BMC BIOTECHNOLOGY
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2019
·Vol. 19
·期 1
·1-11
·
IF 2.303
Zeng Liya,Liu Yongchang,Pan Jun,Liu Xiaowen
Background Norcantharidin (NCTD), a demethylated derivative of cantharidin (defensive toxin of blister beetles), has been reported to exhibit insecticidal activity against various types of agricultural pests. However, NCTD applications are limited by its poor water solubility and high dosage requirement. Nanoemulsions have attracted much attentions due to the transparent or translucence appearance, physical stability, high bioavailability and non-irritant in nature. In general, nanoemulsions with small droplet size can enhance the bioavailability of drugs, whereas this phenomenon is likely system dependent. In present study, NCTD nanoemulsions were developed and optimized to evaluate and improve the insecticidal activity of NCTD against Plutella xylostella (Lepidotera: Plutellidae) by a spontaneous emulsification method.Results Triacetin, Cremophor EL and butanol were selected as the constituents of NCTD nanoemulsions via solubility determination, emulsification efficiency and ternary phase diagram construction. Insecticidal activity of NCTD nanoemulsion was associated with the content of surfactant and cosurfactant: (1) Higher effective toxicity exhibited at Smix (surfactant to cosurfactant mass ratio) = 3:1 that may be associated with the changes in interfacial tension; (2) NCTD nanoemulsion at 3:7 < SOR (surfactant to oil mass ratio) < 6:4 was more effective at lower surfactant level, which was attributed to the relatively slow diffusion rate of NCTD hindering by excess surfactant. Interestingly, nanoemulsions with smaller droplets were not found to be more effective in our study.Conclusion sThe optimized NCTD nanoemulsion (triacetin/Cremophor EL/butanol (60/20/20, w/w)) exhibited effective insecticidal activity (LC50 60.414 mg/l, LC90 185.530 mg/l, 48 h) than the NCTD acetone solution (LC50 175.602 mg/L, LC90 303.050 mg/L, 48 h). Spontaneous emulsifying nanoemulsion employed to formulate this poor water-soluble pesticide is a potential system for agriculture application.
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Journal of Superconductivity and Novel Magnetism
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2019
·Vol. 32
·期 9
·2903-2911
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IF 1.13
Sun Xiaoning,Wang Song,Wang Yaping,Sun Kangning
A simple one-step solvothermal method is proposed to prepare hydrophobic Fe 3 O 4 nanoparticles (MNPs) using iron acetylacetonate (Fe(acac) 3 ), oleylamine (OAm), and ethylene glycol (EG). X-ray powder diffraction, scanning electron microscope, infrared spectroscopy, transmission electron microscopy, X-ray photoelectron spectrometry, and vibrating sample magnetometer are used to characterize the structure, morphology, and properties of products. The testing results indicate that the as-synthesized products are spherical-like hydrophobic MNPs, superparamagnetic at room temperature, with a saturation magnetization up to 76.8 emu/g. The good hydrophobic property of MNPs is attributed to the coverage of oleylamine, without causing a remarkable loss of magnetic property. In addition, the influences of material ratio, aging time, oleic acid, and stearic acid used as additives are studied in our research.
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Phytopathology Research
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2019
·Vol. 1
·期 1
·1-10
·
IF 0
Fan Fei,Hahn Matthias,Li Guo-Qing,Lin Yang,Luo Chao-Xi
Benzimidazole fungicides (MBCs) have been widely used in agriculture since 1970s, and resistance to this class of fungicides in Botrytis cinerea is reported worldwide. Resistance to MBCs in B. cinerea is related to mutations in the target β-tubulin gene ( TUB2 ). Compared with the mutation at codon 200, the substitutions from glutamic acid to alanine (E198A), valine (E198V), or lysine (E198K) at codon 198 are currently the predominant mutations in MBC resistant populations of B. cinerea . In this study, a loop-mediated isothermal amplification (LAMP) method was established for rapid detection of benzimidazole resistance in B. cinerea. On the basis of the three mutations at TUB2 codon 198, three sets of LAMP primers were designed, and each of these primer sets was able to specifically amplify the DNA containing its corresponding mutation, while no amplification was detected with other mutated or the wild type DNA. After optimization, the sensitivity and specificity tests illustrated that this LAMP assay had good sensitivity and specificity to detect specific resistant genotypes in B. cinerea . Result also showed that the LAMP assay had good reproducibility. Above all, boiled mycelia could be used as templates, which simplified the process and increased the efficiency of the assay. Considering its rapidity, simplicity, and high efficiency, the LAMP assay developed in this study is a promising tool for the diagnosis of benzimidazole resistance in B. cinerea , and will contribute to the monitoring of resistance development to MBCs in the future.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2019
·Vol. 30
·期 7
·6469-6474
·
IF 2.195
Ullah Atta,Liu Hanxing,Pengcheng Zhai,Hao Hua,Iqbal Javed,Cao Minghe,Yao Zhonghua,Ahmad Arbab Safeer,Manan Abdul
Solid-state sintering method was used for the synthesis of Mg 1−x Co x SiO 3 (x = 0–0.25) ceramics. Phase, microstructure and microwave dielectric properties of the ceramics were investigated. With increase in Co 2+ content, the increase was observed in the lattice parameters. The Q u f o value of MgSiO 3 was enhanced from 103,453 to 145,846 GHz with increasing the value of x content from 0 to 0.15. The Co 2+ substitution also led to an obvious decrease in the sintering temperature by ~ 100 °C. Clino-enstatite phase formed for the composition with x = 0 while Proto-enstatite formed as the major along with minor clino-enstatite phase for the compositions with x > 0. Good dielectric properties at microwave frequencies i.e. ε r ~ 8.11, Q u f o ~ 145,846 GHz and τ f ~ − 12 ppm/°C were obtained for the composition with x = 0.15 sintered at 1350 °C for 9 h. This is suggested to be a very favorable dielectric material for millimeterwave applications.
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IONICS
·
2019
·Vol. 25
·期 11
·5287-5295
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IF 2.289
Zhang Anping,Shi Hongxia,Liu Weiqi,Wang Xiaojun,Zhou Yiming,Wu Ping
Tin-based alloys have been regarded as promising anodes to replace commercial carbon materials for Li-ion batteries, but their Li-storage performance, especially cycle life, still fails to meet the requirements for electric vehicles and large-scale electricity storages. Herein, we propose a facile and scalable hydrogel-derived route for uniformly immobilizing sub-10 nm Sn-based alloys within three-dimensional (3D) carbon nanocorals, using polymer-hybridized cyano-bridged coordination polymer hydrogels (cyanogels) as precursors. As a representative example, 3D Sn–Fe@C nanocorals have been constructed through freeze-drying and thermal-autoreduction processes using polyethylene glycol (PEG) hybridized Sn(IV)–Fe(II) cyanogels as precursors. PEG plays critical roles in structural tailoring of hybrid cyanogels and size control of Sn–Fe alloys, and as a result, the average alloy size in optimized Sn–Fe@C nanocoral is only 5.9 nm. The ultrasmall alloy size, uniform dispersity of alloy, as well as coral-like framework structure, enable the Sn–Fe@C nanocorals to exhibit long-term cyclic life and high-rate performance.
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Nano Research
·
2019
·Vol. 12
·期 7
·1643-1649
·
IF 8.515
Liu Yang,Tian Xiaorui,Guo Weiran,Wang Wenqiang,Guan Zhiqiang,Xu Hongxing
Integrating surface enhanced Raman scattering with microfluidics is the long-term goal for reduced volume, multiplex and automation fingerprint detection of biomolecules. High sensitivity, repeatability, stability, reusability and real-time detection are the performance goals of Raman detection in the aqueous solution environment. Here, we reported the study on cavity mode enhanced SERS detection of both surface-adsorbed molecules and non-surface-adsorbed molecules in the solution environment. The cavity modes had important influence on the SERS enhancement, especially for the non-surface adsorbed molecules. Uniform, repeatable, reusable and real-time Raman signal detection of the non-surface adsorbed Rhodamine 6G molecules was demonstrated. Our work is an important step for the practical on-chip microfluidic Raman detection applications.
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Journal of Inorganic and Organometallic Polymers and Materials
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2019
·Vol. 29
·期 6
·2116-2123
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IF 1.637
Lu Pin,Qu Zhaoming,Wang Qingguo,Yuan Yang,Cheng Erwei,Zhao Min
Environment adaptive electromagnetic protection for electronic systems with transmitting and receiving electromagnetic information is increasingly important because of rapid development of information technology and the application of strong electromagnetic pulse. Easy-to-prepare materials with stable electrical-field induced nonlinear conductive characteristics are strongly desired. In this study, the core–shell hybrid nanoparticles of SiO 2 -decorated silver nanowire hybrids (AgNWs@SiO 2 ) were synthesized via a sol–gel process employed in a polyvinyl alcohol (PVA) matrix material to prepare composites. Microstructure analysis demonstrated that SiO 2 insulating layer was well-bonded to the surface of AgNWs. The AgNWs@SiO 2 /PVA composites exhibited stable and excellent nonlinear conductive behavior under increasingly applied voltage with high filling concentration of the hybrid nanoparticles, the switching threshold voltage of proposed composites can be tuned by optimizing the loading amount of AgNWs@SiO 2 hybrid fillers and the thickness of the SiO 2 insulating layer. The mechanism of the nonlinear conductive characteristic of the composites was discussed. The shielding effectiveness (SE) of the developed material against the square-wave electromagnetic pulse up to 15 dB, which verified the adaptive protection function of the AgNWs@SiO 2 /PVA composite.
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JOURNAL OF NANOPARTICLE RESEARCH
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2019
·Vol. 21
·期 2
·1-12
·
IF 2.009
Xia Xiaoxiao,Li Wei,Li Song
Ionic liquids/metal-organic framework composites are recognized as promising adsorbents for CO 2 capture due to the outstanding adsorption performance, whereas their water stability, which is critical for the real application of ILs/MOF composites, has not been taken into consideration. In this work, the water stability of two ILs/Cu-BTC composites, i.e., 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF 4 ]) /Cu-BTC and 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF 6 ]) /Cu-BTC, were investigated. We found that the loading of ILs does not impose remarkable impacts on the crystalline structure of Cu-BTC upon water exposure; whereas the thermal stability and surface area of Cu-BTC were decreased by the incorporation of ILs, thereby leading to the reduced CO 2 uptake in spite of the enhanced CO 2 heat of adsorption. Furthermore, it was revealed that the decomposition of Cu-BTC occurred within the first hour of water exposure. Nevertheless, the loading of ILs retarded the decomposition of Cu-BTC according to the variations in BET surface area upon water exposure.
Graphical abstract
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BIOMETALS
·
2019
·Vol. 32
·期 2
·251-264
·
IF 2.455
Liu Xiao-Li,Ye Sen,Li Hua-Wei,Lu Bo,Yu Yan-Qin,Fan Yu-Peng,Yang Wei-Jun,Yang Jin-Shu
Rimicaris exoculata (Decapoda: Bresiliidae) is one of the dominant species among hydrothermal vent communities along the Mid-Atlantic Ridge. This shrimp can tolerate high concentrations of heavy metals such as iron, but the mechanisms used for detoxification and utilization of excess metals remain largely unknown. Ferritin is a major iron storage protein in most living organisms. The central heavy subunit of ferritin (H-ferritin) possesses ferroxidase activity and converts iron from Fe 2+ to Fe 3+ , the non-toxic form used for storage. In the present study, the H-ferritin RexFrtH was identified in the hydrothermal vent shrimp R. exoculata , and found to be highly expressed in the gill, the main organ involved in bioaccumulation of metals, at both RNA and protein levels. Accumulation of RexFrtH decreased from efferent to afferent vessels, coinciding with the direction of water flow through the gills. Fe 3+ was localized with RexFrtH, and in vitro iron-binding and ferroxidase assays using recombinant RexFrtH confirmed the high affinity for iron. Based on these results, we propose a model of iron metabolism in R. exoculata gills; ferrous iron from ambient hydrothermal water accumulates and is converted and stored in ferric form by RexFrtH as an iron reservoir when needed for metabolism, or excreted as an intermediate to prevent iron overload. The findings expand our understanding of the adaptation strategies used by shrimps inhabiting extreme hydrothermal vents to cope with extremely high heavy metal concentrations.
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-12
·
IF 4.011
You Ning,Zhang Chenxi,Liang Yachao,Zhang Qi,Fu Peng,Liu Minying,Zhao Qingxiang,Cui Zhe,Pang Xinchang
An unconventional but facile approach to prepare size-tunable core/shell ferroelectric/polymeric nanoparticles with uniform distribution is achieved by metal-free atom transfer radical polymerization (ATRP) driven by visible light under ambient temperature based on novel hyperbranched aromatic polyamides (HBPA) as a functional matrix. Cubic BaTiO 3 /HBPA nanocomposites can be prepared by in-situ polycondensation process with precursors (barium hydroxide (Ba(OH) 2 ) and titanium(IV) tetraisopropoxide (TTIP)) of ferroelectric BaTiO 3 nanocrystals, because precursors can be selectively loaded into the domain containing the benzimidazole rings. At 1200 °C, the aromatic polyamide coating of cubic BaTiO 3 nanoparticles are carbonized to form carbon layer in the inert environment, which prevents regular nanoparticles from gathering. In addition, cubic BaTiO 3 nanoparticles are simultaneously transformed into tetragonal BaTiO 3 nanocrystals after high temperature calcination (1200 °C). The outer carbon shell of tetragonal BaTiO 3 nanoparticles is removed via 500 °C calcination in air. Bi-functional ligand can modify the surface of tetragonal BaTiO 3 nanoparticles. PMMA polymeric chains are growing from the initiating sites of ferroelectric BaTiO 3 nanocrystal surface via the metal-free ATRP technique to obtain core/shell ferroelectric BaTiO 3 /PMMA hybrid nanoparticles. Changing the molar ratio between benzimidazole ring units and precursors can tune the size of ferroelectric BaTiO 3 nanoparticles in the process of polycondensation, and the thickness of polymeric shell can be tailored by changing the white LED irradiation time in the organocatalyzed ATRP process. The dielectric properties of core/shell BaTiO 3 /PMMA hybrid nanoparticles can be also tuned by adjusting the dimension of BaTiO 3 core and the molecular weight of PMMA shell.
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 23
·14309-14319
·
IF 3.442
Zhou Zekun,Shao Yun,Gao Xiang,Liu Zhitian,Zhang Qi
Nanostructures of polypyrrole with controlled uniform morphologies have been synthesized using assembled surfactant aggregates as templates. The effects of hydrophobic chain length of surfactant on particle size and electrochemical performance of polypyrrole nanospheres are systematically studied. The particle size and morphology of the nanospheres are observed by scanning electron microscope and transmission electron microscope, and at the same time, the nitrogen adsorption and desorption test of polypyrrole spheres are carried out. The results show that changing the length of hydrophobic chain of surfactant is not only an effective control of particle size and morphology, but also a significant improvement on the pore structure. With the increase in alkyl chain length, the particle size decreases, and the specific surface area and pore volume increase. The polypyrrole nanosphere prepared by long hydrophobic chain surfactant shows small impedance and high electrochemical capacity about 232 F g −1 at 1.0 A g −1 , and the results suggest that we can fabricate high specific surface area polypyrrole nanosphere which has excellent electrochemical performance by the regulation of hydrophobic chain length. Our work provides a novel synthetic strategy for the fabrication of nanospheres for the construction of high-performance supercapacitors by optimizing the hydrophobic chain length.
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Nature Communications
·
2019
·Vol. 10
·期 1
·1-16
·
IF 11.878
Li Wei,Yang Jie,Luo Lihua,Jiang Mengshi,Qin Bing,Yin Hang,Zhu Chunqi,Yuan Xiaoling,Zhang Junlei,Luo Zhenyu,Du Yongzhong,Li Qingpo,Lou Yan,Qiu Yunqing,You Jian
Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a double ER-targeting strategy to realize photodynamic therapy (PDT) photothermal therapy (PTT) immunotherapy. This nanosystem consists of ER-targeting pardaxin (FAL) peptides modified-, indocyanine green (ICG) conjugated- hollow gold nanospheres (FAL-ICG-HAuNS), together with an oxygen-delivering hemoglobin (Hb) liposome (FAL-Hb lipo), designed to reverse hypoxia. Compared with non-targeting nanosystems, the ER-targeting naosystem induces robust ER stress and calreticulin (CRT) exposure on the cell surface under near-infrared (NIR) light irradiation. CRT, a marker for ICD, acts as an ‘eat me’ signal to stimulate the antigen presenting function of dendritic cells. As a result, a series of immunological responses are activated, including CD8 + T cell proliferation and cytotoxic cytokine secretion. In conclusion, ER-targeting PDT-PTT promoted ICD-associated immunotherapy through direct ROS-based ER stress and exhibited enhanced anti-tumour efficacy.
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