JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·150
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IF 12.6
Li Bei,Chen Zhengqiang,Sun Yong,Gou Maling,Luo Yuting,Zhang Wenli,Ye Xiwen,Zhao Yaqin,Feng Lei,You Zhen
The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu 2 − x Se nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu 2 − x Se domains, resulting in the formation of a unique “lollipop” nanostructure. This design enables single-wavelength NIR-II laser-activated photothermal therapy and dynamic dual-modal therapy with intrinsic hypoxia tolerance: the nanoprobes achieve exceptional photothermal stability while simultaneously driving photothermally enhanced chemodynamic activity through accelerated Fenton-like catalytic cycles. Crucially, this strategy not only eradicates deep tumors but also activates systemic antitumor immunity. Combined with real-time photoacoustic imaging guidance, the platform establishes an oxygen-independent paradigm for treating hypoxic solid tumors. Graphical
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Polymers
·
2026
·Vol. 18
·期 3
·378
·
IF 4.9
Lin Sun,Zihao Zhang,Bingxin Sun,Zhiheng Yu,Guoyong Wang
Vanadium carbide (V 2 C) MXene shows great potential for addressing challenging implant-associated infections in bone regeneration due to its strong photothermal conversion efficiency. However, its photothermal efficacy is restricted to the near-infrared I (NIR-I) region due to a limited absorption range. To address this, we designed platinum nanoparticle-decorated V 2 C heterostructures (Pt@V 2 C) via an in situ growth method, leveraging Pt’s plasmonic and catalytic properties to extend the photoresponse to the NIR-II window. Subsequently, Pt@V 2 C was integrated into poly-L-lactic acid (PLLA) to fabricate PLLA-Pt@V 2 C scaffolds with photothermal antibacterial function by selective laser sintering. The optimized PLLA-Pt@V 2 C scaffold achieves a record photothermal conversion efficiency (56.03% at 1064 nm), triggering simultaneous hyperthermia (>52 °C) and catalytic ·OH radical generation. In vitro studies demonstrate exceptional antibacterial efficacy against Staphylococcus aureus and Escherichia coli, achieving over 99% killing rates upon 1064 nm near-infrared irradiation. Furthermore, the scaffold demonstrated significant inhibition of biofilm formation, achieving over 90% reduction in biofilm biomass. Moreover, the scaffold demonstrated high cell viability, confirming its dual functionality of potent bactericidal activity and biocompatibility that supports tissue regeneration. This work provides a feasible strategy for combating implant-associated infections.
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Communications Chemistry
·
2026
·
IF 6.9
Yuan Yuan,Liu Yongze,He Lei,Ma Xiaofeng,Wang Heyan,Li Yuanchao,Zhang Zhaoxiang,Zhang Jun,Wu Yongjun,Gao Xia
Acute sinusitis, common across populations, worsens seasonally due to pollution and improper medication, increasing the risk of chronic disease and impairing quality of life. To improve treatment and limit antimicrobial resistance in acute sinusitis, we developed a natural injectable QACS/SA@Py@Ta 4 C 3 hydrogel. It integrates the traditional Chinese medicine phillyrin with Ta 4 C 3 quantum dots and natural polymers—quaternary chitosan and sodium alginate. The hydrogel is designed for NIR II–mediated treatment of acute sinusitis via combined photothermal and photodynamic therapy. It exhibited a photothermal conversion efficiency of 22.6% and generated transient ROS, as demonstrated in vitro. Bacteriostatic experiments revealed that the hydrogel inhibited S. aureus with an efficiency of 99.7%. Furthermore, cell studies showed that the hydrogel was minimally cytotoxic, modulated macrophage cytokine expression, and displayed anti-inflammatory and antioxidant activities. Finally, in a rabbit sinusitis model, hydrogel implantation at the treatment site significantly reduced bacterial burden and decreased inflammation after NIR II laser treatment, demonstrating promising therapeutic potential.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiuxia Wang,Shide Dong,Xinxi Li,Min Wang,Chunjie Yan,Huaming Yang,Yuting Gao
Postoperative tumor recurrence and metastasis have long been challenging issues for cancer patients. In this work, we have developed an implantable carbon foam that uniquely integrates second near-infrared (NIR-II) light triggered drug release, photothermal therapy, and rapid hemostasis by cross-linking a drug-loaded agarose gel with porous carbon foam (DOX@AG/CF). The functionalized carbon foam possessed outstanding photothermal conversion performance, achieving a rapid temperature rise exceeding 108 °C in just 4 s under a low power intensity of 0.25 W cm −2 with 1064 nm laser irradiation, thereby minimizing the risk of severe skin damage. Furthermore, DOX@AG/CF can regulate the release of the loaded drug though the temperature-responsive agarose gel, which synergistically facilitates postoperative therapy. As a result, such all-in-one gel/carbon foam composite, integrating postoperative hemostasis, photothermal therapy and photocontrolled chemotherapy, can effectively eradicate residual tumor cells and prevent the recurrence and metastasis of cancer in vivo . More importantly, the implanted carbon foam demonstrated excellent degradability and biocompatibility, presenting great potential in clinical application.
研究领域:
生物医学工程
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癌症治疗
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材料科学
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LANGMUIR
·
2025
·
IF 3.9
Yujie Ma,Liangbin Xiong,Wenbin Qiu,Zhixin Dong,Xindong Wei,Jilei Li,Yi Fu,Jie Xiong,Hailong Wu
Gold nanobipyramids (Au NBPs), as a novel and emerging plasmonic nanomaterial, have shown larger local electric field enhancements, larger optical cross-sections, and higher refractive index sensitivity compared to other plasmonic nanoparticles. Besides, their localized surface plasmon resonance (LSPR) absorption can be tailored to cover the entire NIR-II light region, which is crucial for clinical cancer treatment. However, strategies to synthesize Au NBPs with an NIR-II light response still have several disadvantages, such as tedious procedures and the use of hazardous chemical substances. In this work, we used a seed-mediated growth method and explored new strategies to synthesize high-yield Au NBPs with an NIR-II light response, especially in the region above 1030 nm, by regulating the conditions during Au seed growth. The yield of Au NBPs with a response at 1060 nm has been improved by 5-fold and 6-fold compared to previous seed-mediated growth methods when 230 μL of sodium citrate or a controlled temperature of 45 °C were used for Au seed growth with an Au seed solution containing 125 μL of NaBH4. The influence mechanism of these factors on Au seed growth and the yield of Au NBPs has been explored in detail. Furthermore, the photodynamic and photothermal behaviors of Au NBPs with LSPR absorption at 1060 nm have been investigated, and the results indicate that Au NBPs have great potential in photothermal therapy. Besides, Au NBPs have been proven to induce immunogenic cell death (ICD), indicating their potential in immunotherapy. This work may provide a new idea for the synthesis and biomedical applications of Au NBPs with an NIR-II response.
研究领域:
生物医学工程
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纳米医学
·
肿瘤学
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Youpei Wang,Xiang Zheng,Shiyun Liang,Danyan Wang,Xiaojun He,Lingxia Pang
Traditional treatments for drug-resistant bacterial keratitis and pneumonia often prove ineffective due to the presence of biofilm barriers and multidrug resistance. Existing nano-antibacterial systems face several limitations, including insufficient tissue penetration depth in the first near-infrared (NIR I) window, the inability of a single treatment modality to simultaneously disrupt biofilms and eradicate residual bacteria, and a lack of efficacy validation in cross-organ (ocular-pulmonary) infection models. In this study, we employed a defect engineering strategy, to construct a palladium-doped TiO 2 nanozyme with oxygen vacancies (PdO V -TiO X ). This nanozyme achieves multiple antibacterial effects through the synergistic combination of second near-infrared (NIR-II) laser-activated photothermal therapy and chemodynamic therapy. Under 1064 nm laser excitation, the system utilizes oxygen vacancy-enhanced peroxidase-like activity to continuously generate hydroxyl radicals (•OH), resulting in a 5.2-fold increase in radical production compared to dark conditions. Additionally, it induces a local temperature rise (ΔT = 28.2 °C). These combined effects—physical disruption of the biofilm matrix and ROS-mediated oxidative stress—effectively dismantle the defense mechanisms of drug-resistant bacteria. In models of drug-resistant Staphylococcus aureus keratitis and pneumonia, PdO V -TiO X demonstrated therapeutic efficacy in both the eye and lung, indicating the broad cross-organ applicability of this treatment. Under NIR-II irradiation, the PdO V -TiO X nanozyme significantly elevated ROS levels at the infection site, achieving efficient bactericidal action while effectively penetrating and disrupting mature biofilms. This work presents a novel defect-engineering-regulated nanozyme synergistic therapeutic strategy for the treatment of multidrug-resistant bacterial infections.
研究领域:
纳米医学
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抗菌治疗
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材料科学
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生物医学工程
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传染病学
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Journal of Innovative Optical Health Sciences
·
2024
·
IF 2.3
Yuxiang Gao,Chi Zhang,Lijun Zhu,Zhong Du,Rong Ma,Le Guo,Nuernisha Alifu,Xueliang Zhang
Triple-negative breast cancer (TNBC) is an aggressive and often fatal disease, especially since the brain metastasis of TNBC has been a particularly severe manifestation. However, brain metastasis in TNBC at early stages often lacks noticeable symptoms, making it challenging to detect. Near-infrared II (NIR-II) fluorescence microscopic imaging obtains long wavelength, which enables reduced scattering, high spatial resolution and minimal autofluorescence, it is also a favorable imaging method for tumor diagnosis. PbS@CdS quantum dots (QDs) are one of the popular NIR-II fluorescence nanoprobes for well brightness. In this study, NIR-II emissive PbS@CdS QDs were utilized and further encapsulated with thiol-terminated poly(ethylene oxide) (SH-PEG, MW = 5000) to form PbS@CdS@PEG QDs nanoparticles (NPs). The obtained PbS@CdS@PEG QDs NPs were then characterized and further studied in detail. The PbS@CdS@PEG QDs NPs had large absorption spectra, exhibited strong NIR-II fluorescence emission at approximately 1300 nm, and possessed good NIR-II fluorescence properties. Then, the mice model of early-stage brain metastases of TNBC was established, and the PbS@CdS@PEG QDs NPs were injected into the tumor-bearing mice for NIR-II fluorescence microscopic bioimaging. The brain vessels and tumors of the living mice were detected with high spatial resolution under the NIR-II fluorescence microscopic imaging system with irradiation of 808 nm laser. The tumor tissues were further restricted and prepared as thin slices. The NIR-II fluorescence signals were collected from the tumor slices with high spatial resolution and signal-to-background ratio (SBR). Thus, the PbS@CdS@PEG QDs NPs-assisted NIR-II fluorescence microscopic system can effectively achieve targeting brain metastases of TNBC imaging, offering a novel and promising approach for TNBC-specific diagnosis.
研究领域:
肿瘤学
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医学影像学
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纳米医学
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Nanoscale Horizons
·
2026
·
IF 6.6
Juxin Gao,Hengze Ding,Qinghua Wu,Yuhang Hu,Yifan Yan,Minming Chen,Chunjie Wang,Zhuang Liu,Liangzhu Feng
Ferroptosis, characterized by iron-dependent lipid peroxidation, represents a promising therapeutic target for cancer treatment. Strategies that disrupt intracellular antioxidant systems to induce ferroptosis in cancer cells have been extensively explored. Herein, we developed a pH-responsive phototheranostic agent (designed as FSB 4 Ca NPs) by encapsulating conjugated boron dipyrromethene tetramers (B4) within ferric ion-sulfasalazine metallo-network polymercoated calcium carbonate hollow nanoparticles. Sulfasalazine, a known ferroptosis inducer that inhibits System X c --mediated cysteine influx, synergizes with ferric ion-driven glutathione (GSH) depletion to collectively amplify intracellular lipid peroxidation. In addition to serving as a second near-infrared (NIR-II) fluorophore for tracking the in vivo distribution of FSB 4 Ca NPs, B4 mediates a photothermal effect that significantly enhances lipid peroxidation induction by boosting the Fenton catalytic activity of ferrous ions. Combined with localized 915-nm laser irradiation, intravenously administrated FSB 4 Ca NPs achieved substantial tumor suppression in mouse models, with a complete remission rate of 80%. This study establishes a facile strategy for developing long-circulating NIR-II phototheranostic agents with self-amplified lipid peroxidation induction capacity, enabling photothermally augmented ferroptosis for cancer therapy.
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ACS Nano
·
2026
·
IF 17.3
Peilong Jiang,Zhurun Fang,Jinyu Li,Jing Wu,Xiaolong Zhu,Chang Jiang,Ming Zhang,Xiaochen Qu
Bacterial infection is now a significant obstacle to the effective repair and regeneration of both soft tissues and bone in clinical settings. Managing infected sites is challenging due to multiple antimicrobial resistance, abnormal inflammatory responses, and an excessive inflammatory microenvironment. To meet the complex healing needs following soft tissue or bone, an immunomodulatory thermosensitive hydrogel was designed and synthesized. The composite hydrogel (CQDs@UPDA@gel) combines carbon quantum dots (CQDs) as the second near-infrared window (NIR-II) photothermal agents (PTAs) and ultrasmall polydopamine nanoparticles (UPDA NPs) as reactive oxygen species (ROS) scavengers and immunomodulators, embedded within a chitosan matrix coordinated with Cu2+ that enhances the good swelling performance and stable rheological properties of the hydrogel. This synergistic approach simultaneously inhibits bacterial infection and alters the immunosuppressive microenvironment, thereby promoting coordinated soft tissue or bone regeneration. In vivo studies have shown that the hydrogel can encourage the regeneration of soft tissue or bone under NIR-II laser irradiation for the treatment of infectious wounds, subcutaneous abscesses, and infectious bone defects in the maxillofacial region. Overall, this project offers a general strategy for creating multifunctional hydrogels that both eradicate pathogens and modulate the immune microenvironment to support the repair of complex soft tissue or bone infections.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-14
·
IF 10.2
Liu Guoyong,Wang Shuxian,Wang Shumin,Wu Rongrong,Li Hui,Zha Menglei,Song Jibin,Yin Yuxin,Li Kai,Mu Jing,Shi Yu
Background Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation of absorption in the NIR-II window, leading to poor effect of PTT. It remains a great challenge to gain photothermal agents with strong and characteristic absorption in NIR-II regions. To overcome this problem, based on carbon dots (CDs)-mediated growth strategy, we proposed a simple and feasible approach to prepare plasmonic gold nanodendrites (AuNDs) with NIR-II absorption to enhance the therapeutic effect of PTT. Results By rationally regulating the size and branch length of AuNDs, the AuNDs exhibited a broadband absorption from 300 to 1350 nm, with two characteristic absorption peaks located at 1077 and 1265 nm. The AuNDs demonstrated desired optical photothermal conversion efficiency (38.0%), which was further applied in NIR-II photoacoustic imaging (PAI) and PTT in human colon cancer cells (HCT 116)-tumor-bearing mice model. The tumor cells could be effectively eliminated in vivo under 1064 nm laser irradiation by the guidance of PAI. Conclusions We reported a simple but powerful synthetic method to obtain the unique AuNDs with strong and characteristic absorption peaks in the NIR-II window. This study provides a promising solution to tuning the growth of nanoparticles for bioimaging and phototherapy in the NIR-II window. Graphical Abstract
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoyang Liang,Ping Liu,Wen Li,Long Binh Vong,Tingting Wang,Lujing Geng,Yue Zhou,Siyu Wang,Qiang Lu,Fengping Tan,Xinxing Wang,Nan Li
Reactive oxygen species (ROS)-mediated cell cycle arrest mechanism shows distinguished potential for the inhibiting of cancer cells. However, poly ADP-ribose polymerase (PARP), an enzyme which can contribute to the repair of single-strand DNA nicks, largely limited the efficiency in cell cycle arrest. Here, polydopamine (PDA)/hyaluronic acid (HA) decorated and protein translation inhibitor homoharringtonine (HHT) loaded tellurium (Te)-prussian blue (PB) nanorods ( [email protected] @PDA-HA/HHT NRs) were synthesized for boosted G2 cell cycle arrest to realize tumor ablation. Under NIR-II irradiation, Te and Fe elements can collectively generate ROS and deplete GSH due to the fenton-like reaction and metal-reducing reaction under tumor microenvironment (TME), thus disturbing the DNA structure to induce cell cycle arrest. More importantly, HHT suppresses PARP production to induce DNA repair dysfunction, thereby boosting DNA oxidative damage. Remarkably, this nanoplatform degrades into ionic form under acid condition, illustrating inherently TME-responsive biodegradability. The anti-tumor evaluation illustrated that [email protected] @PDA-HA/HHT NRs could notably destroy tumor cells in both cellular experiments and mouse models. This study made a successful attempt in boosted cell cycle arrest and encouraged more biological explorations on biodegradation nanomaterials, especially in combating cancers.
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Pengcheng Hu,Yongxin Li,Luchen Zhang,Xiaopeng Lan,Xiaochuan Ren,Wenlong Liang,Shen Wang,Yizhen Wang,Yanhui Zhao,Yanhui Zhang,Chunzhao Liu,Chunlei Liu
Cuproptosis is a newly recognized copper-dependent nonapoptotic form of cell death, which stimulate studies exploring copper-based nanomaterials to treat cancer through distinct mechanistic action. However, it remains a challenge to completely eradicate tumors via monotherapy. Herein, a copper-doped BiSe x (CBS) nanozyme was developed to boost αPD-L1-mediated immune checkpoint blocking (ICB) via synergetic apoptosis/cuproptosis-induced immunogenic cell death (ICD). The defect-engineered CBS nanozyme exhibits strong peroxidase-mimicking activities and generates abundant reactive oxygen species (ROS) production causing cell apoptosis, which could be further augmented by NIR photoirradiation. Meanwhile, the CBS could cause mitochondrial lipoylated protein aggregation, leading to cell cuproptosis. The photothermal/catalytic/cuproprosis synergistic therapy triggered by CBS nanozyme combined with αPD-L1 antibody effectively inhibits the growth of primary tumors and distant tumors in prostate cancer model. Furthermore, CBS nanozyme exhibited significant germicidal effect in wound infection. Collectively, this work provides a new insight into cancer treatment of copper-based nanozyme based on cuproptosis/apoptosis-related combined therapy.
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