ACS Sensors
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2022
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IF 9.618
Yue Xu,Haiyan Chen,Shufen Xu,Ji Liu,Yang Chen,Lijuan Gui,Hua Li,Ruixi Li,Zhenwei Yuan,Bowen Li
Several photosensitizers have recently been proposed as novel approaches against β-lactamase-producing drug-resistant bacteria. However, these reported photosensitizers are rarely used for accurate recognition of drug-resistant bacteria. To tackle this challenge, the structurally modified photosensitizer CySG-2 based on a lipophilic cationic heptamethine indocyanine near-infrared (NIR) dye (IR-780) and an important synthesis intermediate of cephalosporin antibiotic (GCLE) not only achieved the accurate recognition of TEM-1 methicillin-resistant Staphylococcus aureus (MRSA) successfully but also achieved antimicrobial photodynamic therapy (aPDT) in animal models infected by drug-resistant bacteria. Accurate enzyme recognition and efficient photodynamic therapy capabilities allow CySG-2 to achieve one stone with two birds. In addition, CySG-2 could also promote the eradication of internalized MRSA by facilitating the autophagy process, which is synergistic with its capacity of inducing reactive oxygen species generation under NIR laser irradiation for aPDT. Collectively, it is an effective multifunctional photosensitizer with the potential ability to guide the optimal use of different antibiotics and apply them in clinical treatment.
研究领域:
药学
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微生物学
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生物医学工程
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传染病学
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高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2016
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IF 2.336
Tianzhi Yu,Yanjun Bao,Yuling Zhao,Hui Zhang,Zixuan Xu,Xiaomeng Wu
Two new red-emitting Ir(III) complexes containing 2-(1-naphthyl)benzothiazole as cyclometalated ligands and the carrier transporting group-functionalized picolinate as ancillary ligands have been successfully synthesized and characterized. The Ir(III) complexes have good thermal stability with less than 2% weight-reduction occurring at 285 °C, and exhibit strong red emissions. The doped light-emitting devices using the Ir(III) complexes as dopants were fabricated. The result indicated that the light-emitting devices fabricated by the carbazole-functionalized complex and the diaryl-1,3,4-oxadiazole-functionalized complex exhibited red emissions with a maximum brightness of 3074 and 2520 cd/m 2 at 10.7 V and a maximum current efficiency of 4.84 and 5.18 cd/A, respectively.
研究领域:
材料科学
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有机电子学
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无机化学
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光物理
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光电功能器件
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JOURNAL OF PHYSICS D-APPLIED PHYSICS
·
2025
·Vol. 58
·期 41
·415101
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IF 3.2
Jieling Guo,Yaqing Zhai,Tinglun Xing,Baohua Zhu,Jiejuan Yang,Yuzong Gu
Mid-infrared (Mid-IR) pulsed lasers are vital for diverse applications, yet their development is hindered by the scarcity of high-performance saturable absorbers (SAs) for Q-switching and mode-locking. While graphene and its analogs have emerged as promising candidates, their low modulation depth in the mid-IR regime hinders its practical implementation. To overcome this, we engineer a Ti:Sb2Te3/reduced graphene oxide (rGO) heterostructure via hydrothermal synthesis, leveraging synergistic Ti4+ doping and interfacial charge control. Ti4+ introduces tailored trap states in Sb2Te3 nanosheets—selected for their narrow bandgap and high mobility—suppressing non-radiative recombination and extending carrier lifetimes. This defect-mediated design achieves a significantly enhanced modulation depth of 1.8% (2.4× higher than graphene) and a nonlinear absorption coefficient of 6.84 cm GW−1 at 2.8 μm. Transient absorption spectroscopy confirms trap-assisted carrier dynamics and accelerated charge transfer. Integrating the heterostructure as an SA mirror into an Er:YAP laser generates stable 2.8 μm pulses with a 253 ns width, 163 kHz repetition rate, and 230 mW peak power at 5.5 W pump power. This work demonstrates defect-engineered Ti:Sb2Te3/rGO as a promising high-performance mid-IR SA for narrow-pulse lasers.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2017
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IF 2.536
Pengchao Wang,Yongjun Hu,Huaqi Zhan,Jiaxin Chen,Shan Jin,Wentao Song,Yujian Li
Tetrahydrofurfuryl alcohol (THFA, C 5 H 10 O 2 ) is a close chemical analog of the sugar rings present in the phosphate-deoxyribose backbone structure of the nucleic acids . In present report, the infrared (IR) spectra of the size-selected THFA monomer and its dimer have been investigated in a pulsed supersonic jet using infrared-vacuum ultraviolet (VUV) ionization. Herein, the laser light at 118 nm wavelength served as the source of “soft” ionization in a time-of-flight mass spectrometer. The IR features for the monomers located at 3622 cm − 1 can be assigned to the intramolecular hydrogen bonding stretch vibrations mainly referring to A and C conformers . Compared with the monomer, however, characteristic peaks for the dimer centered at 3415 and 3453 cm − 1 , red shifted 207 and 169 cm − 1 , respectively, were associated with the intermolecular hydrogen bonding stretch vibrations. Combined with the quantum-chemical calculations, the dimer in the gas phase preferred cyclic AC conformer stabled by forming two strong intermolecular hydrogen bonds, which shown the high hydrogen bond selectivity in the cluster. The conclusions drawn from the role played in the conformational flexibility by the hydroxyl and ether groups may be extended to other biomolecules.
研究领域:
物理化学
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光谱学
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分子团簇
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气相化学
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生物物理化学
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高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 6
·1595-1601
·
IF 4
Ziwei Wang,Lijuan Li,Weijin Wang,Runlin Wang,Guangzhe Li,Hang Bian,Dongxia Zhu,Martin R. Bryce
Cyclometalated Ir(III) complexes as photosensitizers (PSs) have attracted widespread attention because of their good photostability and efficient 1O2 production ability. However, their strong absorption in the UV-vis region severely limits their applications in photodynamic therapy (PDT) because the short wavelength illuminating light can be easily absorbed by the skin and subcutaneous adipose tissue causing damage to the patient's normal tissue. Herein, mono- and tetra-nuclear Ir(III) complex-porphyrin conjugates are rationally designed and synthesized, especially [TPP-4Ir]4+ exhibits obvious aggregation-induced emission (AIE) characteristics. PSs comprising Ir(III) complex-porphyrin conjugates self-assembled as nanoparticles (NPs) are successfully achieved. The obtained [TPP-Ir]+ NPs and [TPP-4Ir]4+ NPs exhibit long wavelength absorption (500–700 nm) and near-infrared emission (635–750 nm), successfully overcoming the inherent defects of short wavelength absorption of traditional Ir(III) complexes. Moreover, [TPP-4Ir]4+ NPs exhibit good biocompatibility, high 1O2 generation ability, low half-maximal inhibitory concentration (IC50) (0.47 × 10−6 M), potent cytotoxicity toward cancer cells and superior cellular uptake under white light irradiation. This work extends the scope for transition metal complex PSs with promising clinical applications.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 10
·4761-4774
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IF 3.3
Fen Liu,Wenxuan Bai,Zhiping Gu,Jingcong Zhang,Jinxiang Chen,Jiang Yu
The acidic structure in an iron-based ionic liquid (Fe-IL) is significantly affected by the valent variation and solvent effect during the catalytic reaction. However, the magnetic property of Fe-IL limits the utilization of commonly used characterization methods that require a magnetic field for the structural analysis of Fe-IL. Herein, a quantitative pyridine-IR spectrum method was developed by analyzing the slope of straight lines (Slope(X)) in IA(X) ∼ n(Py) relationship graph (IA(X): integrated area of νPyH+ or νPy-L (cm−1); n(Py): the mole of added pyridine (mol)) to determine the structural forms of Brønsted and Lewis acid in Fe-IL, as well as the Lewis activity according to the Beer's law. Different Fe-IL systems, such as Fe-ILaq (from FeCl3·6H2O), Fe-ILnon-aq (from non-aqueous FeCl3) and Fe-ILnon-aq + HCl, were designed and synthesized with similar cationic and anionic structures, in which the Lewis acidity and Lewis activity are significantly influenced by Brønsted acidity. The results showed that the Brønsted acidity in Fe-ILnon-aq is lower than that in Fe-ILaq, and Fe-ILnon-aq can be transferred into Fe-ILaq after protonation. The Slope(L) of FeCl4− has the value of 0.21–0.28 in Fe-ILnon-aq and Fe-ILaq before protonation, and protonation could significantly decrease the value of Slope(L) and Lewis activity, which is mainly caused by the steric hindrance of FeCl4− with the increased amount of the Brønsted acidic structure of Fe–Cl–HCl. In addition, the solvent effect of polyethylene glycol dimethyl ether (NHD), which is a commonly used organic solvent for the absorption of an acidic gas, on the acidic structure and Lewis activity of Fe-IL was also investigated. We found that relatively free HCl that is combined with the Fe–Cl bond in the Fe-ILaq/NHD complex can be predicted by analyzing the slope of IA(X) ∼ n(Py), and the Lewis activity of FeCl4− decreases with increasing volume ratio of NHD. It is confirmed by density functional theory (DFT) calculation that the decreased Lewis activity of Fe-IL caused by the protonation and solvent effect is mainly attributed to the decreased electron-withdrawing ability of FeCl4− and the bond length of the Fe–Cl bond. Furthermore, DFT calculation and CV characterization further demonstrate the reliability of the developed quantitative pyridine-IR method by analyzing the slope of IA(X) ∼ n(Py).
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Fei Wu,Zheng-Qing Yang,Wen Sun,Xu Chen,Hui Qi,Li-Da Wang
Ti/SnO2-Sb-Ir electrodes doped with a low Ir content were prepared, and they were used in acidic water electrolysis for the oxygen evolution reaction (OER). The results showed that an IrO2–SnO2 solid solution was formed, and the electrode surface was relatively compact. The doping of IrO2 could significantly improve the electrocatalytic activity and stability of Ti/SnO2-Sb electrode for OER. The electrode modified with only 5 mol % Ir met the needs of acidic water electrolysis. Meanwhile, the performances of the electrode approached that of Ti/IrO2 when Ir content was only 8 mol %, which resulted from the fact that IrO2 doping improved the chemical stability as well as the electrocatalytic activity of the electrode. Moreover, the deactivation behavior of the electrode was investigated as well. It was mainly ascribed to the chemical composition and morphology change induced by continuous dissolution of the metal oxides, which eventually led to the passivation of the Ti substrate.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yefei Wang,Zhen Zhou,Liang Zhao,Cheng He,Wenlong Sun,Chunying Duan
The activation and transformation of inert alkyl C(sp3)−H bonds to obtain high-value fine chemicals by sustainable solar energy are of great significance. Herein, by incorporating IrIII–porphyrin into metal–organic frameworks (MOFs) to stabilize the highly active carbene, we reported a new approach to combining metallo- and photocatalysis to efficiently accelerate carbene migratory insertion and C–H bond activation via the radical coupling pathway for inert alkane functionalization. The in situ-formed carbene was restricted into the pores of MOFs to produce IrIII–carbene, allowing the first-time isolation and structural characterization of the IrIII–carbene intermediate which are not stabilized by a heteroatom. The product of the reaction, especially the cyclic ethers as substrates, suggested that the functionalization of the α position of the alkoxy group was favored. Additionally, the new approach could be extended to stabilize the metal carbene intermediates to realize C(sp3)−H bond alkylation and arylation.
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ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Yu-Da Zhu,Su-Ping Chen,Huan Zhao,You Yang,Xiao-Qin Chen,Jing Sun,Hong-Song Fan,Xing-Dong Zhang
A medical nanoplatform with small size, low cost, biocompatibility, good biodegradability, and, in particular, multifunctionality has attracted much attention in the exploration of novel therapeutic methodologies. As an emerging material of self-assembled porous structure, metal–organic frameworks (MOFs) have high expectations because of their special properties compared to traditional porous materials. Therefore, integration of MOFs and functional materials is leading to the creation of new multifunctional composites/hybrids. Photothermal therapy (PTT), using near-IR (NIR) laser-absorbing nanomaterials as PTT agents, has shown encouraging therapeutic effects to photothermally ablate tumors. However, the most of widely used PTT agents are inorganic materials and nonbiodegradable. Herein, uniform polypyrrole (PPy) nanoparticles (NPs) with good biodegradability were synthesized by a microemulsion method. The PPy NPs were further coated with the mesoporous iron-based MOF structure MIL-100 by interaction between PPy NPs and MIL-100 precursors at room temperature. As a multifunctional nanoplatform, an anticancer drug could easily be loaded into the mesopores of the MIL-100 shell. The PPy core, as an organic photothermal agent, is able to photothermally ablate cancer cells and improve the efficacy of chemotherapy under NIR irradiation. The composites showed an outstanding in vivo synergistic anticancer capacity. Our work could encourage further study in the construction of a synergetic system using MOFs and organic PTT agents.
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SYNTHETIC METALS
·
2015
·
IF 2.252
Tianzhi Yu,Lijing Ma,Shupei Yu,Zixuan Xu,Yuling Zhao,Hui Zhang
Two new iridium(III) complexes containing the coumarin derivatives as cyclometalated ligands (L) and the carrier transporting group-functionalized dibenzoylmethane as ancillary ligands have been successfully synthesized and characterized. The X-ray crystal structure analyses of the free ligands and the complex containing a carbazole-functionalized dibenzoylmethane as ancillary ligand were described. The photophysical properties of the Ir(III) complexes were examined via ultraviolet-visible, photoluminescence spectroscopic spectra. The good thermal stability of the Ir(III) complexes was demonstrated by the thermogravimetric analysis. The doped light-emitting devices using the Ir(III) complexes as dopants were fabricated. The devices based on the complex containing a carbazole-functionalized dibenzoylmethane as ancillary ligand possess better performance as compared with the devices fabricated by the complex containing a 1,3,4-oxadiazole-functionalized dibenzoylmethane as ancillary ligand. The devices based on the former Ir(III) complex with a 15 wt% doping concentration exhibit a maximum efficiency of 13.8 cd/A and a maximum brightness of 4955.7 cd/m 2 .
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Jialin Liang,Fang Yuan,Ting Liu,Chenguang Qian,Zhangshuo Song,Lijuan Wei,Chunquan Li,Zhiming Sun
Photothermal catalytic oxidation is a promising and sustainable method for the degradation of indoor formaldehyde (HCHO). However, the excessively high surface temperature of existing photothermal catalysts during catalysis hinders the effective adsorption and degradation of formaldehyde under static conditions. Catalyst loading and oxygen vacancies (OVs) modulation are commonly employed strategies to reduce the photothermal catalytic temperature and enhance the efficiency of photothermal catalytic oxidation. In this work, a p-n type CuO/TiO 2 heterojunction is successfully loaded onto diatomite using a wet precipitation method. Under the irradiation of a 300W xenon lamp, the prepared composite material achieved a 100% removal rate of HCHO within 2 h, with a 98% conversion rate to CO 2 , surpassing the performance of both individual photocatalysts and thermocatalysts. Additionally, by adjusting conditions such as light irradiation and temperature, we have demonstrated that this material exhibits synergistic photothermal catalytic properties. Based on HRTEM, XPS, Raman, and EPR analyses, the introduction of diatomite as a catalyst support was shown to effectively increase the number of OVs. Experimental results, along with O 2 -TPD, photoelectrochemical characterization, and radical detection, demonstrate that the presence of OVs enhances the oxidative efficiency of both photocatalysis and thermocatalysis, as well as the UV–Vis-IR photothermal catalytic performance. The ternary composite material generates weak hydroxyl ( • OH) and superoxide ( • O 2 − ) radical under high-temperature with dark conditions, indicating its catalytic oxidation activity under this condition. The increase in temperature and the expansion of the spectral range both enhance the generation of these radicals. In summary, this work demonstrates that the use of diatomite as a support increases the material's specific surface area and OVs content, thereby enhancing adsorption and photothermal catalysis. It elucidates the enhanced catalytic degradation mechanism of this mineral-based photothermal catalyst.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Hao Xu,Run-Song Wang,Yang-Yang Yan,Xing Fan,Xiang Bai,Wen-Long Mo,Xian-Yong Wei
Twelve kinds of base oils were characterized by a series of analytical methods to obtain detailed composition and structure information. Mineral oil and poly alpha olefin oil were mainly composed of long-chain alkanes, while ester oil was mainly composed of ester compounds. Ten of the 12 base oils were selected to synthesize barium lubricating greases . Both base oils and greases were evaluated by molecular simulation , and the corresponding molecular models were constructed based on the structural information of base oils. Grease models constructed by barium 12-hydroxystearate and ester oil exhibited the largest surface adsorption energy and intermolecular interaction energy, respectively, because polar groups in lubricant tend to adsorb on metal surface and form an absorbing film. Comparing physicochemical properties of the synthesized barium lubricating greases. The temperature resistance of grease presents a positive correlation with the simulated intermolecular interaction energy.
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