INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhichao Song,Shujie Xu,Bo Xu,Man Zhou,Ying Liu,Ying Zhang,Li Cui,Ping Wang,Qiang Wang,Yuanyuan Yu
This study prepared high-strength, colored and multifunctional polyphenol-chitosan fibers via a novel strategy of laccase-mediated phenolic-amine crosslinking within chitosan fibers in a swollen state. A dense covalent network within the fiber was formed through Michael addition and Schiff base reactions. Compared to unmodified chitosan fibers, the enzymatically cross-linked fibers exhibited significantly enhanced mechanical properties, with an increase of about 270% in dry tensile strength (up to 156.8 MPa) and excellent wet stability. In addition, the polyphenol-chitosan fibers were given color and different properties by the covalent cross-linking of polyphenols into the fiber. The polyphenol-chitosan fibers had stable colors and did not fade in the environment. They also had an exceptional antibacterial rate of 99.99% and excellent UV protection. This laccase-mediated phenolic-amine crosslinking strategy provides an effective, sustainable method for producing high-performance, bio-based functional fibers.
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Zhuo Xu,Bin Wu,Chunhua Wu,Qian Chen,Kaimeng Xu,Zhengjun Shi,Xiaoping Rao,Yanfei Niu
In order to obtain natural bio-antimicrobial agents with better antifungal activity, the present study compared the antifungal properties of different structural natural resin acid derivatives (dehydroabietic acid (DHA), acrylpimaric acid (APA), and maleopimaric anhydride (MPA)) grafted with chitosan C 2 -OH and investigated the relationship between structure and activity. The structures of the derivatives were determined by FTIR and 1 H NMR. The antifungal properties were determined by mycelial growth rate method. The results demonstrated that CS-DHA (CSDA) exhibited the capacity to inhibit the majority of the tested fungi with notable efficacy, with an optimal antifungal effect observed at 97.53% against Alternaria solani . CS-APA (CSAA) demonstrated a comparatively weaker antifungal effect in comparison to CSDA, yet it exhibited a stronger effect when compared to CS-MPA (CSMA). SEM, TEM and relative permeability of cell membranes proved that the derivatives inhibited fungal growth by destroying the cell wall structure. The in vivo experiments proved that the derivatives all have the effect of protecting chili peppers, which has some application prospects. The best curative effect of CSAA on chili was observed at 1.5 mg/mL concentration (21.04%). At 3 mg/mL concentration, CSDA showed the best protective effect (29.48%) against chili peppers, which was closest to the effect of Imazalil at the same concentration. Meanwhile, the three derivatives had good preservation effect on cherry tomatoes, and the longest one could extend the shelf life by 6 days.
研究领域:
食品科学
·
微生物学
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DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Xiaoyan Song,Siyuan Yu,Junxia Deng,Jia Liu,Jinfeng Xing
The ideal hemostatic dressing should not only achieve the effect of hemostasis but also maintain a suitable moist environment and sufficient physical and mechanical strength and avoid secondary injury to the wound. Here, a stretchable, adhesive, and antibacterial hydrogel (SAQH) for wound hemostasis is facilely prepared by photopolymerization under green LED irradiation, in which acrylamide (AAM) and methacryloylethylsulfobetaine (SBMA) are used as the skeleton and quaternized carboxymethyl chitosan (QCCS) is used as the procoagulant component. The introduction of the macromolecular cross-linking agent methacryloyl hyaluronic acid (HA-GMA) enhances biocompatibility and avoids the addition of small molecular toxic cross-linking agents. The introduction of inorganic nanoparticle hydroxyapatite (HAP) into the hydrogel system not only improves the mechanical properties of the polymer network but also releases calcium ions from HAP to achieve a good coagulation-promoting effect. SAQH hydrogels have excellent mechanical properties (the maximum stress can reach 237 kPa), good adaptability, sufficient tissue adhesion, and effective antibacterial properties. In the mouse liver injury model, hydrogels can adhere to the bleeding site to reduce blood loss, and they will not cause secondary bleeding when removed. This research develops a potential hemostatic hydrogel with broad applicable prospects.
研究领域:
生物材料
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组织工程
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伤口愈合
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止血
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纳米技术
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2024
·
IF 10.7
Taishan Liu,Huan Lei,Linlin Qu,Chenhui Zhu,Xiaoxuan Ma,Daidi Fan
Chronic wounds caused by hyperglycaemia, hypoxia and bacterial infections are common complications in diabetic patients and chronic wound repair is extremely challenging in clinical practice. A series of hydrogels QPMP with good antioxidant and antimicrobial functions were prepared based on quaternized chitosan (QCS), oxidized pullulan polysaccharide (OP), dopamine-coated polypyrrole (PPY@PDA), and Chlorella vulgaris . The Schiff base cross-linking between the quaternized chitosan (QCS) and oxidized pullulan polysaccharide (OP) constitutes the basic skeleton of the hydrogel, and imparts a certain antimicrobial ability to the hydrogel. Chlorella vulgaris continuously produced oxygen under light conditions to relieve wound hypoxia and promote wound healing. The incorporation of PPY@PDA gave the hydrogel near-infrared (NIR) irradiation-assisted bactericidal activity and antioxidant activity, and as a conductive hydrogel, the hydrogel can be used to sense wound exudate and temperature changes, which can help to achieve the integration of diagnosis and treatment of wound healing. Most importantly, in a chronic wound model, the QPMP hydrogel was more effective in controlling the level of wound inflammation and promoting collagen deposition, angiogenesis, and early wound closure compared to the HeraDerm dressing. Therefore, this conductive oxygen-producing hydrogel is extremely beneficial for chronic wound healing in diabetes.
研究领域:
生物医学工程
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材料科学
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伤口愈合
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糖尿病研究
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Que Bai,Fangfang Hu,Siyuan Gou,Qian Gao,Shihao Wang,Wenhui Zhang,Yanni Zhang,Tingli Lu
The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its properties and effects on the S. aureus -infected wound healing was tested. It was found the hydrogel showed good antioxidation on the intracellular reactive oxygen species, inhibition on the growth of S. aureus , and acceleration the infected skin healing. The ablity of hydrogel due to its regulating inflammation, promoting angiogenesis and collagen synthesis in the wound site. This research work suggested that the developed multifunctional hydrogel might be a beneficial treatment for the infected wound healing.
研究领域:
药学
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生物医学工程
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伤口愈合
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感染控制
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DOI
PubMed
高影响因子
Desalination and Water Treatment
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2025
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IF 1
Yunlong Zhao,Hao Peng,Lei Zhang,Wanwan Fu,Man Zhang,Zhishan Chen,Longfei Li,Yutao Chen
As a new type of polymer functional material, magnetic chitosan has been widely used in wastewater treatment. In this study, magnetic chitosan microspheres (MCMs) were prepared by reversed-phase microemulsion cross-linking technology, and the adsorption capacity of MCMs to organic pollutants with high chemical oxygen demand (COD) in coking wastewater was studied. Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and energy dispersive spectrometer (EDS), brunauer - emmett - teller (BET), vibrating sample magnetometer (VSM) were characterized. The effects of Fe 3 O 4 magnetic nanoparticles (MNPs), pH and the amount of adsorbent on the adsorption properties of MCMs were investigated. The following conclusions are obtained: the MCMs prepared in this study are successfully encapsulated, and the MCMs have good magnetic properties; Meanwhile, the removal performance of COD is higher. When the addition amount of Fe 3 O 4 is 10 % of the mass fraction of chitosan, the maximum adsorption amount of COD by MCMs can reach 261.82 mg/g under the conditions of pH 7.5, reaction temperature 298 K and adsorption time 42 h. The adsorption kinetics can be described by a quasi-second-order kinetic model. In addition, after 4 times of adsorption-desorption processes, the adsorbent still has more than 40 % COD adsorption, and has good adsorption performance. In general, because of the high adsorption efficiency, strong regeneration and excellent magnetic separation performance, MCMs have practical application potential in sewage treatment, biomedicine and other fields.
研究领域:
环境科学
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材料科学
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2024
·Vol. 27
·期 1
·1-14
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IF 2.1
Zhang Ziying,Liu Feng,Li Jiale,Wang Bing
Photothermal therapy (PTT), as a non-invasive and selective treatment strategy, has garnered extensive research interest. Photothermal agents (PTAs) are critical components of PTT, whose light-absorbing and thermosensitive properties enable effective conversion of light energy into heat, creating localized high-temperature regions. However, PTAs often face challenges with degradation in vivo, and standalone PTT is insufficient for complete tumor cell ablation. In this study, we successfully developed a biodegradable nanoplatform for synergistic photothermal-photodynamic therapy. This platform is based on degradable antimonene nanosheets, further functionalized with a chitosan coating, and loaded with the photosensitizer Ce6. In vitro experiments demonstrated that this nanoplatform exhibits excellent biocompatibility and biodegradability. Upon laser excitation, the platform induces localized thermal effects for cell ablation and promotes reactive oxygen species generation, leading to superior anti-tumor efficacy compared to monotherapies. These findings suggest that this multifunctional nanoplatform can significantly enhance the therapeutic efficiency of synergistic phototherapy, presenting a promising candidate for cancer treatment.
研究领域:
生物医学工程
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癌症治疗研究
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纳米医学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xinxin Wang,Ruixue Meng,Shiyong Zhao,Zhenyu Jing,Yonghui Jin,Jie Zhang,Xinxin Pi,Qiuju Du,Long Chen,Yanhui Li
Radioactive iodine is considered one of the most dangerous radioactive elements in nuclear waste. Therefore, effective capture of radioactive iodine is essential for developing and using nuclear energy to solve the energy crisis. Some materials that have been developed for removing radioactive iodine still suffer from complex synthesis, low removal capacity, and non-reusability. Herein, covalent organic framework (COF)/chitosan (CS) aerogels were prepared using vacuum freeze-drying, and the COF nanoparticles were tightly attached on the green biomass material CS networks. Due to the synergistic effect of both COF and CS, the composite aerogel shows a three-dimensional porous and stable structure in the recycle usage. The COF/CS aerogel exhibits excellent iodine adsorption capacity of 2211.58 mg g −1 and 5.62 g g −1 for static iodine solution and iodine vapor, respectively, better than some common adsorbents. Furthermore, COF/CS aerogel demonstrated good recyclability performance with 87 % of the initial adsorption capacity after 5 cycles. In addition, the interaction between iodine and imine groups, amino groups, and benzene rings of aerogel are the possible adsorption mechanisms. COF/CS aerogel has excellent adsorption properties, good chemical stability, and reusable performance, which is a potential and efficient adsorbent for industrial radioactive iodine adsorption from nuclear waste.
研究领域:
环境科学
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材料科学
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PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2024
·
IF 4.3
Chen Xiaohua,Liu Hengyu,Zhang Qianqian,Chen Xuehua,Wang Lihui,Yu Yanling,Hao Yuanping
Acidic bacterial biofilms-associated enamel white spot lesions (WSLs) are one of the hallmarks of early caries, causing demineralization and decomposition of dental hard tissues. Therefore, to effectively prevent and treat WSLs, it is important to inhibit the activity of cariogenic bacteria while promoting the remineralization of demineralized enamel. Amorphous calcium phosphate (ACP) favors hard tissue remineralization due to its biological activity and ability to release large amounts of Ca2+ and PO43-. However, ACP-based biomineralization technology is not effective due to its lack of antimicrobial properties. Here, carboxymethyl chitosan (CMCS) was employed as a reducing agent and stabilizer, and dual-functional nanohybrids CMCS/AuNPs/ACP with biofilm resistance and mineralization properties were successfully synthesized. The addition of AuNPs enhances the antimicrobial activity and participates in regulating the formation of hydroxyapatite (HAp). The nanohybrids exhibited significant destructive effects against cariogenic bacteria and their biofilms and showed bactericidal activity under bacteria-induced acidic conditions. More importantly, this nanohybrids showed superior results in promoting the remineralization of demineralized enamel, compared to fluoride and CMCS/ACP in vitro. The CMCS/AuNPs/ACP nanohybrids not only reverse the cariogenic microenvironment at the microbial level, but also promote self-repairing of enamel WSLs regarding the microstructure. The present work offers a theoretical and experimental basis for using the CMCS/AuNPs/ACP nanohybrids as a potential dual-functional agent for the clinical treatment of enamel WSLs.
研究领域:
牙科材料
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纳米技术
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生物材料
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龋齿
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矿化
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抗菌剂
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2024
·
IF 8.4
Jiangnan Wang,Long Li,Jinli Zhang,Xueqin Li
The chitosan (CS)-grafted UiO-66-NH 2 (U6N) (CSGUN) was synthesized and incorporated into Pebax matrix to fabricate mixed matrix membranes (MMMs) for boosting CO 2 transport. The excellent CO 2 separation performance was exhibited for MMMs due to the following reasons: U6N with the suitable porosity and abundant CO 2 transport carriers can provide a unique “expressway” for CO 2 to boost CO 2 transport through MMMs. The grafting CS in CSGUN can connect Pebax (regular roads) and U6N (expressway), acting as an “on-ramp” between them to enrich CO 2 and guide CO 2 through U6N in an orderly manner. Thus, the constructed “on-ramp” and “expressway” in MMMs can improve CO 2 separation performance. Furthermore, the CS-MOF networks were formed in MMMs through using CS molecular chains to connect U6N for enhancing CO 2 separation performance of MMMs. Therefore, Pebax/CSGUN MMMs exhibited the excellent CO 2 separation performance with the CO 2 permeability of 558 ± 7 Barrer and the CO 2 /CH 4 selectivity of 37.5 ± 0.7. The study indicated that MMMs with CS-MOF bridged networks had great potential for boosting CO 2 transport by combining “expressways” and “on-ramp”.
研究领域:
材料科学
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环境科学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Furong Li,Tao Zhu,Bo Yuan,Jun Yang,Qiuge Ju,Weifang Li,Zefu Ye,Xudong Xu,Zhujun Zhu
Formaldehyde, even at low concentrations, poses a significant indoor pollutant risk, underscoring the need for efficient and sustainable sorbents. This study introduces a novel, multifunctional, and fully biodegradable adsorbent derived from waste shrimp shells. The shells were converted into soluble chitosan, which was then physically crosslinked with branched amine-modified alginate, resulting in a porous biuret-modified alginate/chitosan (BCC) polymer. BCC, with a 6 wt% biuret content, demonstrated exceptional adsorption performance for low-concentration formaldehyde, achieving a capacity of 1.97 mg·g −1 —159% higher than alginate and 149 % greater than activated carbon. The adsorption kinetics followed the pseudo-second-order model, and the Sips isotherm model suggested a chemical adsorption-dominated mechanism, with physical adsorption acting as a supplementary process. Additionally, BCC exhibited excellent reusability, maintaining high adsorption efficiency after four regeneration cycles, and incorporated a colorimetric signaling function, with a detection threshold of 0.07 mg·m −3 and a sensitivity of 0.02 mg·m −3 . These findings provide valuable insights and a theoretical basis for developing effective, safe, and environmentally friendly formaldehyde adsorbents.
研究领域:
材料科学
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环境科学
·
生物化学
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DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 3
·387
·
IF 4.9
Rong Sun,Liangliang Li,Jiangjie Zhou,Yongfeng Zhang,Haiya Sun,Datong Zhang,Qi Wu
Zein exhibits excellent biodegradability, thermal stability, UV resistance, and water barrier properties, making it a promising candidate for food packaging applications. However, pure zein films suffer from brittleness and poor mechanical strength, which limit their practical use. In this study, a unique bilayer packaging film (ZP/P-C) was developed using a layer-by-layer solution casting technique, where hydrophobic zein was coated onto a polyvinyl alcohol and chitosan composite layer (P-C). Incorporating PEG400 into the zein layer improved the interfacial compatibility of the bilayer film, increasing its uniformity and toughness. The resulting bilayer films demonstrated enhanced mechanical properties, flexibility, and water vapor barrier performance. Specifically, the ZP7.5/P-C bilayer film showed an elongation at break of 68.74% and a modulus of elasticity of 187.19 MPa. It had a water vapor permeability of 6.60 × 10−11g·m·m−2·s−1·Pa−1and provided near-complete UV protection within the 200–350 nm range. Furthermore, an intelligent detection bilayer film was created by integrating anthocyanin extract into the zein layer. Adding anthocyanin improved the film’s antioxidant properties and allowed it to respond colorimetrically to total volatile basic nitrogen. The bilayer film ZPBA1.0/P-C displayed an excellent antioxidant activity (45.8%) and remarkable color change (ΔE = 20.2) in response to ammonia, effectively indicating shrimp spoilage in 48 h (ΔE > 10). This investigation spotlights the potential of zein-based bilayer films in active and intelligent food packaging, offering innovative strategies to improve food safety and extend the shelf life of perishable goods.
研究领域:
食品科学
·
材料科学
·
包装工程
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PubMed
高影响因子
危险品化学品经营许可证（带存储）