnetic resonance spectra indicate that both SO 4 − and OH are generated during the PMS activation process and SO 4 − is the dominant reactive species. In virtue of its superior catalytic activity, excellent reusability and stability, low metallic ion leaching, Fe-Co-Co PBA@PmPDs could be a promising catalyst for the remediation of contaminated water.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 16
·12364-12371
·
IF 4.6
Chang Man,Chunpeng Xu,Jinfeng Wang,Xiangli Li,Tong Li,Yanhua Ma,Shalu Zhang,Yongfeng Qiao,Qiong Wu
Organic–inorganic hybrid materials have significant potential in the photocatalytic degradation of Rhodamine B (RhB). In this study, five hybrid materials were successfully synthesized by modifying silicotungstic acid (H4SiW12O40, abbreviated SiW12O40) with diverse MnL [L = Salen(L1), 5-Br-Salen(L2), 5-Cl-Salen(L3), 3-Me-Salen(L4), di-tBu-Salen(L5)] complexes, specifically derivatives featuring various substituents. All the compounds are characterized by IR spectra, elemental analyses and thermogravimetric analyses (TGA). The band gaps of 1.33–1.52 eV and energy bands are obtained through the measurement of UV-Vis DRS and Mott–Schottky. Photocatalytic experiments of (MnL1)4SiW12O40 (compound 1), (MnL2)4SiW12O40 (compound 2), (MnL3)4SiW12O40 (compound 3), (MnL4)4SiW12O40 (compound 4) and (MnL5)4SiW12O40 (compound 5) indicate that compound 2 catalyst exhibits the best photocatalytic properties (RhB degrades to 6% during 70 min) while all of them possess catalytic activity for photodegradation of RhB under UV irradiation. Free radical trapping experiments show that the addition of PBQ (·O2− trapping agents) makes the RhB residual ratio increase from 6% to 60% and indicates that ·O2− is playing a pivotal role. A possible mechanism of RhB photodegradation in the presence of compound 2 is proposed based on free radical trapping experiments and the energy bands. Future work could focus on fine-tuning the molecular architecture through strategic modification of the organic ligands and precise control of the metal-to-POM ratio, potentially leading to optimized electronic structures and enhanced charge transfer kinetics for superior photocatalytic performance in environmental applications.
研究领域:
材料科学
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环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Miaomiao Chen,Huili Zhao,Han Xue,Yan Liang,Min Ji,Min Wang
B(C6F5)3-based frustrated Lewis pairs (FLPs) have made remarkable progress in metal-free catalytic reduction. However, the high affinity of B(C6F5)3 for oxygen makes it susceptible to irreversible poisoning when exposed to H2O, limiting its widespread application in reductive amination. To overcome the influence of H2O, a hydrophobic catalyst, B(C6F5)3@Rn–1-MIL-101 (n = 3, 5, 7), was developed by confining B(C6F5)3 within the nanocages of metal–organic frameworks (MOFs) modified with alkyl chains. The hydrophobic strength of the catalyst could be adjusted by varying the length of the alkyl chain. At n = 3, the alkyl chain was too short to be hydrophobic, while the excessively long alkyl chain blocked the pore channels and adversely affected the loading of B(C6F5)3 at n = 7. Only the catalyst B(C6F5)3@R4-MIL-101 synthesized at n = 5 could effectively facilitate the reductive amination of aldehydes or ketones with amines in a “wet solvent.” The strategy of combining hydrophobic MOFs with B(C6F5)3 to prepare heterogeneous catalysts for FLP catalysis not only provides a fresh avenue for investigating catalytic systems for reductive amination but also represents an innovative approach to advancing FLP chemistry.
研究领域:
化学
·
催化科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 37
·15032-15038
·
IF 5.7
Haoran Wang,Jiahao Jiao,Abudukadi Tudi,Shilie Pan,Min Zhang
Two borates, K3Al2B11O21 (KABO) and K3Al2MoB9O21 (KAMBO), with edge-sharing [BO4] (ES-[BO4]) tetrahedra and different B–O configurations in one structure, were rationally designed and prepared at atmospheric pressure by introducing covalent tetrahedra. KABO is the first borate identified to have ES-[BO4] tetrahedra and two different dimensional B–O groups, namely, isolated [B6O12] groups with ES-[BO4] and one-dimensional infinite chains. In addition, KAMBO is a rare borate that features ES-[BO4] tetrahedra and two distinct isolated B–O groups ([B6O12] and [B3O6]). The discovery of these two compounds not only enriches the structures of borates, but also suggests a novel method for creating borates with ES-[BO4] tetrahedral structures and flexible B–O configurations at atmospheric pressure.
研究领域:
材料科学
·
晶体化学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Medical Sciences
·
2025
·Vol. 22
·期 4
·856-872
·
IF 3.2
Li Bowei,Yang Jingyuan,Wang Zhixing,He Mingzhu,Chen Xujing,Chen Yixuan,Shen Baoying,Chen Junru,Yang Chunqi,Li Tian,Lai Chengcai,Gao Yue,Cai Hong
Introduction: Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosaefolia (PS) have been traditionally used in dermatological treatments, though their mechanistic pathways in UVB-induced skin injury are not fully understood.Methods: In this study, a mouse model of UVB-induced solar dermatitis was employed to evaluate the therapeutic potential of combined PO and PS (POPS) extracts. After UVB irradiation, POPS extracts were administered, and their bioactive compounds were identified through ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). Network pharmacology, molecular docking, and pathway analysis were performed to identify key targets, focusing on the IL-17/CCL2 pathway and oxidative stress reduction.Results: Treatment with POPS extracts significantly diminished UVB-induced inflammation, erythema, and epidermal thickening in a dose-dependent manner. Network pharmacology and docking studies identified curvularin and olmesartan medoxomil as bioactive components with high affinity for IL-17 and IL-17RA targets, modulating the IL-17/CCL2 axis. In vivo experiments demonstrated that POPS extracts suppressed the expression of IL-17 and CCL2, reduced macrophage infiltration, and alleviated oxidative stress, effectively mitigating the symptoms of solar dermatitis.Conclusion: This study provides insight into the anti-inflammatory and protective properties of POPS extracts in solar dermatitis, highlighting their potential as a treatment through IL-17/CCL2 pathway modulation and oxidative stress reduction.
研究领域:
药理学
·
皮肤病学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 45
·期 5
·2631-2642
·
IF 3.288
Wei Hong,Chengcai Li,Tao Tang,Huan Xu,Yuan Yu,Guojin Liu,Feng Wang,Caihong Lei,Hailin Zhu
The immobilization of photocatalysts is considered an effective approach to solve the problem of the difficult recycling of powdered nanocatalysts after photocatalytic degradation. In this paper, tin dioxide/titanium dioxide (SnO2/TiO2) composite nanoparticles with excellent photodegradation performance and poly(vinylidene fluoride) (PVDF) resin were used as raw materials to prepare composite membranes for the catalytic degradation of rhodamine B (RhB) dye via a non-solvent-induced phase separation method. Specifically, the basic properties of SnO2/TiO2 composite nanoparticles were systematically analyzed, the photocatalytic performance of SnO2/TiO2/PVDF composite membranes was thoroughly investigated, and the photocatalytic mechanism has been revealed. Experimental results showed that the SnO2/TiO2 composite photocatalyst demonstrates a higher photocatalytic activity than the single photocatalyst with the SnO2/TiO2 composite comprising Sn/Ti in a molar ratio of 1 : 6, showing the highest photocatalytic performance. After SnO2/TiO2 composite particles were used as a kind of raw material for the production of PVDF membrane, the photocatalytic degradation rate of RhB by the SnO2/TiO2/PVDF composite membrane was as high as 91.84%. Moreover, ˙OH and h+ play a very important role in the whole photocatalytic degradation process. In summary, this paper will provide an effective guidance to improve the photocatalytic degradation of SnO2/TiO2/PVDF composite membranes, which will ultimately provide a broad potential application of photocatalysis in the field of water treatment.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 40
·5032-5042
·
IF 4.927
Haoyu Liu,Guolin Lu,Chun Feng,Xiaoyu Huang
A new monomer, 2-(difluoromethoxy)ethyl acrylate (DFMOEA), was first synthesized from commercially available 2-hydroxyethyl acrylate via a one-step difluoromethylation reaction. A series of well-defined poly(2-(difluoromethoxy)ethyl acrylate) (PDFMOEA) homopolymers were prepared via atom transfer radical polymerization (ATRP) of DFMOEA initiated by 2-bromopropionate. The Mn of the obtained polymer increased linearly with the monomer conversion, and the dispersities were low throughout the polymerization (Mw/Mn < 1.20) though some bimolecular recombination and side reactions occurred during the polymerization. The glass transition temperature (Tg) of the homopolymers obtained by using differential scanning calorimeter (DSC) is about −44 °C, 9 °C higher than that of poly(2-methoxyethyl acrylate) (PMOEA) homopolymer, which indicated that the introduction of difluoromethoxyl is beneficial for increasing the Tg. ATRP of DFMOEA initiated by a PEG-based macroinitiator provided poly(ethylene glycol)-b-poly(2-(difluoromethoxy)ethyl acrylate) (PEG-b-PDFMOEA) amphiphilic diblock copolymers with low dispersities (Mw/Mn < 1.26). The critical micelle concentrations (cmc) of PEG-b-PDFMOEA amphiphilic diblock copolymers in aqueous solution were determined by fluorescence probe technique and the cmc values decrease gradually with the increase of the length of hydrophobic PDFMOEA segment. It was found that PEG-b-PDFMOEA amphiphilic block copolymers could self-assemble into spherical micelles with a diameter of around ca. 45 nm in aqueous media which were visualized by transmission electron microscopy (TEM).
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2015
·
IF 1.098
Jianguo Yang,Shuo Liu,Huanan Hu,Shibin Ren,Anguo Ying
A simple and efficient method is proposed for the synthesis of tetrahydrobenzo[b]pyrans with aromatic aldehydes, active methylene compounds, and dimedone using basic ionic liquid catalyst in water. The procedure offers several advantages including short reaction time, good yield, easy procedure, and good recyclability of catalysts, which may be a practical alternative to conventional processes for preparation of 4-hpyrans.
研究领域:
有机化学
·
绿色化学
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DOI
高影响因子
Molecular Medicine Reports
·
2021
·Vol. 24
·期 5
·1-11
·
IF 2.952
Shuang Zhang,Sihan Lin,Qiaofei Tang,Zhiyong Yan
Allergic rhinitis (AR) is an IgE‑mediated upper airway disease with a high worldwide prevalence. MicroRNA (miR)‑205‑5p upregulation has been observed in AR; however, its role is poorly understood. The aim of the present study was to investigate the effect of miR‑205‑5p on AR‑associated inflammation. To establish an AR model, BALB/c mice were sensitized using an intraperitoneal injection of ovalbumin (OVA) on days 0, 7 and 14, followed by intranasal challenge with OVA on days 21‑27. A lentiviral sponge for miR‑205‑5p was used to downregulate miR‑205‑5p in vivo via intranasal administration on days 20‑26. Reverse transcription‑quantitative PCR revealed that miR‑205‑5p was upregulated in AR mice. Notably, miR‑205‑5p knockdown reduced the frequency of nose‑rubbing and sneezing, and attenuated pathological alterations in the nasal mucosa. The levels of total and OVA‑specific IgE, cytokines IL‑4, IL‑5 and IL‑13, and inflammatory cells, were decreased by miR‑205‑5p knockdown in AR mice. In addition, miR‑205‑5p knockdown inhibited nucleotide‑binding oligomerization domain‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome activation by reducing the expression levels of NLRP3, apoptosisassociated specklike protein containing a CARD, cleaved caspase‑1 and IL‑1β by western blot analysis. B‑cell lymphoma 6 (BCL6) was confirmed as a target of miR‑205‑5p by luciferase reporter assay. In conclusion, the present findings suggested that miR‑205‑5p knockdown may attenuate the inflammatory response in AR by targeting BCL6, which may be a potential therapeutic target for AR.
研究领域:
免疫学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
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