INVESTIGATIONAL NEW DRUGS
·
2023
·Vol. 41
·期 5
·664-676
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IF 3.4
Pan Mingzhu,Liu Yali,Sang Tian,Xie Jiajun,Lin Huishu,Wei Jianpeng,Shao Shuai,Zheng Yanying,Zhang Juan
Liposomal doxorubicin exhibits stronger drug accumulation at the tumor site due to the Enhanced Permeability and Retention (EPR) effect. However, the prognosis for the patient is poor due to this drug’s lack of targeting and tumor metastasis during treatment. Vascular epidermal growth factor receptor (VEGFR2) plays an important role in angiogenesis and cancer metastasis. To enhance antitumor efficacy of PEGylated liposomal doxorubicin, we constructed a VEGFR2-targeted and doxorubicin-loaded immunoliposome (Lipo-DOX-C00) by conjugating a VEGFR2-specific, single chain antibody fragment to DSPE-PEG2000-MAL, and then we inserted the antibody-conjugated polymer into liposomal doxorubicin (Lipo-DOX). The immunoliposome was formed uniformly with high affinity for VEGFR2. In vitro, Lipo-DOX-C00 enhanced doxorubicin internalization into LLC and 4T1 cells compared with non-conjugated, liposomal doxorubicin. In vivo, Lipo-DOX-C00 delivered DOX to tumor tissues effectively, which exhibited an improved antitumor and anti-metastasis efficacy in both LLC subcutaneous tumor models and 4T1 tumor models. In addition, the combined therapy of a VEGFR2–MICA bispecific antibody (JZC01) and Lipo-DOX-C00 achieved enhanced inhibition of cancer growth and metastasis due to activation of the immune system. Our study provides a promising approach to clinical application of liposomal doxorubicin.
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CELLULOSE
·
2023
·Vol. 30
·期 12
·7939-7953
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IF 5.7
Ren Hui,Mo Wenxuan,Li Bo
As a kind of chemical additives, surfactants are widely used in the processes of papermaking, which played roles of wetting, dispersing, emulsifying etc. to adjust and maintain the product performance. However, there are few reports about the effect of surfactants on fiber properties, especially during paper recycling. This work investigated the effects of three types of surfactants on the cellulosic fibers and paper properties during five-time recycling. Properties of recycled paper with five times were presented as the index of papermaking potential. The results showed that cetyl trimethyl ammonium bromide (CTAB), a cationic surfactant, had an obvious negative effect on paper properties. For continuous surfactant supplements, the burst, tearing, and tensile index decreased by 50.2%, 41.6%, and 43.6%, respectively. Sodium dodecyl benzene sulfonate (SDBS), an anionic surfactant, had a significant positive effect on fibers’ WRV and inhibited the fibers’ hornification to some extent. However, it had a negative effect on paper properties by affecting the bonding between the fibers. Triton X-100 (TX-100), a nonionic surfactant, improved paper properties according to the papermaking potential. For adding surfactant only once, the burst, tearing, and tensile index increased by 15.0%, 8.59%, and 7.2%, respectively. For these three types of surfactants, TX-100 was generally more beneficial for fiber and paper. This paper revealed the effects of surfactants on the fiber and paper properties and perfected the theory of surfactants applied for fiber and paper in papermaking.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 9
·1-14
·
IF 5.7
Mo Guichun,Qin Dongmiao,Wu Yusheng,Luo Zhi,Mo Keting,Deng Biyang
Abstract A new electrochemiluminescence (ECL) cytosensor is proposed for the simultaneous determination of phosphatidylserine (PS) and epidermal growth factor receptor (EGFR) based on the ECL signals of metal-organic framework-5 (MOF-5) loaded CdS quantum dots and N-(aminobutyl)-N-(ethylisoluminol)-polyethylenimine capped Au and Ag nanoparticles. Apoptosis promotes the exposure of PS and reduces the expression of EGFR in cell membranes. Two spatially resolved areas on dual-disk glassy carbon electrodes were designed to eliminate the interference from different ECL probes. Using HepG2 cells treated with resveratrol to induce apoptosis, the cytosensor exhibited high sensitivity, simplicity, and high reproducibility, demonstrating its potential in drug screening and rapid apoptotic cell detection. The strategy reported provides a promising platform for the highly sensitive cytosensing and convenient screening of clinically relevant anticancer drugs. Graphical Abstract
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-14
·
IF 16.6
Li Caicong,Cheng Jianxiang,He Yunfeng,He Xiangnan,Xu Ziyi,Ge Qi,Yang Canhui
Stretchable ionotronics have drawn increasing attention during the past decade, enabling myriad applications in engineering and biomedicine. However, existing ionotronic sensors suffer from limited sensing capabilities due to simple device structures and poor stability due to the leakage of ingredients. In this study, we rationally design and fabricate a plethora of architected leakage-free ionotronic sensors with multi-mode sensing capabilities, using DLP-based 3D printing and a polyelectrolyte elastomer. We synthesize a photo-polymerizable ionic monomer for the polyelectrolyte elastomer, which is stretchable, transparent, ionically conductive, thermally stable, and leakage-resistant. The printed sensors possess robust interfaces and extraordinary long-term stability. The multi-material 3D printing allows high flexibility in structural design, enabling the sensing of tension, compression, shear, and torsion, with on-demand tailorable sensitivities through elaborate programming of device architectures. Furthermore, we fabricate integrated ionotronic sensors that can perceive different mechanical stimuli simultaneously without mutual signal interferences. We demonstrate a sensing kit consisting of four shear sensors and one compressive sensor, and connect it to a remote-control system that is programmed to wirelessly control the flight of a drone. Multi-material 3D printing of leakage-free polyelectrolyte elastomers paves new avenues for manufacturing stretchable ionotronics by resolving the deficiencies of stability and functionalities simultaneously.
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POLYMER BULLETIN
·
2023
·
IF 3.2
Faqir Yahya,Chai Yunlong,Jakhar Ali Murad,Wu Sanmei,Luo Tong,Liao Shiyu,Kalhoro Mohammad Talib,Li Linqiu,Kaleri Abdul Rasheed,Tan Chengjia,Ma Jiahua,Zhang Qiling,Cao Shidong,Adeel Mohammad
The present study was undertaken with the aim of evaluating the ginger essential oil potential and its urea-loading efficacy in the preparation of control-releasing chitosan microspheres. The ginger oil for hydro-distillation was extracted by applying Clevenger apparatus, chemical composition was characterized by FTIR, and the GC-MS was used to identify the oil compounds. Urea-loaded chitosan microsphere formulations were formulated through modified emulsification and cross-linking procedure. The various factors and levels related to preparation of urea-loaded chitosan microspheres were evaluated using response surface test. The present study was also an effort to observe the yield and content of nitrogen. Additionally, FTIR and SEM were applied to characterize the microspheres. The results show the yield of ginger oil as 6.0%. Main compounds identified by GC-MS were gingerol, decanal, isoshogaol, octanal, and others. FTIR also showed that some typical bands appeared in ginger oil. The nitrogen content % in urea-loaded microspheres showed a significantly higher value in proportion to higher oil volume and cross-linking. However, by decreasing the amount of urea and enhancing acetic acid, nitrogen content was decreased. The lower oil concentrations improved the microsphere surface structure and morphology. Response surface analysis showed that the optimum preparation conditions are as follows: 2.094% of Span 80, 2.302% of acetic acid, and cross-linking agent ratio of formaldehyde to glutaraldehyde 1:8.15. Under these conditions, the theoretical value of nitrogen content of urea-loaded chitosan microspheres was 4.683%. According to release test, the urea diffused uniformly in the microspheres after 48 h. It is concluded that the use of ginger oil in control release of fertilizers is the right option in the formulations of control-releasing micro-fertilizers.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Wang Xiaoning,Tong Yanfu,Feng Wenting,Liu Pengyun,Li Xuejin,Cui Yongpeng,Cai Tonghui,Zhao Lianming,Xue Qingzhong,Yan Zifeng,Yuan Xun,Xing Wei
Designing Pt-based electrocatalysts with high catalytic activity and CO tolerance is challenging but extremely desirable for alkaline hydrogen oxidation reaction. Herein we report the design of a series of single-atom lanthanide (La, Ce, Pr, Nd, and Lu)-embedded ultrasmall Pt nanoclusters for efficient alkaline hydrogen electro-oxidation catalysis based on vapor filling and spatially confined reduction/growth of metal species. Mechanism studies reveal that oxophilic single-atom lanthanide species in Pt nanoclusters can serve as the Lewis acid site for selective OH - adsorption and regulate the binding strength of intermediates on Pt sites, which promotes the kinetics of hydrogen oxidation and CO oxidation by accelerating the combination of OH − and *H/*CO in kinetics and thermodynamics, endowing the electrocatalyst with up to 14.3-times higher mass activity than commercial Pt/C and enhanced CO tolerance. This work may shed light on the design of metal nanocluster-based electrocatalysts for energy conversion.
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IRANIAN POLYMER JOURNAL
·
2023
·Vol. 32
·期 8
·1065-1074
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IF 3.1
Yuan Xu,Xianwu Jing,Yongfan Tang,Lang Zhou,pengfei Zhang
A very simple cationic monomer and a cationic hydrophobically associating polyacrylamide were synthesized, and the polymer was to function as a drag reducer. The structures of monomer and polymer were characterized by IR and NMR, and the drag-reducing rate, below and above the critical association concentration, (CAC) was tested. The modified polyacrylamide is a typical hydrophobically associating polymer, reaching a CAC at a mass concentration of about 0.25% (by weight). It is found from the friction test that the optimum concentration of the drag reducer is about 0.05% in fresh water, and the highest drag-reducing rate reaches as high as 72%. In addition, high concentration and high viscosity of drag reducer may impart negative impact on drag reduction rate in fresh water. While in brine, the optimum concentration is about 0.1%, and the highest drag-reducing rate is 68.4%. A high concentration has little negative impact on drag reduction rate, because viscosity is always very low. From the SEM images, it can be seen that the polymer can form network structure in fresh water. Above the CAC concentration, the network structure is significantly denser than that below the CAC concentration, but this is not conducive to the drag-reducing rate. In practical application, we always recommend using concentrations below CAC. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 35
·84002-84010
·
IF 5.8
Yang Zhenhua,Yang Xintong,Zhang Yuexia,Fan Xiaopeng,Cao Yujuan,Li Zhongping,Dong Chuan
Amphiphilic blue-fluorescence carbon dots (B-CDs) were synthesized via pyrolysis method with citric acid and oleamine as precursors. B-CDs are monodispersed in ethanol, toluene, and ultrapure water with the average particle sizes of 3.33 nm, 2.05 nm, and 4.12 nm, respectively. The maximum emission wavelength of the B-CDs excitation at 370 nm is located at 459 nm. The B-CDs have good optical properties with excellent photostability. The fluorescence quantum yield (QY) of the as-prepared CDs is as high as 30.17%. The fluorescence of B-CDs is quenched because of static quenching by oxytetracycline. A high selective and sensitive fluorescence probe for detecting oxytetracycline was constructed with a linear range of 1.52–27.60 µg/mL and the detection limit of 0.33 µg/mL. The B-CDs-based fluorescence probe can be applied to analyze oxytetracycline in milk; the recoveries and relative standard are satisfactory. Furthermore, the B-CDs were exploited for imaging of SH-SY5Y cells. The results demonstrate that as-synthesized CDs can serve as a cellular imaging reagent owing to remarkable bioimaging performance. This work provides a new strategy for the detection of oxytetracycline in food.
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npj Clean Water
·
2023
·Vol. 6
·期 1
·1-11
·
IF 11.4
Li Chao,Li Jiale,Huang Niu,Kong Xin Ying,Xiao Qingyi,Huang Yingping,Wong Po Keung,Ye Liqun
Advanced oxidation technology based on peroxonosulfate (PMS) has attracted extensive attention in water treatment research due to its fast reaction speed and wide pH range adaptability. Cobalt-based catalysts are considered to be one of the most effective reagents for PMS activation in various PMS activation methods. However, Co-ion leaching and difficulty in recovery have greatly hindered its practical applications. Herein, we developed a robust membrane constructed by nitrogen-doped carbon nanotubes embedded with cobalt nanoparticles (Co-NC) to concurrently address the Co-ion leaching and recovery issues. Based on our customization, continuous water flow reactor, the Co-NC membrane exhibited excellent catalytic activity and stability, in which it demonstrated a remarkable sterilization efficiency of 99.9999% against E. coli , and it retained a superior stability of 96.29% after 40 repeated cycles. Fewer attempts to put such efficient heterogeneous advanced oxidation processes (AOPs) into practical application, to mimic real-life applications, the performance of the Co-NC/PMS system was extended to the water taken from Qiuxi River. Remarkably, there is no deterioration in performance over 12 h of continuous real sewage processing. Mechanistic studies revealed that abundant high-valence metals (Co IV =O) were generated in the system, which can attack and penetrate into the cell membrane to destroy its intracellular defense system. This work provides useful insights into designing robust membranes with superior efficiency and stability for PMS-based advanced oxidation technology.
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POLYMER BULLETIN
·
2023
·
IF 3.2
Zhu Fen,She Xiao,Huang Huabo,Zhang Zhanhui,Ji Jiayou,Li Liang
Stable polypyrrole (PPy)-based hydrogels as soft conducting materials are ideal in wearable electronics and elastic robotics. The development of high-performance PPy-based hydrogels is greatly desired due to the poor mechanical properties of PPy hydrogel. Here, multifunctional stable conducting hydrogels are fabricated by immersing the preprepared brittle PPy hydrogel into polyvinyl alcohol (PVA) solution followed by freeze–thaw cycles. The extensive hydrogen bonding between PPy and PVA and the entangled PVA chains further support the backbone structure of the interconnected PPy network, improving the mechanical performance of the hydrogel. PPy/PVA hydrogel exhibits attractive mechanical property with a compression strength of 70 kPa, satisfactory electrical conductivity (10 S m −1 ), good processability, and self-healing features. PPy/PVA/100 still retained a recovery rate of more than 90% even after 1000 cycles of 30% compression strain. Furthermore, the as-prepared hydrogel is applied to show high-quality electrochemical behavior of 120 F/g subjected to repeated compression and an electrically controlled release of fluorescein sodium with 0.70 μg/mg at − 1 V for 12 h. This facile method supplies a promising strategy to fabricate soft materials with integrated electrical and mechanical properties for the potential applications in wearable devices and flexible energy electronics.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·
IF 4.3
Chen Yi,Jiang Cailing,Huang Feixiang,Yu Zizhen,Jiang Li
Combining the unique advantages of two-dimensional transition metal carbon/nitrogen compounds (MXene) and the excellent surface-enhanced Raman scattering (SERS) performance of noble metal materials, MXene/Ag NPs films were proposed as nanocarriers for SERS-traceable drug delivery. The films were prepared by two-step self-assembly on positively charged silicon wafers using virtue of the high evaporation of ethyl acetate, the Marangoni effect, and an oil/water/oil three-phase system. With 4-mercaptobenzoic acid (4-MBA) as the probe molecule, the SERS detection limit was 10 −8 M and had shown a good linear relationship in the range of 10 −8 –10 −3 M. Simultaneously, the film had good uniformity, repeatability, and stability. When Ti 3 C 2 T x /Ag NPs films were used as nanocarriers, the anticancer drug doxorubicin (DOX) was loaded onto the surface through 4-MBA, and the tracking and monitoring were realized by SERS. The addition of glutathione (GSH) triggered the thiol exchange reaction, resulting in the shedding of 4-MBA from the surface of the film, which indirectly achieved the efficient release of DOX. Furthermore, the loading of DOX and the drug release effect triggered by GSH maintained a certain stability in serum, which provided a potential possibility for the subsequent loading and release of drugs by films with three-dimensional structures as scaffolds in biological therapy. Graphical abstract
Self-assembled MXene/Ag NPs film nanocarriers for SERS-traceable drug delivery and GSH-triggered high-efficiency drug release
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Advanced Fiber Materials
·
2023
·Vol. 5
·期 5
·1759-1772
·
IF 16.1
Zheng Yun,Man Zengming,Zhang Yang,Wu Guan,Lu Wangyang,Chen Wenxing
Stretchable supercapacitors (S-SCs) are of considerable interest as prospective energy-storage devices for wearable electronics and smart products. However, achieving high energy density and stable output under large deformations remains an urgent challenge. Here, we develop a high-performance S-SC based on a robust heterostructured graphene–polyaniline (G-PANI) anchored hierarchical fabric (G-PANI@pcPU). By precisely manipulating centrifugal electrospinning and PANI-induced two-step self-assembly process, the G-PANI@pcPU features an inter-linkage porous backbone, which open ions migration/intercalation pathways, high mechanical flexibility (elongation: 400%), and large production area (> 90 cm 2 ). The resultant G-PANI@pcPU presents ultra-large specific areal capacitance ( C areal ) of 5093.7 mF cm −2 (about 35 mg cm −2 mass loading of G-PANI) and redox reversibility in 1 M H 2 SO 4 electrolyte. Additionally, the G-PANI@pcPU fabric-based solid-state S-SCs show a high energy density of 69.2 μWh cm −2 and capacitance of 3113.7 mF cm −2 . More importantly, the superior stretchable stability (84.1% capacitance retentions after 5000 cycles) and foldable performance (86.7% capacitance retentions after 5000 cycles) of S-SCs are impressively achieved. Finally, the S-SCs realize potential applications of steady powering light-emitting diode (LED) lights at 100% strain, smart watch at bending deformation, toy car, and lamp. This work can offer an overwhelming foundation for designing advanced flexible electrodes toward new energy and smart wearable applications. Graphical Abstract
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