Surfaces and Interfaces
·
2025
·
IF 6.3
Ziqian Ding,Xiaolin Qiu,Huaxuan Liu,Lingli Gu
Functional form-stable phase change materials (FPCMs) offer great promise for thermal management in transport packaging due to their stability after phase change cycle and the extension of service life. However, challenges remain in enhancing thermal conductivity and energy storage efficiencies. In this study, a magnetically aligned h-BN-embedded superporous carbon foam-based FPCM containing paraffin (M-BN-CPCMs) was fabricated via a foam polymerization method followed by high-temperature carbonization. A super-porous hydrogel (SPH) precursor was used to construct a robust, highly porous carbon skeleton to accommodate more PCMs. To further enhance thermal conductivity, h-BN was functionalized with Fe 3 O 4 nanoparticles, and the resulting BN-Fe 3 O 4 was magnetically oriented within the carbon skeleton using a synchronous magnetization process. This novel design achieved a thermal conductivity improvement of over 90% compared to SPH. Additionally, the synergistic photothermal conversion effect achieved by the magnetic nanoparticles and carbon skeleton resulted in an outstanding photothermal conversion efficiency of approximately 90% for M-BN-CPCMs. Notably, the incorporation of BN-Fe 3 O 4 increased pore sizes, enabling higher paraffin loading capacity. The M-BN-CPCMs with large holes exhibit a remarkable phase change enthalpy of 154.9 J/g, demonstrating excellent energy storage capability, which surpasses that of superporous carbon foam skeleton-based FPCMs (CPCMs). The optimized M-BN-CPCMs demonstrated superior thermal energy storage, faster thermal charging rates, and improved thermal regulation, effectively reducing temperature fluctuations within insulated packaging. These findings underscore the potential of M-BN-CPCMs as a groundbreaking solution for energy storage and thermal management in transport packaging, addressing critical challenges in the field.
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Processes
·
2022
·Vol. 10
·期 6
·1165
·
IF 3.352
Erdong Yao,Bojun Li
This paper presents a low-cost, high-temperature-resistant and high-strength polyacrylamide gel system formed by secondary cross-linking. The gel system (named JM186) used phenolic resin and organic zirconium as cross-linking agents, and the performance of the gel system was systematically evaluated under high temperature. The gel properties studied include: gel formation time, gel strength, thermal stability, sand-filled pipe sealing efficiency, and its microstructure. The concentration of polyacrylamide in JM186 gel system was as low as 0.3%, which can control the gelling time in a range of 1–9 h by adjusting the ratio of two cross-linking agents. It can resist temperature up to 120 °C without dehydration, and its highest gel strength can reach H grade. The modulus of elasticity (G’) and viscosity (G”) can reach 32.33 Pa and 3.25 Pa, respectively. DSC (differential scanning calorimetry) test indicated that the temperature of structural failure for this composite gel is 310.5 °C. The average sealing efficiency of the gel is 96.03% in sand-filled pipes. Finally, the gel microstructure was observed by cryo-scanning electron microscopy (Cryo-SEM). It was found that the gel system by secondary cross-linking has a dense and thickened network structure compared with the single cross-linker gel system. The gel is cross-linked by both the coordination bond and covalent bond, and the two cross-linking agents have a synergistic effect. This is the reason why the secondary cross-link gel system is better than the single-cross-linker gel system.
研究领域:
材料科学
·
石油工程
·
化学工程
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高影响因子
Nanomedicine-Nanotechnology Biology and Medicine
·
2021
·
IF 6.458
Song-Bin Yang,Xiao-Liu Li,Kai Li,Xin-Xin Zhang,Mei Yuan,Yi-Sha Guo,Xia Bi
Stroke is one of the most serious problems that seriously affect people's health and brings huge economic burden to society. The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In recent years, nano drug delivery system has developed rapidly and applied to treat ischemic stroke . Here, we report the synthesis and functionalization of monodisperse hollow structured MnO 2 (H-MnO 2 ). The highly monodisperse H-MnO 2 with uniform morphology was obtained by in situ growing MnO 2 on solid silica nanoparticles and subsequently removing the silica core. After successive modification of poly ethylene glycol(PEG), we further verified their protective effect on ischemic stroke in our study.
研究领域:
医学
·
生物材料学
·
神经科学
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PubMed
高影响因子
Scientific Reports
·
2022
·Vol. 12
·期 1
·1-8
·
IF 4.996
Weng Yue,Su Chun-Jen,Jiang Haoyang,Chiang Chien-Wei
Site-selectively chemical bioconjugation of peptides and proteins can improve the therapeutic exploration of modified protein drugs. Only 3.8% natural abundance of phenylalanine in protein and nearly 90% of proteins contain at least one phenylalanine residue in their sequenced, showing the potential in biopharmaceutical utility of the phenylalanine bioconjugation. However, the covalent bioconjugation of native phenylalanine is one of the most challenging problems in protein modification. Herein, an approach to protein modification is described that relies on a photoredox method for the site-selective bioconjugation of phenylalanine. This methodology has been validated on peptides as well as protein insulin using a straightforward and mild condition. In addition, based on characterization by near-UV CD spectroscopy and small angle X-ray scattering (SAXS), this pyrazole labeling approach permitted the insulin hexamer to completely dissociate into the monomeric form, thus making it a potential candidate for use as rapid-acting insulin for the treatment of diabetes.
研究领域:
生物化学
·
药物化学
·
分子生物学
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Molecular Metabolism
·
2024
·
IF 7
Binyu Lu,Shanshan Guo,Jialin Zhao,Xiaoting Wang,Bing Zhou
Objective Ferritin, the principal iron storage protein, is essential to iron homeostasis. How iron homeostasis affects the adipose tissue is not well understood. We investigated the role of ferritin heavy chain in adipocytes in energy metabolism. Methods We generated adipocyte-specific ferritin heavy chain ( Fth , also known as Fth1 ) knockout mice, herein referred to as Fth AKO . These mice were analyzed for iron homeostasis, oxidative stress, mitochondrial biogenesis and activity, adaptive thermogenesis, insulin sensitivity, and metabolic measurements. Mouse embryonic fibroblasts and primary mouse adipocytes were used for in vitro experiments. Results In Fth AKO mice, the adipose iron homeostasis was disrupted, accompanied by elevated expression of adipokines, dramatically induced heme oxygenase 1( Hmox1 ) expression, and a notable decrease in the mitochondrial ROS level. Cytosolic ROS elevation in the adipose tissue of Fth AKO mice was very mild, and we only observed this in the brown adipose tissue (BAT) but not in the white adipose tissue (WAT). Fth AKO mice presented an altered metabolic profile and showed increased insulin sensitivity, glucose tolerance, and improved adaptive thermogenesis. Interestingly, loss of ferritin resulted in enhanced mitochondrial respiration capacity and a preference for lipid metabolism. Conclusions These findings indicate that ferritin in adipocytes is indispensable to intracellular iron homeostasis and regulates systemic lipid and glucose metabolism.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2015
·
IF 2.587
Yujia Xie,Fengyong Zhang,Pingle Liu,Fang Hao,Hean Luo
Direct functionalization of saturated C–H bonds by metalloporphyrin catalysts is among the topical and challenging areas within the chemical industry and synthetic chemistry. In this work, supported CoD(p-Cl)PPCl metalloporphyrin catalysts were prepared and characterized. It has been found that the CoD(p-Cl)PPCl/ZnO catalyst shows better catalytic activity than the supported catalyst (ZrO2, MCM-41, kaolin, Zr(OH)2, and boehmite (BM)) in cyclohexane oxidation with dioxygen. The effects of the reaction pressure, reaction temperature, and reaction time on the catalytic activity were considered by the supported CoD(p-Cl)PPCl/ZnO catalyst. The CoD(p-Cl)PPCl/ZnO catalyst can be facilely recovered and was recycled up to seven times without a significant decrease in catalytic performance. The average cyclohexane conversion and selectivity to KA oil are 10.98% and 84.34%, respectively, and the turnover number is 2.10 × 107.
研究领域:
催化化学
·
有机合成
·
工业化学
·
材料化学
·
绿色化学
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Wei Yang,Chenyuan Weng,Xiaoyun Li,Hongliang He,Jianwen Fei,Wei Xu,Xiaoqiang Yan,Wanying Zhu,Hongsong Zhang,Xuemin Zhou
At present, artificial mimic enzyme has become a powerful substitute for natural enzyme. In particular, the biosensors based on nano-enzymes have been the focus of current research. Herein, a novel magnetic ternary nanocomposite hemin-Fe 3 O 4 @polypyrrole (h-Fe 3 O 4 @ppy) was synthesized by chemical oxidation polymerization. The results showed that the h-Fe 3 O 4 @ppy had stronger peroxidase activity than Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) and h-ppy NPs, and was indicated by Michaelis-Menten constant (K m ) and maximum initial velocity (V max ). Therefore, we used h-Fe 3 O 4 @ppy catalyzing H 2 O 2 to oxidize the chromogenic substrate TMB, and built Hydrogen peroxide (H 2 O 2 ) and Glutathione (GSH) colorimetric biosensors with the help of signal intrinsic exponential amplification and easy operation. The controllable catalysis was realized by h-Fe 3 O 4 @ppy which was prone to separation. The method of removing h-Fe 3 O 4 @ppy by magnetic separation effectively eliminated the effect of residual catalysis when terminating the reaction. The sensor was then applied to the determination of GSH in biological samples from acute coronary syndrome patients. The linear ranges of H 2 O 2 and GSH were 0.2–100 μM and 0.5–80 μM, respectively. The detection limits of H 2 O 2 and GSH are 0.18 μM and 0.15 μM, respectively. This research not only proposes a new type of nanoenzyme, but also shows the multiple advantages of magnetic nano-enzymes for the construction of biosensors.
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高影响因子
LIQUID CRYSTALS
·
2014
·
IF 2.349
Fafu Yang,Jin Yuan,Congcong Li,Hongyu Guo,Xiaoyun Yan
Series of triphenylene derivatives with multiple NH groups 3a, 3b, 4a, 4b, 5a and 5b were designed and synthesised by simple procedures in high yields. Their structures were confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), mass spectrometry (MS) and elemental analysis. Their mesophase behaviours were studied by differential scanning calorimetry, polarising optical microscopy and X-ray diffraction. The triphenylene derivatives 3a and 3b with two NH groups and triphenylene derivatives 4a and 4b with three NH groups possess excellent mesomorphic properties. Compounds 4a and 4b exhibited wider mesophase than compounds 3a and 3b. Triphenylene derivatives 5a and 5b with five NH groups have no mesomorphic properties. These results suggested the units of hydrogen bonds played the crucial roles on mesomorphic properties and acylthiosemicarbazide group with three NH groups was a good functional group for producing excellent mesomorphic properties.
研究领域:
材料化学
·
物理化学
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高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Hongyi Shi,Weiqu Liu,Chunhua Liu,Maiping Yang,Yankun Xie,Shuo Wang,Fengyuan Zhang,Liyan Liang,Ke Pi
Herein, h-BN powders were sonicated in an aqueous solution of polyethylenimine (PEI) to simultaneously exfoliate and functionalize h-BN nanosheets with Lewis acid-base interaction. The structure and morphology of PEI modified h-BN nanosheets (PEI-BNNSs) were characterized by FTIR, TGA, AFM and TEM. The as-prepared PEI-BNNSs were served as anticorrosive nanofillers for waterborne epoxy (EP) coatings on Q235 carbon steel. The corrosion behaviors of EP and PEI-BNNSs/EP coating systems in 3.5 wt % NaCl aqueous solution were evaluated by electrochemical workstation. It is worth noting that the protection efficiency (PE) values of 1 wt % PEI-BNNSs/EP and 2 wt % PEI-BNNSs/EP coating systems are as high as 99.99 % compared to EP coating systems. Moreover, the impedance modulus (|Z| f = 0.01 Hz ) of the 1 wt % PEI-BNNSs/EP coating system was 3–4 orders of magnitude higher than the EP coating after 90 days of immersion. The electrochemical results revealed that PEI-BNNSs can significantly enhanced the corrosion resistance of waterborne epoxy coatings.
研究领域:
材料科学
·
腐蚀与防护
·
纳米技术
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Qu Tang,Xiaobo Zhou,JinXia Liu,Mingmin Wu,Haiwei Ji,Qi Wang,Guo Li,Hui Cong,Yuling Qin
The use of Formic acid as an alternative to fossil fuels is promising, both from economical and ecological standpoints, and has received great of attention owing to its inherently superiority in recent decades. Nevertheless, efficient and low-cost solid catalyst for formic acid dehydrogenation at room temperature still constitutes a biggish challenge. Moreover, comparing to increase the catalytic performance of catalysts, very little attention payed to the kinetic mechanism of dehydrogenation reaction because of the lack of effective characterization artifice. Here, the as-prepared Ni@Pd nanoparticles by a sequential reduction process can be useful catalyst for formic acid decomposition at room temperature without a promoter. Thanks to the effective catalyst and isotope distribution technique, preliminary mechanistic results firstly reveal that hydrogen is obtained via a H-atom recombination on isolated sites after the proton exchange randomly between activated H and solvent.
研究领域:
材料科学
·
催化化学
·
能源科学
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DOI
高影响因子
CURRENT PHARMACEUTICAL DESIGN
·
2022
·Vol. 28
·期 9
·743-750
·
IF 3.31
Ning Zhouyu,Yang Lina,Yan Xia,Wang Dan,Hua Yongqiang,Shi Weidong,Lin Junhua,Meng Zhiqiang
Background: To investigate the effects of the Lenvatinib@H-MnO2-FA administration system on the proliferation and apoptosis of Intrahepatic cholangiocarcinoma (ICC) and the underlying molecular mechanism. Materials and Methods: In this research, hollow MnO2
(H-MnO2) was synthesized via the modified Stöber method, and H-MnO2 was modified with polyethylene glycol-bis (Amine) (NH2-PEG-NH2) and folic acid (FA) to obtain H-MnO2-PEG-FA (H-MnO2-FA).
Lenvatinib was coated in the hollow cavity of H-MnO2-PEG-FA to further form a nanometre drug-carrying system (Lenvatinib@H-MnO2-PEG-FA). Lenvatinib@H-MnO2-FA was characterized through transmission electron microscopy (TEM)
and scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FT-IR) was used to verify that Lenvatinib was loaded on nanoparticles. Functionally, confocal laser scanning microscopy (CLSM), 2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride (DAPI) staining, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide (MTT) assay were performed to determine the effect of Lenvatinib@H-MnO2-FA on the proliferation and apoptosis of ICC cells (9810 cells). Finally, the protein levels of Raf-1MEK1/2-ERK1/2 signalling pathway components were detected through Western blotting analysis.
Results: We successfully synthesised a Lenvatinib@H-MnO2-PEG-FA administration system. The resulting nanomaterials had excellent biological stability and improved targeting effects. Functionally, Lenvatinib@ H-MnO2-FA inhibited the proliferation
of 9810 cells. The Bcl-2 protein level was significantly downregulated, and the caspase-3 protein level was significantly upregulated, indicating that Lenvatinib@H-MnO2- PEG- FA promoted the apoptosis of 9810 cells. Mechanistically, Lenvatinib@H-MnO2-FA
increased the phosphorylation levels of Raf, MEK1/2, and ERK1/2. Conclusion: H-MnO2-FA can more effectively deliver Lenvatinib to inhibit proliferation and promote apoptosis in ICC, which could be the promising drug delivery nano-vehicles for delivery drugs.
研究领域:
药理学
·
肿瘤学
·
纳米技术
·
细胞生物学
·
分子生物学
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PubMed
高影响因子
Nature Catalysis
·
2026
·
IF 48.3
Ding Liang,Yao Ze-Cheng,Tang Tang,Wan Xin,Liu Xiaozhi,Jiang Zhe,Fu Jiaju,Shi Zhuo-Qi,Tai Jing,Lyu Zhen-Hua,Dong Jichen,Li Qing,Su Dong,Shui Jianglan,Hu Jin-Song,Wan Li-Jun
High-performance cathode catalysts are essential for proton-exchange membrane fuel cells. Intermetallic nanocrystals are promising candidates but suffer from intrinsic activity–durability trade-offs because their comprehensive catalytic properties are determined by several intertwined structural factors that cannot be optimized independently by existing synthesis techniques. The challenge lies in the inherent thermodynamic and kinetic constraints during synthesis. Here we develop a decoupled synthesis strategy that leverages block-copolymer micelle confinement, which enables the customized synthesis of libraries of intermetallic nanocrystals, simultaneously achieving ultra-small size, ultra-high ordering degree, tailorable loading density, narrow size distribution, compositional uniformity, and broad compositional and substrate universality. The developed Pt 3 Co intermetallic nanocrystal/Ketjenblack catalyst achieves a rated power density of 1.08 W cm −2 and 92% rated power retention after 30,000 cycles under light-duty-vehicle conditions and 900 h of stable operation at 10 A. It also delivered a 70.2% cell efficiency without degradation and 98.4% specific power retention after 90,000 cycles of heavy-duty-vehicle applications. This performance led us to project a lifetime of 240,000 h.
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