JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Guanghui An,Heming Zheng,Lianshan Guo,Jingmei Huang,Congling Yang,Zhihao Bai,Nannan Wang,Wenhui Yang,Yanqiu Zhu
Tumors produce a hypoxic environment that greatly influences cancer treatment, and conventional chemotherapeutic drugs cannot selectively accumulate in the tumor region because of the lack of a tumor targeting mechanism, causing increased systemic toxicities and side effects. Hence, designing and developing new nanoplatforms that combine multimodal therapeutic regimens is essential to improve tumor therapeutic efficacy. Herein, we report the synthesis of ultrafine Cu nanoparticles loaded with a drug combination of cisplatin (Pt) and 1-methyl- d -tryptophan (1-MT) and externally coated with 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) photosensitizer, polydopamine (PDA) and CaO 2 of MIL-101(Fe) as a new nanoplatform (Cu@MIL-101@PMTPC). The nanoplatform synergistically combined chemodynamic therapy (CDT), photodynamic therapy (PDT), and immunochemotherapy. The Fe 3+ in MIL-101(Fe) and the surface Cu nanoparticles exhibited strong ability to consume intracellular glutathione (GSH), thereby generating a Fenton-like response in the tumor microenvironment (TME) with substantial peroxidase (POD)-like and superoxide dismutase (SOD)-like activities. In this design, we used the indoleamine 2,3-dioxygenase (IDO) inhibitor 1-MT to overcome chemotherapy-induced immune escape phenomena including enhanced CD8 + and CD4 + T cell expression, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) production, and accelerated immunogenic cell death. The targeted release of cisplatin loaded into Cu@MIL-101@PMTPC also reduced toxic side effects of chemotherapy. TCPP generated a large amount of singlet oxygen ( 1 O 2 ) upon specific laser irradiation to effectively kill tumor cells. CaO 2 on the outer layer generated oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) to ameliorate hypoxia in the tumor microenvironment, enhance the PDT effect, and provide a continuous supply of H 2 O 2 for the Fenton-like reaction. Thus, this nanocarrier platform exhibited a powerful chemodynamic, photodynamic, and immunochemotherapeutic cascade, providing a new strategy for cancer treatment.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2024
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IF 2.7
Jianying Huang,Ling Xia,Xiaohua Xiao,Gongke Li
A copper/polydimethylsiloxane (Cu/PDMS) microfluidic chip was designed to synthesize SERS substrates through a displacement reaction between silver and copper in microfluidic channels to form a microfluidic SERS nanoparticles (AgNPs)/Cu chip. This SERS substrate fabrication method doesn’t require complex manufacturing processes or expensive equipment, and it can be achieved at room temperature in just 4 min. Meanwhile, the AgNPs grown on copper foil could offer ample hot spots, effectively boosting Raman signals of target molecules, and the enhancement factor (EF) was 5.12 × 107 for methylene blue, 4.08 × 107 for crystal violet, and 4.81 × 105 for sulfadiazine. The chip could be reused at least 9 times with consistent signal performance. Combined with the concentration gradient microchannel network design, we could establish the standard curve for samples through one injection on a single chip. A rapid SERS method for detecting sulfadiazine in aquatic products was developed. The linear range for sulfadiazine analysis was 75.0–1000 μg L−1 with a limit of detection of 28.4 μg L−1. Sulfadiazine was found in aquatic products (43.8 μg kg−1), with recovery rates ranging from 82.7% to 110%. The result was validated using high-performance liquid chromatography, showing a relative error of 9.3%. The entire detection procedure could be completed in just 20 min to detect sulfadiazine. These results demonstrate that the developed SERS method is fast, accurate, and reliable for analysis of sulfadiazine in aquatic products.
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高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
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2025
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IF 3.8
Jing Fang,Lingzhi Luo,Wenyan Li,Hao Li
Ethanol, as an important solvent and basic chemical feedstock, has widespread applications in the pharmaceutical, food, and fine chemical industries, including processes such as absorption, washing, and extraction. However, methanol and water are inevitable by-products in the industrial production of ethanol, whether through biological fermentation or chemical synthesis. Particularly methanol, which is harmful to both health and the environment, is typically present in ethanol products at low concentrations, posing a significant challenge for its effective removal. We designed citric acid-modified 4 A zeolites and a bimetallic organic framework Cu@ZIF-7. Under optimal modification conditions, the modified 4 A zeolite showed a 39.15% and 37.21% increase in selectivity for methanol and water, respectively, compared to the initial 4 A zeolite. The yield of qualified products increased by 44.71%. Furthermore, Cu@ZIF-7 exhibited a methanol adsorption capacity of 1.125 mg·g -1 , which is 3.42 times that of the initial 4 A zeolites. Density Functional Theory (DFT) calculations confirmed that the introduced Cu sites are associated with this enhanced methanol adsorption capacity. Experimental evidence suggests that these adsorbents perform exceptionally in purifying ethanol, particularly in the removal of trace methanol. As a new, environmentally friendly separation method, it holds great potential for obtaining high-purity ethanol.
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高影响因子
CHEMISTRY OF MATERIALS
·
2024
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IF 7.2
Xiangjie Tian,Hui Xu,FangFang Zhou,Xiyu Gong,Songwen Tan,Yongju He
Cuproptosis is a newly identified copper-dependent cell death and holds great promise for cancer therapy. However, transporting enough copper into cancer cells is a challenge. Herein, an intelligent cupreous nanoplatform (denoted as CuO2-MSN@TA-Cu2+), consisting of in situ formation of CuO2 within mesoporous silica nanoparticles (MSN) and then deposition with a tannic acid (TA)-Cu2+ complex, is designed and developed to realize on-demand copper delivery for cuproptosis-based combination therapy. CuO2-MSN@TA-Cu2+ exhibits tumor microenvironment-triggered therapeutic activity, wherein the outer TA-Cu2+ complex is readily disassembled to release Cu2+ and liberate the internal CuO2 to produce Cu2+ and H2O2. The overloaded Cu2+ can not only directly convert endogenous H2O2 and self-supplied H2O2 into highly toxic hydroxyl radicals for chemodynamic therapy (CDT) via Cu-based Fenton-like reaction but also undergo glutathione-mediated reduction into Cu+ species to induce potent cellular cuproptosis and enhance CDT. The experimental results indicate that CuO2-MSN@TA-Cu2+ produces remarkable cytotoxicity against cancer cells and significantly suppresses tumor growth by 93.42% in mice-bearing 4T1 breast tumors. This work provides a new paradigm to boost cuproptosis-related therapy and may also inspire the design of advanced therapeutic nanoplatforms.
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高影响因子
Energy & Environmental Materials
·
2024
·Vol. 7
·期 5
·e12717
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IF 13
Dongliang Liu,Hang Shang,Chuan Zhou,Jie Miao,Daxiang Xue,Zeping Chen,Meijuan Fei,Fengli Liang,Qiang Niu,Ran Ran,Wei Zhou,Zongping Shao
Solid oxide electrolysis cells (SOECs), displaying high current density and energy efficiency, have been proven to be an effective technique to electrochemically reduce CO 2 into CO. However, the insufficiency of cathode activity and stability is a tricky problem to be addressed for SOECs. Hence, it is urgent to develop suitable cathode materials with excellent catalytic activity and stability for further practical application of SOECs. Herein, a reduced perovskite oxide, Pr 0.35 Sr 0.6 Fe 0.7 Cu 0.2 Mo 0.1 O 3-δ (PSFCM0.35), is developed as SOECs cathode to electrolyze CO 2 . After reduction in 10% H 2 /Ar, Cu and Fe nanoparticles are exsolved from the PSFCM0.35 lattice, resulting in a phase transformation from cubic perovskite to Ruddlesden–Popper (RP) perovskite with more oxygen vacancies. The exsolved metal nanoparticles are tightly attached to the perovskite substrate and afford more active sites to accelerate CO 2 adsorption and dissociation on the cathode surface. The significantly strengthened CO 2 adsorption capacity obtained after reduction is demonstrated by in situ Fourier transform-infrared (FT-IR) spectra. Symmetric cells with the reduced PSFCM0.35 (R-PSFCM0.35) electrode exhibit a low polarization resistance of 0.43 Ω cm 2 at 850 °C. Single electrolysis cells with the R-PSFCM0.35 cathode display an outstanding current density of 2947 mA cm −2 at 850 °C and 1.6 V. In addition, the catalytic stability of the R-PSFCM0.35 cathode is also proved by operating at 800 °C with an applied constant current density of 600 mA cm −2 for 100 h.
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高影响因子
Molecular Catalysis
·
2024
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IF 3.9
Qianyuan Mo,Haoyuan Zheng,Guishang Sheng
In the study presented in this paper, a cobalt and copper codoped bimetallic metal-organic framework (CoCu–MOF) was synthesized by a solvothermal method. The CoCu–MOF was then utilized to activate peroxymonosulfate (PMS) to degrade the tetracycline (TC) present in water. When the concentration of organic pollutants was 20 mg/L, the degradation efficiency of TC by the Co 1 Cu 1 –MOF/PMS system reached 98.17 % within 30 min, which was better than that of the PMS and Cu-MOF/PMS systems alone. The effects of catalyst addition, PMS usage, initial pH, temperature, coexisting ions and initial TC concentration on the degradation of TC by Co 1 Cu 1 –MOF were investigated. The sulfate radical (SO 4 •− ), hydroxyl radical (•OH), superoxide radical (O 2 •− ), and nonradical singlet oxygen ( 1 O 2 ) were identified as the primary reactive species through quenching experiments and electron paramagnetic resonance (EPR) analyses. Moreover, linear sweep voltammetry (LSV) analysis was used to determine the occurrence of an electron transfer-mediated nonradical pathway in the reaction system in addition to 1 O 2 . The concentrations of the TC intermediates were determined using liquid chromatography‒mass spectrometry (LC‒MS), and potential degradation processes were proposed. This study showed that CoCu–MOF is a heterogeneous catalyst that activates PMS for efficient TC degradation.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Tingxiang Chen,Liugen Zhang,Jiang Li,Changyan Guo,Shanshan Qiao,Yansong Zhao,Jide Wang
This paper introduces a facile method to develop core-shell nanocomposite Cu/(Cu 2 O/CuO) through gradually oxidation on Cu nanocomposite precursors. As-prepared catalyst exhibited excellent catalytic activity in the reaction of water oxidation reaction (WOR). Comparing with the reported catalyst, Cu/(Cu 2 O/CuO) posed one of the highest O 2 evolution around 7700 μmol g -1 ·h -1 . By analyzing the composition of catalysts in each reaction stages, the evolution pathway of Cu towards Cu 2 O/CuO and the different roles of each component in catalytic water oxidation reactions were deeply studied. In presence of high conductive Cu element and excellent light absorption Cu 2 O, the photo generated electron and holes can be effectively separated and greatly improve the efficiency of the catalyst. The evolution process and synergistic effects of the three components play a crucial role in improving photocatalytic efficiency, which promoting the nanocomposite to be a highly efficient core-shell catalyst for WOR.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Xitao Qiao,Shuaidong Wang,Xin Han,Jiaye Qin,Yanyan Wang,Guangke Tian
Cu 2 S and Cu–S based materials with the introduction of 15 at% and 63% at% Cr respectively were prepared on carbon cloth (CC) (Cu 2 S/CC, Cu 5.6 CrS 6 /CC and CuCr 1.4 S 5 /CC) by one-pot hydrothermal synthesis. It was found that the phase composition and morphology of Cu–S undergo significant changes with the introduction of Cr content, thereby impacting their electrocatalytic hydrogen evolution reaction (HER) properties. In particular, for Cu 5.6 CrS 6 /CC, 15 at% Cr introduction facilitated the formation of a highly catalytically active Cu 7 S 4 -dominant phase and a hexagonal flake-like morphology with a large specific surface area conducive to fully exposing the catalytically active sites. The synergistic advantages in morphology and phase composition endow Cu 5.6 CrS 6 /CC with the best HER electrocatalytic performance with a low overpotential of 81 mV (10 mA cm −2 ) and 142 mV (100 mA cm −2 ), a Tafel slope of 43 mV dec −1 , and 10000 cycle stability. This study provides an idea for implementing a synergistic strategy of phase engineering and morphology modulation by introducing Cr to construct high-performance HER catalysts.
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高影响因子
JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Huabin Lian,Riming Hu,Lin Zheng,Daowei Gao,Shuai Wang,Rongyao Wang,Bin Wang,Guozhu Chen
The electrocatalytic reduction of biomass-derived furfural represents a sustainable pathway for the production of furfuryl alcohol and 2-methylfuran, serving respectively as value-added chemicals and biofuels. However, the production of these high-value-added products under mild conditions is hampered by low Faradaic efficiency. In this study, we develop a strategy to establish strong metal-support interactions, enabling Cu/NC (nitrogen-doped carbon) catalysts to efficiently produce value-added products under mild conditions. Specifically, we prepare a cost-effective NC support with highly dispersed ultrafine nano-Cu particles of approximately 1 nm in diameter. Under mild pH conditions, our comparative experiments show that the Faradaic efficiency for value-added products (furfuryl alcohol and 2-methylfuran) is nearly four times higher than that of commercial foam copper. We elucidate the influence of nitrogen-doped supports on the behavior of the supported metal Cu. Comprehensive in-situ infrared reflection absorption spectroscopy characterization and DFT theoretical calculations reveal a positive shift in the d-band center of the Cu 3d orbitals. This shift enhances the adsorption of furfural C1=O1 bonds on the Cu/NC catalyst and improves its capacity to bind active hydrogen, thereby increasing the Faradaic efficiency of the value-added products. Our findings advance theoretical understanding and providing practical insights for electrocatalytic hydrogenation of furfural under mild pH conditions.
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高影响因子
Molecular Catalysis
·
2025
·
IF 4.9
Kaixuan Yan,Xin Song,Chunliang Zhou,Junnan Liu,Rongji Cui,Panting Gao,Zhicheng Tang
The presence of sulfur-containing impurities in natural gas not only diminishes its utilization value, but also results in the emission of sulfur-containing pollutants. In this study, a Cu-Ce bimetallic-loaded MCM-41 catalyst was prepared by ammonia evaporation method for the catalytic hydrolysis of carbonyl sulfide (COS). The desulfurization efficiency of Cu 25 Ce 5 /MCM-41 can reach a 100 % COS removal rate and maintain for 3.5 h. CuO furnishes the predominant weakly acidic and weakly basic sites for the desulfurization process, which are conducive to the adsorption of COS. Meanwhile, CeOx provides a greater abundance of moderately basic sites for the desulfurization process, which help to improve the removal efficiency of COS. The incorporation of Ce into the catalyst enhances the resistance to sulfur poisoning of Cu and prolongs the lifespan of the catalyst. The incorporation of Ce is capable of transforming the strongly basic sites on the surface of Cu 25 /MCM-41 into moderately basic sites, avoiding excessive oxidation of H 2 S. Additionally, the introduction of Ce offers a degree of protection for CuO, which improves the ability of the catalyst to resist sulfur poisoning. The combined effect of Cu and Ce was found to be instrumental in enhancing the adsorption of COS and in slowing down the oxidation of H 2 S. The reduction of Cu 2+ and Ce 3+ indicated their direct participation in the oxidation of H 2 S. Firstly, COS adsorbed on the catalyst surface is converted into H 2 S and CO 2 through a catalytic hydrolysis reaction. Subsequently, H 2 S adsorbed on the catalyst surface undergoes partial oxidation to sulfide, and partial further oxidation by oxygen-containing functional groups on the surface to S, SO 3 2- , and SO 4 2- , which results in the toxic deactivation of the catalyst.
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高影响因子
Journal of Materials Chemistry C
·
2024
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IF 5.7
Ruixin Sun,Jinxing Zhao,Ouyang Lin,Yu Li,Xiulin Xie,Wentao Niu,Zhe Yin,Aiwei Tang
I–III–VI-group semiconductor nanocrystals (NCs) have received extensive attention for use in quantum-dot light-emitting diodes (QLEDs) due to their nontoxic nature, large-scale tunable emission wavelength and straightforward synthesis. At present, research on ternary CuGaSe2 (CGSe) NCs is gradually being carried out. CGSe-based semiconductor NCs with a wide and tunable bandgap exhibit significant promise for efficient QLEDs preparation. In order to improve their functionality, stability and dispersion, Zn2+ was introduced into CGSe cores, which were coated with wide-band-gap ZnS to form Cu–Ga–Zn–Se/ZnS NCs to improve their luminescence performance. In this work, a series of Cu–Ga–Zn–Se/ZnS NCs with tunable emission from 603 to 524 nm and a photoluminescence quantum yield (PLQY) of 96% could be acquired by precisely controlling the non-stoichiometric Cu : Ga molar ratios in the synthesis of the CGZSe cores. Furthermore, green luminescent CGZSe/ZnS NCs were obtained by adjusting the amount of crucial Zn precursors during nucleation and shell formation. The green QLEDs based on these NCs show a high external quantum efficiency of 5.8% and a high brightness of 7016 cd m−2. This work reveals new possibilities for the design of novel and efficient Cd-free green QLEDs.
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高影响因子
FUEL
·
2025
·
IF 7.5
Kejie Zhang,Weijian Hua,Renhui Ruan,Baochong Cui,Mingxing Su,Xuebin Wang,Houzhang Tan
The electrochemical reduction of CO 2 into valuable chemicals presents a promising CO 2 mitigation technology. However, rapid preparation of efficient and stable catalysts remains a challenge. The “droplet-to-particle” method allows for the rapid synthesis of catalysts with precise elemental composition control. In this study, Cu-Zn bimetallic nanoparticle catalysts with phase-separated structures and varying elemental compositions were prepared using this method. The formation process of the catalysts was analyzed, and their performance in CO 2 electroreduction was investigated. Aerosol dynamics simulation revealed that the formation process of the catalyst particles involves the transformation from a single droplet to a single particle. TEM observations showed hollow regions in the center of the catalyst particles, attributed to the rapid evaporation of the droplets, which led to the formation of hollow particles in some cases. This also explains why some catalyst particles had a larger actual diameter than the theoretical solid particle size. By calculating the residence time of droplets in the reactor, it was found that the transformation from droplets to particles occurred within approximately 4.37 s, indicating the rapid formation of catalyst particles. On the other hand, electrochemical experiments demonstrated that when the Cu/Zn molar ratio was 2:8, the faraday efficiency (FE) of CO reached up to 73 % at −1.1 V vs. RHE, with stable performance over 8 h of operation. Density functional theory (DFT) calculations indicated that the introduction of Zn lowered the energy barrier for the rate-determining step of *COOH formation, promoting the generation of CO. This study provides an in-depth investigation into the “droplet-to-particle” catalyst synthesis process, which is characterized by simplicity, rapidity, ease of control, and cost-effectiveness. These features offer an effective strategy for the industrial application of CO 2 electroreduction.
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高影响因子
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