Nano Research
·
2023
·
IF 9.9
Zhang Yufei,Cheng Qian,Xue Yuhao,Yao Kai,Syeda Madiha Zahra,Xu Jian,Wu Jianheng,Wang Zhenjie,Tang Longguang,Mu Qingchun
Glioma is the most common primary craniocerebral tumor caused by the cancerous growth of glial cells in the brain and spinal cord. Currently, standard treatment is the surgical resection followed by concurrent radiation and chemotherapy. However, the blood-brain barrier (BBB) prevents most antitumor drugs from entering the brain and reduces their efficacy, especially in low-grade glioma. Since L-type amino acid transporter 1 (LAT1) is highly expressed in glioma cells and mediates drug transport across the BBB, it is a promising target for drug delivery and treatment of glioma. Temozolomide (TMZ) is the first-line treatment for glioma, however, patients often exhibit drug resistance at advanced stage. A multikinase inhibitor and inducer of ferroptosis, sorafenib can improve the therapeutic effects of TMZ. Therefore, to optimize the glioma treatment and cross the BBB, we designed LAT1-targeting nanoparticles co-loaded with TMZ and sorafenib. Our results from both in vitro and in vivo studies confirmed that LAT1-targeting nanoparticles significantly increased the cellular uptake, cytotoxicity, accumulation at tumor site, and the anti-tumor efficacy compared to the non-target nanoparticles. Therefore, LAT1 can be used as a potential target for brain-targeted drug delivery, and sorafenib-induced ferroptosis can aid the anti-glioma efficacy of TMZ.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 4
·1-9
·
IF 5.7
Su Zhanying,Zhang Li,Yu Ying,Lin Bixia,Wang Yumin,Guo Manli,Cao Yujuan
An electrochemical strategy based on bimetallic nanozyme in collaboration with toehold-mediated DNA replacement effect is proposed for the sensitive determination of miRNA-21. The AuPt nanoparticles (AuPt NPs) are prepared as a catalytic beacon; it shows favorable peroxidase properties with a Michaelis contant ( K m ) of 0.072 mM for H 2 O 2 , which is capable of catalyzing H 2 O 2 to induce an intense redox reaction, and causing a measurable electrochemical signal. To further enhance the strength of the signal response, a novel toehold-mediated DNA replacement strategy is employed. DNA strands with specific sequences are modified on electrodes and AuPt NPs, respectively. In the presence of miRNA-21, a cyclic substitution effect is subsequently activated via a specific toehold sequence and leads to a large accumulation of AuPt NPs on the electrodes. Subsequently, a strong signal depending on the amount of miRNA-21 is obtained after adding a small amount of H 2 O 2 . The analytical range of this determination method is from 0.1 pM to 1.0 nM, and the LOD is 84.1 fM. The spike recoveries for serum samples are 95.0 to 102.4% and the RSD values are 3.7 to 5.8%. The results suggests a promising application of the established method in clinical testing and disease diagnosis. Graphical Abstract
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 22
·63109-63120
·
IF 5.8
Yu Le,Wang Zhuang,Wang De-Gao
Layered double hydroxide (LDH) nanomaterials are utilized extensively in numerous fields because of their distinctive structural properties. It is critical to understand the environmental behavior and toxicological effects of LDHs to address potential concerns caused by their release into the environment. In this work, the toxicological effects of two typical LDHs (Mg-Al-LDH and Zn-Al-LDH) on freshwater green algae ( Scenedesmus obliquus ) and the main affecting factors were examined. The Zn-Al-LDH exhibited a stronger growth inhibition toxicity than the Mg-Al-LDH in terms of median effect concentration. This toxicity difference was connected to the stability of particle dispersion in water and the metallic composition of LDHs. The contribution of the dissolved metal ions to the overall toxicity of the LDHs was lower than that of their particulate forms. Moreover, the joint toxic action of different dissolved metal ions in each LDH belonged to additive effects. The Mg-Al-LDH induced a stronger oxidative stress effect in algal cells than the Zn-Al-LDH, and mitochondrion was the main site of LDH-induced production of reactive oxygen species. Scanning electron microscope observation indicated that both LDHs caused severe damage to the algal cell surface. At environmentally relevant concentrations, the LDHs exhibited joint toxic actions with two co-occurring contaminants (oxytetracycline and nano-titanium dioxide) on S. obliquus in an additive manner mainly. These findings emphasize the impacts of the intrinsic nature of LDHs, the aqueous stability of LDHs, and other environmental contaminants on their ecotoxicological effects.
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高影响因子
IONICS
·
2023
·Vol. 29
·期 5
·1721-1729
·
IF 2.8
He Tao,Dai Junjie,Dong Yangtao,Zhu Fangshun,Wang Chao,Zhen Aigang,Cai Yurong
The increasing lithium-ion batteries (LIBs) market causes concerns about environmental issues and the mining of the earth’s metallic minerals. The harmless treatment of the spent LIBs and the effective recovery of scarce metal resources are gradually given high priority worldwide. In this article, p-toluenesulfonic acid-based deep eutectic solvents (DESs) are prepared to leach metal components from spent ternary LIBs. And the ternary LiNi 0.5 Co 0.2 Mn 0.3 O 2 material is regenerated through the co-precipitation method and high-temperature solid phase method. The results show that 97.96% of Li, 99.46% of Ni, 100% of Co, and 100% of Mn can be leached out again under the optimum conditions. The synthesized ternary material possesses an excellent reversible capacity (139.0 mAh·g −1 at 0.5 C) and an adequate long-cycle stability (123.6 mAh·g −1 after 100 cycles). This work provides an efficient and clean approach to recycling spent LIBs and has great potential application in the field of battery sustainability.
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Reaction Kinetics Mechanisms and Catalysis
·
2023
·Vol. 136
·期 2
·771-786
·
IF 1.8
Su Haitang,Yang Zhixiu,Xiao Guomin,Gao Lijing,Wei Ruiping,Zhang Jin
A series of cost-effective (X) K 2 CO 3 /γAl 2 O 3 catalysts for efficient conversion of vinyltrimethoxysilane (VTMOS) to vinyltris(β-methoxyethoxy)silane (VTMOEOS) were synthesized. The microstructure and active site of the synthesized catalysts were analyzed by BET, XRD, FT-IR, SEM, and CO 2 -TPD. The results showed that the synthesized catalysts formed K–O–Al strong basic sites while maintaining the original structure, which greatly improved the basic strength of the catalysts. It was found that the 60%K 2 CO 3 /γAl 2 O 3 possessed the highest the catalytic activity under the activation temperature of 600 °C by optimizing the preparation conditions of K 2 CO 3 /γAl 2 O 3 . Moreover, the optimal reaction process conditions were also determined by optimizing the experimental reaction temperature, reaction time, catalyst dosage, and reactant molar ratio under (60%, 600 °C) K 2 CO 3 /γAl 2 O 3 catalysis. Under the optimal reaction conditions, the conversion of VTMOS was 92.5% and the yield of VTMOEOS was 65%. Meanwhile, the 60%K 2 CO 3 /γAl 2 O 3 catalyst was satisfactorily reusable and maintained a high catalytic activity after four cycles of catalytic reactions.
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Science China-Life Sciences
·
2023
·
IF 9.1
Tang Kegong,Wang Xiaona,Zhao Yu,Li Xiaobei,Jiang Zhenyu,Mei Song,Chen Mingrui,Ma Yiming,Du Xinyi,Qiao Xiangyu,Sun Na,Liu Jiaqi,Jiang Chengyu
Hypertension has become a growing public health concern worldwide. In fact, hypertension is commonly associated with increased morbidity and mortality. Currently, oligonucleotide drugs have proven to be promising therapeutic agents for various diseases. In the present study, we aimed to demonstrate that a herbal small RNA (sRNA), XKC-sRNA-h3 (B55710460, F221. I000082.B11), exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme (ACE) in mice. When compared with captopril, oral administration of the sphingosine (d18:1)-XKC-sRNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice. Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension.
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高影响因子
Scientific Reports
·
2023
·Vol. 13
·期 1
·1-9
·
IF 4.6
Zhang Lijun,Liu Chuhe,Yin Liufang,Huang Cheng,Fan Shengjie
Hepatic fibrosis is a late stage process of many chronic liver diseases. Blocking the fibrosis process will be beneficial to the treatment and recovery of the diseases. Mangiferin has many pharmacological activities. Recently, it has been reported that mangiferin may relieve tissue fibrosis, including renal, myocardial, pulmonary fibrosis via anti-inflammatory and anti-oxidative effects in animal models. Here, we investigate the effects of mangiferin on CCl4-induced liver fibrosis and the underlying mechanism in mice. Thirty-two male C57BL/6 mice were randomly divided into 4 groups (n = 8 in each group), injected with carbon tetrachloride (10% CCl4) for 8 weeks, and oral administrated with mangiferin (50 mg/kg or 100 mg/kg) from the fifth week. The serum levels of ALT, AST were analyzed to evaluate liver function. H&E, Masson’s trichrome and Sirius red staining were used to assess liver morphology and the degree of liver fibrosis. Quantitative RT-PCR and Western blot were used to assay the gene expression and protein levels. The results showed that mangiferin alleviated the serum levels of AST, ALT, ALP, TBA and TBIL, reduced liver lesions, prevented hepatic parenchymal necrosis, and ameliorated collagen accumulation in the liver of CCl4-treated mice. Meanwhile, mangiferin inhibited the expression of inflammatory genes IL-6 and IL-1β, fibrogenic genes α-SMA, TGF-β and MMP-2 and bile acid metabolism genes ABCB4, ABCB11, SULT2A1 in the liver of CCl4-treated mice. Furthermore, mangiferin reduced collagen accumulation and HSCs activation, inhibited the p-IκB and p-p65 protein levels. Our results suggest that mangiferin could alleviate liver fibrosis in CCl4-treated mice through inhibiting NF-κB signaling, and mango consuming may have beneficial effects to hepatic fibrosis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 12
·5319-5333
·
IF 4.5
Wang Yun,Tan Hongjie,Sang Lexian,Xie Yunying,Jia Fuchao,Zhou Tong,Yin Guangchao,Sun Fazhe,Wang Xiaomei
An optimized acetone gas sensor based on Ti 3 C 2 / α -Fe 2 O 3 (TF) composite materials was synthesized using microwave and etching methods. The structures, morphology and composition of the TF composites were characterized via XRD, XPS, SEM and TEM. The crystal of α -Fe 2 O 3 porous nanorods is hexagonal, and the α -Fe 2 O 3 nanoclusters formed from α -Fe 2 O 3 nanorods were adhered adequately on the lamellar Ti 3 C 2 MXene in the TF composite. The specific surface area and surface defects of the TF composites increased compared with pure α -Fe 2 O 3 nanocluster material, thus exposing a large number of gas adsorption sites. Furthermore, the excellent electrical conductivity and high free charges transfer ability of Ti 3 C 2 MXene provided more electrons for the gas-sensitive reaction and enhanced the transmission capacity of gas-sensitive reaction electrical signal, respectively. The Schottky barriers were formed at the interface of α -Fe 2 O 3 and Ti 3 C 2 MXene increasing the resistance of TF gas sensor in air, which is beneficial to the response of TF gas sensor. So, the gas-sensitive performance of TF gas sensor to acetone was greatly improved. The response of TF gas sensor to 100 ppm acetone was up to 23.38, which was nearly 2.3 times higher than pure α -Fe 2 O 3 gas sensor. The lower detection limit of TF gas sensor could be as low as 1 ppm. In addition, the TF gas sensor had excellent selectivity, long-term repeatability and stability for acetone.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 41
·期 11
·1818-1828
·
IF 4.3
Gao Han,Cui Bai-Chuan,Zheng Hong-Bing,Hao Fu-Lan,Shi Yan,Zhang Li-Qun
Epoxidation of the carbon-carbon double bonds on unsaturated rubber macromolecules can produce novel modified rubber species with special properties, and construct eco-friendly crosslinking pathway via the reaction of epoxide groups to solve the problems brought by conventional sulfur vulcanization system. In this contribution, a novel modified product of isobutylene isoprene rubber (IIR), epoxy-functionalized IIR (EIIR) was successfully prepared by in situ epoxidation technique for the first time, and the crosslinking of EIIR was achieved by the reaction of oxirane groups with maleic anhydride (MAH) without additional additives. The reaction conditions for preparing EIIR were optimized through systematic research on the epoxidation process. Under optimal condition, the degree of epoxidation of the rubber reached around 99% without side reactions. The obtained EIIR/carbon black composites cured by MAH had excellent mechanical properties comparable to those of IIR composites. More importantly, compared with IIR composites, the air-tightness of the EIIR composites was improved by about 50%, and the flexural fatigue life of first-level cracks and sixth-level cracks was increased by several times. The significant improvement of these properties is of great significance for the application safety and energy saving of IIR materials.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 41
·期 12
·1836-1845
·
IF 4.3
Li Wen-Jing,Pan Xiang-Qiang,Zhu Jian,Zhang Zheng-Biao
We present a ring-opening polymerization of bridged cyclic lactone utilizing alcohol as the initiator and organic base as the catalyst. Bridged γ -butyrolactone monomers (PhSGBL and PhSeGBL) were synthesized efficiently from commercially available 3-cyclohexene-1-carboxylic acid. Due to the ring strain of the bridged structure, ring-opening polymerization of this type of γ -butyrolactone derivative was successfully carried out under mild conditions, e.g. , using ethylene glycol as the initiator and a commercial catalyst [1,5,7-triazabicyclo [4.4.0 dec-5-ene (TBD)] as the catalyst at 30 °C. The obtained polymer could be degraded to its monomer for recycling in the presence of ZnCl 2 as a catalyst. PhSGBL and PhSeGBL could also be copolymerized with ε -caprolactone to tune the glass transition temperature. Additionally, the hydrophilicity of the obtained sulfur-containing polymers could be adjusted by selectively oxidizing the thioether side group to sulfone/sulfoxide, which offered a way to tune the hydrophilicity of polyester. On the other hand, the obtained selenium-containing compound could be degraded in the presence of m -CPBA (3-chloroperbenzoic acid), which offered potential application in sustained drug release.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Zhao Yuanyuan,Yang Xiaobin,Cheng Zhongjun,Lau Cher Hon,Ma Jun,Shao Lu
Here, we present a proactive fouling prevention mechanism that endows superhydrophilic membranes with antifouling capability against migratory viscous crude oil fouling. By simulating the hierarchical architecture/chemical composition of a dahlia leaf, a membrane surface is decorated with wrinkled-pattern microparticles, exhibiting a unique proactive fouling prevention mechanism based on a synergistic hydration layer/steric hindrance. The density functional theory and physicochemical characterizations demonstrate that the main chains of the microparticles are bent towards Fe 3+ through coordination interactions to create nanoscale wrinkled patterns on smooth microparticle surfaces. Nanoscale wrinkled patterns reduce the surface roughness and increase the contact area between the membrane surface and water molecules, expanding the steric hindrance between the oil molecules and membrane surface. Molecular dynamic simulations reveal that the water-molecule densities and strengths of the hydrogen bonds are higher near the resultant membrane surface. With this concept, we can successfully inhibit the initial adhesion, migration, and deposition of oil, regardless of the viscosity, on the membrane surface and achieve migratory viscous crude oil antifouling. This research on the PFP mechanism opens pathways to realize superwettable materials for diverse applications in fields related to the environment, energy, health, and beyond.
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高影响因子
BIOLOGY AND FERTILITY OF SOILS
·
2023
·Vol. 59
·期 6
·679-696
·
IF 6.5
Hu Ruiwen,Liu Songfeng,Zhao Haiming,Wang Zhigang,Shu Longfei,Zeng Jiaxiong,Cai Quanying,Mo Cehui,He Zhili,Wang Cheng
Di(2-ethylhexyl) phthalate (DEHP), one of the most important plasticizers, is considered a typical endocrine disruptor. Soil contains high levels of DEHP, and acts as the main medium for its migration into food chain, presenting potential risks to human health. Although soil indigenous microbial communities hold a great potential to degrade DEHP, the kinetics and mechanism of microbial biodegradation for soil DEHP on the long-time scale remain unclear. Here, we analyzed microbial communities from time-series (up to 90 days) samples of laboratory microcosms by sequencing of 16S and ITS rRNA gene amplicons. We found that the kinetics processes of DEHP biodegradation were well fitted by a biphasic model with two independent kinetic phases: phase I as a first-order kinetics process (0–10 days, r 2 = 0.975), and phase II as a fractional power kinetics process (11–90 days, r 2 = 0.967). Linear discriminant and partial least square regression analyses showed that bacterial genera Clostridium , Sporotomaculum , Mycoplana , and Hyphomicrobium were involved in DEHP biodegradation during phase I, and genera Bacillus and Nannocystis were responsible for DEHP biodegradation during phase II. Moreover, we observed transition in microbial co-occurrence patterns: closer inter-taxa connections between bacterial degrader and fungal genera Aspergillus , Fusarium , and Pleurotus in phase I. Such divergence in the composition of potential DEHP-degrading bacteria and their interactions with fungi may induce the decreased degradation rates from phase I to phase II. This study systematically deciphers the bacterially driven DEHP biodegradation kinetics, and provides fundamental basis for developing strategies for efficient DEHP removal in soil.
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