ACS Applied Nano Materials
·
2023
·
IF 5.9
Yu Yang,Hao Cheng,Ruijue Chen,Qiying Chen,Si Gao,Li Chen,Wenyi Huang,Hongxing Kong,Lijun Li,Jun Feng
In this work, we have fabricated a surface-enhanced Raman scattering (SERS) magnetic immunosensor using a sandwich structure consisting of an SERS tag, a supporting substrate with magnetic properties, and a target. On the one hand, the SERS tag consists of AgNPs, a metal–organic framework called the zeolite imidazolate framework-67 (ZIF-67), and R6G, which acts as a Raman reporter. Due to the self-selective SERS-enhancing properties of ZIF-67 and better adsorption to analytes, SERS tags with this structure can further enhance the sensing capabilities. On the other hand, after surface functionalization with the human carboxylesterase 1 (hCE1) antibody, the nanostructure containing CoFe2O4 as the magnetic core and Ag NPs as the shell was used as the magnetic support substrate. The introduction of the CoFe2O4 magnetic core can not only realize the rapid separation of biological samples to simplify pre-treatment procedures but also stabilize and uniformly distribute the AgNPs and increase the Raman “hot spots”, thereby further enhancing the SERS intensity and improving the reproducibility. Not only that, the SERS signal can be further enhanced by the synergistic effect generated by the plasmonic coupling of the CoFe2O4 magnetic core–Ag satellite nanostructure (CoFe2O4/Ag). hCE1 in HepG-2 cell lysates and culture supernatants was rapidly determined using the constructed SERS magnetic immunosensor, and hCE1 released from acetaminophen-treated HepG-2 cells into the extracellular medium was also monitored in real time. The limit of detection was as low as 3.6 pg/mL, and the linear response covered a range of hCE1 concentrations (1.0 ng/mL–1.0 mg/mL) spanning 3 orders of magnitude. This strategy can be used for the quantitative detection of complex trace proteins or enzymes in biological samples.
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高影响因子
TALANTA
·
2024
·
IF 5.6
Gao-feng Wu,Jian Zhu,Guo-jun Weng,Hao-yu Cai,Jian-jun Li,Jun-wu Zhao
The development of an ultra-sensitive detection method for carbohydrate antigen 19-9 (CA19-9) is very important for the early diagnosis of pancreatic cancer. In this work, we developed a new strategy to achieve a variety of Au–Ag hybrid nanoparticles from janus to core-satellite which is controlled by the volume of AgNO 3 and the concentration of benzimidazolecarboxylic acid (MBIA). With the volume of AgNO 3 increased, Au–Ag hybrid nanoparticles changed from janus to core-satellite and the characteristic absorption peak showed two opposite trends. The size and number of Ag islands were determined by the concentration of MBIA. Au–Ag core-satellites nanoparticles with a large number of small-sized Ag have the highest SERS intensity. Then we used them as SERS nanotags and Au-Polystyrene nanospheres modified by captured anti-CA19-9 antibody as solid substrates to realize the ultra-sensitive detection of CA19-9 with a low limit of detection of 1.25 × 10 −6 IU/mL and a wide linear range of 1.00 × 10 −5 -1.00 × 10 4 IU/mL. This work not only demonstrates that MBIA and AgNO 3 were the key factors in the growth of Au–Ag hybrid nanoparticles from 2D to 3D structure but also supplies an ultra-sensitive detection method for CA19-9 which has a potential practicability in the clinical early diagnoses of pancreatic cancer.
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高影响因子
Small
·
2024
·
IF 13
Weijin Yang,Cheng Bu,Min Zhao,Yafei Li,Shihai Cui,Jing Yang,Hongzhen Lian
In this work, novel ternary composite ZIF-67/Ag NPs/NaYF 4 :Yb,Er is synthesized by solvothermal method. The photocatalytic activity of the composite is evaluated by sulfadiazine (SDZ) degradation under simulated sunlight. High elimination efficiency of the composite is 95.4% in 180 min with good reusability and stability. The active species (h + , ·O 2 − and ·OH) are identified. The attack sites and degradation process of SDZ are deeply investigated based on theoretical calculation and liquid chromatography-mass spectrometry analysis. The upconversion mechanism study shows that favorable photocatalytic effectiveness is attributed to the full utilization of sunlight through the energy transfer upconversion process and fluorescence resonance energy transfer. Additionally, the composite is endowed with outstanding light-absorbing qualities and effective photogenerated electron–hole pair separation thanks to the localized surface plasmon resonance effect of Ag nanoparticles. This work can motivate further design of novel photocatalysts with upconversion luminescence performance, which are applied to the removal of sulphonamide antibiotics in the environment.
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高影响因子
Food Frontiers
·
2026
·Vol. 7
·期 4
·e70334
·
IF 6.3
Zongda Li,Yukun Zhang,Youning Zhang,Yu Zhang,Jiangxia Xu,Fanxing Meng,Minwei Zhang
Combining high-electroactive nanomaterial with enzyme immobilization, the development of the electrochemical biosensor is a frontier approach to improve the sensitivity and selectivity for the detection of organophosphorus pesticides (OPs). In this study, a core–shell nanostructure (Ag-HMPB@UiO-66) was prepared with the Ag-HMPB as a core and a UiO-66 forming the shell as an advanced platform for acetylcholinesterase (AChE) immobilization. The innovation lies in the synergistic integration of the excellent electron transfer capability of Ag-HMPB with the good structural stability of UiO-66. Based on Lewis acid–base theory, the form of Zr─O─P coordination bond could improve the efficiency of aptamer (Apt) immobilization (131.65 nM mg −1 ) compared with physical adsorption. Electrochemical analysis revealed that the as-prepared biosensor exhibited exceptional substrate affinity, with a low K m of 0.234 mM. Under optimized conditions, the biosensor exhibited sensitive detection of trichlorfon over a wide range (1 × 10 −13 to 2.5 × 10 −9 g L −1 ), with a low LOD of 0.44 pg L −1 (3σ/slope). Additionally, the biosensor can also be applied to the cucumber with good recovery (97.34% to 103.35%), as well as good storage stability and reproducibility. This provides a reliable and powerful tool for the trace detection of OPs in complex agricultural products.
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CHEMICAL PHYSICS LETTERS
·
2026
·
IF 2.9
Kaicheng Zhou,Xiaomin Jian,Zhongli Wu,Xingjun Li,Xinchi Duan,Yingchun Luo
Directionally aligned MXene-PVA@AG aerogel with anisotropic water channels. • 97.22% solar-thermal conversion efficiency under 1 sun. • Stable evaporation for 7 days and under extreme pH conditions. • Excellent oil-resistance in oil-water emulsion systems. • 99% removal of metal ions and efficient dye purification. Solar interfacial evaporation has emerged as a potential solution for wastewater treatment. In this study, an MXene-PVA@AG composite aerogel evaporator (PAMX) with vertically oriented channels is fabricated via directional freeze drying. Results show that the PAMX evaporator exhibits an evaporation rate of 1.82 kg·m −2 ·h −1 under 1 sun illumination, corresponding to a photothermal conversion efficiency of 97.22%. Furthermore, the PAMX evaporator exhibits remarkable purification effects on metal salt ions and organic dyes, such as MO and MB, and sustain strong evaporation performance in oil-containing systems. Overall, this work presents a feasible strategy for treating complex water bodies. Scheme 1. Flow chart for the preparation of PAMX aerogel. Solar interfacial evaporation has emerged as a potential solution for wastewater treatment due to its high energy utilization efficiency. However, evaporators often face problems such as limited photothermal conversion capacity, poor stability, and insufficient water supply. In this study, an MXene-PVA@AG composite aerogel evaporator (PAMX) with vertically oriented channels is fabricated via directional freeze drying. Utilizing the broad-spectrum absorption of MXene and the continuous water supply from the PVA/AG porous network, synergistic regulation of solar absorption, localized heat management, and water transport is achieved. Results show that the PAMX evaporator exhibits an evaporation rate of 1.82 kg·m −2 ·h −1 under 1 sun illumination, corresponding to a photothermal conversion efficiency of 97.22%, while maintaining stable output under different light intensities. Owing to the excellent photothermal conversion performance of MXene, the PAMX evaporator exhibits remarkable purification effects on metal salt ions and organic dyes, such as MO and MB. Furthermore, using polyvinyl alcohol and agarose as matrix materials endows the evaporator with good structural stability, allowing it to maintain high evaporation rates even after one week of continuous evaporation, and sustain strong evaporation performance in oil-containing systems. Overall, this work presents a feasible strategy for the design of efficient, environmentally friendly, and pollution-resistant interfacial evaporators for treating complex water bodies. Download: Download high-res image (161KB) Download: Download full-size image
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·270
·
IF 5.4
Wang Yuqing,Liu Yutong,Liu Ziqi,Wang Xinyue,Yu Menglu,Gao Guanghui,Zhao Yunli,Hong Jing
A novel MXene nanosheet-supported Fe₃O₄@Ag nanozyme, designed for the dual-mode colorimetric and surface-enhanced Raman scattering (SERS) detection of the pesticide thiram in fruits is presented. The composite ingeniously integrates three key functions: magnetic enrichment, SERS signal amplification, and peroxidase-like nanozyme activity. The resulting nanozyme sensor demonstrates high sensitivity and specificity for thiram detection. The colorimetric method showed a linear range of 0.05 µM to 30 µM with a LOD of 0.016 µM, while the SERS method exhibited a linear range of 10 − 4 M to 10 − 8 M with a LOD of 3.44 × 10 − 9 M. This performance satisfies the demands for agricultural safety monitoring. The present work highlights the significant potential of the developed colorimetric-SERS dual-mode nanozyme platform for on-site pesticide residue determination .
Section
Graphical
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高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 6
·125519
·
IF 7.5
Xiaoshi Yi,Lijun Zhang,Yarui Song,Baochuan Qi,Zhiwei Zhao
A simple carbothermal reduction–galvanic displacement route enables confined Ag–Bi heterostructures. • Dual Ag/AgCl–Bi/BiOCl conversion delivers 171 .0 mg g −1 Cl⁻ capture. • N,S-doped carbon confinement suppresses Ag dissolution below 0.03 mg L −1 . • Solvation-corrected DFT reveals Ag-enhanced Cl⁻ adsorption and charge transfer. • Stress buffering enables 88% capacity retention during prolonged cycling. Developing high-capacity and durable chloride-storage electrodes is crucial for selective electrochemical desalination. Herein, Ag and Bi nanoparticles were confined within an N, S-doped carbon framework (Ag, Bi@NSCx) through sequential carbothermal reduction and galvanic displacement. By integrating Ag/AgCl and Bi/BiOCl dual-conversion chemistry with conductive carbon confinement, the optimized Ag, Bi@NSC1 electrode enabled an asymmetric capacitive deionization system to deliver a high Cl⁻ capture capacity of 171.0 mg g −1 and a rapid initial removal rate of 40.45 mg g −1 min −1 . The electrode retained approximately 88% of its initial capacity after 50 adsorption–desorption cycles, and the dissolved Ag concentration remained below 0.03 mg L −1 , indicating limited metal leaching during prolonged operation. It also exhibited preferential Cl⁻ capture in multianion solutions and effectively desalinated saline–alkali agricultural drainage water. Solvation-corrected density functional theory calculations revealed that Ag incorporation strengthened Cl⁻ adsorption and induced a favorable charge redistribution across the Ag–Bi interface. Multiphysics simulations further demonstrated that the NSC framework mitigated the stress localization caused by the mismatched volume changes of the Ag/AgCl and Bi/BiOCl phases. The research establishes a dual-conversion and interfacial confinement strategy for achieving selective, high-capacity, and durable chloride capture. Download: Download high-res image (470KB) Download: Download full-size image
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Molecular Catalysis
·
2026
·
IF 4.3
Junyan Chen,Bin Guan,Lei Zhu,Tiankui Zhu,Shiying Chang,Jiangli Ma,Rong Wang,Qingji Ying,Dongxia Yang,Zhen Huang
Ag-loaded KFI-type ZK-5 zeolites with tunable Si/Al ratios serve as hydrocarbon traps for gasoline cold-start control. • SAR2.5: highest C₂H₄ capacity (623 μmol/g); SAR5: superior C₇H₈ adsorption (850 μmol/g), higher desorption temperature. • Dual regulation of Si/Al ratio on zeolite crystallinity and Ag speciation clarifies structure–performance correlation. • In-situ DRIFTS reveals pathways: π-complexation for ethylene and synergistic hydrogen-bonding/π-complexation for toluene. Cold-start hydrocarbon (HC) emissions from gasoline engines remain a critical challenge in automotive exhaust purification, as three-way catalytic converters remain inactive below their light-off temperature. Ag-modified zeolites are promising HC trap materials, yet the structure–performance relationship regulated by the silica-to-alumina ratio (SAR) requires further systematic clarification. In this work, Ag/ZK-5 zeolites with SAR values of 2.5, 5, 10, and 20 were fabricated via the ion-exchange method, and their adsorption–desorption properties for ethylene and toluene were evaluated in combination with multi-technique characterizations and in-situ DRIFTS analysis. The results demonstrate that SAR exerts a well-defined dual regulatory effect on two interconnected levels: the zeolite framework (crystallinity, textural properties, and surface acidity) and the supported silver species (loading, chemical state, and dispersion degree). The SAR2.5 sample achieves the highest ethylene adsorption capacity of 623 μmol/g owing to its abundant ionic Ag⁺ sites, but suffers from severe silver agglomeration and limited toluene uptake. The SAR5 sample delivers the optimal comprehensive performance, with a toluene adsorption capacity of 850 μmol/g and desorption temperatures for both hydrocarbons higher than those of both the lower-SAR SAR2.5 and the higher-SAR SAR10/SAR20 counterparts, which benefits from its well-preserved crystallinity, highly dispersed Ag⁺ active sites, and balanced pore structure and surface acidity. High-SAR samples (SAR10, SAR20) exhibit inferior adsorption performance for both hydrocarbons due to framework amorphization and poor silver dispersion. In-situ DRIFTS characterizations reveal that ethylene adsorption follows a π-complexation pathway with partial oxidative transformation, while toluene adsorption is driven by the synergism of O–H···π hydrogen bonding and π-complexation. This work provides experimental guidance for the rational design of zeolite-based HC traps for cold-start emission control. Download: Download high-res image (155KB) Download: Download full-size image
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高影响因子
TALANTA
·
2026
·
IF 6.7
Wen Qing Jia,Jian Bing Li,Jiang Zhu,Qiao Wan,Yuan Yuan Zhang,Shi Gang Liu,Lei Han
It is of high importance yet a challenge to devise a sensor for direct and rapid sensing of pesticides based on a target-mediated nanoenzyme activity strategy. Herein, we design an effective colorimetric sensor for enzyme-free and rapid sensing of propiconazole (PC) pesticide based on the target-induced coordination effect mediated the oxidase (OXD)-like activity of Ph-Ag nanoparticles (Ph-Ag NPs). The Ph-Ag NPs were facilely fabricated via the coordination-driven self-assembly of the ligand L-phenylalanine (L-Phe) with Ag + . The fabricated Ph-Ag NPs exhibit robust OXD-like activity that can catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) into oxidative TMB (oxTMB). Interestingly, the OXD-like activity of Ph-Ag NPs can be inhibited by PC because the Cl atoms in PC molecular coordinate with Ag + , leading to the decline in absorbance and color of the system. Based on the PC-induced coordination effect that mediates the OXD-like activity of Ph-Ag NPs, we design a colorimetric sensor for sensing of PC in the linear range of 0.1−40 μM. This sensor shows some significant superiorities for PC detection, such as simple, rapid response, low cost, and high sensitivity with a detection limit of 0.0187 μM. The potential application of this sensor has also been verified by determining the PC in food samples with a satisfactory recovery range from 86.8% to 108.0%. This study not only affords a valid method for high sensitivity detection of PC pesticide but also offers a new sight for the rational design of enzyme-free sensor for direct and rapid detection of pesticides.
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高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 5
·e05063
·
IF 2
Yu Huai,Heyang Gong,Yueran Zhang,Hongbo Huang,Yan Gao,Yun Gao
As essential trace elements in the organism, Ag + plays crucial roles in living systems. Deficiency or excess of Ag + can induce various diseases. Notably, hypochlorite (ClO − ), as a critical component of reactive oxygen species, not only participates in fundamental metabolic processes such as thyroid hormone synthesis but also exerts a crucial function in immune regulation and antibacterial defense. In this study, a bifunctional probe ( BHZ ) based on benzimidazole was designed and constructed. In the presence of Ag + , the fluorescence wavelength of the probe experienced a slight redshift, accompanied by a decrease in fluorescence intensity. The mechanism is attributed to the ICT effect induced by the complexation of BHZ with Ag + , leading to changes in the fluorescence spectrum. Meanwhile, the probe selectively recognize ClO − via a fluorescence “OFF-ON” response, and the weak blue light of the probe turned into strong green light upon addition of ClO − . The mechanism of ClO − recognition involves addition reaction between ClO − and the probe, thereby inducing structural modifications in the probe that consequently modulated its optical properties. The detection limits of probe BHZ toward Ag + and ClO − were 1.57×10 −8 M and 4.28 nM, respectively. Mass spectrometry was utilized to investigate the response mechanisms of the probe toward Ag + and ClO − . By combining the smartphone color recognition, the rapid and real-time detection of Ag + by BHZ in real water samples was achieved by using fluorescence ratiometric recognition and test paper. Moreover, the probe BHZ has been effectively deployed for ClO − bioimaging in mice in vivo.
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2026
·Vol. 27
·期 12
·5411
·
IF 5.6
Zhaoping Sang,Bowen Tang,Yunhao Zhuo,Lixin Li,Qi Zhang,Yinan Jin,Huiming Zhang,Gang Zhao
Prolonged use of clear aligners promotes bacterial colonization and biofilm formation, which can compromise orthodontic outcomes. There is a clear clinical demand for approaches that can suppress pathogenic activity while preserving the fundamental functional and material characteristics of the aligners. To address this need, a novel strategy of fabricating metal–organic framework (MOF) coatings on aligners was adopted. Metal–organic frameworks (MOFs) have emerged as promising antibacterial coating materials by combining antimicrobial metal ions with biocompatible organic ligands. Three distinct porphyrin-based MOFs (Ag-, Cu-, and Ce-TCPP) were synthesized and fabricated as coatings on clear aligner surfaces via a coordination-driven self-assembly approach. The coated aligners were comprehensively assessed in vitro to determine their antibacterial performance, anti-inflammatory potential, biocompatibility, and key physical characteristics. Among the three coatings, Ag-TCPP showed the most favorable overall antibacterial and anti-biofilm performance in the present experimental system and facilitated macrophage polarization toward an anti-inflammatory M2-like phenotype. Ag-TCPP exhibited a significant inhibition zone of 6.75 ± 0.25 mm and reduced biofilm biomass by 72.2%. All MOF coatings exhibited excellent biocompatibility, and their application did not compromise the aligners’ mechanical integrity or aesthetic properties (light transmittance). This study reports the successful development of a novel metal–organic framework (MOF)-based coating strategy for clear aligners. Among the formulations investigated, the Ag-TCPP coating exhibited outstanding antibacterial and immunomodulatory performance while maintaining the critical mechanical integrity and aesthetic qualities of the aligner. The findings of this work offer a practical approach to designing multifunctional orthodontic devices that may reduce biofilm-related complications and improve clinical outcomes.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Zhaoying Liu,Yuan Kong,Kan Yang,Guangyun Chen,Ming Li
Background The overuse of ampicillin (AMP), a pivotal antibiotic, poses severe environmental and ecological risks, necessitating portable and precise monitoring. Results A highly integrated Lab-in-Tube biosensing platform based on Ag + -coupled hairpin (Ag@hairpin) aptamer and gold nanoparticles-immobilized DNA (AuNP@DNA) hydrogel for the portable and ultrasensitive detection of AMP was developed. In this pre-assembled tube platform, Ag@hairpin aptamers and AuNP@DNA hydrogels were immobilized on the inner bottom and cap of the tube, respectively. Upon introduction of AMP, the released Ag + triggered Ag-DNAzyme to cleave S-DNA, generating abundant AuNP. These AuNP were subsequently introduced into a glucose/FeNi-doped polydopamine nanozyme (FeNi@PDA) system to generate ultrasensitive colorimetric signals. The biosensing requires only a simple two-step upside down operation in the sealed tube, achieving an excellent limit of detection (LOD) of 1.02 pg/mL. The platform demonstrated high specificity (cross-reactivity less than 4.31%) and practical applicability in environmental samples. Furthermore, the advantages of miniaturized platform, simplified operation and portability had demonstrated. Significance By integrating accurate biosensing with an ultrasensitive enzyme cascade system, this Lab-in-Tube platform may offer an advanced strategy for the portable and on-site detection of other targets.
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危险品化学品经营许可证（带存储）