JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-20
·
IF 10.2
Huang Yufen,Kou Qinjie,Su Yanrong,Lu Lu,Li Xisheng,Jiang Haiye,Gui Rong,Huang Rong,Nie Xinmin,Li Jian
Strategies to overcome toxicity and drug resistance caused by chemotherapeutic drugs for targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous studies revealed that high oxidored-nitro domain-containing protein 1(NOR1) expression in HCC was associated with cisplatin (DDP) resistance. Herein, a novel dual-targeting nanocarrier system AR-NADR was generated for the treatment of DDP resistance in HCC. The core of the nanocarrier system is the metal–organic frameworks (MOF) modified with nuclear location sequence (NLS), which loading with DDP and NOR1 shRNA (R). The shell is an A54 peptide inserted into the erythrocyte membrane (AR). Our results show that AR-NADR efficiently internalized by tumor cells due to its specific binding to the A54 receptors that are abundantly expressed on the surface of HCC cells and NLS peptide-mediated nuclear entry. Additionally, DDP is more likely to be released due to the degradation of Ag-MOF in the acidic tumor microenvironment. Moreover, by acting as a vector for gene delivery, AR-NADR effectively inhibits tumor drug resistance by suppressing the expression of NOR1, which induces intracellular DDP accumulation and makes cells sensitive to DDP. Finally, the anti-HCC efficacy and mechanisms of AR-NADR were systematically elucidated by a HepG2/DDP cell model as well as a tumor model. Therefore, AR-NADR constitutes a key strategy to achieve excellent gene silencing and antitumor efficacy, which provides effective gene therapy and precise treatment strategies for cisplatin resistance in HCC. Graphical Abstract
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FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 2
·413-422
·
IF 2.5
Zhou Jianhua,Liu Geng,Niu Zhuanli,Li Xinyue,Zhao Jiaojiao,Li Xiang
Hyperbranched waterborne polyurethane solid–solid phase change material was prepared by A 2 + B 3 method in water. Hyperbranched polyurethane solid–solid phase change material (HBPUPCM) was synthesized through reaction of isocyanate terminated prepolymer (A 2 ) with trimethylolpropane (B 3 ). Fourier transform infrared spectroscopy and 1 H nuclear magnetic resonance were used to confirm the prepared HBPUPCM. Differential scanning calorimetry showed that the maximum latent heat of HBPUPCM was Δ H m of 161.57 J/g and Δ H c of 153.44 J/g. The thermal storage ability was stable even after 500 consecutive heating/cooling cycles. The as-prepared HBPUPCM had excellent thermal stability as was shown by thermogravimetric analyzer. In addition, X-ray diffraction and polarized optical microscopy showed that HBPUPCM had crystalline structure. Meanwhile, when the poly(ethylene glycol) content was 80 wt%, the cotton fabric finished with HBPUPCM had a lower heating and cooling rate, higher phase change enthalpy and better temperature regulation performance in comparison with the unfinished cotton fabric. The HBPUPCM may be highly feasible and promising in the field of intelligent thermoregulation fabric industry.
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IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
·
2023
·Vol. 59
·期 1
·61-73
·
IF 2.6
Li Xiaofang,Fang Pingping,Li Mingxuan,Xu Pei
Structural analogs of enzyme substrates involved in plant hormone biosynthesis can either inhibit or enhance hormone-related responses depending on their specific chemical characteristics. Ethylene is an important gaseous phytohormone regulating a myriad of physiological and developmental processes. The substrate of the ethylene biosynthesis key enzyme ACC oxidase (ACO), 1-aminocyclopropane-1-carboxylate acid (ACC), is the direct precursor of ethylene. Previous studies have identified a series of ACC analogs as ethylene antagonists competitively binding with ACO. Here, this study identified methyl 1-aminocyclopropanecarboxylate (methyl-ACC), a structural analog of ACC, as an agonist of ethylene response in plants. Methyl-ACC triggered enhanced ethylene-related responses in plants similar to the effects of ACC, such as restrained root elongation, increased root hair number, promoted dark-induced leaf senescence, and accelerated ripening of postharvest tomato fruit. A higher amount of ethylene release was detected from the tomato leaves treated with methyl-ACC than from the mock control. These bioactivities of methyl-ACC render it a potential plant growth regulator (PGR) for the agricultural and postharvest industries. RT-qPCR revealed a generally upregulated expression of the ethylene biosynthesis genes in detached tomato leaves under methyl-ACC treatment. In vivo and in vitro enzymatic activity analyses showed that methyl-ACC had no obvious effect on the total ACO activity in detached tomato leaves nor on the activity of recombinant SlACO1, the predominantly expressed ACO family member in this tissue. This study offers a promising new PGR and adds to the current knowledge on the structure–function-regulation relationship of compounds associated with ethylene biosynthesis. The mechanism by which methyl-ACC exerts its function is discussed.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 17
·51271-51287
·
IF 5.8
Li Zhishuncheng,Yang Can,Qu Guangfei,Cui Qingyuan,Yang Yixin,Ren Yuanchuan,Yang Yuyi,Wang Fang
Hexavalent chromium Cr(VI) is one of the most hazardous oxygen-containing anions to human health and the environment. Adsorption is considered to be an effective method for the removal of Cr(VI) from aqueous solutions. Based on an environmental perspective, we used renewable biomass cellulose as carbon source and chitosan as functional material to synthesize chitosan-coated magnetic carbon (MC@CS) material. The synthesized chitosan magnetic carbons were uniform in diameter (~ 20 nm) and contain a large number of abundant hydroxyl and amino functional groups on the surface, meanwhile owning excellent magnetic separation properties. The MC@CS exhibited high adsorption capacity (83.40 mg/g) at pH 3 and excellent cycling regeneration ability when applied to Cr(VI) removal in water, removal rate of Cr(VI) (10 mg/L) was still over 70% after 10 cycles. FT-IR and XPS spectra showed that electrostatic interaction and reduction with Cr(VI) are the main mechanisms of Cr(VI) removal by MC@CS nanomaterial. This work provides an environment-friendly adsorption material that could be reused for the removal of Cr(VI) in multiple cycles. Graphical Abstract
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CHEMICAL PAPERS
·
2023
·Vol. 77
·期 7
·3703-3712
·
IF 2.2
Zhou Zhiqiang,Cen Jianfang,Wang Huixiao,Sun Yu,Yang Liyun
Due to the high importance of transferrin in targeting tumor, the investigation on the functionalization process of quantum dots (QDs) using transferrin is very essential. In this paper, the interaction between CdSe and CdSe@ZnS QDs with transferrin was studied by various spectroscopies. It was found that the two types of QDs triggered the fluorescence quenching of transferrin by the static quenching mechanism. At 298 K, the binding constant for CdSe@ZnS QDs (8.03 × 10 6 L·mol −1 ) is higher than CdSe QDs (2.84 × 10 6 L·mol −1 ), implying that CdSe@ZnS QDs could bind stronger to transferrin. In addition, the values of enthalpy change (∆ H ), entropy change (∆ S ) and Gibbs free energy change (∆ G ) were negative, indicating that the binding procedures between both QDs and transferrin were spontaneous and the main binding forces were hydrogen bonding and van der Waals force. The results of CD spectra indicated that both QDs induced the conformational change of transferrin, which further caused the release of iron ions from transferrin. Compared with CdSe QDs, less contents of iron ions in transferrin were detected after interaction with CdSe@ZnS QDs. Additional cytotoxicity tests showed that both QDs were toxic to Hela and 293T cells, but the cytotoxicity of CdSe QDs was stronger than that of CdSe@ZnS QDs. Moreover, the combination of transferrin failed to promote the cytotoxicity of CdSe QDs and CdSe@ZnS QDs, which is ascribed to the release of iron ions during the interaction process between QDs and transferrin.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2023
·
IF 2.3
Hong Xiaozhe,Zheng Zhijun,Gao Yan
Although a large number of bionic superhydrophobic surfaces have been reported in recent years, their poor robustness remains to be improved. Herein, we present a method to fabricate a hierarchical micro-nanostructure on Ti6Al4V with excellent robustness by combining laser direct writing technology and hydrothermal treatment. Microscale pore array pattern with hard oxide layer was generated by laser irradiation, which provided protection for the nanowires later grown in situ by hydrothermal treatment. After low surface energy molecular modification, the composite surface exhibited outstanding wetting properties with a contact angle of 165.2° and a roll-off angle less than 1°. We focused on the mechanical and chemical stability of the as-prepared superhydrophobic surface (SHS), and the performance tests included water jet impact, cyclic friction, solution immersion, heat treatment and UV irradiation. Additionally, the SHS was transformed into slippery liquid-infused porous surface (SLIPS) by lubricant injection, which expends the applications of the hierarchical micro-nanostructure surface. Considering the loss degree and the self-repairing performance of the lubricants with different viscosities, we can conclude that the lubricant with a viscosity of 350 mPa·s matches the SHS substrate best. The constructed SHS and SLIPS show remarkable robustness and versatility and may be applied in various fields.
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COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 8
·879-891
·
IF 2.4
Li Danyang,Xu Wenshuang,Liu Hui
Stimuli-responsive hydrogel could respond rapidly to environmental changes, whereas the limitation of gel scale usually led to a single route of drug delivery and restricted application. Herein, a pH and temperature dual responsive nanogel CS/P(MAA-co-NIPAM) was successfully prepared by radical polymerization. The change of both turbidity and hydration diameter at different conditions indicated that the nanogel possessed obvious pH and temperature sensitive properties. Specifically, the hydration diameters of the nanogel were 234 nm at T = 20 °C and 145 nm at T = 45 °C. The schematic flowable characteristic by injection experiment indicated that CS/P(MAA-co-NIPAM) might have the potential application possibility of injectable drug delivery. In addition, with doxorubicin as the model drug, the drug loading efficiency of the nanogel was 84.00% and the maximum release efficiency reached 66.30% at pH = 2.0 & T = 20 °C. The nanogel was able to realize drug delivery process in physiological environment according to in-vitro controlled releasing experiments.
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JOURNAL OF FLUORESCENCE
·
2023
·Vol. 33
·期 5
·2015-2021
·
IF 2.7
Qin Danni,Han Yaqi,Hu Liang
Coumarin 3-carboxylic acid (CCA)-loaded radio-fluorescent hydrogels have attracted interest for ionizing radiation dosimeters, but their sensitivity needs to be improved. In this study, we added ammonium persulfate (APS) to a polyacrylamide (PAAm)-CCA hydrogel. The introduction of APS improved the hydrogel dose sensitivity to 336.02 Gy − 1 , which is 1.8 times that of the counterpart without APS. Our hydrogel can measure the X-ray dose in a range of 0 − 15 Gy with a lower limit of detection (LOD) of 0.1 Gy. Additionally, the hydrogel can sense X-ray doses within a wide range of the dose rate and temperature, and the dose‒response can be well retained 7 days postirradiation. Therefore, we think this study provides a simple and robust method to improve the sensitivity of CCA hydrogel dosimeters, presenting great potential in clinical radiotherapy.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Li Zheng,Zhu Yabo,Zeng Haowen,Wang Chong,Xu Chen,Wang Qiang,Wang Huimin,Li Shiyou,Chen Jitang,Xiao Chen,Yang Xiangliang,Li Zifu
Nanomedicine has been developed for cancer therapy over several decades, while rapid clearance from blood circulation by reticuloendothelial system (RES) severely limits nanomedicine antitumour efficacy. We design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Stiff nanogels are injected preferentially to abrogate uptake capacity of macrophages and temporarily block RES, relying on inhibition of clathrin and prolonged liver retention. Afterwards, soft nanogels deliver doxorubicin (DOX) with excellent efficiency, reflected in high tumour accumulation, deep tumour penetration and outstanding antitumour efficacy. In this work, we combine the advantage of stiff nanogels in RES-blockade with the superiority of soft nanogels in drug delivery leads to the optimum tumour inhibition effect, which is defined as mechano-boosting antitumour strategy. Clinical implications of stiffness-dependent RES-blockade are also confirmed by promoting antitumour efficacy of commercialized nanomedicines, such as Doxil and Abraxane.
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JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 3
·1-17
·
IF 2.8
Chen Dongming,Li Ziwei,Li Dacheng,Li Shanrong,Mo Jing,Zheng Zijian,Lu Shaorong
In this study, a new type of compatibilizer, benzamide-grafted polyethylene polyamine (PEPA) containing solvent chain (PDABA-g-PEPA-O) was prepared from PEPA, 3,5-diaminobenzoic acid (DABA) and Oleoyl chloride (OC) and used to modify sisal microcrystalline cellulose (MCC). The natural rubber (NR) was filled with the modified MCC to prepare composites. The compatibilization effect of the prepared compatibilizer on the NR/MCC/PEPA-g-PDABA-O composites was investigated and its compatibilization mechanism was analyzed by molecular dynamics simulation (MD). The results show that adding 3wt% (calculated by MCC mass) PDABA-g-PEPA-O can improve the interfacial interaction between NR and MCC. The highest tensile strength of the NR composites was 25.319 MPa when 2.5phr MCC and 3wt% of PDABA-g-PEPA-O were added and is improved by 13.07% compared with that of NR/2.5phr MCC composites. In addition, the MD results showed that the amide and amine groups in the molecular structure of PDABA-g-PEPA-O formed a strong hydrogen bond and a strong van der Waals interaction with the hydroxyl groups of cellulose and PDABA-g-PEPA-O exhibited good compatibility with NR, which achieved the purpose of compatibilization. Moreover, the properties of tensile, deformation and shear resistance of the composites were enhanced with the addition of PDABA-g-PEPA-O in molecular simulation. The MD results provided a basis for the molecular design and preparation of compatibilizers and understanding their compatibilization mechanism in the polymer composites at a molecular level.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 7
·1-13
·
IF 2.8
Hu Qi,Teng Yuancheng,Zhao Xiaofeng,Zhou Fei,Arslanov Temirlan,Dai Bo
Zn 1− x Ni x ZrTa 2 O 8 ( x = 0.02, 0.04, 0.06, 0.08, 0.10, 0.12) microwave dielectric ceramics were synthesized by traditional solid-state method. The effect of introducing Ni–O bonds to replace part of Zn–O bonds on the ceramic lattice and microwave dielectric properties was systematically studied. An appropriate amount of Ni 2+ substitution improves the microscopic morphology of crystal, including the grain size, number of pores, number of grain boundaries, and the grain uniformity, giving rise to an increase in the compactness of ceramics and, thereby enhancing the microwave dielectric properties. The Raman analysis prove that the introduction of Ni 2+ is beneficial to enhance the vibrational peak intensity of the oxygen octahedron and effectively improve the Q × f value. However, the introduction of excessive Ni 2+ will lead to the decrease of lattice oxygen and the increase of adsorbed oxygen, and the crystal will become relatively active and unstable, and the microwave performance will decrease. In addition, the substitution of Ni 2+ can also effectively control the resonance temperature coefficient, which is beneficial to improve the τ f value. As a result, Zn 0.94 Ni 0.06 ZrTa 2 O 8 exhibits excellent microwave dielectric properties: ε r = 32.15, Q × f = 15,7500 GHz, τ f = − 33.1 ppm/°C, presenting as a potential candidate for low-loss microwave dielectric materials.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
·
IF 16.6
Zhou Rui,Sui Laizhi,Liu Xinbao,Liu Kaikai,Guo Dengyang,Zhao Wenbo,Song Shiyu,Lv Chaofan,Chen Shu,Jiang Tianci,Cheng Zhe,Meng Sheng,Shan Chongxin
Multiphoton excited luminescence is of paramount importance in the field of optical detection and biological photonics. Self-trapped exciton (STE) emission with self-absorption-free advantages provide a choice for multiphoton excited luminescence. Herein, multiphoton excited singlet/triplet mixed STE emission with a large full width at half-maximum (617 meV) and Stokes shift (1.29 eV) has been demonstrated in single-crystalline ZnO nanocrystals. Temperature dependent steady state, transient state and time-resolved electron spin resonance spectra demonstrate a mixture of singlet (63%) and triplet (37%) mixed STE emission, which contributes to a high photoluminescence quantum yield (60.5%). First-principles calculations suggest 48.34 meV energy per exciton stored by phonons in the distorted lattice of excited states, and 58 meV singlet-triplet splitting energy for the nanocrystals being consistent with the experimental measurements. The model clarifies long and controversial debates on ZnO emission in visible region, and the multiphoton excited singlet/triplet mixed STE emission is also observed.
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