ACS Applied Materials & Interfaces
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2026
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IF 7.8
Linqing Wang,Huahui Zhao,Jun Li,Siyu Wang,Shi Zhou,Xiaoyi Chen,Jiali Liu,Li Yang,Hong Liu,Xianyou Wang
All-solid-state fluoride-ion batteries (ASSFIBs) integrate high theoretical energy density, high safety characteristics, and low manufacturing costs, making them a promising candidate for next-generation energy storage technologies. However, the intrinsic shortcomings of high-performance fluoride-ion solid electrolytes severely limit their practical application. Herein, a potassium/strontium dual-doping strategy is designed to synthesize the fluoride-ion conductor β-Pb0.88Sr0.08K0.04F1.96 with a fluorite structure via a straightforward solid-state reaction method. It has been found that KF doping can introduce abundant fluorine vacancy defects to effectively enhance vacancy concentration, while SrF2 and PbF2 can form a continuous solid solution that not only disperses fluorine vacancies generated by K+ doping and suppresses defect aggregation to significantly enhance phase stability, but also induces moderate lattice distortion through the incorporated Sr2+. Through reconfiguration of the local coordination environment of F–, the electrostatic interaction between F– and Pb2+ can be weakened, thereby reducing the ionic migration energy barrier. Owing to the higher vacancy concentration and lower migration barrier, the as-prepared material exhibits a high ionic conductivity of 4.77 × 10–4 S·cm–1 at room temperature, exceeding most reported fluoride ion conductors. ASSFIBs assembled with the fluoride ion conductor as the solid electrolyte present a discharge specific capacity of approximately 132.5 mAh·g–1 over 400 cycles and a capacity retention rate of 97.4%. Therefore, this work offers unique insights into the rational design of PbF2-based solid electrolytes featuring both high ionic conductivity and exceptional phase stability.
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Frontiers in Bioengineering and Biotechnology
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2026
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IF 5.8
Adilai Abula,Kudelaiti Abudukelimu,Yueying Pan,Zilalai Ainiwaer,Boling Li,Xin Yuan,Hongbin Dong,Maihefuzi Aishan
Objective This study evaluated and compared the efficacy of five scaffold materials—AP (Antler Powder)/CS (Chitosan)/β-GP (β-Glycerophosphate)/PVA (Polyvinyl Alcohol) composite scaffold with Platelet-Rich Fibrin (PRF), the same scaffold without PRF, an AP/PVA scaffold, PRF gel alone, and Bio-Oss® bone powder—in repairing periodontal bone defects and promoting periodontal tissue regeneration. Methods Fifty-four New Zealand White rabbits were randomly divided into six groups (n = 9/group). A unilateral periodontal bone defect model was established in each rabbit. The defects were treated as follows: (1) AP/CS/β-GP/PVA-PRF composite scaffold; (2) AP/CS/β-GP/PVA scaffold; (3) AP/PVA scaffold; (4) PRF gel; (5) Bio-Oss® (positive control); and (6) no implantation (blank control). Three rabbits per group were sacrificed at 4, 8, and 12 weeks postoperatively. Outcomes were assessed via gross observation, radiographic imaging, and histological analysis. Quantitative measurements included newly formed alveolar bone area, periodontal ligament width, and mineralization degree within the defect area. Results Gross observation revealed normal gingival color, contour, and texture, with probing depths ≤1 mm in all implanted groups, including the Bio-Oss® group. In contrast, the blank control group exhibited reduced alveolar bone height and 2–3 mm of gingival recession by 8 weeks. Radiographic analysis at 4, 8, and 12 weeks demonstrated continuous bone regeneration in all implanted groups, which showed significantly superior repair outcomes compared to the blank control (P < 0.05). Histologically, all implanted groups displayed the formation of cementum-like tissue, periodontal ligament-like fibers, and alveolar bone-like tissue on the root surface, with progressive maturation over time. Statistical analysis (one-way ANOVA with post hoc tests) indicated that at 12 weeks, the AP/CS/β-GP/PVA-PRF composite scaffold achieved significantly better regenerative outcomes than the blank control, the Bio-Oss® positive control, and the other three experimental groups (P < 0.05). Conclusion The AP/CS/β-GP/PVA-PRF composite tissue-engineered scaffold significantly promotes periodontal tissue regeneration and bone mineralization in periodontal bone defects, which shows good clinical application potential for periodontal defect repair.
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Dandan Chen,Yang Ding,Zhihui Feng,Lei Hu,Yupeng Tian,Jiahan Cheng,Xiaohe Tian
Methylglyoxal (MGO), a reactive dicarbonyl metabolite generated during glycolysis, has been implicated in oxidative stress and neuroinflammation associated with Alzheimer’s disease (AD), but its spatial relationship with amyloid-β (Aβ) pathology in brain tissue remains incompletely characterized. Here, we report two cyclometalated iridium(III) complexes, Ir-MA and Ir-DA, for reaction-based phosphorescent sensing of MGO. Ir-DA contains an ortho-diamino recognition unit that reacts with MGO to form the quinoxaline product Ir-DA-Qx, producing a pronounced phosphorescence turn-on response consistent with attenuation of photoinduced electron-transfer-mediated quenching. Compared with the mono-amino analogue Ir-MA, Ir-DA exhibited a preferential response toward MGO over structurally related dicarbonyl species under the tested conditions, with a regression-derived detection limit of 0.32 μM and nonlinear optical properties suitable for multiphoton imaging. Ir-DA enabled imaging of exogenous and endogenous MGO-related changes in living cells and revealed increased phosphorescence signals under inflammatory and amyloidogenic stress. In APP/PS1 mouse brain sections, Ir-DA-associated signals were elevated at 6 months relative to wild-type controls and further increased at 12 months, with quantitative colocalization analysis demonstrating a close spatial association with Aβ-positive plaque core and peri-plaque regions. Collectively, these results establish Ir-DA as a reaction-based phosphorescent platform for imaging MGO-associated carbonyl stress and provide quantitative imaging evidence linking MGO dysregulation with amyloid pathology.
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FOOD AND BIOPRODUCTS PROCESSING
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2026
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IF 4.7
Lei Hao,Can Wang,Jin Mao,Baocai Xu,Jie Shi
Developing efficient delivery vehicles for hydrophobic nutrients remains a critical challenge due to the poor stability of conventional emulsifiers. This study fabricated an innovative bovine serum albumin fiber-succinate cyclodextrin (BSAF-SACD) complex via electrostatic complexation to stabilize Pickering emulsions for β-carotene delivery. Zeta potential analysis identified the optimal complexation conditions at a mass ratio R=2 and pH 5.0, where cationic BSAF interweaves with anionic SACD to form a cross-linked protective network. Microstructural and structural analyses confirmed that this matrix effectively integrates protein fibril rigidity with the inclusion capabilities of modified cyclodextrin. Compared to BSAF-stabilized emulsions, the dual-functional BSAF-SACD emulsions exhibited significantly enhanced performance, showing 5.5% increase in β-carotene retention after 35 days of storage and 6.0% improvement in UV photostability. Furthermore, in vitro gastrointestinal digestion models demonstrated that the complex network provided pH-responsive release, ultimately leading to 10.7% increase in β-carotene bioaccessibility. Overall, this work provides a sustainable and innovative approach for constructing multi-component protein-polysaccharide interfacial assembly systems, advancing the formulation of functional foods and targeted bioactive delivery systems.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Haolin Li,Zhen Ren,Luyao Yu,Xuan Liu,Lei Wang,Yusen Yang
The selective oxidation of furfural to succinic acid represents a promising route for producing biobased polymer precursors. This work develops an efficient and stable H2SO4-modified β-zeolite catalyst for succinic acid production. Systematic screening revealed that treatment with 0.25 M H2SO4 for 60 min yielded the optimal catalyst (β-H2SO4-60), achieving 99% furfural conversion and 75.1% succinic acid selectivity. Comprehensive characterization indicates that controlled acid treatment induced selective surface dealumination, transforming framework aluminum into extra-framework species. This process generates a high density of Lewis acid sites while maintaining a low Brønsted-to-Lewis acid ratio, which is conducive to the formation of succinic acid. Through a three-step purification process comprising rotary evaporation, dichloromethane extraction, and ethanol recrystallization, succinic acid powder with a high purity of 99.5% was successfully obtained. Coupled with a techno-economic analysis that confirms the economic viability of the biobased succinic acid production route, this work provides a holistic strategy from catalyst design to process integration for the sustainable production of biobased succinic acid.
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FOOD CHEMISTRY
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2026
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IF 10.4
Shixiao Wei,Shu Wang,Hao Zhang,Xiaowei Chen,Xing Qiao,Shangde Sun,Yanlan Bi,Mingfu Wang,Yueliang Zhao
The accumulation of toxic α,β-unsaturated aldehydes in lipid-rich foods poses significant safety risks. This study elucidated the formation patterns of nine aldehydes in bulk flaxseed oil versus oil-in-water (O/W) emulsions, while evaluating the inhibitory mechanisms of gallates. In simulated systems, acrolein-trapping capacity declined with increasing alkyl chain length due to steric hindrance. Crucially, in simulated lipid models, gallates failed to scavenge acrolein, proving their inhibitory effect in bulk oil relied solely on upstream antioxidant activity, with octyl gallate being most effective. Conversely, emulsions promoted a catastrophic 519-fold aldehyde surge and favored accumulation of toxic hydroxy-alkenals. The superior performance (85.5% inhibition) and rapid depletion of propyl gallate in emulsions suggested a more complex mechanism involving both interfacial antioxidant activity and potential carbonyl scavenging. These findings highlight that simply increasing lipophilicity of polyphenols does not guarantee the enhancement of their inhibitory effect on aldehydes accumulation, necessitating matrix-specific strategies.
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FOOD CHEMISTRY
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2026
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IF 10.4
Yantong Meng,Siqi Li,Keyi Zhou,Zhuoma Suonan,Zijian Dai,Qun Shen,Yong Xue
Dietary fibers-induced gut microbiota changes influence diabetes through bile acid metabolism. Oat β-glucan is a beneficial dietary fiber that improves glucose metabolism, but its mechanism of regulating gut microbiota-mediated bile acid metabolism and exerting hypoglycemic effects remains unclear. Here, we found that oat β-glucan improved glucose intolerance and insulin resistance and promoted glucagon-like peptide-1 (GLP-1) secretion in obese mice. The enhanced production of secondary bile acids such as lithocholic acid (LCA) and deoxycholic acid (DCA), which were associated with the enriched Faecalibaculum , norank_f_Muribaculaceae , Bifidobacterium and Akkermansia induced by oat β-glucan, were proven to promote GLP-1 secretion via inhibiting FXR. Simultaneously, succinic acid, which was elevated in fecal metabolites by oat β-glucan, was linked to enhanced intestinal gluconeogenesis and contributed to GLP-1 secretion. Overall, oat β-glucan modulated gut microbiota to increase secondary bile acids and succinic acid, thereby stimulating GLP-1 secretion to promote glucose metabolism in mice fed a Western diet.
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Food Quality and Safety
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2026
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IF 4.9
Lu Yanling,Bi Huimin,Feng Yiting,Yang Jiaojiao,Han Long,Guo Lei,Fan Fangyu
ObjectivesTo enhance the stability of proliposomes co-encapsulating Rosa roxburghii Tratt seed oil (RSO) and β-carotene (βC), sodium alginate (SA) and chitosan (CS) were utilized for bilayer surface modification. In this study, the proliposomes containing RSO and βC are referred to as Ps, while the modified formulations are denoted as sodium alginate–chitosan-modified proliposomes (SA-CS-Ps).Materials and methodsThe physicochemical properties, structural characteristics, thermal stability, microstructure, rheological behavior, storage stability, and oxidation kinetics of SA-CS-Ps were investigated and compared with those of unmodified Ps and CS monolayer-modified Ps (CS-Ps).ResultsThe particle size and turbidity of Ps increased with the addition of modification layers, reaching 563.73 nm and 0.697, respectively, for SA-CS-Ps. CS and SA formed a protective bilayer through electrostatic interactions, which preserved the spherical structure of Ps while enhancing its apparent viscosity and stress. Thermal stability analysis indicated that the phase transition temperatures of CS-Ps and SA-CS-Ps were elevated by 10.57 and 15.76 °C, respectively, compared with that of unmodified Ps. During storage, the retention rates (RRs) of RSO and βC followed the order SA-CS-Ps>CS-Ps>Ps, whereas malondialdehyde and peroxide values exhibited the opposite trend. Elevated temperatures accelerated oxidation, thereby compromising the protective effect of the carriers. After 24 d at 4 °C, SA-CS-Ps demonstrated superior stability, with malondialdehyde of 0.016 μg/mg, peroxide value of 2.697 mmol/kg, and RRs of RSO of 97.15% and βC of 96.37%. The oxidation kinetics conformed to a first-order reaction model.ConclusionsGiven its enhanced protection against degradation and stability, SA-CS-Ps represents a promising candidate for the delivery of sensitive bioactive compounds. This study provides a theoretical basis for the application of bilayer-modified proliposomes in functional food delivery systems requiring enhanced stability.
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Advanced Science
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2026
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IF 14.1
Hao Dong,Chuanliu Liu,Yiming Luo,Dongyu Si,Menghan Zhao,Fangyu Zhao,Yixue Zhang,Wei Zeng,Eman Ramadan Elsharkawy,Terence Xiaoteng Liu,Zeinhom M. El-Bahy,Hua Hou,Zhanhu Guo,Huige Wei
As the key sensing component of flexible sensors, conductive hydrogels are prone to mechanical property degradation and signal deterioration owing to water absorption and swelling in underwater environments. Herein, an anti-swelling ion-conducting hydrogels are designed by incorporating ferric chloride (FeCl 3 ) and β-cyclodextrin (β-CD) into acrylamide-acrylic acid copolymer (MA) via a one-pot method, short for MAF x D y . Thanks to the synergism of β-CD and Fe 3+ , the swelling ratio of MAF x D y is significantly reduced comparted to its counterparts, for example, 4% for MAF 0.2 D 0.3 , compared to 760% for MAF 0.2 hydrogel without β-CD and 526% for MAD 0.3 without Fe 3+ after soaking in deionized water for 30 days. Notably, the multimodal underwater sensor constructed based on the MAF 0.2 D 0.3 hydrogel can not only monitor underwater human joint motion but also realizes the accurate transmission of underwater information with the help of Morse code. Moreover, aided by machine learning algorithms, this study proposes a novel shortcut key recognition strategy to achieve precise and rapid information transmission via letter recognition (with a recognition accuracy of 98.6%), dramatically shortening the time required for underwater communication. This study provides innovative solutions by the rational design of anti-swelling ion-conducting hydrogels for reliable and fast underwater communications.
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Bioengineering & Translational Medicine
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2026
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IF 6.2
Lingyun Zhao,Anqi Li,Shijing Chen,Wei Hua,Ru Dai,Lingyu Pan,Meng Hu,Nan Huang,Runke Zhou,Yuanyuan Han,Lidan Xiong,Li Li
Stem cells and their paracrine factors hold promise for alopecia treatment, yet research on human skin-derived precursors (hSKPs), which are closely related to hair follicles in biological positioning and function, remains limited. We demonstrated that extracellular vesicles of human transformed skin-derived precursors (htSKP-EVs), harvested utilizing our directed induction, culture transition and gradient ultracentrifugation technology, exhibited superior efficiency and quality determined by transmission electron microscopy, nanoparticle tracking analysis, and detection of specific markers. Using CCK8, scratch assay, immunofluorescence, H&E staining, immunohistochemistry staining, dermoscope, qRT-PCR and Western blotting, it was found that htSKP-EVs significantly promoted the proliferation of hair follicle stem cells (hHFSCs) by effectively modulating the Wnt signaling pathway, thereby enhancing overall hair follicle growth. Notably, miR-221-3p, highly expressed in htSKP-EVs, suppressed DKK2 expression, activated the Wnt pathway in human dermal papilla cells (hDPCs), and induced hair follicles to enter and sustain the anagen phase, based on the aforementioned similar in vivo and in vitro experiments. These findings, validated in hHFSCs, hDPCs and human hair follicles in vitro and in a murine alopecia model in vivo, revealed the potential mechanism of htSKP-EVs in hair growth and identified a new therapeutic target for alopecia in regenerative medicine.
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JOURNAL OF PHARMACEUTICAL SCIENCES
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2026
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IF 3.9
Dexue Liu,Sajid Asghar,Dan Gao,Wenrong Li,Haijuan Dong,Tingmei LYU,Zhipeng Chen,Yanyu Xiao
Combination therapy, which integrates diverse treatment modalities to induce synergistic anti-tumor effects, has emerged as a promising strategy in oncology. In this study, we developed a near-infrared (NIR) laser-triggered nitric oxide (NO)-releasing and enzyme-sensitive targeted drug delivery system BNN6/EPI-HA@HP-PDA) for the synergistic treatment of breast cancer via combined chemotherapy, NO gas therapy, and photothermal therapy. The system was constructed based on polydopamine (PDA) nanoparticles modified with hyaluronic acid (HA) and hydroxypropyl-β-cyclodextrin (HP-β-CD), co-loaded with epirubicin (EPI) and the NO donor BNN6 (N, N'-di-sec-butyl-N, N'-dinitroso-1,4-phenylenediamine). The resulting spherical nanoparticles exhibited a uniform size of 180.26 nm and a zeta potential of -27.69 mV, with high drug loading and encapsulation efficiencies of 12.04% and 98.10% for EPI and 46.91% and 88.14% for BNN6, respectively. In vitro release studies confirmed nanoparticles’ responsiveness to hyaluronidase, pH, and NIR irradiation. Cellular assays revealed significantly enhanced cytotoxicity of BNN6/EPI-HA@HP-PDA in both MCF-7 and MCF-7/ADR cells, attributable to the combined effects of PDA-mediated hyperthermia, EPI-induced chemotherapy, and NO-mediated gas therapy. Pharmacokinetic evaluation showed a 4.62-fold increase in the area under the curve of BNN6/EPI-HA@HP-PDA compared to free EPI solution. In vivo experiments further demonstrated potent tumor growth inhibition (96.71%) in MCF-7/ADR tumor-bearing Balb/c mice treated with BNN6/EPI-HA@HP-PDA plus laser irradiation, with no detectable systemic toxicity. In general, BNN6/EPI-HA@HP-PDA presents a combination strategy of photothermal/gas/chemotherapy for the synergistic therapy of breast cancer.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2026
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IF 4
Ying Wang,Yi-Tong Du,Wen-Bo Yan,Zi-Tao Jiang,Jin Tan
BACKGROUND Cherry tomatoes are prone to postharvest deterioration and spoilage at room temperature, whereas chemical preservatives pose safety and environmental risks. Clove essential oil (CEO) has excellent antibacterial activity but is limited by high volatility, poor water solubility and dosage sensitivity. Cyclodextrin metal-organic frameworks (β-CD-MOFs) can improve CEO stability, but their poor processability and aqueous dispersibility hinder fruit preservation applications. Chitosan (CS), a natural hydrogel with film-forming and antibacterial properties, offers an ideal matrix to address these limitations. RESULTS A CEO-loaded CS/β-CD-MOFs composite coating (CS-CEO/MOFs) was constructed and evaluated on cherry tomatoes stored at 25 °C via physicochemical analysis, electronic eye color detection and texture profile analysis (TPA). Compared with control, CS and high-concentration CEO-chitosan (CS-CEO-H) groups, high-concentration CS-CEO/MOFs (CS-CEO/MOFs-H) delayed spoilage. Principal component analysis of electronic eye data showed the recognition index (a parameter reflecting the distinguishability of color characteristics among groups) increased from −3 (day 0) to 97–98 (days 6–21), indicating distinct inter-group ripening rate differences. TPA results indicated CS-CEO/MOFs-H slowed hardness decline (effect positively correlated with hydrogel concentration) and maintained higher soluble sugar, vitamin C and titratable acid contents, as well as reduced weight loss, extending room-temperature shelf life to 21 days. CONCLUSION The CS-CEO/MOFs coating combined the gas barrier property of CS and the controlled release capability of β-CD-MOF, forming a synergistic fresh-keeping mechanism. As a safe, natural preservative, it provides a promising solution to reduce cherry tomato postharvest losses and lays a foundation for the development of plant-derived composite preservatives with controlled-release and gas barrier synergistic properties. © 2026 Society of Chemical Industry.
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