POLYMER DEGRADATION AND STABILITY
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2025
·
IF 7.4
Ping Wang,Hongyu Tian,Yiyang Zhou,Tongtong Zhang,Shi Dong,Longen Cheng,Wenbin Luo,Li Yang,Wenxiu Liu,Tian Cao,Mingdi Yang,Daosheng Sun
Developing high-performance composites for maglev train cables that combine excellent flame retardancy, mechanical properties and fatigue resistance is currently a significant challenge in special cable industry. Herein, a multifunctional reactive phosphorus nitrogen flame retardants (UPMDM) with flame retardant and filler surface modification functions was synthesized, and it was employed to control the polymer matrix-filler interactions and the microstructure of ethylene-vinyl acetate copolymer (EVA)-based composite during melt blending. Phosphorus-nitrogen composite flame retardant (MH@UPMDM) could be preformed before melt blending or formed in-situ during melt blending by the reaction between the isocyanate group (-NCO) of UPMDM and the hydroxyl group on the surface of magnesium hydroxide (MH), and the effect of processing type (physical blending/chemical grafting/in-situ reaction) on dispersion kinetics of MH in EVA matrix was investigated. The results indicate preformed MH@UPMDM can play a role in rigid crosslinkers to construct organic-inorganic hybrid network, thus effectively control the dispersion kinetics of the fillers and the filler-matrix interaction in the EVA matrix. Compared with EVA/MH composites, the elongation of EVA/MH@UPMDM composites is increased by nearly 2.2-fold, while it also exhibits an excellent fatigue-resistance under 1.0 × 10 4 th cycles. Furthermore, MH@UPMDM can significantly enhance the flame retardant properties of the composites, the limiting oxygen index (LOI) of EVA/MH@UPMDM composite reaches 33.6%, while its peak heat release rate (PHRR) and total heat release (THR) decreases to 277.82 kW/m 2 and 74.71 MJ/m 2 from 436.66 kW/m 2 and 88.67 MJ/m 2 compared to EVA/MH composites, which may be attributed to the multi-phase synergistic flame retardant mechanism of UPMDM.
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Journal of Macromolecular Science Part B-Physics
·
2024
·
IF 1.2
Chunbo Pan,Guanghua Gu
Potentially beneficial novel approaches to cancer treatment, particularly for drug-resistant malignancies, include synergistic therapies that combine chemotherapy with photothermal therapy. In our research described here we developed a unique silk protein-functionalized gold nanoparticles (AuNP) formulation for effective combinatorial photothermal therapy (PTT) and chemotherapy against ovarian cancer cells. The main goal of the present investigation was the fabrication of silk protein-functionalized gold nanoparticles (AuNPs) embedded with Dichlororuthenium (II) (p-cymene) (1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) molecules (RC@Au-SF NPs) to improve apoptosis in ovarian cancer cells. The structural and morphological analyses of the prepared nanoformulations confirmed the successful fabrication and uniform distributions of Au-SF NPs with RAPTA-C. We observed the RC@Au-SF NPs showed enhanced toxicity to ovarian cancer cell lines with near infrared (NIR)-light exposure. The RAPTA-C loaded Au-SF NPs significantly improved the internalization of the nanoparticles inside the cells resulting in intracellular reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP) and cell apoptosis on ovarian cancer (SKOV-3 & A2780) cells. We suggest the outcome of the developed formulation for anti-ovarian cancer action will be highly promising for future cancer control research.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Kangdi Guan,Ziwei Zhang,Qiang Zhang,Pinghua Ling,Feng Gao
Herein, this paper reports a simple and label-free photoelectrochemical (PEC) sensor based on the organic semiconducting conjugated polymer-polyfluorene derivative, poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(6-{4-ethyl-piperazin-1-yl}-2-phenyl-benzo{de}isoquinoline-1,3-dione)] (PFNA). The PFNA was designed and obtained the lowest unoccupied molecular orbital (LUMO)/highest occupied molecular orbital (HOMO) values via spectral characterizations. The PFNA modified electrode produced a stable and enhanced photocurrent signal under white light irradiation at a bias of −0.1 V in phosphate buffer solution. A sensitive increment of the photocurrent was observed with the addition of p -phenylenediamine ( p -PD). A possible mechanism for this photoelectrochemical process including the photoexcitation of the polymer, electron injection from polymer toward the electrode, and the hole-scavenging process by the reductants were studied. The π bond in the polymer might facilitate the photoelectrochemical process owing to the enhanced electronic coupling between the polymer and the reductants. A PEC analysis on p -PD has been carried out to evaluate the photoelectrochemical performances of the modified electrode, which presents the wide linear ranges of 0.2–400 μM, with a lower detection limit of 0.13 μM. This work reports the PEC performance of organic semiconducting conjugated polymer-polyfluorene derivative, which would promote more efficient photoelectrochemical design of sensors and devices.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
·
IF 2.369
Miyangzi Suo,Bokun Chen,Yu Qian,Siyu Yang
The synergistic effect for a solvent mixture of diisopropyl ether and n-Pentanol to extract hydroquinone from aqueous solution was investigated. Liquid–liquid equilibrium data of the quaternary (n-Pentanol + diisopropyl ether + water + hydroquinone) system were measured at T = 298.15 K and P = 101.3 kPa, using various compositions of solvent mixture. It can be seen from the slope of the tie lines that with the increase of distribution coefficients of hydroquinone, the size of the immiscible solution region decreased slightly. The extraction efficiency was evaluated by calculating the separation factor and distribution coefficient. Using the universal quasichemical (UNIQUAC) and nonrandom two-liquid (NRTL) models to correlate with experimental data, the corresponding binary interaction parameters were obtained. The RMSD values of UNIQUAC and NRTL models showed that the calculated results were in good agreement with the liquid–liquid equilibrium data.
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Environmental Technology & Innovation
·
2024
·
IF 6.7
Zhuanxi Luo,Haiming Wang,Zhenhong Wang,Xin Zhang,Changzhou Yan,Ruilian Yu,Hualan Zhang,Gongren Hu,Baoshan Xing
Tire and road wear particles (TRWPs) have received much attention due to their substantial emission and potentially adverse environmental impacts. The specific contribution of observed contaminants, as critical additives of tires, from TRWPs has not yet been comprehensively studied in the environment. As one of TRWPs generated hotspots, driving school grounds in China were chosen to identify source contributions of heavy metals (HMs) and N-(1,3-dimethylbutyl)-N′ -phenyl-p-phenylenediamine (6PPD) from TRWPs. Significant correlations ( P < 0.05) were found between TRWPs and 6PPD and zinc (Zn). The average measured content of 6PPD in road dust was 0.47 ± 0.18 μg/g (n = 50). The estimated level of 6PPD in road dust (5.68 ± 3.36 μg/g, n = 50) was far higher than the measured level of 6PPD in road dust on driving school grounds, implying that TRWPs contributed to 6PPD in road dust from driving school grounds. Compared to the levels of 6PPD in other road dusts, 6PPD in road dust from driving school grounds was higher, exhibiting more significant exposure risks to children with the higher estimated daily intakes. Furthermore, source apportionment through the lead isotopic analysis and positive matrix factorization model revealed that TRWPs were confirmed to contribute more Zn, cadmium (Cd) and lead (Pb) on driving school grounds, notably accounting for 76 %, 31 % and 29 %, respectively. These three HMs presented relatively moderate to strong pollution and corresponding potential ecological risks. Our findings can help identify specific contributions of tire-related additives released from TRWPs in the environment and their potential risks.
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2017
·
IF 3.756
Yixian Liu,Bingjie Liu,Yan Zhang,Youmei Peng,Chenzheng Huang,Ning Wang,Jinhua Jiang,Qingduan Wang,Junbiao Chang
2′-Deoxy-2′-β-fluoro-4′-azidocytidine (FNC), a cytidine analog, has attracted great interest because of its potent activity against wild-type and multidrug-resistant HIV. The purpose of current study was to investigate the absorption mechanisms of FNC in the small intestine, as well as the interactions between FNC and P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). The experiments were performed using Caco-2 cells and the rat small intestine. The uptake experiment indicated that FNC concentration, extracellular pH and the incubated temperature could influence the uptake of FNC in Caco-2 cells. NaN 3 , verapamil , probenecid , MK571 and GF120918 could significantly increase the FNC uptake in Caco-2 cells. The transport experiment showed that both the absorption and secretion of FNC were concentration dependent. The secretion of FNC was approximately 2-fold greater than the absorption. In the presence of verapamil, probenecid, MK571 or GF120918, the efflux ratio decreased by > 50%. In everted rat intestine, the absorption of FNC also depended on its concentration and was not significantly different in the different segments of the small intestine. Real-time RT-PCR results indicated that the gene expressions of P-gp, MRP2 and BCRP were up-regulated after exposure to FNC. The reduction in accumulation of rhodamine 123 after treatment with FNC revealed its ability to up-regulate P-gp activity. In conclusion, FNC was completely absorbed by passive diffusion and active transport mechanisms. P-gp, MRP2 and BCRP could influence the absorption of FNC in the small intestine. FNC could modulate the gene expressions of P-gp, MRP2 and BCRP, and increase the activity of P-gp.
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高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Xubo Zhao,Mingzhu Qi,Shuo Liang,Kun Tian,Tingting Zhou,Xu Jia,Jiagen Li,Peng Liu
Novel photo- and pH dual-sensitive amphiphilic copolymers containing photolabile o-nitrobenzyl (NB) groups were designed via combination of ATRP, hydrolyzation, and simple esterification reaction and self-assembled into stimuli-regulated amphiphilic micelles in aqueous solution. On the basis of the optimization of the morphology and particle size of the micelles via modulating the number of the photocleavable o-nitrobenzyl acrylate (NBA) units, the unique ones assembled from PEG43-b-P(AA76-co-NBA35-co-tBA9) with an average hydrodynamic diameter (Dh) of 163 nm was selected as a potential drug delivery system (DDS) for UV-triggered delivery of doxorubicin (DOX). The micelles possessed a favorable drug-loading capacity (DLC) of 27.5%, with the hydrodynamic diameter of 213 nm after DOX-loading. Most importantly, the DOX-loaded PEG43-b-P(AA76-co-NBA35-co-tBA9) micelles exhibited a cumulative DOX release ratio of only 3.69% in the simulated physiological medium within 6 days without UV-irradiation, indicating their potential as leakage-free DDS. As in the acidic media mimicking the tumor microenvironment, a high cumulative DOX release ratio of 74.70% was achieved within 6 days after UV-irradiation for 20 min, showing a sustained release behavior. Under UV-irradiation, the photolabile o-nitrobenzyl moieties were cleaved off, the amphiphilic copolymer transformed into a water-soluble polymer, favoring the metabolism of drug carriers, and the micelles were demicellized to accelerate the drug release in a triggered or on-demand manner.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2024
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IF 4.8
Xiuwen Zheng,Qianrong Xue,Yinghuan Wang,Lu Lu,Yipeng Pan,Jian Xu,Junqing Zhang
Ethnopharmacological relevance Alpinia officinarum Hance is a perennial natural medicine herbivorous plant, has been used in the management of treat stomach pain and diabetes, it is abundantly cultivated in Qiongzhong, Baisha and other places. P. cablin (Blanco) Benth, one of the most important traditional Chinese plants, which plays functions in antioxidant and gastrointestinal regulation, has been extensively planted in Hainan, Guangdong and other regions. Aim of the study In this study, we investigated the role and underlying molecular mechanism of AP on diabetic gastroparesis (DGP) in vitro and in vivo . Materials and methods In this study, using ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UPLC-MS/MS) to identify active compounds in A. officinarum Hance– P. cablin (Blanco) Benth drug pair (AP). Molecular docking were utilized to explore the potential mechanism of AP treatment of DGP. In in vitro assays, gastric smooth muscle cells (GSMCs) were treated with 35 mM glucose to promote apoptosis and construct the DGP model, which was treated with different concentrations of AP. Furthermore, transfection technology was used to overexpress RAGE in GSMCs and elucidate the underlying mechanisms of alleviation of DGP by AP. Results Using UPLC-MS/MS analysis, nine components of AP were identified. We found that AP effectively blocked the increase in apoptosis, oxidative stress, and intracellular Ca 2+ concentrations. For in vivo experiments, mice were fed with a high-fat irregular diet to construct DGP model, and AP was co-administered via oral gavage daily to prevent the development of DGP. Compared with DGP mice, AP significantly decreased fasting blood glucose levels and increased gastric emptying levels. Consistent with in vitro experiments, AP also considerably decreased the increase in oxidative stress in DGP mice. Mechanistically, AP alleviates apoptosis and DGP by decreasing oxidative stress and intracellular Ca 2+ concentrations via the inhibition of the AGE/RAGE axis. Conclusions Collectively, this study has established that AP can improve DGP, and the mechanism may be related to the inhibition the AGE/RAGE axis to mitigate apoptosis and DGP. To summarize, this study provides a novel supplementary strategy for DGP treatment.
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RSC Advances
·
2016
·Vol. 6
·期 50
·44865-44872
·
IF 3.289
Yazhen Niu,Junlin He,Yuliang Li,Yilin Zhao,Chunyong Xia,Guolin Yuan,Lei Zhang,Yuchan Zhang,Chao Yu
Sialylated glycans are crucial molecular targets for cancer diagnosis and clinical research. α2,3-Sialylated glycans and α2,6-sialylated glycans are the predominant sialic acids found in nature. Different expression of the quantity of glycans can result in development of different disease. However, there are no ideal methods for discriminating α2,3-sialylated glycans and α2,6-sialylated glycans. In this work, a multi-purpose biosensor is fabricated for sensitive detection of α2,3-sialylated glycans and α2,6-sialylated glycans. To improve the sensitivity of the biosensor, p-MWCNTs were integrated with PAMAM, as PAMAM has highly branched and abundant amino groups, providing a large available surface area for linking with other substances. To achieve distinguishable recognition, Maackia amurensis lectin (MAL) and Sambucus nigra agglutinin (SNA) were included. To facilitate the lectin fixation, PDITC, a kind of green homobifunctional cross-linker, was selected. Under optimized detection conditions, the linear range of detection for α2,3-sialylated glycans is 10 fg mL−1 to 50 ng mL−1 with a lower detection limit of 3 fg mL−1, and the linear range of detection for α2,6-sialylated glycans is 10 fg mL−1 to 50 ng mL−1 with a detection limit of 3 fg mL−1. This work not only provides a method for distinguishing detection of α2,3-sialylated glycans and α2,6-sialylated glycans, but also provides a reference for future clinical testing.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2024
·
IF 4.1
Lei Shi,Shuping Zhang,Liren Yang,Yinhai Su,Yuanquan Xiong
As a more reliable form of energy storage than lead-acid battery, lead–carbon battery plays a key role in the field of electric vehicles and energy storage systems, but it still faces some problems in the application process. To prolong the cycle life of lead–carbon batteries under high rate partial state of charge (HRPSoC) duty and focus on solving the problem of hydrogen evolution reaction (HER) of batteries, a facile strategy using phosphoric acid as activator for preparing P-doped biomass-derived mesoporous carbon was proposed. Compared with commercial activated carbon (AC) and carbon material obtained under other preparation conditions, the P-RHMC-2 using material ratio with 1:2 as well as activated at 550 ℃ has the highest mesoporous rate and excellent P-doping effect. In the electrochemical test, P-RHMC-2 inhibits HER dramatically and improves the cycle life of lead–carbon battery significantly under HRPSoC duty when it applied to the negative electrode of the batteries.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2019
·
IF 3.17
Yaqian Zhou,Junjie Zhou,Ping Li,Qiushi Xie,Binbin Sun,Ying Li,Yang Chen,Kaijing Zhao,Tingting Yang,Liang Zhu,Jiong Xu,Xiaodong Liu,Li Liu
Liver failure altered P-glycoprotein (P-gp) function and expression at blood-brain barrier (BBB), partly owing to hyperammonemia . We aimed to examine the effects of partial portal vein ligation (PVL) plus chronic hyperammonemia (CHA) on P-gp function and expression at rat BBB. Experimental rats included sham-operation (SH), PVL, CHA and PVL+CHA. The PVL+CHA rats were developed by ammonia-containing diet for 2 weeks after operation. The brain-to-plasma concentration ratios (K p ) and apparent unidirectional influx constants (K in ) of rhodamine123 and sodium fluorescein were measured to assess function of P-gp and BBB integrity, respectively. Human cerebral microvascular endothelial cells (HCMEC/D3) were used to assess effects of ammonia on P-gp expression and function. It was found that PVL+CHA significantly decreased K p and K in of rhodamine123 without affecting brain distribution of fluorescein. The P-gp expressions in membrane protein in cortex and hippocampus were significantly increased in CHA and PVL +CHA rats, especially in PVL + CHA rats, while remarkably increased phosphorylated ERK1/2 was only found in PVL +CHA rats. Expressions of tight junction proteins claudin-5 and occluding in rat brain remained unchanged. In vitro data showed that NH 4 Cl increased reactive oxygen species , membrane expression and function of P-gp as well as phosphorylated ERK1/2 levels in HCMEC/D3. The NH 4 Cl-induced alterations were reversed by reactive oxygen species scavenger N-acetylcysteine and ERK1/2 inhibitor U0126 . In conclusion, PVL+CHA increased function and membrane translocation of P-gp at rat BBB partly via ammonia. Reactive oxygen species/ERK1/2 pathway activation may be one of the reasons that ammonia upregulated P-gp expression and function at BBB.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 47
·期 3
·1328-1341
·
IF 3.925
Fan-Zhi Bu,Yue-Ming Yu,Yu Yu,Cui-Wei Yan,Zhi-Yong Wu,Yan-Tuan Li
The current work aims to take full advantage of the structural superiority and hepatoprotective effect of the nutrient trans-p-coumaric acid (TPCA) to decrease the solubility and dissolution rate of the antimycotic agent 5-fluorocytosine (FLCY) by using a co-crystallization strategy, thereby giving a novel understanding into conquering the dose-limiting hepatotoxicity induced by the quick and almost complete absorption of FLCY. To that end, FLCY–TPCA, as the first cocrystal of FLCY and phenolic acid (a nutrient of the hydroxycinnamic acid type), is orientationally self-assembled and fully characterized. The single crystal structure shows that TPCA molecules in the crystal lattice locate at the polar sites in situ of FLCY via robust hydrogen bond interaction, thus creating a vital planar construction (VPC) possessing hydrophobicity, which results in the simultaneous down-regulation for the cocrystal of solubility and dissolution rate versus the parent FLCY. The outcomes of the experiment are strongly supported by related theory research. Molecular electrostatic potential (MEP) calculation showed that the VPC polarity in the cocrystal is lower than that of free FLCY, which conforms with the reduction in polarity due to intensifying hydrogen-bond energy based on topology analysis with atoms in molecules (AIM) theory, hence conferring a conspicuous improvement in hydrophobicity on the cocrystal. Furthermore, the molecular planarity analysis based on Multiwfn's wave function calculation module confirms the convergence in planarity at a two-dimensional infinite level, which undoubtedly contributes to forming a tight three-dimensional supramolecular superposition landscape, corresponding with the coinstantaneous reinforcement of π–π stacking interaction evidenced by the reduced density gradient (RDG), and all these results further support the fact that the hydrophobicity of the FLCY–TPCA cocrystal is significantly enhanced. As a result, the current contribution exemplifies a feasible cocrystallization strategy using integrated experimental and systematic theoretical approaches to overcome the intractable toxicity issues of antifungal agents.
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