ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2021
·Vol. 29
·期 7
·9780-9791
·
IF 4.223
Huang Wenqiu,Zhou Yuping,Zhao Ting,Tan Liju,Wang Jiangtao
In this study, the marine microalgae Skeletonema costatum and Nitzschia closterium were exposed to different forms of copper, such as a metal salt (Cu 2+ ), a nano-metal (nano-Cu), and nano-metal oxide (nano-CuO). During a 96-h exposure to nanoparticles (NPs) and salt, the cell number, Cu 2+ concentration in the culture medium, morphology, and intracellular amino acids were measured to assess the toxicity of the copper materials and the toxicity mechanism of the NPs. As results, the toxicity of Cu 2+ , nano-Cu, and nano-CuO to marine phytoplankton decreased in order. The EC 50 values of Cu 2+ and nano-Cu for S. costatum and N. closterium ranged from 0.356 to 0.991 mg/L and 0.663 to 2.455 mg/L, respectively. Nano-Cu inhibits the growth of marine phytoplankton by releasing Cu 2+ ; however, nano-CuO is harmful to microalgae because of the effect of NPs. The secretion of extracellular polymeric substances by microalgae could also affect the toxicity of nano-Cu and nano-CuO to microalgae. S. costatum was more sensitive to copper than N. closterium . Cu 2+ , nano-Cu, and nano-CuO all reduced per-cell amino acids and the total output of algae-derived amino acids by affecting the growth of the phytoplankton. This study helps to understand the risk assessment of nano-Cu and nano-CuO to marine microalgae.
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高影响因子
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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2021
·Vol. 49
·期 3
·847-860
·
IF 9.236
Liu Jing-Jing,Wang Zun,Nie Li-Ming,Zhu Yuan-Yuan,Li Ge,Lin Lin-Ling,Chen Min,Zhang Guo-Jun
Purpose Obtaining tumour-free margins is critical for avoiding re-excision and reducing local recurrence following breast-conserving surgery; however, it remains challenging. Imaging-guided surgery provides precise detection of residual lesions and assists surgical resection. Herein, we described water-soluble melanin nanoparticles (MNPs) conjugated with cyclic Arg-Gly-Asp (cRGD) peptides for breast cancer photoacoustic imaging (PAI) and surgical navigation. Methods The cRGD-MNPs were synthesised and characterized for morphology, photoacoustic characteristics and stability. Tumour targeting and toxicity of cRGD-MNPs were determined by using either breast cancer cells, MDA-MB-231 tumour-bearing mice or the FVB/N-Tg (MMTV-PyVT) 634Mul/J mice model. PAI was used to locate the tumour and guide surgical resection in MDA-MB-231 tumour-bearing mice. Results The cRGD-MNPs exhibited excellent in vitro and in vivo tumour targeting with low toxicity. Intravenous administration of cRGD-MNPs to MDA-MB-231 tumour-bearing mice showed an approximately 2.1-fold enhancement in photoacoustic (PA) intensity at 2 h, and the ratio of the PA intensity at the tumour site to that in the surrounding normal tissue was 3.2 ± 0.1, which was higher than that using MNPs (1.7 ± 0.3). Similarly, the PA signal in the spontaneous breast cancer increased ~ 2.5-fold at 2 h post-injection of cRGD-MNPs in MMTV-PyVT transgenic mice. Preoperative PAI assessed tumour volume and offered three-dimensional (3D) reconstruction images for accurate surgical planning. Surgical resection following real-time PAI showed high consistency with histopathological analysis. Conclusion These results highlight that cRGD-MNP-mediated PAI provide a powerful tool for breast cancer imaging and precise tumour resection. cRGD-MNPs with fine PA properties have great potential for clinical translation.
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Nano Research
·
2021
·Vol. 15
·期 3
·1973-1982
·
IF 8.897
Tan Xianjun,Ding Wenhui,Jiang Zhenying,Sun Linxiao,Huang Yuxiong
To better understand the mechanisms of hydrogen peroxide (H 2 O 2 )’s decomposition and reactive oxygen species (ROS)’s formation on the catalyst’s surface is always a critical issue for the environmental application of Fenton/Fenton-like reaction. We here report a new approach to activate H 2 O 2 in a co-catalytic Fenton system with oxygen incorporated MoS 2 , namely MoS 2− x O x nanosheets. The MoS 2− x O x nanosheets assisted co-catalytic Fenton system exhibited superior degradation activity of emerging antibiotic contaminants (e.g., sulfamethoxazole). Combining density functional theory (DFT) calculation and experimental investigation, we demonstrated that oxygen incorporation could improve the intrinsic conductivity of MoS 2− x O x nanosheets and accelerate surface/interfacial charge transfer, which further leads to the efficacious activation of H 2 O 2 . Moreover, by tuning the oxygen proportion in MoS 2− x O x nanosheets, we are able to modulate the generation of ROS and further direct the oriented-conversion of H 2 O 2 to surface-bounded superoxide radical (·O 2 surface − ). It sheds light on the generation and transformation of ROS in the engineered system (e.g., Fenton, Fenton-like reaction) for efficient degradation of persistent pollutants.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2021
·Vol. 32
·期 23
·27524-27533
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IF 2.478
Wang Wenbo,Liu Botao,Lv Xiaomeng
To achieve adaptation to the heat dissipation effect of electronic devices in the 5G era and improvement of the anisotropic thermal conductivity of the insulating polymer, three-dimensional (3D) PU@BNNS-OH network structure was constructed via layer-by-layer assembly with polyurethane (PU) foam as the robust skeleton of three-dimensional structure, and hydroxylated boron nitride nanosheet (BNNS-OH) as thermal conductive filler. Then PU@BNNS-OH was composited with polyvinyl alcohol (PVA) via microwave-assisted curing method to get the final thermal conductivity composites (PVA/PU@BNNS-OH). The result showed that the interconnected thermal conductivity network was significantly effective in improving the anisotropic thermal conductivity of the composite with high-temperature endurance and moderate mechanical property. When the BNNS-OH coating is 10 wt%, the optimal thermal conductivity of the composite is 4.68 W · \({\mathrm{m}}^{-1}\) · \({\mathrm{K}}^{-1}\) and the thermal conductivity enhancement efficiency is 45.50, which is significantly higher than others reported in the literature. Both the finite element analysis and thermal infrared analysis indicated that the thermal conductivity of the composites was significantly improved and paved the way for its potential application. The present microwave-assisted synthesis strategy is fast and energy-saving and can be widely used for synthesizing different insulated polymer-based thermal interface materials.
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POLYMER BULLETIN
·
2021
·Vol. 79
·期 10
·8617-8631
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IF 2.87
Wang Shihai,Zhou Yu,Tao Wangwang,Liu Jingyi,Chen Hongxiang,Zhao Zuyi
In order to obtain polyurethane micelles with targeting property and excellent stability, Fe 3 O 4 -modified magnetic amphiphilic polyurethane (MAPU) was successfully synthesized by grafting amphiphilic polyurethane to the surface of Fe 3 O 4 nanoparticles. The structure of MAPU was confirmed by Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy ( 1 H NMR), gel permeation chromatography and thermogravimetric analyzer. MAPU could form micelles with the particle size of less than 45 nm, and the micelles showed excellent stability of anti-dilution and storage, determined by dynamic light scattering. MAPU micelles had superparamagnetic property, and magnetically targeted property in HeLa cells measured by vibrating sample magnetometer (VSM) and Prussian blue staining method, respectively. Methyltetrazolium (MTT) assay experiment indicated that MAPU micelles were almost non-cytotoxic. In addition, MAPU micelles could encapsulate hydrophobic model drugs such as Indometacin (IMC) and had a release-sustained effect for IMC.
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Science China-Technological Sciences
·
2021
·Vol. 64
·期 12
·2744-2754
·
IF 3.572
Zou Yang,Jin Xin,Zhang XiaoPing,Kong XiaoLing,Zhang Qian,Xie XianHua,Liu ChangJun,Ke LinNan,Liu WenGuang,Wang Wei
Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration. The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications. Herein, an epoxy network loading curcumin and Ti 3 C 2 T x MXenes were developed as a hybrid biomedical patch. The hybrid patch was basically prepared through an epoxy/thiol curing chemistry, and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature. The resulted hybrid patch exhibits shape-morphing capability, multi-substrate adhesion, self-healing ability, and photothermal effects under 980 nm near infrared (NIR). Additionally, the as-prepared hybrid patch possesses strong UV-shielding, excellent oxidation resistance (ROS scavenging efficiency was 89.3% in 3 min), highly effective antibacterial vitality (more than 99%) against S. aureus and E. coli , and good cytocompatibility. As a proof of concept, the present multifunctional hybrid patch broadens the potential applications in the biomedical field.
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Nano Research
·
2021
·Vol. 15
·期 4
·3161-3169
·
IF 8.897
Xi Min,Xu Longchang,Li Nian,Zhang Shudong,Wang Zhenyang
Copper sulfide (Cu x S) as a plasmonic solar photothermal semiconductor material that expands the light collection range by altering localized surface plasmon resonance (LSPR) to the near- to mid- infrared (IR) spectral region. The versatile synthesis strategies of Cu x S nanostructure offer its variability of morphology and provide additional freedom in tuning the optical property. Particularly, nanocage (or nanoshell) has hybridized plasmon resonances as a result of super-positioned nanosphere and nanocavity, which extends its receiving range of solar spectrum and increases light-to-heat conversion rate. Here, we offer novel “nanoink” and “nanofilm” developed from colloidal Cu 27 S 24 nanocages with excellent solar photothermal response. Via combining experimental measurement and theoretical calculation, we estimated the optical properties of covellite Cu 27 S 24 . And based on obtained dielectric functions, we then calculated its solar photothermal performance, which was further validated by our experimental measurement. The simulation results showed that hollow Cu 27 S 24 nanocages have excellent solar photothermal performance, and exhibit much higher solar photothermal conversion efficiency than solid Cu 27 S 24 nanospheres.
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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
·
2021
·Vol. 40
·期 1
·1-16
·
IF 11.161
Ye Lili,Chen Yaoming,Mao Jizong,Lei Xiaotian,Yang Qian,Cui Chunhui
Background The exploitation of novel nanomaterials combining diagnostic and therapeutic functionalities within one single nanoplatform is challenging for tumor theranostics. Methods We synthesized dendrimer-modified gold nanorods for combinational gene therapy and photothermal therapy (PTT) of colon cancer. Poly(amidoamine) dendrimers (PAMAM, G3) grafted gold nanorods were modified with GX1 peptide (a cyclic 7-mer peptide, CGNSNPKSC). The obtained Au NR@PAMAM-GX1 are proposed as a gene delivery vector to gene (FAM172A, regulates the proliferation and apoptosis of colon cancer cells) for the combination of photothermal therapy (PTT) and gene therapy of Colon cancer cells (HCT-8 cells). In addition, the CT imaging function of Au NR can provide imaging evidence for the diagnosis of colon cancer. Results The results display that Au NR@PAMAM-GX1 can specifically deliver FAM172A to cancer cells with excellent transfection efficiency. The HCT-8 cells treated with the Au NR@PAMAM-GX1/FAM172A under laser irradiation have a viability of 20.45%, which is much lower than the survival rate of other single-mode PTT treatment or single-mode gene therapy. Furthermore, animal experiment results confirm that Au NR@PAMAM-GX1/FAM172A complexes can achieve tumor thermal imaging, targeted CT imaging, PTT and gene therapy after tail vein injection. Conclusion Our findings demonstrate that the synthesized Au NR@PAMAM-GX1 offer a facile platform to exert antitumor and improve the diagnostic level of tumor.
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 5
·3348-3359
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IF 4.682
Zhang Liren,Jiang Yingqiu,Zhou Lingyue,Jiang Zhihong,Li Lu,Che Wenbo,Yu Youming
Abstract Transparent wood (TW) is a promising optical material, which provides a potential choice for windows applications. As a polymer composite material, the mechanical, thermal stability, and flame retardant of TW are crucial properties in practical applications. In this study, the delaminated Ti 3 C 2 T x (MXene) were dispersed into polyvinyl alcohol (PVA) and then infiltrated into delignified wood to prepare MXene-reinforced transparent wood (TW-MXene). The MXene addition leads to an interlocking mechanism between MXene fillers with a polymer matrix (e.g., PVA, cellulose scaffold), thereby improving the tensile strength of TW. Besides, the dynamic mechanical analysis also proved that the tensile strength of TW-MXene is significantly higher than pure transparent wood with changing the temperature at −50 to 150 °C. The TW added with 1 wt% MXene maintained a lower thermal conductivity of 0.31 W m −1 K −1 , and it showed better UV resistance than TW. Besides, the thermal decomposition rate of TW-MXene composite slows down, and its weight loss rate decreases with the addition of MXene. Furthermore, the presence of 1 wt% MXene endowed TW with 9.3 and 22.0% reductions for PHRR and THR, respectively. This strategy provides an insight into the development of high-performance transparent wood composites with the potential to be used in building fields. Graphical abstract
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AAPS Journal
·
2021
·Vol. 24
·期 1
·1-13
·
IF 4.009
Zhao Xuan,Huang Chengyuan,Su Meiling,Ran Yu,Wang Ying,Yin Zongning
Celastrol (CLT) has shown anti-rheumatic activity against rheumatoid arthritis, while its poor water solubility and high organ toxicity restrict its further therapeutic applications. To mitigate these challenges, a reactive oxygen species (ROS)–responsive nanoparticle was developed for celastrol delivery based on the excessive ROS at the pathologic sites, which was synthesized by conjugating bilirubin to a polyethylene glycol (PEG) chain. The PEGylated bilirubin self-assembled into nanoparticle (BRNP) in aqueous solution had a hydrodynamic diameter of around 68.6 nm, and celastrol was loaded into BRNP (CLT/BRNP) with a drug encapsulation efficiency of 72.6% and a loading capacity of 6.6%. In vitro study revealed that CLT/BRNP exhibited the capacity of scavenging intracellular ROS and down-regulating the level of nitric oxide after it was effectively internalized by activated macrophages. Furthermore, in adjuvant-induced arthritis rats, BRNP was accumulated preferentially at inflamed joints, alleviating the joint swelling and bone erosion, which significantly decreased the secretion of pro-inflammatory cytokines to suppress the RA progression. Importantly, CLT/BRNP markedly enhanced its anti-arthritic effect and attenuated the toxic effect compared with free celastrol. Taken together, our results suggested that CLT/BRNP could be used for targeted drug delivery in rheumatoid arthritis. Graphical abstract
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高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 152
·期 9
·2832-2839
·
IF 3.186
Zhang Fengming,Li Ran,Zhang Jiapeng,Dong Hua
Dendritic fibrous KCC-1 supported CuCo bimetal catalysts (CuCo/KCC-1) are fabricated by coprecipitating Cu 2+ and Co 2+ on the surface of KCC-1 nanospheres. The microstructure and composition of the fabricated CuCo/KCC-1 bimetal catalysts are analyzed with ICP-OES, SEM, TEM, and XPS. The CuCo/KCC-1 catalysts demonstrate excellent performance in catalyzing ammonia borane hydrolysis to produce hydrogen in alkaline solutions. As an example, the hydrolysis of ammonia borane catalyzed by Cu 3 Co 1 /KCC-1 (with a Cu/Co molar ratio about 3:1) gives a hydrogen generation rate of 5.43 L/(min g metal ), and an activation energy of 23.96 kJ/mol. The synergic effect between Cu and Co in the CuCo/KCC-1 catalysts maintains the excellent catalytic activity while reducing the usage of Co, making it possible to decrease the cost of the catalyst. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 24
·28321-28334
·
IF 2.478
Jiang Yinying,Wang Yizheng,Zhou Kuan,Ding Senxu,Yu Jiang
In recent years, heterojunction photocatalytic materials have received more and more attention. Ball milling and microwave–assisted heating were used in this work to prepare the g–C 3 N 4 /TiO 2 heterojunction photocatalytic nanocomposites with different g–C 3 N 4 /TiO 2 mass ratios (0.5:1, 1:1, 2.5:1, 5:1, 10:1, 20:1, 30:1, and 40:1, labeled as TCN–1, TCN–2, TCN–3, TCN–4, TCN–5, TCN–6, TCN–7, and TCN–8, respectively). The crystal structure, morphology, and optical properties of the samples were characterized by various analytical techniques. The photocatalytic activity was evaluated by the degradation efficiency of Rhodamine B (RhB) and methylene blue (MB) under visible light and UV irradiation. After 120 min at visible light illumination, TCN–7 had the best degradation efficiency with 99.41% for RhB and 91.75% for MB, whereas after 120 min at UV light illumination, TCN–7 exhibited the best degradation effect, and the efficiency reached at 48.66% for RhB and 71.64% for MB, respectively. The analysis of crystal structure of the as–prepared TCN samples confirmed that TCN–7 has a good crystallinity, which is facilitated for photocatalytic activity. In photocatalytic reactions, superoxide radical (·O 2 − ), hydroxyl radical (·OH), and hole (h + ) are recognized as the main active groups, and ·O 2 – plays the main role for TCN–7 in the photocatalytic reaction system for the degradation of RhB.
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