Journal of Chemistry
·
2020
·
IF 1.79
Yueyuan Chen,Jiaoyang Dang,Xiaojie Yan,Fenglai Lu,Dianpeng Li
Deep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides from Premna fulva Craib. DES-F, which was composed of choline chloride and 1,3-propanediol, showed the best extraction efficiency for the flavone di-C-glycosides, exceeding that of the conventional industrial solvent (40% ethanol). Subsequently, the extraction parameters for ultrasonic-assisted extraction (liquid-solid ratio, water content (%) in the selected DES, and extraction time) were optimized using response surface methodology. Furthermore, the microstructural alterations in the samples after extraction were evaluated using scanning electron microscopy. In addition, we further verified the recovery of flavone di-C-glycosides from the DESs using macroporous resins and evaluated the reusability of the DESs as solvents. The results indicated that DES-F was an efficient and sustainable solvent for the extraction of bioactive flavone di-C-glycosides from Premna fulva Craib. Therefore, this novel strategy may represent a sustainable approach for the extraction of bioactive products and could make phytochemistry more attractive and environmentally friendly.
研究领域:
植物化学
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环境科学
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DOI
高影响因子
JOURNAL OF CHEMICAL SCIENCES
·
2024
·Vol. 136
·期 3
·1-11
·
IF 1.7
Zhao Zhicai
A series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by recyclable10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost calcium carbide, an easy-to-handle acetylene source, and recyclable Pb/C catalysts. Graphic abstract The synthesis of a series of 1-carbonyl-1 H -indoles were prepared by 2-iodoanilines and calcium carbide in a one-pot reaction catalyzed by 10% Pb/C, resulting in the corresponding substituted indoles in good yields. This protocol offers several advantages, including the utilization of sustainable, low-cost feedstock, an easy-to-handle acetylene source, and recyclable Pb/C catalysts.
研究领域:
有机化学
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绿色化学
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DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 15
·7145-7157
·
IF 11.301
Jinling Xue,Yinshi Li,Jue Hu
It remains a major challenge to develop a facile method to prepare non-noble metal electrocatalysts with high activity and durability to drive the sluggish oxygen reduction reaction (ORR) for proton exchange membrane fuel cells (PEMFCs). Herein, a highly efficient bimetallic Zn/Fe@N-doped hierarchical porous carbon (Zn/Fe–N–C) catalyst derived from ZIF-8 and hemin (host–guest) was firstly reported by one-step thermal treatment. Fe2+ spatially separated by using the hemin guest in the ZIF-8 framework and hydrocarbon-branched chains form rich Fe–Nx active sites, and the evaporation of Zn2+ generates a highly porous structure in the Zn/Fe–N–C catalysts. Benefitting from this unique structure and composition, the resulting Zn/Fe2–N–C catalyst exhibits excellent ORR activities in both 0.1 M KOH (onset potential, Eonset = 1.08 V, and half-wave potential, E1/2 = 0.86 V vs. RHE) and 0.5 M H2SO4 media (Eonset = 1.04 V and E1/2 = 0.81 V), which are even comparable to those of the commercial Pt/C catalyst, and ranks among the top reported electrocatalysts. In addition, it also has outstanding long-term durability and good methanol resistance, much better than those of Pt/C in both acidic and alkaline media, which makes it one of the best non-noble alternatives of Pt-based catalysts for ORR electrocatalysis. This work highlights the potential to rationally design and fabricate high-performance ORR catalysts for fuel cell applications.
研究领域:
材料科学
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电化学
·
催化
·
能源材料
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2021
·Vol. 22
·期 11
·5680
·
IF 5.924
Long Tang,Jianchun Jiang,Guoqiang Song,Yajing Wang,Ziheng Zhuang,Ying Tan,Yan Xia,Xianfeng Huang,Xiaoqing Feng
Urolithins (hydroxylated 6H-benzo[c]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6H-benzo[c]chromen-6-one derivatives were designed and synthesized. Furthermore, their biological activities were evaluated as potential PDE2 inhibitors, and the alkoxylated 6H-benzo[c]chromen-6-one derivative1fwas found to have the optimal inhibitory potential (IC50: 3.67 ± 0.47 μM). It also exhibited comparable activity in comparison to that of BAY 60-7550 in vitro cell level studies.Keywords:alkoxylated 6H-benzo[c]chromen-6-one;phosphodiesterase II;inhibitors;biological activities
研究领域:
药理学
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有机化学
·
神经科学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 2
·1454-1459
·
IF 3.086
Limei Zhou,Mengyun Yin,Xiaohui Jiang,Qiang Huang,Wencheng Lang
1,3-Diamino-graphene (NH2-G-NH2) materials were synthesized using a simple chemical method. The as-prepared materials were characterized using FT-IR, TG, XRD, XPS, and SEM measurements. The results revealed that a 1,3-diamino group was successfully grafted on graphene and could immobilize CuI by coordination interactions. The NH2-G-NH2 materials can be used as heterogeneous ligands for CuI-catalyzed C–N coupling reactions, and the desired products were obtained with good yields. The reaction system is much smoother at lower temperature compared with others previously reported. Additionally, the new method can easily realize the purification of products and recycling of catalysts.
研究领域:
材料科学
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有机化学
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催化化学
✓ 已验证
DOI
高影响因子
JOM
·
2022
·Vol. 75
·期 6
·1982-1992
·
IF 2.597
Qiu Yuchao,Shi Junjie,Hou Changle,Dong Jingjing,Zhai Yumo,Li Kaixuan,Yan Sen,Yu Kai,Li Jianzhong,Liu Changsheng
The spinel and pseudobrookite type ceramic materials have been widely used in different industries including ceramics, refractory and metallurgy. Therefore, their physicochemical properties are important for the development of related processes. In this regard, it is important to understand the formation principles of the spinel and pseudobrookite solid solutions. In the present work, the equilibrium phase relations for the MgO-Al 2 O 3 -TiO 2 system at 1700°C in air were experimentally determined by high-temperature equilibration-quenching technique followed by XRD and SEM–EDS analyses. The pseudobrookite solid solution was found to be coexisting with spinel solid solution and rutile phase, respectively. The composition evolution and formation principles of the pseudobrookite and spinel solid solutions were further elucidated from the corresponding crystal structures and composition relations. Furthermore, great discrepancies were observed when the 1700°C isotherm from the present work was compared with the isotherm simulated by FactSage 8.1. The evolution of the solid solution existing area was intuitively presented with reference to the experimental data from the literature. The results from present work are important for the development of spinel and pseudobrookite solid solution ceramics as well as the optimization of the thermodynamic database for oxide systems.
研究领域:
材料科学
·
陶瓷工程
·
热力学
✓ 已验证
DOI
高影响因子
STAR Protocols
·
2022
·
IF 0
Tao Shen,Wenhao Li,Yan Zhao,Yunqi Liu,Yang Wang
Summary Syntheses using classic coupling reactions can be tedious, leading to a dearth of ambipolar semiconducting polymers. Here, we detail the rapid synthesis of balanced ambipolar polymers by using a carbon-hydrogen (C–H) activation strategy. Using this protocol, two C–H reactive hydrogenated monomers and six ambipolar polymers can be rapidly synthesized within 2 h via C–H activation and the optoelectronic properties of the resultant polymers can be characterized. We also describe the fabrication process and performance evaluation of the ambipolar polymers-based organic transistors. For complete details on the use and execution of this protocol, please refer to Shen et al. (2022) .
研究领域:
材料科学
·
有机电子学
·
化学合成
✓ 已验证
DOI
PubMed
FOOD AND CHEMICAL TOXICOLOGY
·
2022
·
IF 5.572
Ke Zhang,Hui Zeng,Jingyu Feng,Zhengkun Liu,Zhenyu Chu,Wanqin Jin
Allura red (AR) is a member of azo dyes is commonly used as an additive in foods and soft drinks. However, due to the special harm of the azo structure to the human body, the dosage control of AR becomes particularly necessary. The present detection methods are time-consuming, expensive and complicated. In order to address the above issues, a core-shell nanocubes constructed sensor has been developed to determine the ultrawide detection range and selective recognition of AR with a long-term reusability. The core-shell architecture is composed of carbon material of 12.64 nm thickness covering 600 nm Mn 3 O 4 nanocube. This nanocomposite combines the advantages of Mn 3 O 4 @C, possessing high electrocatalysis and chemical stability. As confirmed in using sports drinks as real samples, the as-prepared AR sensor exhibites excellent selectivity with an ultra-wide linear range from 0.1 to 1748.4 μM, and meanwhile, this sensor can also meet the requirements of remarkable anti-interference and reusability over 30 days.
研究领域:
材料科学
·
分析化学
·
食品科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Cancer
·
2019
·
IF 3.182
Mingtong Ye,Nengzhi Pang,Ting Wan,Yuanling Huang,Tianyi Wei,Xuye Jiang,Yujia Zhou,Yufeng Huang,Hainan Yang,Zhenfeng Zhang,Lili Yang
Switching aerobic respiration to anaerobic glycolysis of cancer cells plays an important role in development and progression of acquired resistance. Since vitamin C enabled the inhibition of glycolysis of cancer cells, and erlotinib-resistant sub-line of HCC827 (ER6 cells) switched its metabolic features to higher glycolysis for survival, we hypothesize that vitamin C is able to inhibit glycolysis of ER6 cells. In this study, we found that both reduced vitamin C and oxidized vitamin C (DHA) could selectively suppress the viability of ER6 cells. DHA was efficient in inhibiting glycolysis and leading to energy crisis, which could be one mechanism for overcoming drug resistance to erlotinib of ER6 cells. Our data suggest that applying DHA could be a novel treatment strategy for NSCLC with acquired resistance to targeted therapy.
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale Research Letters
·
2020
·Vol. 15
·期 1
·1-10
·
IF 3.578
Wang Shan,Fu Jing,Zhang Fang,Huan Ruirui,Liu Ting,Zeng Xingguo
Abstract A 0D/2D (0-dimensional/2-dimensional) nanostructure was designed by self-assembly of N–C QDs and carboxylated g-C 3 N 4 nanosheets and used as a fluorescence resonance energy transfer (FRET) fluorescent sensor. The N–C QDs/g-C 3 N 4 nanosheets were synthesized via the amino group on the N–C QD surface and the –COOH of the carboxylated g-C 3 N 4 nanosheets. The mechanism of detection of metronidazole (MNZ) by N–C QDs/g-C 3 N 4 nanocomposites is based on FRET between negatively charged N–QDs and positively charged carboxylated g-C 3 N 4 nanoparticles. N–C QDs/g-C 3 N 4 nanostructures displayed good responses for the detection of MNZ at normal temperature and pressure. The decrease in the fluorescence intensity showed a good linear relationship to MNZ concentration within 0–2.6 × 10 −5 mol/L, and the detection limit was 0.66 μM. The novel FRET sensor will have a great potential in clinical analysis and biological studies. Graphical Abstract
研究领域:
分析化学
·
生物医学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 106
·104398-104406
·
IF 3.289
Cong Zhang,Jingbo Qi,Jing Xing,Si-Fu Tang,Liang Song,Yuanyuan Sun,Chuanhui Zhang,Hongchuan Xin,Xuebing Li
Aqueous phase catalytic upgrading of lignin monomers to hydrocarbons via hydrodeoxygenation (HDO) has been explored using a combination of Pd/C and HZSM-5 catalysts under 2 MPa of H2 (ambient temperature). Model monomers with varying numbers of methoxy groups, including phenol, anisole, guaiacol and 2,6-dimethoxy-phenol, were chosen as lignin model compounds. Mechanistic studies revealed cascade and parallel reaction pathways via hydrogenation and dehydration (hydrolysis) processes, which were catalyzed by Pd/C and HZSM-5, respectively. Hydrogenation was preferred at lower temperature, whereas higher temperature was favorable for the removal of oxygen-containing functional groups. The effect of methoxy groups on the HDO of these monomers was also investigated systematically. Basically, the conversion of multi-substituted monomers was tougher than that of mono-substituted ones, due to steric constraint and the inhibition of the electron-donating hydroxyl group. The selectivities to cyclohexane from phenol and anisole were improved significantly by increasing the temperature to 413 K. However, cyclohexanone was preferably produced over cyclohexane when using model compounds with multi-substituents (guaiacol and 2,6-dimethoxy-phenol), even at temperatures above 513 K. Comparative experiments were also conducted on the HDO of 1,2-cyclohexanediol with or without the presence of phenol, which clearly suggested that the further HDO of guaiacol and 2,6-dimethoxy-phenol was inhibited, probably due to the strong interactions between cyclohexanediol molecules and Brønsted acid sites.
研究领域:
化学工程
·
催化反应
✓ 已验证
DOI
高影响因子
CARBON
·
2023
·
IF 10.9
Jie Li,Jie Sheng,Ziyue Yang,Zhaoyuan Liu,Yunzhong Wu,Changsheng Xing,Jiaxu Shuang,Bin Liu,Tong Zhang,Zhaoyu Chen,Lidong Wang,Weidong Fei
Graphene is the strongest material ever identified. However, the fabrication of graphene-based bulk materials from graphene powders presents a significant challenge. Here, a new strategy to fabricate high performance graphene based bulk materials by introducing silicon nanoparticle is proposed. Consequently, ultra-high compressive strength and high flexural strength are achieved, measuring as high as 1102 MPa and 455 MPa, respectively. The compressive strength at the microscale even reaches a remarkable 5.17 GPa. The superior strength of the bulk material is primarily attributed to the Y-type carbon structure and Si-C bonds. The Y-type carbon structures in graphene, produced by the self-propagating high-temperature synthesis (SHS) method, and the Si-C covalent bonds formed at the interface between graphene and SiC contribute to a tight linkage of graphene sheets , thereby preventing slippage of graphene sheets. In addition, the microstructure evolution process of Si-SHS-graphene bulk material is clarified. With the introduction of silicon nanoparticles, the oxidation resistance of graphene based bulk materials is substantially improved, the weight loss is around 6% after oxidized at 1000 °C. This study carries extensive implications for understanding the impact of Y-type carbon structures and the effect of Si-C bonds in graphene-based bulk materials.
研究领域:
材料科学
·
力学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）