JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 16
·967
·
IF 2.8
Zhang Qi,Wang Qing,Dai Jianfeng
ZnCo 2 O 4 is considered a highly promising anode material for lithium-ion batteries (LIBs), attributed to its impressive capacity and excellent electrochemical characteristics. However, its practical application is constrained by significant volume expansion during repeated charge–discharge cycles, leading to structural instability and performance degradation over time. To address this challenge, a composite material consisting of reduced graphene oxide (rGO) coating the exterior of ZnCo 2 O 4 microspheres (denoted as ZCO@r-3) was designed and synthesized in this study, making it an anode material with high cycling stability for LIBs. This design aims to increase the structural stability and electrochemical properties through the effective incorporation of rGO, mitigating volume expansion during redox reactions when redox reactions occur. In this composite structure, rGO serves as a conductive network that significantly enhances ion diffusion, while its excellent mechanical properties help mitigate the volume expansion of ZnCo 2 O 4 during redox reactions. This dual action of rGO not only strengthens the structural stability of ZnCo 2 O 4 microspheres but also enhances their electrochemical performance, providing an effective and practical solution. As expected, the ZCO@r-3 composite exhibited an initial discharge capacity of 1582.1 mAh g −1 in the first cycle and initial reversible specific capacity of 1087.9 mAh g −1 after the second cycle at 0.1 A g −1 . Even after 500 charge/discharge cycles under the same conditions, the composites maintained a reversible capacity of 966.7 mAh g −1 . This demonstrates exceptional cycling stability, validating the effectiveness of the rGO coating in enhancing the material's long-term performance. This confirms that the method proposed in this study effectively addresses the volume expansion issue of ZnCo 2 O 4 .
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高影响因子
CHROMATOGRAPHIA
·
2025
·Vol. 88
·期 11
·891-903
·
IF 1.3
Li Wei-Si,Zhang Zhe-Meng,Wang Xue-Ying,Sun Chun-Xia,Liu Zhen,Ma Xiao,Qiao Zhou,Zhu Hai-Bin,Han Ling-Fei
Esomeprazole magnesium (EMO) is the S -enantiomer of omeprazole. As a second-generation proton pump inhibitor, it is more effective than omeprazole in inhibiting gastric acid secretion. Therefore, it is of great necessity to establish a quality control method to support its pharmaceutical development. The starting materials for the preparation of EMO may contain six potential genotoxic impurities (PGIs), designated as RC16, RC17, RC18, RC20, RC21, and RC23. These impurities have similar chemical structures, all containing benzene rings or pyridine rings with small differences in substituents, which leads to similar retention behaviors in the chromatographic column, and peak overlap is likely to occur during HPLC analysis, making it impossible to accurately determine the content of impurities. To enhance the quality control, this study established a sensitive and specific HPLC–MS/MS method. Utilizing electrospray ionization (ESI) in positive multiple reaction monitoring (MRM) mode, this method was used to determine the trace amounts of six PGIs in EMO raw material. On a 40 °C Inertsil ODS-SP C18 chromatographic column (4.6 × 150 mm, 5 μm), the six PGIs were well separated in an equilibrated elution mode at a flow rate of 0.5 mL min⁻ 1 . 0.5% formic acid in water and methanol were used as the mobile phase A and B, respectively. The method was rigorously validated in terms of precision, accuracy, limit of detection, limit of quantification, linear range, and robustness, and with all parameters meeting pre-defined acceptance criteria. Graphical
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高影响因子
Frontiers of Chemical Science and Engineering
·
2012
·Vol. 6
·期 3
·339-347
·
IF 0
Zhou Dongjiao,Shen Shaochuan,Yun Junxian,Yao Kejian,Lin Dong-Qiang
Dextran-hyaluronate (Dex-HA) based supermacroporous cryogel scaffolds for soft tissue engineering were prepared by free radical cryo-copolymerization of aqueous solutions containing the dextran methacrylate (Dex-MA) and hyaluronate methacrylate (HA-MA) at various macromonomer concentrations under the freezing condition. It was observed that the suitable total concentration of macromonomers for the preparation of Dex-HA cryogel scaffold with satisfied properties was 5% (w/w) at the HA-MA concentration of 1% (w/v), which was then used to produce the test scaffold. The obtained cryogel scaffold with 5% (w/w) macromonomer solution had high water permeability (5.1 × 10 −12 m 2 ) and high porosity (92.4%). The pore diameter examined by scanning electron microscopy (SEM) was in a broad range of 50–135 μm with the mean pore diameter of 91 μm. Furthermore, the cryogel scaffold also had good elastic nature with the elastic modulus of 17.47±1.44 kPa. The culture of 3T3-L1 preadipocyte within the scaffold was investigated and observed by SEM. Cells clustered on the pore walls and grew inside the scaffold indicating the Dex-HA cryogel scaffold could be a promising porous biomaterial for applications in tissue engineering.
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JOURNAL OF POROUS MATERIALS
·
2020
·Vol. 27
·期 5
·1455-1466
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IF 2.183
Yuan Zhishuai,Cheng Yuchun,Ma Shoutao,Jiang Zhen,Zhou Yisi,Wang Yingjun,Zhang Wei,Suo Yanhua
A new method called Instant Exactness Synthesis (IES), which was applied to prepare SAPO-11 molecular sieve, was introduced innovatively. The metal–acid bifunctional Ni/SAPO-11-IES catalyst with a Ni content of 4% was prepared by the impregnation method. Ni/SAPO-11-H catalyst was prepared as a comparative sample through the traditional hydrothermal method. In addition, the growth mechanism was used to explain the excellent performance of catalyst prepared by IES method in detail. The structure of Ni/SAPO-11-IES was confirmed via XRD and TEM characterization. The pore structure of the molecular sieve was determined by nitrogen adsorption and desorption. 29 Si MAS NMR measurement was used to illustrate multiple silicon environment which supported the excellent acidity in NH 3 -TPD measurement. Furthermore, the favourable dispersibility of Ni species was proved by the mapping of the elements and EDS. Benefiting from the superior performance of materials, Ni/SAPO-11-IES catalyst exhibited a higher catalytic performance for n-heptane hydroisomerization with n-heptane conversion of 82% and isoheptane selectivity of 86%, respectively, compared with other catalysts in the same system. The study also provides new ideas for the preparation of molecular sieve materials.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Wu Jing,Yang Jingying,Liu Qisijing,Zhang Pixian,Zheng Bowen,Liu Linyuan,An Tingtao,Wang Hao,Xu Fupei,Shen Yudi,Wang Shuo
Characterizing exercise-induced fatigue is challenging due to difficulties in monitoring biochemical and electrophysiological signals consistently. While wearable sensors able to monitor both signals are available, they struggle to maintain stable signal acquisition across exercise-rest scenarios because of significant sweat variation. Here we describe the development of a system, FatigueVisual, combining an adaptive sweat-regulating hybrid electronic textile (e-ASRHT) patch with artificial intelligence (AI) analytics to improve fatigue management. The key innovation lies in the precise regulation of the breakthrough pressure of micropores in fabric electrodes and sweat-excreting areas, allowing for accurate sweat management. This design enables efficient enrichment at an ultralow sweat rate (5.0×10 −4 ml cm −2 min −1 ) while rapidly transporting excess sweat at a rate 2533 times the human physiological limit, ensuring stable chemical-electrophysiological sensing from exercise to rest. A cloud-connected AI model, trained on over 200,000 time-resolved observations collected from 10 participants, recognizes six fatigue-related states and provides personalized exercise management via a mobile app. Validation in three participants showed 87.3% agreement with clinical assessments. The system reduced exercise fatigue by 51.8% and accelerated recovery by 48 h compared with the control group. In practice, FatigueVisual may enable intelligent sports health management.
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高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2026
·
IF 4.7
Zhang Pan,Sun Xuelin,Liu Longteng,Zhang Yatong,Bo Jiaqi,Huang Wenli,Na Yifan,Zhang Jingyi,Qin Xiaoyun,Luo Qingfeng
Gastric precancerous lesions (GPLs) are a pivotal stage in the gastritis-gastric cancer sequence, and the absence of effective treatments presents a clinical challenge. Veratramine is a natural anti-inflammatory and analgesic steroid alkaloid; however, its effects on GPLs and the mechanisms have remained unexplored. This study investigated the effects of veratramine on GPLs using 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced GES-1 cells and rat models, utilizing RNA-seq to elucidate the underlying mechanisms. In vitro, veratramine inhibited malignant cells (MC) proliferation, induced apoptosis, and triggered G0/G1 cell cycle arrest. It also suppressed epithelial-mesenchymal transition (EMT), migration, and invasion by upregulating E‑cadherin and downregulating Slug and vimentin. Transcriptomic and molecular docking analyses highlighted the Wnt/β-catenin pathway as a key target, regulated via DDX60, MUC1, APOL1, and MSH5. Veratramine reduced Wnt10B, β-catenin, and cyclin D1 expression and blocked β‑catenin nuclear translocation; these effects were reversed by the Wnt activator BML-284. In vivo, treatment with veratramine ameliorated the GPLs-induced pathological changes in rats. It restored body weight and preserved gastric mucosal integrity, as evidenced by intact glandular and cellular morphology, reduced hyperplasia, and attenuated intestinal metaplasia. These improvements were associated with a modulation of key molecular markers, specifically a decrease in the expression of N-cadherin, Wnt10B, and β-catenin, alongside an increase in E-cadherin expression in gastric tissues. These results collectively indicate that veratramine exerts its therapeutic effects against GPLs primarily by suppressing the Wnt/β-catenin signaling pathway. Taken together, our findings suggest that veratramine is a promising candidate small-molecule drug for the treatment of GPLs.
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PubMed
高影响因子
Science China-Life Sciences
·
2026
·Vol. 69
·期 8
·2700-2715
·
IF 9.6
Gong Heng,Gan Tingjiang,Ma Xikun,Wu Ye,Li Yaxing,Yin Shijiu,Cao Biao,Deng Xiangtian,Zheng Cheng,Wang Yunbing,Zhang Hui
Diabetic foot ulcers (DFUs) pose significant therapeutic challenges owing to their intricate microenvironment. Conventional biomaterials often target only a single pathological factor, rendering them inadequate for halting the progressive deterioration of DFUs. To address this limitation, we developed a multifunctional drug delivery platform based on amine-yne click chemistry. The system was constructed using quaternized chitosan (QCS) and tetra-arm polyethylene glycol propiolate (4A-PEG-PA), incorporating metal-polyphenol nanoparticles (MPNs) formed by epigallocatechin gallate (EGCG) and magnesium ions (Mg 2+ ) as the drug-loading component. This platform not only fills ulcer cavities to eliminate dead space but also adheres firmly to irregular wound surfaces, minimizing physical disruption. Additionally, the drug delivery system exhibits pH-responsive behavior, along with potent antioxidant and hypoglycemic effects, effectively lowering reactive oxygen species (ROS) and glucose levels in the wound microenvironment by modulating pH, thereby promoting healing. In vitro studies revealed that the material safeguards mitochondrial function and integrity by counteracting oxidative stress. In vivo evaluations further demonstrated its antimicrobial, anti-inflammatory, pro-angiogenic, and re-epithelialization properties. Collectively, this hydrogel-based platform integrates multiple bioactive functions, presenting a promising strategy for the clinical management of DFUs.
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高影响因子
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
·
2026
·Vol. 45
·期 1
·153
·
IF 14.3
Wang Lifen,Xu Hongxia,Liu Tianyu,Zhu Dongliang,Chen Liping,Liu Tzu-ming,Lin Shuhai,Liu Xueyi,Feng Hao,Wang Li,Di Li-jun
Background Triple-negative breast cancer (TNBC) is characterized by aggressive clinical behaviour and frequent resistance to chemotherapy. While ferroptosis—an iron-dependent form of cell death driven by lipid peroxidation—holds promise as a therapeutic strategy, its efficacy is often limited by adaptive resistance mechanisms that remain incompletely understood. C-terminal binding protein (CtBP) is an oncogene associated with poor prognosis in TNBC; however, whether CtBP confers resistance to oxidative stress and ferroptosis, thereby contributing to its oncogenic function, remains unknown. Methods We utilized both in vitro cell lines and in vivo mouse models to investigate the role of CtBP in regulating oxidative stress and ferroptosis sensitivity. Integrative analyses, including transcriptomics, metabolomics, and clinical data interrogation, were employed to elucidate the mechanisms underlying CtBP-mediated resistance. Key mechanistic findings were further validated in clinical TNBC specimens using protein correlation analysis. Results We identified CtBP as a stress-inducible gene that is essential for ferroptosis resistance in TNBC. Mechanistically, CtBP promotes resistance by transcriptionally upregulating Prolyl 4-Hydroxylase Subunit Beta (P4HB). P4HB, localized to the endoplasmic reticulum (ER), functions as a chaperone to facilitate the correct folding and membrane maturation of SLC7A11, the catalytic subunit of the system xc - cystine/glutamate antiporter pivotal for glutathione (GSH) biosynthesis. We demonstrated that P4HB-mediated SLC7A11 maturation relies on its disulfide isomerase activity and ER retention signal (KDEL). Depletion of either CtBP or P4HB impaired SLC7A11 membrane trafficking, lead to accumulation of lipid peroxides and sensitization to ferroptosis. Conversely, P4HB overexpression restored SLC7A11 function and ferroptosis resistance in CtBP-deficient cells. Furthermore, significant positive correlations among CtBP, P4HB, and SLC7A11 expressions in clinical samples underscore the critical role of CtBP/P4HB/SLC7A11 axis in driving cancer aggressiveness. In vivo, targeting the CtBP/P4HB/SLC7A11 axis sensitized TNBC xenografts to the ferroptosis inducer RSL3, significantly suppressing tumor growth and lung metastasis. Conclusions This study identifies the CtBP/P4HB/SLC7A11 axis as a critical mediator of ferroptosis resistance in TNBC. These findings highlight this pathway as a potent therapeutic target to overcome resistance and enhance the efficacy of ferroptosis-inducing regimens in TNBC treatment.
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高影响因子
Journal of Sustainable Metallurgy
·
2026
·
IF 3.5
Luo Shuliang,Zhang Yijun,Ge Cui,Xiao Xiao,Yuan Yan,Lu Hai
The overpotential of the oxygen evolution reaction (OER) accounts for the primary energy loss in the electrolytic metallurgical process of non-ferrous metals, and enhancing the catalytic performance of electrodes is an effective approach to address this issue. Herein, a series of active oxides (MnO 2 , SnO 2 , Ta 2 O 5 , Nb 2 O 5 , PbO 2 ) from coated titanium anodes were incorporated into the lead-based anode via a powder compacting process to enhance the electrode's catalytic performance. The anodic behavior was systematically studied via various electrochemical methods. The results demonstrate that pure lead and its oxides suffer from poor catalytic activity for OER. However, the introduction of MnO 2 and Nb 2 O 5 could enhance the adsorption of intermediate products and reduce the charge transfer impedance in the electrochemical reaction process, thereby increasing the electrode's electrochemical performance. Notably, the Pb–MnO 2 anode exhibited a potential reduction of 220 mV compared to the pure lead anode, demonstrating pronounced energy-saving effects. Furthermore, the evolution of film structure on the electrode surface was also investigated using X-ray diffraction (XRD) and scanning electron microscopy (SEM). Results indicate that lead sulfate, lead dioxide, and active oxides coexist on the electrode surface after electrolysis and act as the reaction site between electrode and solution. Upon introducing active particles, this oxygen evolution layer becomes more compact, enhancing the electrode's stability. Graphical
The alternative text for this image may have been generated using AI.
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高影响因子
Journal of Orthopaedic Surgery and Research
·
2026
·Vol. 21
·期 1
·101
·
IF 3.8
Li Gui,Song Qianbo,Song Ye,Liao Wenxing,Zhao Dong,Hong Binqing,Cao Guangru
Background To meet the needs of local treatment for spinal tuberculosis, this study developed a thermosensitive gel microsphere composite with both anti-tuberculosis and osteogenesis-promoting functions for efficient drug sustained release. The composite consists of anti-tuberculosis drugs (Pretomanid, Pa-824; Moxifloxacin, M; Pyrazinamide, Z) and bone morphogenetic protein-2 (BMP-2) to optimize drug release kinetics and enhance local therapeutic effects. Methods PaMZ/BMP-2 microspheres were prepared using microfluidics and characterized by SEM, particle size analysis, and XRD. LC–MS and ELISA measured drug and BMP-2 release. The thermosensitive gel (P407/P188) ratio was optimized to ensure it remained liquid at room temperature and formed a gel at 37 °C for sustained release. Results Microspheres were spherical with an average size of 203.92 ± 27.76 μm. Encapsulation rates were 112.69%, 24.15%, and 15.18% for Pa, M, and Z, respectively. In vitro release showed Pa and M sustained release for over 17 days, with the gel prolonging drug release. Conclusion This study successfully prepared PaMZ/BMP-2 microspheres with good morphology and drug loading capacity, achieving controlled sustained release through thermosensitive gel. This offers a potential formulation approach for future localized therapy of spinal tuberculosis and lays the foundation for subsequent in vivo experiments and clinical translation.
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高影响因子
Science China-Life Sciences
·
2025
·
IF 9.5
Liu Yaqi,Wang Yalei,Zhang Ni,Xiong Haijuan,Zhao Lipan,Qi Ying,Xie Jiping,Duan Xiaofeng,Yue Dongsheng,Qie Shuo
The hyperactivation of cyclin D1-CDK4/6 signaling is correlated with tumour metastasis and poor prognosis in patients with non-small cell lung cancer (NSCLC), suggesting the therapeutic potential of targeting CDK4/6 to treat NSCLC. Our preliminary data indicate CDK4/6 inhibitors are sequestered in lysosomes in NSCLC cells, a phenomenon that is termed lysosomal trapping and is associated with intrinsic drug resistance. It is promising to search for new compounds that could be co-administered with CDK4/6 inhibitors to reduce lysosomal trapping, thereby enhancing the sensitivity of NSCLC cells. Here, we find that metformin reduces the activity of the lysosomal pathway through genome-wide analyses; consistently, metformin reduces lysosomal trapping of CDK4/6 inhibitors in NSCLC cells. Biologically, metformin enhances the suppressive effects of CDK4/6 inhibitors on cell cycle progression, cell proliferation, and colony formation. Mechanistically, metformin suppresses lysosomal trapping by: (i) reducing translocation of TFEB into nuclei that leads to decreased lysosome biogenesis and (ii) disrupting lysosomal acidic environment through reduced V-ATPase activity and decreased interaction between LAMP1/LAMP2 and TMEM175. Clinically, combined treatment with metformin and CDK4/6 inhibitors decreased the growth of mouse xenografts and tumour cell organoids. In conclusion, our study provides a new mechanism for utilizing metformin to treat NSCLC by reducing lysosomal trapping, thereby increasing cellular sensitivity to CDK4/6 inhibitors.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 20
·1612
·
IF 3.2
Yao Long,Xu Fang,Yang Hongwei,Ren Yong,Liu Guixiang,Dai Bo
This study demonstrated that magnetic properties of the LiZnTi ferrite can be enhanced by precisely controlling the dosage of Nb 2 O 5 and Bi 2 O 3 additives. XRD results indicated that the ferrite possessed a spinel structure. Furthermore, SEM revealed that the synergistic effect of Nb 2 O 5 and Bi 2 O 3 not only effectively suppressed the growth of big grains but also promoted the densification of the LiZnTi ferrite. Moreover, the magnetic performance was further enhanced when doped with 0.40 wt.% Nb 2 O 5 and 1.50 wt.% Bi 2 O 3 . Specifically, the ferromagnetic resonance linewidth ( ΔH ) decreased to 220 Oe and the saturation magnetization (4π M s ) of LiZnTi ferrite increased to 2619 Gs. The improvements of magnetic performance indicated that Nb 2 O 5 and Bi 2 O 3 are promising composite additives for the preparation of low-loss ferrite materials for microwave devices.
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高影响因子
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