Small
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2024
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IF 13
Yun-Yun Quan,Tingting Pan,Zhongda Zhang,Shihua Wang,Guiyun Wang,Lichao Yu,Ye Wang,Xu-Feng Zang,Fangjun Zhang,Xiaoxia Ye,Xuebo Pan,Zu-Sheng Huang
Bacterial infections are closely correlated with the genesis and progression of cancer, and the elimination of cancer-related bacteria may improve the efficacy of cancer treatment. However, the combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image-guided photodynamic therapy is a highly precise and potential therapy to treat tumor and microbial infections. Herein, four donor–acceptor–π-bridge–acceptor (D–A–π–A) featured near-infrared (NIR) aggregation-induced emission luminogens (AIEgens) ( TQTPy , TPQTPy , TQTC , and TPQTC ) with type I and type II reaction oxygen species (ROS) generation capabilities are synthesized. Notably, TQTPy shows mitochondria targeted capacity, the best ROS production efficiency, long-term tumor retention capacity, and more importantly, the three-in-one fluorescence imaging guided therapy against both tumor and microbial infections. Both in vitro and in vivo results validate that TQTPy performs well in practical biomedical application in terms of NIR-fluorescence imaging-guided photodynamic cancer diagnosis and treatment. Moreover, the amphiphilic and positively charged TQTPy is able to specific and ultrafast discrimination and elimination of Gram-positive (G+) Staphylococcus aureus from Gram-negative (G−) Escherichia coli and normal cells. This investigation provides an instructive way for the construction of three-in-one treatment for image-guided photodynamic cancer therapy and bacteria elimination.
研究领域:
癌症研究
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光动力疗法
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材料科学
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生物医学工程
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微生物学
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PubMed
高影响因子
ACS Catalysis
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2026
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IF 13.6
Guosong Wang,Dong Zhang,Yihui Song,Haitao Meng,Dan Li,Chong Peng
Abstract Hydrodeoxygenation (HDO) of lignin derivatives is a promising strategy for biomass utilization, but its catalytic performance is often unsatisfactory for non-noble metal catalysts. This hinders the industrialization process of biomass utilization. Herein, we obtained a FeNi-Cop catalyst with a tightly coupled interface between FeNi alloy and NiO by a hydrotalcite-derived strategy. The effect of this interface on the p-cresol HDO was studied by XRD, HRTEM, H2-TPR, NH3-TPD, XPS, in situ FTIR, and DFT calculations. FeNi-Cop catalyst facilitates hydrogen activation and can promote the dehydration reaction of methylcyclohexanol, a key intermediate, through the electronic regulation of the interface and acid sites. High space-time yield (STY) of methylcyclohexane was obtained, and good catalytic performance could be maintained after 10 cycles. This tightly coupled alloy/oxide interface provides a feasible approach for the design of non-noble metal catalysts.
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Chemistry-Switzerland
·
2025
·Vol. 7
·期 3
·75
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IF 2.4
Jing Zhang,Xiaoxing Ji,Qingxiu Yu,Xixi Zhang,Chuanlin Li,Na Li,Mengzhen Kong,Dingzheng Li,Wenjie Liu,Chenggang Wang,Xijin Xu
Zinc-halogen batteries are usually based on two-electron transfer reactions from X−to X2. However, the halogen is capable of being further oxidized to higher valence states, thereby achieving the higher capacity of zinc- halogen batteries. Here, a six-electron reaction based on I−/I+and Br−/Br0is activated successfully by introducing KI into the electrolyte. ZIF-8-derived porous carbon (ZPC), serving as the host of halogen, effectively suppresses polybromide/polyiodide shuttle owing to the chemisorption/physical adsorption. Additionally, the adsorption of I−on the surface of the zinc anode effectively inhibits the growth of dendrites and the formation of by-products. Consequently, zinc-bromine batteries exhibit outstanding electrochemical performance, including a specific capacity of 345 mAh g−1at 1 A g−1and an excellent capacity retention of 80% after 3000 cycles at 2 A g−1. This strategy provides a novel way for enhancing the electrochemical performance of zinc-halogen batteries.
研究领域:
能源材料
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电化学
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高影响因子
Nature Communications
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2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Xiao Kui,Zhang Niyuan,Li Feifei,Hou Dayong,Zhai Xiaoyi,Xu Wanhai,Wang Gelin,Wang Hao,Zhao Liang
Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6- exo - dig cyclization of polymetalated precursors. The on-bench and in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding in PAA4 and PAA5 not only guarantees their stability under common physiological conditions, but also facilitates a glutathione (GSH)-triggered prompt and synergetic release of active Au(I) ions in the GSH-overexpressed and acidic microenvironment of human bladder cancer EJ cells. The instantly massive release of coordination unsaturated Au(I) ions causes the efficient inhibition of thioredoxin reductases and then induces a rapid pro-oxidant response, consequently causing the occurrence of accelerated ferroptosis of EJ cells. As a result, these hypercarbon-centered gold(I) cluster prodrugs show high cytotoxicity to bladder cancer cell lines and thus exhibit a significant inhibition effect towards bladder tumors in vivo. Correlation of the synergetic domino dissociation of carbon-polymetal multi-center bonding in metal clusters with the accelerated ferroptosis of cancer cells provides a strategy for metallo-prodrugs and opens a broader prospect for the biological application of metal cluster compounds.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
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IF 2.4
Jun Wang,Junmeng Sha,Gang Li,Teng Liu,Chunxiang Huang,Xueni Sun,Hui Shao
Abstract The thin-film release solution for photoresists, formulated with propylene glycol methyl ether (PM) and cyclopentanone (CPO), is widely used in semiconductor processes; however, it is difficult to separate due to concentration-dependent effects. This research focused on examining the vapor–liquid phase equilibria of three binary mixtures composed of the extractive distillation entrainer N-methylpyrrolidone (NMP) and the close-boiling components─propylene glycol monomethyl ether (PM) or cyclopentanone (CPO)─namely, the NMP–PM, NMP–CPO, and CPO–PM systems. In contrast, the intermolecular interactions between NMP and PM are stronger than those in the other two systems. Furthermore, the relative volatility of CPO compared to PM is also influenced by NMP. The experimental data have demonstrated excellent thermodynamic consistency upon verification. A regression analysis of binary-system vapor-liquid equilibrium data was conducted using the Wilson, NRTL, and UNIQUAC models, with the UNIQUAC model demonstrating superior predictive performance. At solvent molar fractions of 0.7, 0.8, and 0.9, employing the UNIQUAC model, compositional impacts on PM/CPO relative volatility were evaluated to estimate the minimum equilibrium stages necessary for effective distillative separation. This research has demonstrated the feasibility and effectiveness of using NMP for extraction and distillation separation of PM/CPO at both experimental and theoretical levels.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2015
·Vol. 2015
·期 13
·2229-2236
·
IF 2.942
Long Zhang,Shulin Zhao,Yafei Li,Yaqian Lan,Min Han,Zhihui Dai,Jianchun Bao
Graphical Monoclinic Cu 2 Se nanocrystals and Cu 2 Se/Pd heterostructures have been synthesized by simple and facile methods. Owing to strong synergistic effects and phase-dependent characteristics, the surface-enhanced Raman scattering performance of the Cu 2 Se/Pd heterostructure is superior to those of Cu 2 Se, Pd, CuSe/Pd, and Cu 2– x Se/Pd. We have developed a simple and facile approach to the fabrication of monoclinic Cu 2 Se nanocrystals and Cu 2 Se/Pd heterostructures. [(C 2 H 5 ) 4 N] 2 [CuCl 4 ] was chosen as the copper source and SeO 2 /terpineol was used as the Se –II precursor for the generation of hexagonal CuSe and cubic Cu 2– x Se through the “hot-injection” and “one-pot” methods, respectively. Both CuSe and Cu 2– x Se could be further transformed into monoclinic Cu 2 Se through heat treatment with trioctylphosphine (TOP) at 220 °C. Cu 2 Se/Pd as well as CuSe/Pd and Cu 2– x Se/Pd were readily obtained by simply mixing copper selenides and Pd(NO 3 ) 2 in a 2-propanol solution. The Pd nanoparticles were distributed on the surface of the copper selenides. The effect of certain reaction parameters on the formation of copper selenides was studied. The amount of terpineol used played an important role in the phase-selective synthesis of CuSe and Cu 2– x Se. The surface-enhanced Raman scattering (SERS) performance of the heterostructures was investigated with 4-mercaptopyridine (4-Mpy) as a probe molecule. Owing to the strong synergistic effects between Cu 2 Se and Pd, Cu 2 Se/Pd showed greater SERS performance than pure Pd or Cu 2 Se. Moreover, compared to those of CuSe/Pd and Cu 2– x Se/Pd, Cu 2 Se/Pd exhibited the highest SERS sensitivity to 4-Mpy with a detection limit as low as 1.0 × 10 –9 M , which revealed its phase- and composition-dependent characteristics. This Cu 2 Se/Pd heterostructure exhibits potential applications in the chemical and biological sensing fields.
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高影响因子
Journal of the American Chemical Society
·
2015
·
IF 12.113
Xiao-Li Pei,Yang Yang,Zhen Lei,Shan-Shan Chang,Zong-Jie Guan,Xian-Kai Wan,Ting-Bin Wen,Quan-Ming Wang
The activation of C(sp3)–H bonds is challenging, due to their high bond dissociation energy, low proton acidity, and highly nonpolar character. Herein we report a unique gold(I)–silver(I) oxo cluster protected by hemilabile phosphine ligands [OAu3Ag3(PPhpy2)3](BF4)4 (1), which can activate C(sp3)–H bonds under mild conditions for a broad scope of methyl ketones (RCOCH3, R = methyl, phenyl, 2-methylphenyl, 2-aminophenyl, 2-hydroxylphenyl, 2-pyridyl, 2-thiazolyl, tert-butyl, ethyl, isopropyl). Activation happens via triple deprotonation of the methyl group, leading to formation of heterometallic Au(I)–Ag(I) clusters with formula RCOCAu4Ag4(PPhpy2)4(BF4)5 (PPhpy2 = bis(2-pyridyl)phenylphosphine). Cluster 1 can be generated in situ via the reaction of [OAu3Ag(PPhpy2)3](BF4)2 with 2 equiv of AgBF4. The oxo ion and the metal centers are found to be essential in the cleavage of sp3 C–H bonds of methyl ketones. Interestingly, cluster 1 selectively activates the C–H bonds in −CH3 rather than the N–H bonds in −NH2 or the O–H bond in −OH which is traditionally thought to be more reactive than C–H bonds. Control experiments with butanone, 3-methylbutanone, and cyclopentanone as substrates show that the auration of the C–H bond of the terminal methyl group is preferred over secondary or tertiary sp3 C–H bonds; in other words, the C–H bond activation is influenced by steric effect. This work highlights the powerful reactivity of metal clusters toward C–H activation and sheds new light on gold(I)-mediated catalysis.
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PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Ming Huang,Changsheng Zhou,Ke-Fang Yang,Ze Li,Guo-Qiao Lai,Pinglu Zhang
An effective (NHC)AgCl catalysis was developed in the hydroborylation of cyclopropenes with B2pin2, delivering a variety of cyclopylboronates in a stereoselective manner, which could be easily transformed for the construction of versatile cyclopropanes. This protocol works effectively under mild reaction conditions in an open-air atmosphere, and it was easy to apply on a gram scale. This novel method in detail was also explored by control experiments, providing a number of key insights. The kinetic process followed by 1H NMR indicated that the reaction was finished in 15 min. Furthermore, the mechanism of silver(I)-catalyzed hydroborylation of cyclopropenes was proposed, with the protonation by methanol as the rate-determining step.
研究领域:
有机化学
·
催化
·
合成化学
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DOI
PubMed
高影响因子
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
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2023
·
IF 5.3
Xingjian Sun,Ping Rao,Xitao He,Canhui Yang,Wei Hong
Do materials prepared from identical compositions of constituting ingredients always exhibit similar mechanical properties? The answer is negative for most structural materials, as has been demonstrated by extensive studies on various factors such as the effects of processing and microstructures. However, the same question has seldom been addressed in the case of polymeric gels. In this work, by using a simple chemically crosslinked hydrogel as a model system, the mechanical properties, including elastic stiffness , fracture toughness , and fatigue threshold, of gels with identical chemical compositions are systematically investigated. The distinct material properties are then rationalized and quantitatively correlated to synthesis conditions and manufacture processes through scaling laws derived from basic physics. Different scaling laws are identified between samples prepared from swelling and deswelling. Extreme mechanical properties, such as the remarkable fracture energy of hydrogels prepared by deswelling from highly swollen samples, are observed and attributed to the structural characteristics of the polymer network , and further correlated to the synthesis processes. This study provides insights into the synthesis-property correlations of polymeric gels, which may have profound influences on the design of new polymeric materials and their applications in various fields.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Zhang Huang,Weijie Zhou,Jiani Dong,Lin Zhu,Yayang Xu,Xuesong Chang,Lei Ye,Weibin Bai
Abstract The crude anthocyanin extract isolated from cranberry (Vaccinium macrocarpon Aiton) was enzymatically acylated with fatty acids of varying chain lengths using Novozyme 435 (Candida antarctica lipase B immobilized on acrylic resin). After optimization, the highest acylation rates of 65.72% and 70.64% for cyanidin-3-O-galactoside and peonidin-3-O-galactoside, respectively, were obtained by acylating with octanoic acid under the conditions of lipase dosage of 10 mg/mL, molar ratio of 1:418, at 50 °C for 30 h in 2-methyl-2-butanol. Acylated anthocyanins with high purity (>97%) were obtained through liquid–liquid extraction and medium-pressure liquid chromatography and identified as cyanidin-3-O-(6″-octanoyl) galactoside and peonidin-3-O-(6″-octanoyl) galactoside by MS/MS and 2D NMR. The acylated cranberry anthocyanins exhibited enhanced lipophilicity, photostability, thermostability, and excellent antioxidant activity in both aqueous and lipid systems. These findings demonstrate enzymatic acylation in a crude anthocyanin matrix and provide insights into acylation-induced structure–property relationships, supporting the rational development of functionalized anthocyanins from natural extracts.
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高影响因子
ACS Applied Polymer Materials
·
2026
·
IF 5.2
Jiru Jia,Fangqing Ge,Xiaotian Chen,Zhihe Zhang,Lvyi Yang,Jing Qu,Jun Peng,Qi Xiao,Ya Yang,Wei Ma,Jie Chen
Abstract To address the challenge of balancing high-water content with structural stability in hydrogels, gelatin methacryloyl (GelMA) was introduced into a poly(acrylic acid-co-hydroxyethyl acrylate) system. GelMA/PAH composite hydrogels (Gel-PAH) were then prepared through one-step ultraviolet (UV) photocuring, and their network formation and overall properties were tuned by varying the glycerol dimethacrylate (GDMA) content. The Gel-PAH hydrogels exhibited higher hydration capacity and greater surface wettability than the corresponding PAH hydrogels. As the GDMA content increased, the gel fraction and tensile strength of both the PAH and Gel-PAH series generally increased. The tensile strength of the Gel-PAH hydrogels ranged from approximately 1.6 to 2.5 MPa. Gel-PAH-0.15 exhibited an equilibrium water content of 82.55%, a water contact angle of approximately 39°, and a relative cellular metabolic activity of approximately 84% after 24 h. Overall, Gel-PAH-0.15 achieved a favorable balance among network stability, hydration capacity, mechanical performance, and preliminary direct contact cytocompatibility. These results show that a compositionally simple AA/HEA-GelMA system provides a straightforward route to tune hydration and mechanical performance through one-step UV photocuring and adjustment of GDMA content, without introducing additional reinforcing fillers or sequential cross-linking processes.
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高影响因子
ACS Synthetic Biology
·
2026
·
IF 4.5
Jiao Liu,Niling He,Yi Zhang,Bin Zhang,Jie Bao
Abstract Achieving highly coordinated metabolism and efficient conversion of lignocellulose-derived non-glucose sugars remains a major challenge for biorefinery microbial cell factories. Herein, we report an evolutionary rewiring of an engineered lactic acid bacterium Pediococcus acidilactici G1 with enhanced co-utilization of glucose, xylose, arabinose, mannose, and galactose for l-lactic acid generation. Transcriptomic analysis revealed the extraordinary upregulation of a unique sugar transporter gene cluster, manXYZ, while genome re-sequencing identified two convergent mutations in the transcriptional regulators CcpA (T65I) and LevR (E159G). Back mutation, reverse metabolic engineering, and electrophoretic mobility shift assays (EMSA) were then employed to investigate the regulation of manXYZ expression by CcpA T65I and LevR E159G. Collectively, our findings demonstrate that recurrent mutations in transcriptional regulators CcpA and LevR drove the significant upregulation of the manXYZ sugar transporter cluster during adaptive evolution, highlighting the importance of sugar transport in improving non-glucose sugar metabolism. This study not only develops a promising strain for practical biorefinery applications but also provides a new sugar transporter solution, rather than regular intracellular metabolic pathway engineering, for highly efficient non-glucose sugars utilization in P. acidilactici.
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高影响因子
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