JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Hongjing Chen,Lin Wu,Huali Chen,Wen Wu,Qianyu Zhang
PEG remains a central focus of numerous preclinical and clinical studies owing to its distinctive advantages. Notably, the molecular weight of PEG and its modification density are critical factors influencing PEGylated nano drug delivery systems; however, this area remains inadequately explored. In this study, we assessed the effects of different PEG molecular weights (1000, 2000, 5000, and 10000 Da) and densities on the in vitro and in vivo properties of liposomes. Results showed that, in the in vitro studies, PEGylated liposomes with different PEG MWs and densities maintained adequate physical or serum stability compared to liposomes without any surface modification. Meanwhile, liposomes with varying PEG molecular weights and densities exhibited excellent membrane stability and integrity and showed little cytotoxicity against HUVEC and RAW 264.7. PEGylated liposomes with varying MWs and densities of PEG did not significantly affect the release of the fluorescence dye DiD and exhibited good stability. On the other hand, both MWs and densities of PEG had a major influence on the pharmacokinetic properties of liposomes. The optimal enhancement of in vivo circulation time was observed at a PEG density of 10 % for liposomes modified with PEG 1000 , PEG 2000, and PEG 5000 , with group PEG 2000 showing the highest AUC. For PEG with a molecular weight of 10000 Da, the elimination rate of PEGylated liposomes decreased as the density of PEG increased. These findings indicated that PEG MWs and densities both play critical roles in the formulation and physiochemical properties of nanomedicines, preliminarily providing guidance in selecting PEGs of suitable length and density in the designing of nanomedicines.
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JOURNAL OF NANOPARTICLE RESEARCH
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2024
·Vol. 26
·期 10
·1-13
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IF 2.1
Zhou Keyun,Liu Xiaowen,Tong Yu,Jiang Wei,Li Yujie,Zhu Tianyu,Xu Defeng,Hu Hang
Dimethylcurcumin (DMC) is a synthetic curcuminoid which can enhance androgen receptor (AR) degradation to suppress AR-associated cancers. However, the poor water solubility and low bioavailability of DMC limit its biomedical applications. In our study, a water-soluble methoxypolyethylene glycol-dimethylcurcumin conjugate (cDMC-mPEG) was synthesized and further used for preparation of DMC loaded nanoparticles for effective DMC delivery. cDMC-mPEG was synthesized and characterized by proton nuclear magnetic resonance, fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy, thermogravimetric analysis and differential scanning calorimetry. cDMC-mPEG self-assemble into nanoparticles in aqueous solution and can be used to encapsulate free DMC to form DMC-loaded cDMC-mPEG nanoparticles with small sizes and spherical morphology. The in vitro drug release study shows that DMC@cDMC-mPEG (15.3%) nanoparticles exhibit pH-triggered DMC release behaviors. The cellular uptake study shows that cDMC-mPEG and DMC@cDMC-mPEG (15.3%) nanoparticles exhibit enhanced cellular uptake as compared to free DMC, and DMC@cDMC-mPEG (15.3%) nanoparticles exhibit the highest cellular uptake amount. As a result, DMC@cDMC-mPEG (15.3%) nanoparticles exhibit enhanced cytotoxicity against 22Rv1 cells as compared to cDMC-mPEG and free DMC in in vitro antitumor effect study. The DMC@cDMC-mPEG (15.3%) nanoparticles developed in this work provide an effective nano-formulation for anti-prostate cancer DMC delivery.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2011
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IF 2.13
Huirui Zhou,Ke Tao,Jing Ding,Zhaofeng Zhang,Kang Sun,Weibin Shi
By using a facile and versatile physical grinding method, poly (ethylene glycol) (PEG) was coated on oil-soluble Fe 3 O 4 and Fe 3 O 4 –CdSe nanoparticles stabilized by various ligands to render them hydrophilicity. The successful coating of PEG was not only identified by Fourier transform infrared spectroscopy and thermogravimetric analysis, but also confirmed by the dispersibility of nanoparticles in aqueous solution against centrifugation. The PEG-coating would not obviously reduce the magnetic and fluorescent properties of Fe 3 O 4 and Fe 3 O 4 –CdSe nanoparticles. We also found that the coating efficiency in terms of dispersibility and fluorescence is related to the molecular weight of PEG, from which we proposed that the driving force for coating is the hydrophobic interaction between the methylene groups of PEG and alkyl chain of ligands. Additionally, cytotoxicity evaluation of PEG-stabilized Fe 3 O 4 nanoparticles on renal NRK cells showed that the coated nanoparticles would not increase the early-stage apoptosis of cells, and we found PEG-coated cubic Fe 3 O 4 nanoparticles can be uptaken by adipose derived stem cells. Our results indicated that the grinding approach is facile, efficient and versatile for coating PEG on different nanoparticles, and potentially can be extended to other kinds of surface modification for biomedical applications.
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Surfaces and Interfaces
·
2025
·
IF 6.3
Jingying Wang,Zengyue Chen,Xiaochen Liu,Zhansheng Wu,Li Jin
Glyphosate herbicide is commonly used to kill weeds in crops because of its high efficiency and low cost. However, excessive use of glyphosate not only leads to soil, surface water, and groundwater pollution, but also presents a potential risk to human health. Photocatalysis as an advanced oxidation technology can efficiently and environmentally degrade glyphosate, and bismuth-based photocatalysts have garnered extensive attention for their strong photo-oxidation capabilities. In this work, a green reaction route was developed to synthesize Bi-based/g-C 3 N 4 /CdS ternary heterojunction photocatalysts for glyphosate removal, by combining acetic acid-glycol synergistic systems with atmospheric pressure microwave methods. By regulating the structure and composition of the catalyst, excellent photodegradation and stabilization of glyphosate by BiOCl/g-C 3 N 4 /CdS (> 98% removal of glyphosate in 90 min). This study is of great significance for the green preparation and application of efficient photocatalysts for glyphosate removal, and the development of other recyclable systems.
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Polymers
·
2020
·Vol. 12
·期 5
·1124
·
IF 3.426
Shuang Yang,Feng Ding,Zhiliang Gao,Jianman Guo,Jiwei Cui,Peiyu Zhang
To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. The obtained capsules composed of 8-arm-PEG result in a lower cell association (2.2%) compared to those composed of linear PEG (7.3%) and, therefore, demonstrate the stealth property. The functionalization of cyclic peptides containing Arg-Gly-Asp (cRGD) on PEG capsules induce high cell targeting to U87 MG cells. A cell cytotoxicity assay demonstrates the biocompatibility of PEG capsules and high drug delivery efficacy of the targeted capsules. The reported capsules with the stealth and targeting property provide a potential platform for improved drug delivery.Keywords:emulsion;poly(ethylene glycol);polymer capsules;targeting drug delivery
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Molecular Catalysis
·
2024
·
IF 3.9
Shengya Ge,Chenzhang Li,Peiyan Bi,Wei Hong
The operation of direct ethylene glycol fuel cells (DEGFCs) to generate electric energy from ethylene glycol rely on the effective electrocatalysts for the ethylene glycol oxidation reaction (EGOR). The fabrication of EGOR electrocatalysts with high activity, high durability and high resistance for corrosion, is essential important for the DEGFCs. Herein, we report a fabrication of Pd nanoparticles immobilized by the Ce-doped ZIF-67-derived carbon (Pd-CeO 2 /ZDC). The Pd nanoparticles are generated by the in-situ reduction reaction between the H 2 PdCl 4 and the Co nanoparticles formed during the ZIF-67 pyrolysis. Owe to the porous structure and N-doping inherited from the ZIF-67, the Pd and CeO 2 nanoparticles show a uniform distribution. Due to the enhanced EGOR electrooxidation kinetic promoted by the ZIF-67-derived support, the multiple-components and structure synergies, the resultant Pd-CeO 2 /ZDC catalyst affords a EGOR current density of 32.4 mA cm -2 , which is higher than the commercial Pd/C as well as the counterpart Pd/ZDC catalyst without CeO 2 . Furthermore, the Pd-CeO 2 /ZDC catalyst also present a better EGOR durability. This work provides a strategy for the design of EGOR catalyst with multiple-components and desired structure, which may inspire the new tactics for controllable design and synthesis of other electrocatalysts for various electrocatalysis.
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Materials
·
2024
·Vol. 17
·期 16
·4135
·
IF 3.1
Zijia Wang,Yawen Chang,Siyang Jia,Fujuan Liu
In this study, polyimide (PI) and polysulfonamide (PSA) were used as base materials, and polyethylene glycol (PEG) was added to successfully prepare PI/PSA/PEG nanofiber membranes through electrospinning technology. Subsequently, water etching was performed on the membranes, utilizing the water solubility of PEG to form the rough wrinkled structure, further enhancing the surface hydrophobicity. The experimental results showed that under the conditions of a spinning voltage of 10 kV, PI/PSA mass fraction of 15 wt.%, and PEG-to-PI/PSA mass ratio of 1/3, the obtained fiber membranes exhibit a uniform morphology (an average diameter of 0.73 µm) and excellent hydrophobicity (the initial water contact angle (WCA) reaching 130.4°). After PEG water etching, the surface of the PI/PSA/PEG hydrophobic membranes formed the rough wrinkled structure, which not only improved their mechanical properties but also further enhanced their hydrophobicity (the initial WCA increasing to 137.9°). Hence, fiber membranes are expected to have broad application prospects in fields such as waterproofing and moisture permeability.
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高影响因子
ADVANCED ENGINEERING MATERIALS
·
2024
·
IF 3.4
Gongxian Yang,Bin Zou,Xinfeng Wang,Lei Li,Qinghua Chen,Xingguo Zhou,Qingguo Lai,Chuanzhen Huang
To enhance the mechanical properties of bioceramic composite bone scaffolds, a composite paste of polyethylene glycol diacrylate (PEGDA) and hexagonal boron nitride (h-BN) with a solid content of up to 42 wt% was developed in this study. The part was produced using stereolithography (SLA). The SLA printing parameters and material ratios of the paste were optimized through a homogeneous design and mechanical property tests. The results indicate that the single-line curing width of the PEGDA/h-BN paste in the XY plane ranged from 172 to 209 μm, while the curing depth of a single layer along the Z-axis ranged from 99 to 154 μm. Laser power was identified as the primary factor influencing both the width and depth of curing. The compressive strength of the printed sample of PEGDA/h-BN ceramic composite paste was measured at 222.4 ± 5.6 MPa, which is 61 times greater than the compressive strength of a pure PEGDA structure and comparable to that of cortical bone (100-230 MPa). Finally, the superior biocompatibility of PEGDA/h-BN ceramics was confirmed through cytotoxicity experiments. Consequently, PEGDA/h-BN ceramic composites meet the mechanical properties and biocompatibility requirements necessary for bone tissue applications, indicating promising potential in the field of bone tissue engineering.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Jinyu Lu,Jian You,Ben Chang,Wei Wang,Yongzhao Li,Jiabin Lin,Xiangbo Luo,Huaiyin Chen,Yuekun Lai,Meihua Wu,Weilong Cai
Green hydrogen is currently the dominant trend in the evolution of hydrogen energy, producing almost no greenhouse gas emissions. Alkaline water electrolysis (AWE) is recognized as a leading and well-established technology for producing green hydrogen. However, safety hazards may occur during hydrogen production currently as defective commercial separate membranes used in the AWE process. Therefore, it is imperative to create a membrane characterized by low area resistance, high stability, and high bubble point pressure (BPP) to realize high-performance AWE. Herein, we synthesize alumina-based composite membranes with Y 2 O 3 -added and polyethylene glycol functionalized Al 2 O 3 for AWE through a phase inversion method. The porous composite membrane exhibits excellent hydrophilicity, with a lower contact angle of approximately 55°. It also presents exceptional performance metrics, including a low area resistance of about 0.17 Ω cm 2 , an ultra-high BBP of approximately 4.4 bar, and excellent mechanical properties with a tensile strength of around 25 MPa. The membranes achieved a current density of up to 2.5 A cm -2 under 2.0 V voltage in a 30 wt% KOH solution at 80 °C by utilizing commercial catalysts. Notably, the composite membranes exhibited remarkable stability, maintaining operation for over 1200 hours at a 2.0 A cm -2 current density without any performance degradation at 80°C. Furthermore, this composite membrane possesses outstanding gas-barrier capability with H 2 and O 2 purity higher than 98.70% and 99.69%, respectively. The above results demonstrate that the prepared novel high-performance alumina-based composite membrane for hydrogen generation has significant potential for applications within the AWE process.
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Materials
·
2025
·Vol. 18
·期 4
·827
·
IF 3.2
Yamin Chen,Dianyang Li,Yougen Chen,Hui Fang
Four kinds of silicone hydrogel transparent contact lenses (CLs) with different formulations were prepared by the free radical photocuring polymerization. By mixing polyethylene glycol diacrylate (PEGDA) of 1000 Da with ethylene glycol dimethacrylate (EGDMA) and adding other silicone monomers and hydrophilic monomers, the transparency and flexibility of the material were successfully achieved. By optimizing the weight percentage of each component, the best balance of optical performance can be achieved. The photocuring properties of the materials were characterized by electronic universal test, double-beam UV-visible spectrophotometer, Atomic Force Microscope (AFM), Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). The results showed that the addition of higher PEGDA content reduces the elastic modulus, improves curing efficiency, improves equilibrium water content (EWC), and enhances light transmission. Hydrogels containing only high PEGDA but no EGDMA showed similar curing rates, water content, and elastic modulus, but had the worst optical transparency, far inferior to the materials mixed with PEGDA and EGDMA. Additionally, imaging performance of the CLs was further evaluated through simulation analysis using Ansys Zemax OpticStudio2024 software. This research provides a new choice of material consideration to improve the performance and wearing comfort of CLs.
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Polymers
·
2024
·Vol. 16
·期 10
·1384
·
IF 4.7
Kai Wang,Dagui Chen,Chenxi Zhang,Lu Lu,Fusheng Shang,Yinghua Li
Acute pneumonia (AP), triggered primarily by pathogens like bacteria and viruses, is a leading cause of human mortality. Ribavirin, a broad-spectrum antiviral agent, plays a pivotal role in the treatment of AP. However, its therapeutic use is hindered by the need for high dosages and the associated cardiac and hepatic toxicities. In this study, we synthesized polyethylene glycol-modified cationic liposomes to encapsulate ribavirin (RBV-PCL) and formulated it into a spray, aiming to enhance the effectiveness of RBV through respiratory administration. Lipopolysaccharide (LPS), a compound known to induce AP models in animals, was utilized in our research. Successfully, we established an acute pneumonia model in mice using aerosol inhalation. Through animal experiments, we investigated the therapeutic effects of RBV-PCL on mice with AP. In vivo studies revealed promising results. RBV-PCL effectively prolonged the survival of mice with AP, significantly reduced the levels of inflammatory markers such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and inhibited the infiltration of neutrophils in the lungs and spleens of mice. These findings suggest that RBV-PCL can effectively suppress the inflammatory response in mice with AP, thus holding significant potential as a novel therapeutic approach for the treatment of acute pneumonia.
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Journal of Rubber Research
·
2025
·
IF 1.5
Yuan Yizhong,Shen Jie,Tian Xiaohui,Li Pengcheng,Gao Jiayang
With the depletion of petrochemical resources, natural rubber (NR) shows its application potential. On the basis of deproteinised natural rubber (DPNR), a hydrophilic and water-absorbent polymer network composed of a deproteinised natural rubber-grafted-poly(acrylic acid) (DPNR-g-PAA) system and linear polyethylene glycol (PEG) was designed and fabricated. The graft copolymerisation of DPNR with acrylic acid (AA) was initiated by a redox initiator system consisting of potassium persulfate (KPS) and sodium hydrogen sulfite (NaHSO 3 ) under nitrogen, followed by the addition of PEG to the system. The key factors influencing the grafting efficiency of DPNR-g-PAA were investigated, including reaction temperature, mixing time and AA content. The grafting system was finally attached to the hydrophilic polymer PEG. Water adsorption behaviour tests and water contact angle experiments indicated that grafting PAA and linking PEG in DPNR latex increased hydrophilicity. The results indicated that the maximum water absorption of DPNR-g-PAA was 78.24 ± 5.06% and the minimum of water contact angle of DPNR-g-PAA@PEG was 9.58 ± 1.37°. Through the modification of PAA and PEG, the DPNR-g-PAA@PEG product improves the hydrophilicity of DPNR, which has the potential for application in water retention agents and slow-release fertilizers.
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