Biomaterials Advances
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2026
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IF 6.7
Chenkai Zhu,Xinyue Zhang,Zhenzong Shao,Baoning Chang,Yong Wang,Lei Sun,Yang Yang,Xilun Ding,Wuxiang Zhang
To address the challenges on repair of articular cartilage defects in clinic, drug-loaded bioactive hydrogels remain desirable for cartilage support and simulate the cellular microenvironment. However, the reconstruction of cartilage through all-in-one advanced drug delivery hydrogel system is still limited. Herein, we fabricated biocompatible PVA-SF hydrogel composites embedding dual-drug loaded recombinant human collagen microspheres (MS), which were engineered to internally encapsulate Kartogenin (KGN) and externally conjugated Transforming Growth Factor-beta 1 (TGF-β1) via activated heparin. The optimized hydrogel composite (PS-2MS@K-T) loaded with 2 wt% MS, exhibited favorable porous architecture with enhanced compressive strength of 0.59 MPa and Young's modulus of 1.28 MPa, alongside fatigue resistance (>87% retention). This hierarchical structure could establish dual-barrier system for long-term controllable drug release up to >28 days. In vitro studies indicated compatibility of hydrogel composites to support robust cell activity and proliferation. The sustained co-delivery of KGN and TGF-β1 could orchestrate synergistic effect, to upregulate expression of chondrogenic gene, whereas simultaneously suppressing the hypertrophic gene induced by TGF-β1. This cell-free platform provides a promising strategy for functional cartilage regeneration by combining mechanical support, controlled drug release, and biomimetic signaling.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2015
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IF 2.752
Xue Jiao Liu,Hai Qiang Li,Xin Yu Lin,Heng Yi Liu,Guang Hui Gao
Microspheres could be utilized in the industrial waste water treatment due to their huge specific surface areas and surficial functional groups, which possibly adsorb heavy metal ions in the industrial waste. Melamine-formaldehyde (MF) microspheres were easily prepared as mono-dispersed micro-sized particles with a smooth surface. However, these rich amine groups in MF microspheres were frequently ignored for heavy metal ions adsorption owing to coordination effects. In this paper, a rough and bumpy siloxane-modified melamine-formaldehyde (Si–MF) microsphere was prepared using a dispersion polymerization method. Based on the experimental measurement, it is found that the particle size, surface morphology and dispersion state of Si–MF microspheres were significantly influenced by dispersing agent dosages, reaction temperature and pH. And Si–MF microspheres can be degraded in low pH. Moreover, the adsorption of the metal ions (Cu 2+ , Pb 2+ and Ni 2+ ) by Si–MF microspheres was also measured by an Inductive Coupled Plasma (ICP) instrument. The result indicated that the Si–MF microsphere showed a high adsorption capability for metal ions, especially Pb 2+ as a potential metal ion trapping agent.
研究领域:
环境科学
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材料化学
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水处理技术
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高分子化学
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
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2024
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IF 3.1
Yu Yan,Dongxiao Li,Zhimin Guo,Hao Ren,Yubiao Huang,Bei Yan,Ruihuan Zhao,Xin Yao
Developing efficient, low-price non-noble metal-based electrocatalysts for overall water splitting in alkaline medium remains a formidable challenge. In our work, Cr-doped CoP/Fe2P (Cr-CoP/Fe2P) flower-like microsphere was synthesized through a simple hydrothermal and phosphating process. The resulting Cr-CoP/Fe2P electrocatalyst shows significantly enhanced oxygen evolution reaction performance (262 mV @ 10 mA cm-2) and has a satisfactory hydrogen evolution reaction performance (114 mV @ 10 mA cm-2), coupled with favorable stability in an alkaline medium. Furthermore, when assembling Cr-CoP/Fe2P into an electrolytic cell, the two-electrode system can provide a current density of 10 mA cm-2 at a voltage of 1.61 V. At high current density, the performance of the electrolytic cell composed of Cr-CoP/Fe2P is superior to that of noble metal catalyst electrode pair. Electronic structure analysis and various characterizations confirm that Cr doping and the formation of CoP/Fe2P heterogeneous interfaces redistribute the electron densities of the active sites, enlarge the specific surface area, and enhance the aerophobicity of the catalysts, thereby improving the electrocatalytic property. This work provides a referable method for engineering highly efficient and stable non-noble polymetallic phosphides, which serve as bifunctional electrocatalyst for overall water splitting.
研究领域:
材料科学
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电化学
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催化
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能源材料
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Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment
·
2023
·
IF 2.9
Hao Zhe Hou,Yan Su,Ge Lin Liu,Yao Jia Peng,Jian Ping Wang
Niclosamide is usually used for the treatment of parasite infections in animals. However, niclosamide and one of its metabolites 2-chloro-4-nitroaniline are mutagenic substances, and their residues in animal-derived foods are potential risks to consumers. As far as we know, there has been no immunoassay or pseudo immunoassay reported to determine niclosamide and its metabolites in animal-derived foods. In this study, a molecularly imprinted microsphere for niclosamide was first synthesized, and a streptavidin-horseradish peroxidase labelled conjugate was also synthesized. The two reagents were used to develop a pseudo enzyme-linked immunosorbent assay on conventional microplates for the determination of niclosamide and its two metabolites (2-chloro-4-nitroaniline and 5-chlorosalicylic acid) in fish. Because biotinylated horseradish peroxidase was used to amplify the signal, the method sensitivities for the three analytes were increased fivefold to 27.5-fold (limits of detection of 0.004–0.03 ng/mL) in comparison with the use of single horseradish peroxidase labelled conjugate (limits of detection of 0.11–0.16 ng/mL). Their recoveries from the standards fortified blank fish samples were in the range of 70.6–95.5%. This is the first study reporting a molecularly imprinted polymer-based pseudo immunoassay for screening of niclosamide and its metabolites in food sample.
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ANALYTICAL LETTERS
·
2023
·
IF 2
Ge Lin Liu,Hao Zhe Hou,Yan Su,Yao Jia Peng,Yin Liang Wu,Jian Ping Wang
The residues of xylazine and its metabolite in foods of animal origin are dangerous to consumers, but there has been no enzyme-linked immunosorbent assay (ELISA) or ELISA-like method reported to determine them so far. In this study, molecularly imprinted microspheres with xylazine as the template were synthesized, and 2,6-dimethylaniline (the metabolite of xylazine) was used as a hapten to prepare a streptavidinated horseradish peroxidase-labeled conjugate. A direct competitive pseudo-ELISA was developed on a microplate for xylazine and 2,6-dimethylaniline in milk. Because biotinylated horseradish peroxidase was employed to enhance the signal, the limits of detection for xylazine (0.003 ng/mL) and 2,6-dimethylaniline (0.005 ng/mL) were increased by 16.7- and 14-fold, respectively, compared to a horseradish peroxidase-labeled conjugate. Moreover, this material may be reused three times. The analysis of milk samples was consistent with values obtained by liquid chromatography tandem mass spectrometry. This is the first paper reporting a molecularly imprinted polymer-based method for the determination of xylazine and its metabolites in food.
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ELECTROCHIMICA ACTA
·
2023
·
IF 6.6
Chunxia Yan,Jie Guan,Zhimao Li,Fangyue Cheng,Ziqiang Shao
Due to the growing demand for clean and renewable energy, the effective utilization of renewable resources in energy storage and has been concerned. And high specific capacitance and stable electrochemistry for energy storage devices are challenging to develop. Learning from unique structure of goniastrea coral, we design to construct three-dimensional layered conductive electrodes material made of MoS 2 @chitosan carbon spheres (MNCCS) composite. The NiCoLDH nanosheets construct on the surface of conductive chitosan carbon spheres to effectively form open permeable channels and rich conductive networks, improves the efficient energy storage and electrochemical stability. MoS 2 is strongly coupled with NiCoLDH nanosheets through heterointerface, which resembles tentacles on the surface of coral, exposing more active sites to efficiently trap ions. Besides, the obtained material possesses favorable heterojunction interface and defects, which provide sufficient available electroactive sites and numerous storage charge area. Hence, The MNCCS presents an outstanding specific capacitance of 2605.9 F g −1 at 1 A g −1 . Notably, a supercapacitor fitted with MNCCS electrode and CCS electrode achieves high specific capacitance (234.4 F g −1 at 1 A g −1 ), the maximum energy density of 77.0W h kg −1 at highest power density of 667.4W kg −1 , along with the excellent cycling stability of 90.8% retention over 10,000 cycles. This work provides a new perspective for fabricating high-performance and stable supercapacitors electrode material for clean energy storage.
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PROGRESS IN ORGANIC COATINGS
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2023
·
IF 6.6
Tongyu Chen,Xiaoyue Yang,Zhanxiong Li
2 Spraying rough microspheres on the cotton fabrics' surface is an ingenious way to develop textiles with superhydrophobic properties. This paper reports a convenient and low-cost technique for synthesising hydroxyl-terminated polystyrene by atom transfer radical polymerisation (ATRP) and preparing PS-b-PFPE by introducing perfluorinated polyether chain segments through esterification. Simultaneously, PS-b-PFPE was prepared as a finishing solution, and the PS-b-PFPE microspheres were prepared by electrostatic spraying. The effects of different receiving distances, solvents, concentrations, voltage and flow velocity on the morphology and its size distribution of the spray microsphere were studied. The results show that when chloroform was used as a solvent, the working liquid concentration was 80 mg/mL, the flow rate was 0.8 mL/h, the receiving distance was 10 cm and the voltage was 10 kV, the obtained size distribution of the microspheres was narrow. In addition, the static contact angle of the PS-b-PFPE microspheres coating was 159° ± 1°, and the rolling angle was 1.8° ± 0.3°. Consequently, the PS-b-PFPE-coated cotton fabric had good oil–water separation and self-cleaning function with good mechanical stability.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Lan Wang,Zhaoya Fan,Feng Yue,Shuo Zhang,Shuo Qin,Chenhao luo,Long Pang,Jianguo Zhao,Jingjing Du,Baodan Jin,Hongzhong Zhang
Nitrite pollution poses a serious threat to human health and the environment. In this study, a reliable and selective electrochemical (EC) sensor was developed for the quantitative determination of nitrite by combining flower-like three-dimensional (3D) MoS 2 microspheres with two-dimensional (2D) C 3 N 4 nanosheets. Benefiting from the synergistic effects of MoS 2 and C 3 N 4 , the 3D MoS 2 /2D C 3 N 4 nanocomposite displayed numerous active sites, a 3D mesoporous structure, high conductivity and excellent catalytic activity. The 3D MoS 2 /2D C 3 N 4 -modified glassy carbon electrode (GCE) exhibited a superior electrocatalytic activity toward nitrite oxidation, with a wider linear detection range (0.1–1100 μM), a lower detection limit (LOD) (0.065 μM, S/N = 3), outstanding stability, remarkable reproducibility and strong selectivity. Furthermore, the nitrite EC sensor was successfully applied to detect actual food and environmental samples involving sausage, pickled vegetables, river water and tap water, thus demonstrating the potential of the prepared 3D MoS 2 /2D C 3 N 4 /GCE for food analysis and environmental monitoring.
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COMPOSITES PART B-ENGINEERING
·
2023
·
IF 13.1
Li Zhang,Qian Zhang,Weihong Cao,Zhenghong Guo,Zhengping Fang,Juan Li,Peng Chen
A phosphorous-silicon (SiP) precursor was synthesized using p-phthalaldehyde, (3-aminopropyl) triethoxysilane and 9,10-dihydro-9-oxa-10-phosphaphenantrene-10-oxide. The SiP was used to fabricate a phosphorous-silicon hybrid microsphere (SiP-M) via the sol-gel method. The SiP-M was employed to enhance the flame retardancy of poly (butylene adipate-co-terephthalate) (PBAT). The results indicate that PBAT containing 0.1 wt% of SiP-M displays a UL-94 V0 rating and a limiting oxygen index (LOI) value of 26.5 vol%. Meanwhile, PBAT containing 1.0 wt% SiP-M exhibits a UL-94 V0 rating and a LOI value of 29.8 vol%, and some reductions in peak heat release rate , total heat release, and total smoke production. The SiP-M functions in both the gas phase and condense phase in the PBAT blend, and the former is predominant. In addition, a coupling agent KH560 was used to modify the interface adhesion between PBAT and SiP-M. The tensile strength and elongation at the break of PBAT blends are enhanced by an appropriate amount of KH560. This work provides an efficient method for preparing flame-retardant PBAT without deteriorating its mechanical properties .
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Fan Zhao,Siqi Gong,Huiting Xu,Meng Li,Lina Li,Junjie Qi,Honghai Wang,Chunli Li,Wenchao Peng,Jiapeng Liu
As candidates of the next generation batteries, aqueous zinc-ion batteries (ZIBs) have drawn widespread attention owing to the advantages of environmental friendliness, low cost and ultrahigh theoretical capacity. In order to obtain superior zinc ions (Zn 2+ ) storage ability, the cathode materials with eminent electrochemical property are placed great expectations. Herein, the hierarchical 3D a-V 2 O 5 @Ti 3 C 2 T x microsphere is prepared by a simple spray drying process. In the heterostructure, the amorphous V 2 O 5 not only endows abundant active sites for Zn 2+ storage but also effectively alleviates Ti 3 C 2 T x MXene nanosheets restacking. Meanwhile, the presence of conductive Ti 3 C 2 T x MXene framework significantly enhances the conductivity and reaction kinetics of the electrode material. As a result, the 3D a-V 2 O 5 @Ti 3 C 2 T x exhibits an impressive Zn 2+ storage ability, including the high reversible capacity (604 mAh g −1 at 0.5 A g −1 ), the superior rate performance and the splendid cycling stability. Furthermore, the relevant mechanism is illustrated via various characterizations. Moreover, the as-fabricated pouch ZIBs based on the 3D a-V 2 O 5 @Ti 3 C 2 T x displays a potential practical application prospect as flexible energy storage devices. Hence, this work may provide an inspiration for the rational design of high performance ZIBs cathode materials.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 22
·22362-22371
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IF 2.914
Du Hongxue,Shi Shuyun,Liu Wei,Che Guangbo,Piao Mingyue
Polyethylene glycol diacrylate (PEGDA) hydrogel microsphere was synthesized by UV-assisted reverse emulsion polymerization as an efficient adsorbent for water purification. Optical microscopy and TEM proved its spherical and hollow structure, while XRD pattern proved that it was amorphous with limited crystallinity. Abundant oxygen-containing functional groups such as hydroxyl were detected by FTIR. The hydrogels exhibited low swelling capacities ranging from 0.19 to 0.77 g/g in water and would decrease in salty solutions. The effects of operation parameters on the bisphenol A (BPA) adsorption were studied, including the polymer composition between PEGDA and polyethylene glycol methacrylate (PEGMA), initial concentration of BPA, pH, and operation temperature. The resulting hydrogel, especially for PDM 2 (the ratio between PEGDA and PEGMA is 2), was able to effectively enrich BPA in water. The adsorption capacity was nearly stable below pH 8.0 and decreased when beyond 8.0. Thermodynamic parameters reflected that BPA adsorbed by hydrogel was a spontaneous ( ΔG 0 < 0) and exothermic ( ΔH 0 < 0) progress. The adsorption capacity increased with the increase of the concentration of NaCl, exhibiting salinity-enhanced adsorption capacity driven by hydrophobic force. Excellent results were also achieved by applying hydrogel for spiked real surface waters, which accounted for more than 91% compared to simulated solution. As-prepared hydrogel was expected to be good candidate for treatment of endocrine disruptors with lower solubility in water.
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Polymers
·
2019
·Vol. 11
·期 9
·1417
·
IF 3.164
Wei Wang,Zufeng Xiao,Chaofan Huang,Kewang Zheng,Yin Luo,Yumin Dong,Zitong Shen,Wei Li,Caiqin Qin
Chitosan microspheres modified by 2-pyridinecarboxaldehyde were prepared and used in the construction of a heterogeneous catalyst loaded with nano-Cu prepared by a reduction reaction. The chemical structure of the catalyst was investigated by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and X-ray Photoelectron Spectroscopy (XPS). Under mild conditions, such as no ligand at room temperature, the catalyst was successfully applied to catalyze the borylation of α,β-unsaturated receptors in a water-methanol medium, yielding 17%–100% of the corresponding β-hydroxy product. Even after repeated use five times, the catalyst still exhibited excellent catalytic activity.Keywords:chitosan microspheres;copper;organoboron compounds
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