LAB ON A CHIP
·
2023
·Vol. 23
·期 20
·4493-4503
·
IF 6.1
Wei Liu,Yongan Feng,Yapeng Yao,Zihang Liang,Fei Xiao,Zhongliang Ma
Integrating energetic materials with microelectromechanical systems (MEMS) to achieve miniaturized integrated smart energetic microchips has broad application prospects in miniaturized aerospace systems and civil explosive systems. In this work, MEMS compatible [Cu(BODN)·5H2O]n arrays and [Cu(BODN)·5H2O]n@nano-Al composite energetic films were successfully fabricated on copper substrates by the in situ reaction method and drop-coating method. Single crystal X-ray diffraction, powder X-ray diffraction, scanning electron microscopy, infrared spectroscopy, differential thermal analyses, and pulsed laser ignition were employed to characterize the prepared samples. The results show that [Cu(BODN)·5H2O]n arrays formed by the coordination reaction between the Cu(OH)2 template and the BODN ligand exhibit a porous supramolecular structure with excellent thermal and energy properties. Their morphology and composition on a copper substrate can be effectively regulated by adjusting the reaction time and solution concentration. In addition, adjustable energetic properties of [Cu(BODN)·5H2O]n@nano-Al composite films can be achieved after the encapsulation of nano-Al. Their heat release, flame height and ignition duration can reach as much as 1987.5 J g−1, 13.2 mm, and 5900 μs, respectively, indicating that [Cu(BODN)·5H2O]n@nano-Al can be used as an excellent pyrotechnic agent in MEMS ignition chips. Overall, this work provides a reference for the integration and application of energetic materials in MEMS systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 19
·2011073
·
IF 18.808
Huiying Chen,Linlin Zhou,Zhi Fang,Shuize Wang,Tao Yang,Laipan Zhu,Xinmei Hou,Hailong Wang,Zhong Lin Wang
Inorganic lead halide perovskite has become an emerging material for modern photoelectric and electronic nanodevices due to its excellent optical and electronic properties. In view of its huge dielectric and electrical properties, inorganic CsPbBr 3 perovskite is introduced into the piezoelectric nanogenerator (PENG). Based on one-step electrospinning of solutions containing CsPbBr 3 precursors and polyvinylidene difluoride (PVDF), in situ growth of CsPbBr 3 nanocrystals in PVDF fibers (CsPbBr 3 @PVDF composite fibers) with highly uniform size and spatial distribution are synthesized. The CsPbBr 3 @PVDF composite fibers based PENG reveals an open-circuit voltage ( V oc ) of 103 V and a density of short-circuit current ( I sc ) of 170 µ A cm −2 , where the V oc is comparable to the state-of-the-art hybrid composite piezoelectric nanogenerators (PENGs) and the density of I sc is 4.86 times higher than that of lead halide perovskites counterpart ever reported. Moreover, CsPbBr 3 @PVDF composite fibers based PENG exhibits fundamentally improved thermal/water/acid–base stabilities. This study suggests that the CsPbBr 3 @PVDF composite fiber is a good candidate for fabricating high-performance PENGs, promising application potentials in mechanical energy harvesting and motion sensing technologies.
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Physiology
·
2021
·
IF 4.566
Zhang Xiaofang,Liu Panjing,Qin Qiuju,Li Min,Meng Runjie,Zhang Tao
An accurate olfactory system for recognizing semiochemicals and environmental chemical signals plays crucial roles in survival and reproduction of insects. Among all olfaction-related proteins, olfactory receptors (ORs) contribute to the conversion of chemical stimuli to electric signals and thereby are vital in odorant recognition. Olfactory receptor co-receptor (Orco), one of the most conserved ORs, is extremely essential in recognizing odorants through forming a ligand-gated ion channel complex with conventional ligand-binding odorant receptors. We have previously identified aggregation pheromone in Protaetia brevitarsis (Coleoptera: Scarabaeidae), a native agricultural and horticultural pest in East-Asia. However, to our best knowledge, its olfaction recognition mechanisms are still veiled. To illustrate how P. brevitarsis recognize aggregation pheromone and host plants, in the present study we cloned and sequenced the full-length Orco gene from P. brevitarsis antennae (named PbreOrco) and found that PbreOrco is highly conserved and similar to Orcos from other Coleoptera insects. Our real-time quantitative PCR (qRT-PCR) results showed that PbreOrco is mainly expressed in antenna. We also demonstrated that silencing PbreOrco using RNA interference through injecting dsOrco fragment significantly inhibited PbreOrco expression in comparison with injecting control dsGFP and subsequently revealed using electroantennogram and behavioral bioassays that decreasing PbreOrco transcript abundance significantly impaired the responses of P. brevitarsis to intraspecific aggregation pheromone and prolonged the time of P. brevitarsis spending on food seeking. Overall, our results demonstrated that PbreOrco is crucial in mediating odorant perception in P. brevitarsis.
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 24
·2100969
·
IF 18.808
Juan Li,Jianglong Kong,Sihan Ma,Jiacheng Li,Meiru Mao,Kui Chen,Ziteng Chen,Jiaxin Zhang,Yanan Chang,Hui Yuan,Tong Liu,Zizhu Zhang,Gengmei Xing
Novel boron-containing carbon dots (BCDs) are designed and prepared for boron neutron capture therapy (BNCT) with superior water solubility and excellent optical property for tracking 10 B in vitro and in vivo. Encapsulation of BCDs using exosomes (Exos) from macrophages yields BCD–Exos of ≈100 nm. Fluorescent imaging shows that the BCD–Exos are internalized and distributed around the nuclei of U-87-MG glioma cells. BCD–Exos are also verified to cross the blood–brain barrier and significant accumulation in tumor tissue of the orthotopic U-87-MG glioma tumor-bearing mice model 4 h after administration. Using inductively coupled plasma mass spectrometry (ICP-MS), it is detected that 10 B in tumor tissue is 107.07 ± 1.58 ppm, and T/N ratios are enhanced from 2.03 ± 0.08 of boron phenylalanine (BPA) to 5.28 ± 0.29 of the BCD–Exos. In BNCT, the neutron radiation dose is 8.40 ± 0.12 Gy when a 500 mg kg −1 10 B dosage is given. Finally, there is a prominent BNCT effect of the BCD–Exos-treated brain glioma in the mice model, and the survival ratio is 100% at the end of the experiment. The excellent curative effect of BNCT using BCD–Exos to brain glioma is achieved through adjusted biodistribution of boron in the cancer cell, enhanced T/N ratios, and the precise match between boron and neutron exposure in the site of the tumor in vivo with fluorescence imaging of BCD–Exos.
✓ 已验证
产品关联
DOI
高影响因子
Scientific Reports
·
2021
·Vol. 11
·期 1
·1-10
·
IF 4.38
Chen Huanyu,Cai Ping,Feng Yue,Sun Zhanliang,Wang Yinwen,Chen Yue,Zhang Wei,Liu Nan,Zhou Zhijun
68 Ga-radiolabeled small molecules that specifically target prostate-specific membrane antigen (PSMA) have been extensively investigated, and some of these tracers have been used in the diagnosis of prostate cancer via 68 Ga-positron emission tomography ( 68 Ga-PET). Nevertheless, current 68 Ga-labeled radiotracers show only fair detection rates for metastatic prostate cancer lesions, especially those with lower levels of prostate specific antigen (PSA), which often occurs in the biochemical recurrence of prostate cancer. The goal of this study was to design and synthesize a new PSMA-targeted radiotracer, 68 Ga-SC691, with high affinity for prostate cancer cells and excellent pharmacokinetics. To this end, structural optimization was carried out on the bifunctional group, target motif, and linker while the high affinity targeting scaffold remained. To explore its potential in the clinic, a comparative study was further performed in vitro and in vivo between 68 Ga-SC691 and 68 Ga-PSMA-11, a clinically approved tracer for PSMA-positive prostate cancer. SC691 was radiolabeled to provide 68 Ga-SC691 in 99% radiolabeling yield under mild conditions. High uptake and a high internalization ratio into LNCaP cells were observed in in vitro studies. In vivo studies showed that 68 Ga-SC691 had favorable biodistribution properties and could specifically accumulate on PSMA-positive LNCaP xenografts visualized by micro-PET/CT. This radiotracer showed excellent PET imaging quality and comparable, if not higher, uptake in LNCaP xenografts than 68 Ga-PSMA-11.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2021
·
IF 4.556
Xiuming Jiang,Denghui Yang,Guoqiang Xiang,Leqian Hu
In this work, cis and trans fatty acid (FA) contents in edible oils was determined using 1 H nuclear magnetic resonance ( 1 H NMR) spectroscopy. The comparison of 1 H NMR spectra of edible oil and cis-trans isomerized oil showed that they were different in three regions: (1) 2.880 - 2.650 ppm caused by bis-allylic protons; (2) 2.140 - 1.900 ppm due to allylic protons; and (3) 1.030 - 0.930 ppm due to methyl protons of linolenic acyl groups. The 1 H NMR signals in these regions were combined with partial least squares method to predict contents of cis/trans fatty acids in edible oils. The results showed that the predicted values were consistent with the gas chromatography-measured values and had a good linear relationship with a correlation coefficient (R 2 ) of above 0.98. This work demonstrates that 1 H NMR spectroscopy was successfully used to determine the composition of both cis and trans fatty acids in edible oils.
✓ 已验证
产品关联
DOI
高影响因子
TOXICOLOGY LETTERS
·
2021
·
IF 4.374
Zhe Wang,Xiaoyu Wang,Zhen Wang,Yaqin Jia,Yuyi Feng,Lili Jiang,Yangliu Xia,Jun Cao,Yong Liu
Osimertinib is the only third-generation epidermal growth factor receptor tyrosine-kinase inhibitor (EGFR-TKI) approved by Food and Drug Administration (FDA). This study aimed to know the inhibitory effect of osimertinib on human UDP-glucosyltransferases (UGTs) and human liver microsomes (HLMs), as well as to identify its potential to cause drug-drug interaction (DDI) arising from the modulation of UGT activity. High inhibitory effect of osimertinib was shown towards UGT1A1, 1A3, 1A6, 1A7, 1A8, 1A10, 2B7 and 2B15. Especially, osimertinib exhibited competitive inhibition against UGT1A1 with a K i,u of 0.87 ± 0.12 μM. It also noncompetitively inhibited SN-38 glucuronidation in pooled HLMs with a K i,u of 3.32 ± 0.25 μM. Results from quantitative prediction study indicated that osimertinib administered at 80 mg/day may result in a 4.83 % increase in the AUC of drugs mainly metabolized by UGT1A1, implying low risk of DDI via liver metabolism. However, the ratios of [ I ] gut / K i,u are much higher than 11 in HLMs and recombinant UGT1A1, indicating a risk for interaction in intestine. The effects of osimertinib on intestinal UGT should be paid more attention on to avoid unnecessary clinical DDI risks.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2021
·Vol. 12
·期 12
·5551-5562
·
IF 5.396
Mengjie Ma,Han Wang,Yongkai Yuan,Yuanhong Wang,Shuang Yang,Zhihua Lv
The purpose of this study was to investigate the absorption and transport of glycosaminoglycan from Apostichopus japonicus (AHG) and its depolymerized derivatives (DAHG-1, DAHG-2, DAHG-3). The AHG and depolymerized AHGs (DAHGs) were characterized by high-performance gel permeation chromatography (HPGPC), Raman spectroscopy and atomic force microscopy (AFM). The results showed that there was no significant difference of an AHG primary structure and functional groups during the depolymerization. Meanwhile, AFM observation showed that AHG and DAHGs possessed linear structures. In this study, a rapid and sensitive liquid chromatographic post-column derivatization method was used to investigate the absorption of AHG and DAHGs with the Caco-2 cell model, the M cell model and the intestinal recirculating perfusion. It was found that AHG and DAHGs can be absorbed in the intestine, and their transport involved endocytosis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2021
·
IF 14.593
Yamin Chai,Zhuang Liu,Yunzheng Du,Lichun Wang,Jinyan Lu,Qian Zhang,Wenyan Han,Tingting Wang,Yameng Yu,Lisha Sun,Lailiang Ou
Highly efficient removal of bilirubin from whole blood directly by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to the low adsorption capacity, poor mechanical strength and low biocompatibility of adsorbents. In this work, a new class of nanocomposite adsorbents was constructed through an inorganic-organic co-crosslinked nanocomposite network between vinyltriethoxysilane (VTES)-functionalized hydroxyapatite nanoparticles (V-Hap) and non-ionic styrene-divinylbenzene (PS-DVB) resins (PS-DVB/V-Hap) using suspension polymerization. Notably, our adsorbent demonstrated substantially improved mechanical performance compared to the pure polymer, with the hardness and modulus increasing by nearly 3 and 2.5 times, respectively. Moreover, due to the development of a mesoporous structure, the prepared PS-DVB/V-Hap3 exhibited an ideal adsorption capacity of 40.27 mg g −1 . More importantly, the obtained adsorbent beads showed outstanding blood compatibility and biocompatibility. Furthermore, in vivo extracorporeal hemoperfusion verified the efficacy and biosafety of the adsorbent for directly removing bilirubin from whole blood in pig models, and this material could potentially prevent liver damage and improve clinical outcomes. Taken together, the results suggest that PS-DVB/V-Hap3 beads can be used in commercial adsorption columns to threat hyperbilirubinemia patients through hemoperfusion, thus replacing the existing techniques where plasma separation is initially required.
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Xiaoxue Liu,Jiao Yang,Jing Cheng,Yi Xu,Wen Chen,Yingchun Li
Development of nanomaterials with multienzyme-like activities (nanozymes) via a simple way has attracted paramounting attention. Generally, enzymatic activity is closely related to the size, surface state, material type, etc. Bimetallic oxides are very appealing owing to their mixed valence and structural advantages. Herein, we reported an eco-friendly strategy to synthesize Co 1.5 Mn 1.5 O 4 nanozyme via sol-gel method. This nanozyme functionally mimics four major enzymes, i.e. laccase, peroxidase (POD), oxidase (OXD), and catalase (CAT). Accordingly, a colorimetric sensing platform was designed to distinguish isomers of organic pollutants ‒catechol (CC) and hydroquinone (HQ) by using Co 1.5 Mn 1.5 O 4 as the sole catalyst. In particular, laccase-like activity of Co 1.5 Mn 1.5 O 4 enables it to directly oxidize CC into yellow o -benzoquinone with good linearity in the range of 1∼1000 μM and a detection limit of 0.35 μM. Meanwhile, HQ can discolor the oxidized substrate that was pre-oxidized with the aid of oxidase-like activity of the nanozyme (linear range: 0.05∼100 μM, detection limit: 0.04 μM). The established colorimetric method has been successfully utilized for selective sensing of CC, HQ in water samples with good selectivity and high sensitivity. Our study contributes to green synthesis of metal-based nanomaterials with multi-enzyme mimicking activities and uncovers new usage of nanozyme in discriminating of environmental pollutants.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Magnesium and Alloys
·
2021
·
IF 10.088
Baojing Feng,Guonan Liu,Peixu Yang,Sensen Huang,Dongqing Qi,Peng Chen,Chengduo Wang,Jiang Du,Shaojun Zhang,Jinhui Liu
Effect of the second phase in the micro-galvanic corrosion of a commercial Mg alloy containing rare earth elements, cast WE43 alloy, was investigated in 0.6 M NaCl solution and 0.6 M Na 2 SO 4 solution by scanning electron microscopy (SEM) observations, scanning Kelvin probe force microscopy (SKPFM) analysis, hydrogen evolution, weight loss measurement, and electrochemical techniques. It is confirmed that the second phase of cast WE43 alloy is more active than Mg matrix and exhibits an anodic role in the micro-galvanic corrosion with α-Mg matrix as cathode and dissolves preferentially in Na 2 SO 4 solution, in contrast to the situation in NaCl solution. The corrosion rate of cast WE43 alloy in Na 2 SO 4 solution is much higher than that in NaCl solution, which is different from the conventional wisdom and could be attributed to the different role of the second phase in the micro-galvanic corrosion in two solutions.
✓ 已验证
产品关联
DOI
高影响因子
ACS Catalysis
·
2021
·
IF 13.084
Lipeng Wu,Bin Li,Yang Li,Xiaobin Fan,Fengbao Zhang,Guoliang Zhang,Qing Xia,Wenchao Peng
Herein, a series of Co@N–C materials are synthesized using nitrates (LiNO3, NaNO3, and KNO3) as templates to control the preferential growth of the cobalt (200) facet. Co@N–C–X (X = LiNO3, NaNO3, and KNO3) exhibit excellent activities and long-term stabilities for Fenton-like degradation of bisphenol A (BPA) with peroxymonosulfate (PMS) as an oxidant. The texture coefficient (TC) is used to investigate the relationship between the Co facets and their catalytic activities, and a linear relation is built between the TC of Co(200) and the reaction rate constant (k). Co(200) is therefore the most active facet for PMS activation, while nitrates can promote the preferential growth of the Co(200) facet. Moreover, the Co(200) facet is more stable against leaching and can achieve more quick transformation between Co2+/Co3+. Quenching tests, electron paramagnetic resonance spectra, and electrochemical tests show that singlet oxygen (1O2) plays the dominant role for BPA degradation. Density functional theory verifies that Co nanoparticles coated with a graphitic nitrogen-doped carbon layer have the best activity for PMS activation. This work first proposes the strategy of using nitrates to control the preferential growth of Co facets and reveals the relationship between the TC value and k, thus attracting great interest in the environmental field.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）