CARBON
·
2023
·
IF 10.9
Linzi Huang,Jiaodi Li,Yilin Wang,Xuan Hu,Kai Shi,Chunyan Li,Yixi Xie,Pengcheng Zhao,Junjie Fei
l -cysteine (L-Cys) plays an important role in human health as well as in the biological environment. Here, a simple physical mixing technique was used to create the p-n heterojunction by homogeneously immobilizing cuprous oxide/copper@microporous carbon (Cu 2 O/Cu@mC) on the surface of a sheet of g-C 3 N 4 (CNS). Among them, the porous structure of Cu 2 O/Cu@mC after heat treatment is favorable for charge storage. Meanwhile, the carbon element in Cu 2 O/Cu@mC acts as a photosensitizer and electron mediator to extend visible light absorption. Compared with bulk g-C 3 N 4 (CNB), the sheet-like structure and high specific surface area of CNS can be used as a carrier for the binding of Cu 2 O/Cu@mC with L-Cys. Based on the interaction between L-Cys and Cu 2 O/Cu@mC through the formation of Cu–S bonds, Cu 2 O/Cu@mC/CNS was proposed as a light-driven enzyme-free photoelectrochemical sensor for the detection of L-Cys. In the best case, the Cu 2 O/Cu@mC/GCE sensor has a low limit of detection of 1.26 × 10 −9 M for L-Cys and a wide linear range (1.0 × 10 −8 M − 4.0 × 10 −6 M). The repeatability, reproducibility, stability, selectivity and specificity of the sensor were satisfactory. In addition, the potential applicability of the proposed photoelectrochemical sensor was evaluated in tap water and human serum.
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高影响因子
ACTA PHARMACOLOGICA SINICA
·
2021
·Vol. 42
·期 11
·1942-1950
·
IF 6.15
Wu Tong,Sheng Yun,Qin Yuan-yuan,Kong Wei-min,Jin Meng-meng,Yang Han-yu,Zheng Xiao-ke,Dai Chang,Liu Ming,Liu Xiao-dong,Liu Li
Breast cancer resistance protein (BCRP) and P-glycoprotein (P-gp) are co-located at blood–brain barrier (BBB) cells, preventing their substrates from entering brain. Accumulating evidence demonstrates that liver failure impairs P-gp and BCRP expression and function in the brain. In the current study, we investigated how liver failure influenced the expression and function of brain BCRP and P-gp in rats subjected to bile duct ligation (BDL). The function of BCRP, P-gp and BBB integrity was assessed using distribution of prazosin, rhodamine 123 and fluorescein, respectively. We showed that BDL significantly decreased BCRP function, but increased P-gp function without affecting BBB integrity. Furthermore, we found that BDL significantly downregulated the expression of membrane BCRP and upregulated the expression of membrane P-gp protein in the cortex and hippocampus. In human cerebral microvascular endothelial cells, NH 4 Cl plus unconjugated bilirubin significantly decreased BCRP function and expression of membrane BCRP protein, but upregulated P-gp function and expression of membrane P-gp protein. The decreased expression of membrane BCRP protein was linked to the decreased expression of membrane radixin protein, while the increased expression of membrane P-gp protein was related to the increased location of membrane ezrin protein. Silencing ezrin impaired membrane location of P-gp, whereas silencing radixin impaired membrane location of BCRP protein. BDL rats showed the increased expression of membrane ezrin protein and decreased expression of membrane radixin protein in the brain. We conclude that BDL causes opposite effects on the expression and function of brain BCRP and P-gp, attributing to the altered expression of membrane radixin and ezrin protein, respectively, due to hyperbilirubinemia and hyperammonemia.
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高影响因子
ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
Shifu Wang,Zuoyi Xiao,Shangru Zhai,Guoxiang Wang,Wensha Niu,Longfei Qin,Zhongcheng Li,Qingda An
Efficient pseudocapacitive energy storage devices have attracted considerable attention due to the growing demand of electrical power supply. Still, the design and fabrication of electrode materials with high power and energy densities is challengeable. Herein, an in-situ reduction and competitive cross-linking strategy is presented to construct a novel Sn–Mo bimetallic oxide nanoparticle-grown on P-doped hierarchical porous carbon (SnMo–O@P-HPC). The attractive electrochemical performance of SnMo–O@P-HPC composite with an ultrahigh specific capacitance of 2121.3 F g −1 and excellent cycle stability of 92.5% over 5000 cycles is resulted from unique active component, abundant active sites, and well-organized 3D porous structure. An asymmetric supercapacitor composed of activated carbon and SnMo–O@P-HPC displays an amazing specific energy density of 114.9 W h kg −1 at 515.5 and 98.8 W h kg −1 even at 20,900 W kg −1 . Importantly, it also displays a wonderful stability with excellent capacitance retention of 92.5% after 5000 cycles. The work will provide an effective and novel method to obtain the promising electrode materials for supercapacitors .
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 66
·61630-61640
·
IF 3.289
Lei Li,Beibei Lu,Qikui Fan,Jianning Wu,Lulu Wei,Jun Hou,Xuhong Guo,Zhiyong Liu
In this work, well-defined amphiphilic polyhedral oligomeric silsesquioxane (POSS) star-shaped inorganic/organic hybrid block copolymers with poly(ε-caprolactone)-poly(2-(dimethylamino)ethyl methacrylate)-co-poly(ethylene glycol) methacrylate (POSS-PCL-P(DMAEMA-co-PEGMA))16 were synthesized with different PCL segments via thiol-ene click reaction, ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP), which were confirmed by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). Subsequently, the polymers could self-assemble into micelles in aqueous solution, which were investigated by dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-vis) and transmission electron microscopy (TEM). The pH-responsive self-assembly behavior of these triblock copolymers in water was investigated at different pH values of 5.0 and 7.4 for controlled doxorubicin release; the results indicated that the release rate of DOX could be effectively controlled by altering the pH and the release of drug loading efficiency (DLE) was up to 82% (w/w). Furthermore, CCK-8 assays and confocal laser scanning microscopy (CLSM) against HeLa cells indicated that the micelles had no associated cytotoxicity, possessed good biodegradability and biocompatibility, and identified the location of the DOX in HeLa cells. The DOX-loaded micelles could easily enter the cells and produce the desired pharmacological action, and minimize the side effects of free DOX. Moreover, these flexible micelles with on-off switched drug release may offer a promising method to deliver a wide variety of hydrophobic payloads to tumor cells for cancer therapy.
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高影响因子
POLYMER
·
2024
·
IF 4.1
Yanxu Tian,Jiangang Zhang,Wen Cao,Xiong Liu,Xianming Zhang,Wenxing Chen,Jianna Bao
Poly(lactic acid) (PLA), which is recognized as a potential biodegradable material, brings serious fire concern because of its flammability with heavily molten drips. In this investigation, a bio-based flame retardant named CS@ATMP@MI (CAM) consisting of chitosan (CS), amino trimethylene phosphonic acid (ATMP), and methionine (MI) was developed through a simple and environmental-friendly synthesis approach. CAM provided effective flame retardancy and anti-dripping ability without compromising mechanical properties. PLA/CAM composites achieved a UL-94 V-0 rating with 1.0 wt% CAM and a limited oxygen index value of 28.4 % with 3.0 wt% CAM. The high efficiency is due to the high phosphate content in ATMP and the strong coordination between CS, ATMP, and MI. The cone calorimetry tests showed that adding 2.0 wt% CAM increased the total smoke production from 0.2 to 0.6 m 2 , and thermogravimetric analysis/infrared spectrum analysis indicated that combustible gas production was reduced over 50 % with 3.0 wt% CAM, demonstrating that phosphorus-nitrogen synergy in CAM could effectively capture free radicals and released inert gases. Char analysis showed that the PLA/CAM composites could form a thicker and denser char layer during combustion due to phosphorus-sulfur synergy, which promoted char formation to shield mass transfer. PLA/CAM composites maintained excellent mechanical performance, with a 3.0 wt% CAM increasing tensile strength from 53.9 to 57.3 MPa and Young's modulus from 1782 to 2262 MPa. This study presented a sustainable method for synthesizing an effective bio-based flame retardant and a strategy for producing eco-friendly, fire-resistant PLA composites for industrial applications.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Yulan Song,Cuilan Tang,Tao Wang,Yansong Liu,Xiaoshan He,Chunping Xie,Guo Chen,Chengfu Deng,Zhibing He,Jinglin Huang
Constructing electronic structures with abundant surface/interface structures and effective regulation of catalytic active centers is an effective strategy to improve electrocatalytic performance, but designing efficient bifunctional non-noble metal oxygen evolution reaction (OER) and urea oxidation reaction (UOR) electrocatalysts remains challenging. Studies have shown that p-n heterojunctions can effectively regulate the electronic structure of catalytic active sites while having abundant surface/interface structure, which plays an important role in improving the native catalytic activity. Herein, FeNi-OH/Co(OH) 2 /NF p-n heterojunction structure was constructed by a simple electrochemical deposition method, and the effects of content, deposition time, and number of cycles on catalytic performance were investigated. The results show that Fe(0.02 M)Ni(0.07 M)–OH(100 s)/Co(OH) 2 (5)/NF composite material has the best OER and UOR catalytic performance. For OER, the electrocatalyst only requires an overpotential of 271 mV to obtain a current density of 50 mA cm −2 , and an applied voltage of 1.56 V to obtain a total water decomposition of 10 mA cm −2 (FeNi-OH/Co(OH) 2 /NF||Pt). For UOR, a voltage of only 1.314 V ( vs. RHE) is required to achieve a current density of 10 mA cm −2 , and an applied voltage of 1.44 V can achieve a current density of 10 mA cm −2 . Experimental, in situ measurements and theoretical results indicate that the improvement in catalytic activity is mainly due to the potential difference between FeNi-OH and Co(OH) 2 , which induces self-driven charge transfer at the interface, promoting the adsorption of reactant molecules, optimizing reaction barriers, accelerating chemical bond cleavage, and thus promoting catalytic reactions.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Shaopei Jia,Yanfeng Gao,Xiaofei Ma,Quan Huang,Qian Zhang,Xiaozhe Cheng,Qisong Li,Yan Zhang,Wei Cheng,Menghui Liu,Yunchao Mu
Designing and synthesizing cost-effective hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) catalysts is still the critical impetus for electrocatalytic alkaline water splitting for green hydrogen production. We present a novel strategy to synthesize Ni 12 P 5 –Ni 2 P heterojunction nanoparticles anchored in the three-dimensional (3D) graphene composite bonded by N–P co-doped porous carbon (NPC) through a single high-temperature carbonization. The as-obtained Ni 12 P 5 –Ni 2 P@NPC/3DG possessed an open pore structure, promoting electrolyte diffusion and enhance bubble release. The synergistic effect of the Ni 12 P 5 –Ni 2 P heterojunction with high intrinsic catalytic activity and the N–P co-doped carbon enabled the composite to exhibit high catalytic activity and stability for HER and OER. The optimized Ni 12 P 5 –Ni 2 P@NPC/3DG-0.5 exhibited overpotentials of 209.8/206.1 mV at 10 mA cm −2 and Tafel slopes of 67.9/92.3 mV dec −1 for HER/OER. Furthermore, when Ni 12 P 5 –Ni 2 P@NPC/3DG-0.5 was used as both the cathode and anode for overall water splitting, the cell only required a low voltage of 1.58 V to achieve a current density of 10 mA cm −2 , which was comparable to the catalytic activities of commercial noble metal catalysts. Meaningfully, this synthetic method provided a new strategy to improve electrocatalytic performance of Ni-based phosphides, extensively promoting the development of highly efficient electrocatalysts for alkaline overall water splitting.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yichan Huo,Xiong Wang,Yang Yi,Zhirong Yang,Wenchang Wang,Huaijie Yao,Pingping Liu,Wenfen Zhang,Shusheng Zhang
p -Phenylenediamine antioxidants (PPDs) and their quinone derivatives (PPDQs) have emerged as concerning environmental contaminants due to their widespread presence and biological toxicity. Herein, a novel tetraazacalix[2]arene[2]triazine functionalized 2D transition metal carbide (TCT@MXene) with electron-rich and electron-deficient sites, porous structures, abundant adsorption sites was first synthesized and characterized. Combining the advantages of extraordinary adsorption capacities and rates towards PPDs and PPDQs, a dispersive solid-phase extraction coupled with high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) strategy was developed for highly sensitive and selective determination of PPDs and PPDQs in environmental water. The method featured acceptable linearity (R 2 ≥ 0.999), high sensitivity (LOD ranged from 0.10 to 2.96 ng L −1 ), and qualified precision (RSD ≤ 5.90 %). Compared with published works, the LODs of the developed technique were improved 3.8–250 times. Furthermore, its exceptional thermal and chemical stability allows for at least 10 reuse cycles under varying pH conditions. The adsorption mechanism revealed that the complementary charge distribution and robust conjugated system of TCT@MXene enabled the simultaneous and efficient co-adsorption of both PPDs and PPDQs. Besides, the established method was successfully applied to the analysis of trace targets in Yellow River basin in Henan Province. All these results proved the promising application of the developed method for organic pollutants analysis in water samples.
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高影响因子
Chemical Biology & Drug Design
·
2020
·Vol. 96
·期 6
·1433-1446
·
IF 2.548
Yibing Guo,Liancheng Xu,Changchun Ling,Tao Yang,Wenjie Zheng,Jin Lv,Qingsong Guo,Bohua Chen
Eighteen new β-carboline-based indole-4,7-quinone derivatives ( 12a–i and 13a–i ) were designed and synthesized, and their in vitro and in vivo antiproliferative activities were studied. Most of target compounds showed strong inhibition on three human tumor cells' proliferation. In particular, the most active compound 13g not only displayed more prominent antiproliferative activities than β-lapachone, a clinical antitumor candidate, but also exerted significant NAD(P)H: quinone-oxidoreductase-1 (NQO1) inhibitory activity and NQO1-dependent cytotoxicity in HT29 cells. Furthermore, 13g dose-dependently induced high ROS levels in HT29 cells, and selectively inhibited cancer cell but not non-tumor colon cell proliferation in vitro. Importantly, 13g promoted HT29 cell apoptosis and DNA damage by regulating relative apoptotic proteins and H2AX expression. Finally, 13g displayed significant growth inhibition of HT29 human colorectal adenocarcinoma xenograft in mice without overt toxicity.
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Bo Wang,Qiao Liu,Ao Yuan,Qing Shi,Lan Jiang,Weiyou Yang,Tao Yang,Xinmei Hou
One key step for advancing the widespread practical application of rechargeable metal-air batteries and water electrolysis fundamentally relies on the development of cost-effective multifunctional electrocatalysts toward oxygen and hydrogen-involving reactions. The present work initiates a tofu-derived one-pot strategy for green, facile, and mass production of highly active and stable catalyst toward oxygen reduction/evolution and hydrogen evolution reactions, through the preparation of Fe/Co cross-linked tofu gel and the subsequent pyrolysis. Despite the free use of additional N/P precursors or pore-forming agents, the as-prepared materials comprise highly dispersive FeCo-rich phosphides nanoparticles and porous N,P co-doped carbon network inherited from the tofu skeleton. The resultant catalysts exhibit remarkably enhanced trifunctional activities as compared to the Fe 2 P and Co 2 P counterparts, along with better long-term stabilities than the benchmark RuO 2 and Pt/C catalysts. Accordingly, the as-assembled Zn-air battery delivers a large power density (174 mW cm −2 ) with excellent cycle stability (the gap of charge/discharge voltage@10 mA cm −2 increases by 0.01 V after 720 h of operation, vs . 0.16 V of Pt/C-RuO 2 based battery after 378 h). Furthermore, the as-constructed alkaline electrolyzer just requires a small voltage of 1.55 V@10 mA cm −2 , which outperforms nearly all of those of biomass-derived electrocatalysts ever reported, and that of noble metal catalysts-based electrolyzers (1.72 V@10 mA cm −2 for Pt/C-RuO 2 ), underscoring their bright future toward commercial applications in green energy conversion devices.
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高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 7
·1-10
·
IF 6.232
Li Shanshan,Zhang Yintang,Mu Shuai,Ma Minrui,Liu Xiaoyan,Zhang Haixia
A novel magnetic organic porous polymer (denoted as Fe 3 O 4 @PC-POP) was developed for magnetic solid-phase extraction (MSPE) of two gastric cancer biomarkers (P-cresol and 4-hydroxybenzoic acid) from urine samples prior to high-performance liquid chromatographic analysis. The adsorbent was characterized by scanning electron microscope, transmission electron microscope, FTIR, powder X-ray diffraction, and other techniques. The result of dynamic light scattering shows that the particle size of the adsorbent is mainly distributed around 400 nm. Based on the design concept of the Fe 3 O 4 @PC-POP, the proposed material can effectively capture the target analytes through electrostatic and hydrophobic interaction mechanism. Furthermore, the enrichment conditions were optimized by the response surface method, and the method was utilized for the determination of P-cresol and 4-hydroxybenzoic acid in real urine samples from health and gastric cancer patients with high enrichment factors (34.8 times for P-cresol and 38.7 times for 4-hydroxybenzoic acid), low limit of detection (0.9–5.0 μg L −1 ), wide linear ranges (3.0–1000 μg L −1 ), satisfactory relative standard deviation (2.5%–8.5%), and apparent recoveries (85.3–112% for healthy people’s and 86.0–112% for gastric cancer patients’ urine samples). This study provides a guided principle for design of the versatile polymer with specific capturing of the target compounds from complex biological samples.
Graphical abstract
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 62
·39153-39168
·
IF 3.361
Bo Wu,Baizhao Tan,Guizhen Tan,Ming Zeng,Jinyi Luo,Guanghui Hu,Jiye Luo,Zhifeng Hao,Shaomei Lai,Binyun Liu
The green cyanide-free gold deposition is an important development direction in electroless gold plating. However, the commonly Au(I) based cyanide-free gold plating bath always suffers from severe corrosion to the Ni–P layer and unsatisfactory service life of the bath. In this work, a green and environmentally friendly cyanide-free gold plating bath was developed with hypophosphite added as a reducing agent into the Au(III)–DMH (5,5-dimethylhydantoin) based plating bath to retard the corrosion of the Ni–P layer. SEM micrographs combined with XRD and XPS analysis indicated that the electroless deposited gold was pure and compact. And XRD also revealed that the oriented deposition of gold was growing preferentially on Au (111). Corrosion tests, including salt spray tests, potentiodynamic polarization tests, and electrochemical impedance spectroscopy tests, indicated that the obtained Cu/Ni–P/Au coatings had significantly improved corrosion resistance performance with the loading of hypophosphite as the reducing agent. The baths remained transparent and no turbidity or precipitates were detected for 210 days, reflecting good stability. The detection for the Ni2+ concentration in the bath showed that adding hypophosphite could retard the replacement reaction between Au3+ and the Ni–P layer in part and this is important for decreasing the severe corrosion of the Ni–P layer. Moreover, Au was inactive for catalyzing the oxidation of hypophosphite during the deposition process which was confirmed furthermore via quantum chemical calculations. Therefore, our developed green cyanide-free electroless gold deposition process can beneficially provide research value and application prospects in microelectronic industry.
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高影响因子
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