Nanomedicine-Nanotechnology Biology and Medicine
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2020
·
IF 5.182
Xiuying Yang,Dongliang Zhai,Jia Song,Rui Qing,Bochu Wang,Jingou Ji,Xiaoliang Chen,Shilei Hao
Bone-targeted therapies have been the choice of treatments for cancer metastases in bone to minimize skeletal morbidity and preserve patients' quality of life . Rhein is of particular interest due to its high bone affinity. Here we reported a novel Rhein- polyethylene glycol (PEG)-nano hydroxyapatite (nHA) conjugate to deliver doxorubicin (DOX) and Phosphorus-32 ( 32 P) simultaneously for enhanced cancer chemo-radiotherapy. The synthetic Rhein-PEG-nHA conjugates were sphere in shape with an average diameter of ~120 nm . Their morphology, drug release and bone affinity were confirmed in vitro . The release profiles of DOX depend on pH condition , but 32 P exhibited good stability. Rhein-PEG-nHA also showed high bone affinity in vivo , and the tumor volume decreased after the [email protected] and 32 [email protected] treatments. Most importantly, the DOX/ 32 [email protected] showed the strongest inhibition on the growth of bone metastases of breast cancer. We revealed the potential of Rhein-PEG-nHA in combined chemo-radiation treatment for bone metastases of breast cancer.
研究领域:
药学
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肿瘤学
·
材料科学
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Leilei Zhang,Mengxiao Zhang,Jingyu Lu,Anqi Tang,Liping Zhu
The incorporation of nanofillers in interfacial polymerization is a promising approach to elevate the permeability of thin-film nanocomposite (TFN) membranes. However, commonly-used inorganic nanomaterials (e.g., silica , zeolites , and carbon nanotubes) often bring defects, and thus low selectivity to the membranes due to their poor interfacial compatibility with polymeric matrix. In this work, organic polydopamine/poly(ethylene glycol) (PDA/PEG) nanocapsules were designed as fillers of the TFN membranes prepared by interfacial polymerization of piperazine with trimesoyl chloride. No aggregation phenomenon was observed for the nanocapsules in the membranes, which is attributed to their good dispersity brought by the grafted PEG brushes on the shells. Defect-free separation layer was obtained for the TFN membranes due to good miscibility of polymeric nanocapsules with polyamide matrix. The inner cavities of the embedded nanocapsules played a role of shortcuts for water permeation through the thin-films. The resultant PDA/PEG-TFN membranes showed a high water permeance of 11.7 L·m −2 ·h −1 ·bar −1 , approximately 2.2 times that of the control TFC membrane , while maintained high solute rejections ( R Na2SO4 = 95% and R Vitamin B12 = 98%). Moreover, the PDA/PEG-TFN membranes exhibited high selectivity towards di-/mono-valent salts. This work presents a novel strategy of constructing water transport channels in selective layer to develop high performance nanofiltration membranes.
研究领域:
材料科学
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膜技术
·
环境工程
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DOI
高影响因子
Journal of Materials Chemistry A
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2014
·Vol. 2
·期 45
·19315-19323
·
IF 0
Chunli Gong,Fangli Deng,Chi-Pong Tsui,Zhigang Xue,Yun Sheng Ye,Chak-Yin Tang,Xingping Zhou,Xiaolin Xie
The poor electronic conductivity and low lithium ion diffusion rate of a LiFePO4 cathode material are the two major obstacles for its commercial applications in the power lithium ion batteries. This article utilized an electroactive and ion conductive copolymer, polyaniline–poly(ethylene glycol) (PANI–PEG), to modify carbon-LiFePO4 (cLFP) by a facile in situ chemical copolymerization method. The structure and morphology of the cLFP/PANI–PEG composite were confirmed by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compared with a cLFP/PANI composite, the cLFP/PANI–PEG composite exhibited a more uniform and full polymer coating layer. Furthermore, this cLFP/PANI–PEG cathode material exhibits excellent cyclic stability (95.7% capacity retention after 100 cycles at 0.1 C) and high rate capability (125.3 mA h g−1 at 5 C) as the PANI–PEG copolymer coating layer facilitated electron and ion transport within the electrode. Electrochemical impedance spectroscopy (EIS) proved that the lithium ion diffusion in the cLFP/PANI–PEG composite was increased significantly by one order of magnitude compared with cLFP, indicating its possibility to be served as a cathode material for high-performance lithium ion batteries.
研究领域:
材料科学
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电化学
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DOI
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
·
IF 5.091
Dongya Li,Shiyu Zuo,Haiming Xu,Jie Zan,Lei Sun,Donghui Han,Wei Liao,Binyang Zhang,Dongsheng Xia
A g-C 3 N 4 -Cu 2 O was successfully synthesized in the presence of PEG-400 surfactant via a hydrothermal method and high-temperature calcination method. Based on the results of TEM , XPS , EPR , and other techniques, it was verified that a heterojunction was formed. The synthesized g-C 3 N 4 -Cu 2 O show excellent photocatalytic activity and stability was confirmed through cycling experiments, XRD and XPS. At a suitable addition amount, the value of band gap of g-C 3 N 4 -Cu 2 O is reduced to 1.87 eV, the PL intensity decreases effectively, the specific surface area is increased to 12.8114 m 2 /g, and the photocatalytic degradation rate is increased to 94%. Adding the surfactant PEG-400 in the precursor solutions leads to a reduction in the crystallite size, which can improve the morphology and specific surface area to form abundant heterojunction interfaces as channels for photo-generated carrier separation, and improve its light utilization and quantum efficiency.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2026
·
IF 8.8
Zhang-Fu Shi,Peng Cheng,Yi-Fan Li,Jie Yang,Yan Chen,Xiao-Jing Guo,Xi Yan,Wan-Zhong Lang
Polyethylene glycol (PEG), a versatile non-ionic surfactant with excellent biocompatibility and robust chemical stability, offers significant potential for the precise regulation of interfacial polymerization (IP). In this study, PEG was introduced into the aqueous phase as an additive to modulate the interfacial diffusion behavior of piperazine (PIP). By systematically optimizing its molecular weight, concentration, and terminal group parameters, a polyamide (PA) active layer with a smaller and more uniformly distributed pore structure was successfully constructed. This optimized architecture effectively strengthened both the size exclusion and charge repulsion mechanisms of the nanofiltration (NF) membrane. Consequently, the optimal MP 1000 -10 membrane exhibited highly competitive NF performance, achieving an impressive Na 2 SO 4 rejection of 98.0% and a high water permeance of 11.5 L m −2 h −1 bar −1 . More importantly, tailoring the PEG terminal groups facilitated targeted control over the pore size and surface charge properties, significantly enhancing the removal of structurally and physicochemically diverse emerging organic contaminants (EOCs). Across a broad set of experimental parameters, PEG modification consistently delivers improved separation performance for membranes. With excellent stability, high efficiency and economic feasibility, this strategy provides solid technical and theoretical support for developing advanced separation membranes targeting high-efficiency EOCs removal.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Yinuo Zhang,Dong Yang,Yuxi Wang,Dengke Li,Tao Mei,Qihao Guo,Ming Xia,Pan Cheng,Ke Liu,Dong Wang
Vacuum-assisted fabrication of EVOH nanofiber membrane with uniform nanopores for virus removal. • In-situ GA/PEG modification endows superior hydrophilicity and protein antifouling performance. • Optimized PNFM achieves high flux of 857.45 L·m −2 ·h −1 , > 95% protein recovery rate and virus LRV > 5. • The membrane breaks permeability–fouling trade-off for biopharmaceutical virus filtration. Achieving high-throughput virus clearance without compromising protein recovery remains a critical challenge in biopharmaceutical processing. This study is predicated on the hypothesis that the assembly of ultrafine nanofibers, coupled with synergistic in-situ PEG crosslinking, can create a mechanically robust membrane with precisely tailored nanopores and a good hydrophilic surface to overcome the permeability-selectivity trade-off. Herein, ultrafine ethylene vinyl alcohol (EVOH) nanofibers (∼50 nm) were produced via melt extrusion phase separation and fabricated into membranes through vacuum-assisted wet-laying. Subsequent in-situ crosslinking with glutaraldehyde (GA) and polyethylene glycol (PEG) yielded a modified membrane (PNFM-2) featuring a narrow pore size distribution (33.18 nm) and good hydrophilicity (water contact angle: 28.9°). The membrane demonstrated an exceptional steady-state water flux of 857.45 L m −2 h −1 , a 30 nm Au nanoparticle rejection rate above 99%, and a bovine serum albumin (BSA) recovery rate exceeding 95%. Crucially, PNFM-2 achieved a log reduction value (LRV) > 5 for PP7 bacteriophages in intravenous immunoglobulin solutions, fulfilling the stringent international conference on harmonization (ICH) Q5A regulatory requirements. These results validate the proposed hypothesis and offer a simple, scalable strategy for engineering high-performance, antifouling nanofibrous membranes for industrial-scale viral clearance. Download: Download high-res image (243KB) Download: Download full-size image
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Nesma S. Abdelaty,Mostafa Gouda,Amel Thanina Amrouche,Cheng Chen,Baiyi Lu
Casein-based gel delivery systems often exhibit limited loading efficiency and functional performance under conventional formulation approaches. We present a novel UV-induced photo-crosslinking strategy for generating porous casein–polyethylene glycol gels, enhancing resveratrol stabilization and enabling controlled delivery during processing and storage. Structural characterization by FTIR and 13 C NMR supported the formation of an enhanced covalent network via ester and amide linkages. Formulation optimization showed that 10% casein achieved a crosslinking degree of 93.32 ± 0.43% ( p < 0.05), accompanied by rapid gelation (18 s) and a sixfold increase in storage modulus compared with the control, while gel electrophoresis profiles supported controlled degradation behavior. Resveratrol was efficiently encapsulated at 96.31 ± 1.40%, as evidenced by reduced fluorescence intensity in the cross-linked matrix, and the optimized gel retained 86% of the drug during storage. The optimized formulation exhibited enhanced antioxidant performance, with 27.03% higher DPPH radical-scavenging activity and 46.12% higher ABTS response compared to the non-crosslinked system, highlighting that structurally engineered casein-based gels can significantly enhance encapsulation efficiency and the controlled release of sensitive bioactives in pharmaceutical applications.
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Menghan Guo,Yifan Wang,Wenqing Wang,Fuyang Li,Gang Ye,Yifan Yan,Pengfei Qi,Kexin Luo,Rui Wang
Thermal sensing materials capable of monitoring critical fire risks of combustible materials with a rapid response show great potential in early fire warning. However, the thermoelectric materials used in current fire-warning systems usually have low mechanical strength and poor flexibility, limiting their application in harsh environments and in wearable devices. In this work, a class of multilaminated MXene/aramid nanofiber (ANF)/poly(ethylene glycol) (PEG) composite film (MAP) was developed by a vacuum-induced self-assembly method. Because of the compatibility of the hybrid building units with reinforced interconnections, the MAP films exhibit excellent mechanical properties in terms of tensile strength (139.9 MPa), toughness (20.7 MJ/m3), strain (23.1%), modulus (6.1 GPa), and durability (fold times: 39,991). Moreover, the MAP films showed superior fire retardancy with the LOI value of 35%, exhibiting rapid self-extinguishing capability. Significantly, taking advantage of the thermoelectric effect and continuous conductive paths of MXene nanosheets, rapid cyclic contact/noncontact fire warning (<1 s) was achieved. Integrating the MAP film into the IoT system enabled remote real-time fire monitoring and feedback with a rapid response. In addition, the MAP film can be employed as an early fire-warning coating on textiles, further expanding its wearable fire alarm scope. This work provides a perspective for designing robust wearable early fire detection sensors and fire protection applications.
研究领域:
材料科学
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智能纺织品
·
纳米技术
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DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Jia-Qi Luo,Yong-Cong Huang,Jing-Yang Zhang,Qi-Song Tong,Areesha Batool,Jinzhi Du,Yuyou Duan
Antigen-presenting cells (APCs), such as macrophages and dendritic cells (DCs) are key players in modulating the immune responses of cytotoxic T lymphocytes (CTLs). Resiquimod (R848), a toll-like receptor (TLR) agonist, has demonstrated the capacity to enhance APC function and reprogram the phenotype of macrophages; however, the unfavorable in vivo performance constrains its therapeutic potential. Here, we developed R848-loaded mesoporous silica nanoparticles (denoted as R848@MSN-bi-PEG) with pH-responsive surface PEG detachment to effectively modulate APCs. The acidic tumor pH triggered PEG detachment when R848@MSN-bi-PEG accumulated at the tumor site, thereby promoting APC uptake and R848 release, which facilitated DCs maturation and macrophage repolarization to a pro-inflammatory phenotype. The in vivo antitumor study indicated that R848@MSN-bi-PEG led to potent anti-tumor immunity by modulating the immunosuppressive tumor microenvironment. This approach offers a novel strategy to improve the effectiveness of cancer immunotherapy.
研究领域:
生物医学工程
·
免疫学
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Qi Jiang,Bin Li,Senwei Wu,Xiujian Zhao,Shouqin Tian
Thermochromic hydroxypropyl cellulose (HPC) hydrogel-based smart windows have attracted considerable attention owing to their significant potential to reduce the building energy consumption. Lowering their low critical transition temperature (LCST, >40 °C) to room temperature (∼25 °C) is the primary goal for practical application, but this is always accompanied by a compromise in solar modulation efficiency (Δ T sol ). To address this issue, we proposed a ‘two birds with one stone’ approach: introducing polyethylene glycol (PEG) into hydrogels. By adjusting the content and molecular weight of PEG, LCST could be flexibly controlled from 45.5 to 24 °C by tailoring the hydrogen bonding strength between HPC and water. Meanwhile, the introduction of PEG formed a denser double network structure. This induced more pronounced aggregation upon phase transition, thereby completely blocking near-infrared light and resulting in enhanced NIR modulation efficiency (Δ T NIR ) and Δ T sol . The HPC/PEG composite hydrogel smart window with PEG2000 content of 30 wt% showed optimal overall performance with luminous transmittance ( T lum ) of 92.9 %, Δ T NIR of 73.7 %, Δ T sol of 84.2 % and a low LCST of 26.7 °C. The proof-of-concept experiment demonstrated that the smart window reduced the indoor temperature by 12 °C compared to the blank glass, indicating good energy-saving potential.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Shihong Zhu,Daohang Du,Shuli Yu,Ting Tao,Xianfeng Chu,Yunhua Jiang,Jia Yang,Jiefu Li,Zhifei Wang
Chemiluminescent immunoassays utilizing magnetic nanoparticles exhibit critical importance in in vitro diagnostics, attributed to their remarkable superparamagnetic properties, high specificity, and uniform monodispersity. Current surface functionalization strategies for antibody conjugation predominantly rely on carboxyl or amino groups, requiring pre-activation steps for both amino- and carboxyl-modified nanoparticles prior to antibody labeling. However, the complex activation protocols and persistent challenges in developing efficient chemiluminescent detection methods highlight significant technical obstacles. To address these limitations, we developed vinyl sulfone-functionalized magnetic beads (VSF-GMP), enabling rapid antibody conjugation via specific reactions between vinyl sulfone groups and lysine residues exposed on the surface of creatine kinase MB isoenzyme antibodies (CK-MB). This approach facilitates highly efficient chemiluminescent immunoassays. The engineered VSF-GMP magnetic beads demonstrated molecular weight-dependent adsorption profiles, achieving maximal binding capacity (86.32 μg/mg) for mouse IgG (150 kDa) compared to β-lactoglobulin (18.2 kDa) and bovine serum albumin (66.4 kDa). Moreover, compared with the protein coupling method using EDC/NHS-activated carboxylated magnetic beads, our VSF-GMP beads exhibited superior coupling efficiency. Additionally, bis-functionalized poly(ethylene glycol) (NH 2 -PEG-NH 2 ) was employed as a blocking agent to optimize the reactivity and stability of antibody conjugation, reducing non-specific protein labeling on the magnetic beads by 97.8 %. The analytical performance of the proposed chemiluminescent immunoassay (CLIA) was rigorously evaluated. Finally, the practical utility of VSF-GMP magnetic beads for CK-MB determination in plasma samples was investigated. These engineered magnetic beads showcase exceptional analytical sensitivity, specificity, and operational simplicity, establishing a robust platform for advanced chemiluminescent diagnostics with enhanced throughput capabilities.
研究领域:
生物医学工程
·
分析化学
·
免疫学
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产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2025
·
IF 4.1
Shijie Wang,Shanshan Xiao,Ning Li,Yue Xu,Ziyuan Song
Poly(ethylene glycol) (PEG)-polypeptide drug nanocarriers have garnered increasing attention during last decades. However, the tedious polymer synthesis and the stability issue greatly limit their further development. Herein the biphasic polymerization platform is reported for the easy access of a series of crosslinked PEG-polypeptide nanoparticles for enhanced drug loading and selective drug release. The accelerated polymerization allows for the preparation of a library of PEG-polypeptides from crude monomers with different polypeptide segments for structural optimization. Nanocarriers with redox-responsive de-crosslinking and enhanced drug loading are therefore obtained based on the model drug, doxorubicin, which exhibits selective killing of cancer cells. This study provides a synthetic method for efficient preparation of PEG-polypeptide nanocarriers, benefiting the downstream drug loading and therapeutic studies.
研究领域:
生物材料
·
药物化学
·
高分子科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）