TALANTA
·
2018
·
IF 4.244
Jing Bao,Changjun Hou,Yanan Zhao,Xintong Geng,Mickey Samalo,Huisi Yang,Minghong Bian,Danqun Huo
In present study, a sensitive and effective electrochemical microRNA (miRNA) sensing platform is successfully developed by integrating gold nanoparticles/polypyrrole-reduced graphene oxide (Au/PPy-rGO), catalyzed hairpin assembly (CHA) and hybridization chain reaction (HCR) multiple signal amplification strategy. Firstly, Au/PPy–rGO was employed onto a bare GCE by electrodeposition that can greatly enhanced conductivity and effectively immobilize probes. Then, the thiolated capture probes (SH-CP) were self-assembled on the Au/PPy–rGO modified GCE via Au-S bond. The target miRNA triggered the dynamic assembly of the two hairpin substrates (H1 and H2), leading to the cyclicality of the target miRNA and the formation of H1–H2 complexes without the assistance of enzyme. Subsequently, the newly emerging DNA fragment of H2 triggered the HCR when a mixture solution (hairpins H3 and H4) and produced dsDNA polymers. Finally, a substantial amount of methylene blue (MB) as signal indicator was intercalated into the minor groove of the long dsDNA polymers to achieve detected electrochemical signal. The fabricated sensor is able to detect miRNA-16 (model target) with concentration range from 10 fM to 5 nM with a low detection limit (LOD) of 1.57 fM (S/N = 3). Current research suggests that the developed multiple signal amplification platform has a great potential for the applications in the field of biomedical research and clinical analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Mingliang Ma,Yuying Yang,Wenting Li,Yong Ma,Zhouyu Tong,Weibo Huang,Liu Chen,Guanglei Wu,Huanli Wang,Ping Lyu
Yolk-shell magnetic Fe 3 O 4 /P(MAA-MBAA)-PPy/Au/void/TiO 2 microspheres have been prepared as visible light active photocatalyst . In this structure, the Fe 3 O 4 /P(MAA-MBAA)-PPy core-shell support provides magnetic properties for the catalyst and a large number of binding sites for the Au nanoparticles . In addition, coupling TiO 2 with Au nanoparticles can extend the range of absorbable sunlight and enhance electron hole separation. The test of degrading rhodamine B (RhB) under simulated visible light was used to verify the photocatalytic activity of the photocatalyst. The results showed that the photocatalyst exhibited favorable catalytic properties within 90 min in the case of using 4 mg itself. The improved performances were ascribed to the unique yolk-shell structure, which on the one hand greatly improves the light utilization, on the other hand favors full contact of the dye because of the porous appearance of the outer shell. Furthermore, the existence of magnetic core was beneficial to the recycling of the photocatalyst. And the recycling results demonstrated that the catalyst efficiency was maintained at 70.2% even after six recycling experiments. This work not only displays a new material for the degradation of organic dyes, but also provides a new approach for the synthesis of yolk-shell structure photocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Wenli Bao,Yuanjun Liu,Xiaoming Zhao
To solve the problem of electromagnetic radiation pollution, it is especially important to develop electromagnetic wave-absorbing materials with excellent performance. The preparation of composite multifunctional textile materials with excellent wave-absorbing properties is one of the research hotspots for practical personal protection applications. In this work, PPy/Fe 3 O 4 /rGO polyester/cotton composite fabrics were prepared by impregnation, chemical reduction, chemical co-precipitation and in situ polymerization. When the thickness is 0.97 mm, the minimum reflection loss ( RL min ) of PPy/Fe 3 O 4 /rGO polyester/cotton composite fabric is −12.12 dB, and the effective absorption bandwidth (EAB) is 4.7 GHz, which is excellent in wave absorption. Meanwhile, the PPy/Fe 3 O 4 /rGO polyester/cotton composite fabrics have excellent UV resistance (UV transmittance ratio of UVA and UVB bands as low as 0.02 %, UPF value of 100+), antistatic properties (static voltage half-life of 0.2 s), and excellent thermal management properties (thermal conductivity as low as 0.05796 W/(m·K)), and so on. The PPy/Fe 3 O 4 /rGO polyester/cotton composite fabrics prepared in this study are suitable for a variety of application scenarios, such as individual electromagnetic protection, individual protection in extremely cold environments, and individual heating physiotherapy, which is of great reference significance for the research of wearable individual protective textile materials.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qi Zhao,Zhencheng Chen,Chen-Wei Shan,Tao Zhan,Chen-Yang Han,Guo-Cheng Han,Xiao-Zhen Feng,Heinz-Bernhard Kraatz
Human chorionic gonadotropin (HCG), a vital protein for pregnancy determination and a marker for trophoblastic diseases , finds application in monitoring early pregnancy and ectopic pregnancy . This study presents an innovative approach employing electrochemical immunosensors for enhanced HCG detection, utilizing Anti-HCG antibodies and gold nanoparticles (AuNPs) in the sensor platform. Two sensor configurations were optimized: BSA/Anti-HCG/c-AuNPs/MEL/e-AuNPs/SPCE with [Fe(CN) 6 ] 3−/4− as a redox probe (1) and BSA/Anti-HCG/PPy/e-AuNPs/SPCE using polypyrrole (PPy) as a redox probe (2). The first sensor offers linear correlation in the 0.10–500.00 pg∙mL −1 HCG range, with a limit of detection (LOD) of 0.06 pg∙mL −1 , sensitivity of 32.25 μA∙pg −1 ∙mL∙cm −2 , RSD <2.47 %, and a recovery rate of 101.03–104.81 %. The second sensor widens the HCG detection range (40.00 fg∙mL −1 -5.00 pg∙mL −1 ) with a LOD of 16.53 fg∙mL −1 , ensuring precision (RSD <1.04 %) and a recovery range of 94.61–106.07 % in serum samples. These electrochemical immunosensors have transformative potential in biomarker detection, offering enhanced sensitivity, selectivity , and stability for advanced healthcare diagnostics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Materials Science
·
2026
·
IF 17.9
Yingying Wang,Shangmin Si,Taipeng Jiang,Sheng Chen,Jingjing He,Jianyong Tang,Jian Wu,Weijie Wei,Lingling Zeng,Jin Li,Zhuwei Gao
Frequent oil spills pose severe environmental and ecological threats, necessitating the development of materials capable of effective all-weather remediation of high-viscosity crude oil. In this study, a self-assembly strategy was employed to integrate covalent organic framework (COF) and polypyrrole (PPy) on a flexible cotton fabric (CF). Subsequent hydrophobic modification with polydimethylsiloxane (PDMS) produced a multifunctional composite membrane (PDMS@PPy@COF@CF) that integrated photothermal conversion, electrothermal response, and superhydrophobicity. The membrane exhibited excellent superhydrophobicity (WCA = 153.5°), superior oil-water separation efficiency (≥98.5%), and a high separation flux (≥24 010.4 L m – 2 h –1 ). Notably, the construction of micro/nanostructures via π-π stacking and hydrogen bonding between PPy and COF layers endowed the material with outstanding photothermal and electrothermal conversion performances. Specifically, the surface temperature rapidly increased to 73.8 °C within 180 s under 1.0 kW m – 2 irradiation and attained 145.9 °C at 10 V. Synergistic utilization of photothermal (0.5 kW m – 2 ) and electrothermal (4 V) effects enabled rapid crude oil adsorption within merely 45 s. Furthermore, the composite membrane maintained stable conductivity and superhydrophobicity under mechanical strain, ensuring its reliability and durability for practical applications. In summary, the multifunctional PDMS@PPy@COF@CF membrane enables energy-efficient all-weather cleanup of high-viscosity crude oil spills with practical oil recovery potential.
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Xueqin Wang,Anjiang Lu,Zhongchen Bai,Tianwen Xu
A highly sensitive multilayer interlaced silver (Ag) nanosheet (MISN) film was prepared on a PPy@PEDOT:PSS film via an electrodeposition method for surface-enhanced Raman scattering (SERS) applications. After the PPy@PEDOT:PSS film was pretreated with ascorbic acid solution, many sparse Ag nanoparticles (NPs) could be directly reduced on the surface of the PPy@PEDOT:PSS film in AgNO3 solution. Then, the MISN film was directionally grown along the surface of sparse Ag NPs by using an electrochemical galvanostatic method to form a Ag/PPy@PEDOT:PSS film for a SERS substrate. The results indicated that with the increase in electrodeposition time, the density of Ag nanosheets was also increased for boosting the SERS effect. Accordingly, owing to the directional growth of Ag NPs, the increase in the length–width ratio of single Ag nanosheets would further promote the SERS signal of the substrate. Moreover, the maximum enhancement factor of the SERS substrate could reach to 12,478, and the minimum limit of detection of melamine solution was down to 5.42 ng/mL. The SERS sensitivity of the Ag nanosheet film reached 100.65. This method of preparing the SERS substrate provides a novel and robust strategy for the low-cost and high-sensitivity detection in biomedicine, drugs, and food.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Xiangyu Ma,Kun Qian,Onome Ejeromedoghene,Martha Kandawa-Schulz,Yihong Wang
MicroRNAs (miRNAs) are becoming biomarkers for the clinical diagnosis of many diseases. However, their intrinsic properties such as low enrichment and short sequence restrict their applications. Here, we designed an ultrasensitive dual signal amplification electrochemical biosensor based on sodium alginate-polypyrrole/Au nanoparticles (SA-PPy/AuNPs) nanocomposite for the detection of miRNAs. Firstly, a planar intercalated copper(II) complex was synthesized to be the signal molecule. Then, catalytic hairpin assembly (CHA) reaction and catalytic reaction between ferric ion and copper ion were combined as a dual signal amplification to improve the sensitivity of the biosensor. In the presence of target miRNAs, multiple double helix structure formed for the CHA reaction was triggered, which immobilized more copper(II) complex on the surface of the working electrode and a strong signal was obtained in the square wave voltammetry (SWV) test. Also, the signal can be re-amplified again in the presence of ferric ion in the electrolyte. Under the optimal conditions, based on these strategies, a sensitive electrochemical biosensor was constructed for the detection of miRNAs in the range of 1 fM to 1 nM and the limit of detection was as low as 0.34 fM. Furthermore, the developed biosensor with excellent selectivity and reproducibility tested on human serum samples shows broad application prospects in the early stage of tumor diagnosis.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2014
·Vol. 215
·期 14
·1378-1387
·
IF 2.451
Haochuan Chen,Changwen Zhao,Ruibo Li,Yuhong Ma,Lianying Liu,Wantai Yang
A novel strategy, based on surface-initiated grafting polymerization and post-polymerization thiol-yne click chemistry, with Ir(ppy) 3 as a sole photoredox catalyst, under visible light irradiation is developed. The “livingness” of the grafting polymerization is demonstrated by the linear increase of the graft yield with irradiation time and the block grafting polymerization. Then, acetenyl groups of poly(propargyl methacrylate) (PPMA) grafting chains are reacted with pentaerythritoltetra-(3-mercaptopropionate) via the thiol-yne click reaction. The successful introduction of reactive thiol groups onto the low-density polyethylene- graft -poly(propargyl methacrylate) (LDPE- g -PPMA) films is demonstrated by Fourier transform IR (FTIR) and X-ray photoelectron spectra (XPS) spectroscopy, and the thiol-ene click reaction with N -(1-pyrenyl) maleimide.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 8
·4483-4493
·
IF 11.301
Liyun Zhang,Yi He,Pingya Luo,Lan Ma,Yi Fan,Shihong Zhang,Heng Shi,Shuangshuang Li,Yiling Nie
Developing superhydrophilic/underwater superoleophobic surfaces to restrict oil pollution during oil/water separation processes has been an effective approach. However, the inevitable adsorption and aggregation of organic contaminants onto the membrane surface from complex oily sewage usually causes an irreversible decrease in flux, damages the anti-oil-fouling properties and shortens the lifespan of the separation membrane. Thus, neoteric antifouling and renewable membranes are highly desired. Herein, based on stabilized PAN nanofibers and following the assembly of a heterostructured PPy/ZnO layer with hierarchical structure onto the nanofiber surfaces, we report a robust visible-light-induced self-repairable oil/water separation membrane. The SPAN–PPy/ZnO membrane displays superhydrophilicity (≈0°) and underwater superoleophobicity (>150°) toward different oils, with robust mechanical strength (Young's modulus ≈ 408 MPa) and a high underwater oil intrusion pressure (>120 kPa). Importantly, the as-prepared membrane not only exhibits ultrafast permeation flux and high separation efficiency for oil/dye/water emulsions, but it also displays robust recovery abilities (96%) from organic pollutants after 20 min of light irradiation. We anticipate that this composite membrane with outstanding separation capabilities and robust flux recovery capabilities can provide a novel method for the treatment and purification of large volumes of wastewater.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Caiyu Rong,Xiang Dong,Shidai Zhang,Shuqin Ding,Zhaoxin Zhang,Yan Ma,Zixin Lin,Yuhe Song,Jiayi Zhang,Shibin Nie,Konghu Tian
Inspired by Viper scales, a cotton-based smart textile named PMCOT has been developed. • PMCOT exhibits thermosensitive properties, enabling graded fire alarm. • PMCOT demonstrates piezosensitive properties, achieving body language recognition and remote control. To address the challenge of simultaneously achieving superior fire resistance and intelligent sensing in next-generation firefighting suits, we herein report a viper scale-inspired organic-inorganic hybrid smart armor, PPy@M(OH)(OCH 3 ) (M = Co, Ni), which was further utilized to fabricate a cotton-based smart fabric, PMCOT. PMCOT exhibits excellent flame resistance, thermosensitivity, and piezosensitivity. Specifically, it withstands 1300 °C flame jet for over 60 s while maintaining structural integrity; its peak heat release rate was reduced by 87.38% compared with pure cotton, and the residual mass reached 41.6% after thermal decomposition. Endowed with a piezoresistive sensing mechanism, PMCOT realized real-time resistance monitoring of shoulder, elbow and knee joints, capturing distinguishable signals for typical firefighting postures. It also achieved graded fire alarm via thermosensitive resistance variation (37.2–95.9 °C). In addition, PMCOT can capture finger joint signals of firefighters and operate a robotic arm remotely with stable cyclic performance. PMCOT possessed excellent comprehensive wearable performance with increased elongation at break (27.6%), only 4.8% lower water vapor transmission rate than cotton, and high-efficiency antibacterial performance. The bionic strategy proposed in this study provides critical support for the design of fireproof smart fabrics and the development of next-generation intelligent firefighting suits. Download: Download high-res image (293KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Linchun Nie,Jiazhi Xia,Jiawei Liao,Na Liu,Meiling Xu,Dejing Meng,Wenjing Liu,Qingxiang Zhou,Chunmao Chen
In this work, polypyrrole-coated Cu, Ni co-doped ZIF-67 (PPy@CuNi-ZIF-67) was designed and prepared via a facile method. Calcined PPy@CuNi-ZIF-67 exhibited highly efficient oxidase-like activity and possessed excellent capacity to oxidize colorless 3,3′,5,5′-tetramethyl benzidine (TMB) into blue oxidation products (oxTMB) within 4 min. Glutathione (GSH) and sulfur-containing compounds can inhibit its oxidase-like activity. Based on this principle, an effective colorimetric method was developed in combination with a smartphone for efficient, sensitive, and visual detection of GSH. Under optimal conditions, good linearity was achieved in the range of 0.83–33.33 μM, and the visual detection limit was 0.27 μM. Moreover, based on the response difference of different sulfur-containing compounds to different chromogenic substrates, a new array sensor was constructed with three chromogenic substrates. The array sensor was proven to quickly distinguish five sulfur-containing compounds at a concentration as low as 8.3 μM in combination with principal component analysis and hierarchical clustering analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）