Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 16
·9665-9672
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IF 10.733
Kanghua Li,Siyu Wang,Chao Chen,Rokas Kondrotas,Manchen Hu,Shuaicheng Lu,Chong Wang,Wei Chen,Jiang Tang
Sb2Se3 is a promising non-toxic, Earth-abundant, stable thin-film solar cell absorber material. However, the low built-in potential caused by the low intrinsic doping density (∼1013 cm−3) and the low carrier collection efficiency due to the low carrier mobility (∼1.5 cm2 V−1 s−1) hinder further efficiency improvement of Sb2Se3 solar cells. Therefore, an effective hole-transport layer (HTL) is necessary to further boost the built-in potential and assist carrier collection. Herein we attempt to improve the efficiency of Sb2Se3 solar cells by using CuSCN as an HTL. CuSCN as an HTL suppresses the back surface recombination, and enhances the built-in potential and carrier collection efficiency. Meanwhile, materials and physical properties characterization reveals that CuSCN provides Cu ions which induce grain boundary inversion, and therefore separate photo-generated carriers more efficiently. Consequently, we obtained a device efficiency of 7.50%.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 3.8
Wang Li,Li Lei,Chen Wei,Zhang Mingcui
Acute myocardial infarction (AMI) poses a severe threat to human health, making its rapid and sensitive diagnosis crucial. Cardiac troponin I (cTnI) has been established as the gold standard biomarker for AMI diagnosis. Herein, a dual-mode immunosensor was constructed by integrating manganese dioxide (MnO 2 ) nanozyme and fluorescence carbon dot (B-CDs) in silica (SiO 2 ), termed B-CDs@SiO 2 @MnO 2 , for the colorimetric and fluorescent detection of cTnI. The sensing signal mainly included two parts: B-CDs@SiO 2 @MnO 2 -based catalytic color reaction and B-CDs@SiO 2 fluorescence recovery after etching MnO 2 . The MnO 2 nanozyme catalyzes the oxidation of TMB to generate blue-colored TMBox, which turns yellow upon acid addition, enabling colorimetric detection. Concurrently, the MnO 2 nanosheets quench the fluorescence of B-CDs@SiO 2 . In the presence of ascorbic acid (AA), MnO 2 is reduced to Mn 2+ , leading to fluorescence recovery and thus enabling fluorescent detection. Profiting from the superior self-correction features of B-CDs@SiO 2 @MnO 2 dual-mode sensor, this method exhibits good linearity and sensitivity toward cTnI among 0.05–50 ng/mL, with detection limits of 0.0074 ng/mL for the colorimetric mode and 0.0063 ng/mL for the fluorescent mode. In addition, the human serum samples’ recoveries show good agreement between the colorimetric mode (90.0–117.8%) and the fluorescent mode (90.2–115.8%). Furthermore, we employ this platform to monitor cTnI levels in both cellular and blood samples from AMI patients, indicating the promising clinical application potential of this platform.
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Nature Communications
·
2026
·
IF 15.7
He Qingyun,Wang Junbo,Wu Mengyang,Zhong Chongyu,Li Lei,Zhao Xiangru,Ding Mengzhu,Yang Pinghui,Li Renzhi,Huang Wei,Qin Tianshi,Wang Fangfang
Formamidinium lead iodide (FAPbI 3 ) perovskite is a leading candidate for high-efficiency solar cells, but its application is hindered by the kinetic instability of its α-phase crystallization. Here, a highly effective strategy for directing the ordered crystallization of α-FAPbI 3 in the n-i-p architecture is developed by incorporating a self-assembled molecule (SAM) into the anti-solvent, unlike conventional phosphate-based SAMs requiring polar protic solvents, the -SCN SAM are processed from non-polar, aprotic solvents compatible with perovskite surfaces. An in-situ formed, self-assembled layer acts as a dynamic template, guiding the top-down crystallization process to yield highly ordered α-phase films. Through a series of in-situ measurements, it is rigorously demonstrated that this SAM treatment suppresses undesirable intermediate phases, accelerates the δ-to-α transition, and strategically slows crystal growth, promoting highly ordered films. This meticulously designed strategy culminates in high-quality perovskite films, enabling single-junction devices with a champion power conversion efficiency (PCE) of 26.18% (certified at 25.67%) and mini-modules with a PCE of 21.70%. These results underscore the power of directed self-assembly in fabricating highly efficient and stable n-i-p perovskite solar cells.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Yuanheng Mu,Yun Ling,Tangkun Wang,Bin Sun,Nan Yang,Meng Zhang,Pengpeng Dai
Near-infrared (NIR) luminescence capable of covering NIR-I and NIR-II is highly promising for biomedical imaging and non-invasive inspection. However, achieving both broadband and long-wavelength emission remains challenging due to the activator ion site-occupation constraints. In this work, we report La 3 TiGa 5 O 14 :Cr 3+ (LTG:Cr 3+ ) phosphor that exhibits an ultrawideband NIR emission spanning the spectral range of 650–1400 nm. The underlying mechanism involves Ti and Ga site exchange, which triggers local polyhedral reorganization. This structural transformation creates a weak crystal field, large Stokes shift, lower energy barrier of activator ion site occupancy, and more sites favorable for Cr 3+ incorporation ─ collectively relaxing Cr 3+ site-occupation constraints. The optimized LTG:0.03Cr 3+ phosphor exhibits NIR emission at 1017 nm with an exceptionally broad full width at half maximum (FWHM) of 476 nm. Moreover, introducing Ta 5+ as a charge-compensating dopant boosts NIR emission intensity by nearly 3.9-fold. A prototype NIR LED device fabricated with this phosphor demonstrates effective multi-channel signal detection. This work advances site-occupancy engineering from extrinsic doping to intrinsic polyhedral reorganization, providing a molecular design framework for high-performance NIR phosphor.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Yi Tan,Yuxuan Chen,Renren Wang,Shouye Liu,Feiyang Hu,Quan Yu,Yawen Liu,Guangyuan Chen,Zilin Zeng,Hao Xiao,Chuan Tan,Tao Duan,Lin Zhu
Two cationic functional woods with highly density nitrogen functional group are synthesized. • Q-BW and Gua-BW exhibit the fast uptake adsorption kinetics (within 5 min) of I - and IO 3 - through strong electrostatic interactions. • Gua-BW containing guanidine groups achieves roughly ten times the maximum IO3- sorption capacity of Balsa wood via electrostatic and redox. • Gua-BW, derived from renewable Balsa wood with low cost, displays excellent adsorption capacity and favorable reusability. Compared to conventional adsorbent carriers, Balsa wood (BW) has the superiority of being low-cost and environmentally friendly. Herein, quaternary ammonium-functionalized Balsa wood (Q-BW) and guanidine-functionalized Balsa wood (Gua-BW), as two cationic functional woods, are synthesized directly from natural Balsa wood via grafting high-density nitrogen-containing groups. The two modified woods exhibited remarkably high adsorption rates for I - and IO 3 - through electrostatic interactions, reaching adsorption equilibrium within 5 min. The maximum adsorption performance reached 120 mg·g −1 for I - and 220 mg·g −1 for IO 3 - , which was 10 times higher than that of natural Balsa wood. Notably, grafting with guanidino groups endows Gua-BW with redox ability, thereby significantly enhancing its adsorption performance for IO 3 - . Furthermore, Gua-BW demonstrates excellent reusability, retaining stable adsorption efficiency after 5 cycles. As a cationic porous wood material with ultrahigh positive charge density, Gua-BW possesses properties of being green, low-cost, renewable, and having significantly higher adsorption rates for I - and IO 3 - , which provides a new approach for applications in the field of iodine-containing wastewater purification. The synthetic pathway of two cationic wood material and adsorption of iodide ions and iodate ions. Download: Download high-res image (199KB) Download: Download full-size image
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Antioxidants
·
2026
·Vol. 15
·期 9
·1064
·
IF 8.2
Yuri P. Tsentalovich,Nataliya A. Osik,Maxim V. Fomenko,Nikita A. Dmitriev,Vadim V. Yanshole
Ergothioneine (ESH) is one of the most abundant antioxidants in the human body, but its biological functions remain unclear. In this work, we elucidated the detailed mechanism of the deactivation of divalent copper ions Cu(II) by ESH using optical spectroscopy, NMR, and LC-MS. We found that the reduction of Cu(II) ions to Cu(I) by ESH occurs in a bimolecular reaction of CuII(ES−)2complexes, leading to the formation of the disulfide ESSE. Cu(I) ions remain bound in stable complexes with ESH, preventing their reactions with molecular oxygen. Over longer timescales, ESSE decomposes, regenerating reduced ESH and forming the final reaction product, hercynine (EH). The conversion of one ESH molecule to EH causes the reduction of four Cu(II) ions. We determined the rate constants of the bimolecular reaction between CuII(ES−)2complexes to be k3= (8 ± 4) × 104M−1s−1and of ESSE hydrolysis to be k4= (1.7 ± 0.4) × 10−5s−1and also estimated the formation constant K12≈ 1.2 × 1017M−2for the CuII(ES−)2complex. The high efficiency of Cu(II) reduction and the chelation of the resulting Cu(I) ions in a stable complex supports the hypothesis that protecting cells from oxidation by metal ions is likely one of the main functions of ESH.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
·
IF 2.4
Sai Li,Shiyu Zhang,Jia Tong,Xingxing Shi,Yue Xu,Jie Lu
The solubility and thermodynamic profile of anastrozole (I) were comprehensively examined across diverse solvent systems through equilibrium gravimetric measurements conducted between 283.15 and 323.15 K under ambient pressure. The measured solubility of anastrozole (I) showed a positive correlation with temperature. Subsequently, the experimental data were correlated using four thermodynamic models, namely, the van’t Hoff, modified Apelblat, RK-4, and λh models. The results indicated that all models can reproduce the experimental data with high accuracy, among which the Apelblat equation exhibited a superior fitting performance compared with the other models. Then, thermodynamic analysis based on the van’t Hoff and Gibbs equations indicated that the dissolution process of anastrozole (I) is endothermic and enthalpy-driven in all the studied systems. Moreover, FT-IR, PXRD, and TG-DSC analyses indicated that anastrozole (I) possessed a stable structure during the solubility experiments. Furthermore, molecular simulation results supported the experimental observations by indicating that hydrogen bonding and dispersion forces play key roles in solute–solvent interactions. The dissolution behavior was dependent on solvent polarity and the solvation free energy.
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Materials Today Chemistry
·
2026
·
IF 7.4
Mengjiao Zhao,Xianjie Xu,Sheng Huang,Xiuquan Gu,Wufan Xuan
The CsCu 2 I 3 /ZnO-heterojunction-based sensor enables H 2 S detection with a response value of 0.83 at 1 ppm, with response and recovery times of 240 s and 834 s. • The CsCu 2 I 3 /ZnO heterojunction improves structural stability and ensures continuous and stable sensor response. • The CsCu 2 I 3 /ZnO-heterojunction-based sensor achieves self‐calibration for different H 2 S concentrations with 99% detection accuracy. Hydrogen sulfide (H 2 S), a colorless and toxic gas, poses serious health risks upon prolonged exposure, including damage to respiratory and cardiovascular systems, which can be fatal in severe cases. Current H 2 S sensors suffer from limited response, particularly in detecting ultra‐low concentrations. To overcome this limitation, we developed a CsCu 2 I 3 /ZnO heterojunction‐based gas sensor via vacuum evaporation. This composite material enables highly responsive H 2 S detection at room temperature. The heterojunction not only improves structural stability but also ensures continuous and stable sensor response. At 1 ppm H 2 S, the sensor exhibits a sensitivity of 0.72, the response value of 0.83, the limit of detection (LOD) of 14.25 ppb, with response and recovery times of 240 s and 834 s, respectively. Furthermore, an intelligent calibration framework was developed by integrating Gramian Angular Summation Fields with the AlexNet algorithm, operating as a robustness enhancer. The sensor achieves self‐calibration for different H 2 S concentrations with 99.33% detection accuracy through 5-Fold Cross-Validation, significantly enhancing quantification capability. These results demonstrate the excellent potential of our CsCu 2 I 3 /ZnO-heterojunction-based sensor in H 2 S monitoring. The combination of responsive materials with machine learning offers a robust strategy for advancing ultra‐low concentration gas detection technologies.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Brahim El Allaoui,Tao Wu,Cheng Heng Pang
Cellulose beads are produced through dissolution–regeneration processes that are solvent- and water-intensive and disrupt the native microfibrillar organization by converting cellulose I to cellulose II. Here, we establish a dissolution-free chemomechanical pathway that converts lignocellulosic biomass into spherical cellulose assemblies via architecture-governed cell-wall remodeling and shear-driven consolidation. Six feedstocks spanning agricultural residues (date palm, rice straw, corn straw, soybean straw) and woody biomasses (pine and peach wood) were subjected to sequential alkaline extraction, oxidative bleaching, and high-shear agitation. Comparative compositional, structural, and morphological analyses reveal that successful spheronization does not depend solely on cellulose content but requires the formation of a deformable continuity-preserving fibrillar intermediate. In this state, partial matrix removal induces wall swelling and delamination while maintaining load-bearing connectors that enable fibrillar bending, entanglement, and densification under hydrodynamic shear. Date palm and rice straw satisfy these criteria and produce stable cellulose I beads with fiber-assembled interiors. In contrast, corn and soybean residues undergo excessive fragmentation into fines that disperse as pulps/flocs, whereas pine and peach wood retain stratified, locked wall domains and yield irregular, rigid fragments. These findings establish an architecture-based mechanistic framework and selection rules for solvent-minimal, dissolution-free manufacturing of cellulose beads directly from low-value lignocellulosic biomass.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 33
·26115-26132
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IF 6.7
Liu Songtao,Zhang Wanting,Zhu Xiyuan,Yang Ziyang,Yang Shuai,Li Linwei,Li Lianshan,Zhu Hong,Lei Renkai,Liu Yulan,Geng Yiming,Chu Xinyan,Li Wangyang,Xu Shu,Ouyang Bo,Wang Bi,Song Wei,Chen Yu,Feng Xu,Yan Jiaxing,Liu Fei,Zhang Feng
Fusarium head blight (FHB) is a devastating wheat disease
causing
yield losses and mycotoxin contamination. Phenamacril, a myosin I-targeting
fungicide, has a limited antifungal spectrum. Using structure-based
drug design focusing on M375 in Fusarium graminearum myosin I (FgMyoI), we synthesized 25 phenamacril derivatives. The II-2 emerged as the most potent inhibitor (EC 50 = 0.0077 mg/L against F. graminearum ), with broad-spectrum activity against various phytopathogens. Biochemical
and computational analyses confirmed that II-2 tightly
binds FgMyoI and inhibits its ATPase activity. In vivo tests demonstrated excellent protective and curative efficacy against
FHB in wheat and corn, while toxicity assays revealed low risk to
nontarget organisms. These results identify II-2 as a
promising myosin inhibitor and a novel candidate for FHB management.
This work also provides a foundation for the rational design of myosin-targeting
fungicides against diverse plant fungal diseases.
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ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Juan Huang,Mingjing Yang,Xingyu Zhou,Jigang Luo,Xiaoxia Yan,Guanghui Lin,Shijie Li,Shihui Liu,Zhuoyue Song,Chunzhi Tang,Nenggui Xu,Tao Liu,Jian Liang
Drug repurposing has received increasing attention in the field of oncology drug development as an alternative strategy to de novo drug synthesis. Disulfiram (DSF) has a long history of clinical application in alcohol withdrawal, and recent studies have revealed that its metabolite diethyldithiocarbamate (DDTC) can be coordinated with copper ions in vivo to form Cu-DDTC complexes with anticancer activity. However, the insufficient in vivo stability of DSF remains a challenge. In this study, the nanomedicine Cu-BTC@DDTC with DDTC-Cu(I) chemical valence and polycrystalline structure was prepared by incorporation of DDTC into the nanosized metal–organic framework (MOF) Cu-BTC. The in vitro cellular evaluation results showed that Cu-BTC@DDTC exhibited high inhibition of tumor cell growth, migration, and invasion. Animal experiments on the xenograft tumor model further demonstrated the excellent antitumor activity and biosafety of Cu-BTC@DDTC, and the antitumor activity was found to be closely related to the regulation of the SLC7A11/GPX4 signaling pathway to induce ferroptosis. This study provides a feasible option for antitumor drug development based on a drug repurposing strategy.
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Journal for ImmunoTherapy of Cancer
·
2025
·Vol. 13
·期 9
·e011893
·
IF 10.6
Zhengning Yang,Zhongxuan Meng,Shangyuan Liu,Yuxin Chen,Xuhong Gan,Zi‑Mei Zhang,Xiaoshan Luo,Jiahong Yan,Huijin Chen,Danqing Huang,Lihong Huang,Xiaomin Zeng,Wenyu Ma,Jun Liu,Linlin Wang,Haotian Huang,Xinyi Yang,Mei Hu,Lin Chen,Hongli Du,Qibin Leng,Li Qiu,Xiaoling Wang
Background Nonsense-mediated messenger RNA decay (NMD) is a highly conserved surveillance system that degrades mRNAs with premature termination codons (PTCs), and regulates the mRNA quantity. Cancer cells hijack NMD to compensate for the imbalanced DNA levels and modulate their antigenicity. We identified the LTO1/YAE1 complex as NMD factors regulating ribosome biogenesis. Our study aimed to investigate their roles in modulating NMD and major histocompatibility complex class I (MHC-I) antigen presentation, which is vital for cancer immunotherapy. Methods Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9)-mediated gene knockouts, overexpression, and mutational analysis were used to explore the role of LTO1 and YAE1 in NMD and MHC-I expression across various tumor cell lines, assayed by fluorescent reporter-based assays, fluorescence-activated cell sorting analysis, reverse transcription-quantitative PCR, mRNA decay assay, and polysome profiling. Transcriptomic analyses were used to assess the expression of LTO1/YAE1 and their correlation with MHC-I molecules in human cancers. T cell receptor (TCR)-T cells and tumor cells coculture were employed to monitor the effect of LTO1 and YAE1 loss on T cell activation. Iron chelators were further tested as NMD inhibitors to enhance cancer immunotherapy using in vitro coculture assay and a mouse tumor model for immune checkpoint blockade (ICB) therapy. Results We demonstrate that deficiency in LTO1, YAE1, or their downstream target ABCE1 impairs NMD, causes the overexpression of key regulators of MHC-I, including NLR family CARD domain containing 5 (NLRC5), interferon regulatory factor 1 (IRF1), and nuclear factor-kappa B (NFκB), which results in enhanced T cell activation and tumor cell killing in TCR-T models. Transcriptomic analyses reveal that the LTO1/YAE1 complex is frequently overexpressed in human cancers, where it negatively regulates MHC-I. Moreover, low doses of iron chelators inhibit NMD and enhance MHC-I expression, leading to improved recognition and activation of CD8 + T cells, thereby promoting antigen-specific killing and increasing the efficacy of TCR-T and ICB therapy. Conclusions Collectively, our findings establish novel roles for the LTO1/YAE1 complex in regulating MHC-I expression via NMD. As MHC-I is crucial for antigen presentation and T cell activation, these results reveal a previously unappreciated link between NMD and tumor immunogenicity, with potential implications for cancer immunotherapies.
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