Nano Research
·
2019
·Vol. 12
·期 7
·1733-1738
·
IF 8.515
Dong Lvming,Chen Zhuo,Ye Lei,Yu Yan,Zhang Jianbing,Liu Huan,Zang Jianfeng
Mn-doped all-inorganic perovskite quantum dots (QDs) provide prominent applications in the fields of low-cost light source or display, because of their remarkable properties including dual-color emission and reduced lead content, as well as high photoluminescence quantum yields (PLQYs) and high stability. However, the existing synthesis approaches usually require hash conditions, such as high temperature and nitrogen protection, which is a major hurdler for the practical manufacturing. In addition, the significantly high Mn substitution ratio in CsPbX 3 QDs is still challenging. The real dual-color emission with two strong emission peaks in the Mn-doped all-inorganic perovskite QDs has attracted great interest. Here we present a gram-scale approach to synthesize both CsPb x Mn 1− x Cl 3 and CsPb 1− x Mn x Cl y Br 3− y QDs at 100 °C in the air with high Mn substitution ratio, up to 55.64% atomically. The as-prepared CsPb 1− x Mn x Cl y Br 3− y QDs exhibit high PLQYs of 62.41% and dual-color emission with two strong emission peaks around at 400–450 nm and 600 nm, respectively. The enhanced peak at 400–450 nm is a result of the hybrid halides in CsPbBr x Cl 3− x host. Furthermore, the unique advantage of the optical emission and high PLQYs properties of the CsPb x Mn 1 − x Cl 3 QDs has been demonstrated as invisible ink for encryption applications and polymer composites. Our gram-scale synthesis approach for Mn-doped all-inorganic perovskite QDs may boost the future research and practical applications of QDs-based white LED, spintronics, and molecular barcoding.
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Nature Communications
·
2018
·Vol. 9
·期 1
·1-15
·
IF 12.353
Usman Waqas Muhammad,Pham Tin Chanh,Kwok Yuk Yan,Vu Luyen Tien,Ma Victor,Peng Boya,Chan Yuen San,Wei Likun,Chin Siew Mei,Azad Ajijur,He Alex Bai-Liang,Leung Anskar Y. H.,Yang Mengsu,Shyh-Chang Ng,Cho William C.,Shi Jiahai,Le Minh T. N.
Most of the current methods for programmable RNA drug therapies are unsuitable for the clinic due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could solve these problems because they represent a natural mode of intercellular communication. However, current cellular sources for EV production are limited in availability and safety in terms of horizontal gene transfer. One potentially ideal source could be human red blood cells (RBCs). Group O-RBCs can be used as universal donors for large-scale EV production since they are readily available in blood banks and they are devoid of DNA. Here, we describe and validate a new strategy to generate large-scale amounts of RBC-derived EVs for the delivery of RNA drugs, including antisense oligonucleotides, Cas9 mRNA, and guide RNAs. RNA drug delivery with RBCEVs shows highly robust microRNA inhibition and CRISPR–Cas9 genome editing in both human cells and xenograft mouse models, with no observable cytotoxicity.
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PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 7
·1-14
·
IF 1.434
Gao Yang,Tan Ni,Wang Juan,He Dianxiong,Ji Kang,Han Jingwen,Yan Xueming
Using hepatoprotective component silybin as the template, MAA as the functional monomer, EGDMA as the cross linker, acetonitrile as the solvent, and Fe 3 O 4 as the magnetic substrate, the silybin magnetic molecularly imprinted polymer(S-MIP) was successfully prepared by the reverse atom transfer radical precipitation polymerization(RATRP), and non-ion imprinted polymer(NIP) was also synthesized by the same procedure only in the absence of silybin. On the basis of computer simulation and L 9 (3 4 ) orthogonal array design matrix, the optimal preparation conditions were finally obtained as follows that the molar ratio of silybin, MAA, and EGDMA was 1:5:60. The prepared materials were respectively characterized by SEM, XRD, FT-IR, VSM and TGA, and the kinetic analyses explored that the adsorption process of S-MIP was better describled by the pseudo-second order kinetic equation, meanwhile, scatchard analysis illustrated that the heterogeneous binding sites existed in S-MIP. Both the selectivity factor α (2.232) and the relative selectivity factor β (2.201) of S-MIP showed the aim material had the excellent specific recognition capacity and selection adsorption property to silybin. Additionally, the recycling reuse experiments explored S-MIP was of a good stability and could be used repeatedly at least five times with only 15.8% decrease of adsorption capacity when applied in the fifth experiment, and the evaluation experiments by HPLC for silybin extraction from the medicinal herb milk thistle seeds indicated that S-MIP had the potential application in separating the natural hepatoprotective component silybin from the herbal plants.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2018
·Vol. 33
·期 3
·744-748
·
IF 0.524
Xu Renxin,Cheng Shixin,Zhou Jing,Shen Jie,Li Zheng,Tan Xing
A novel epoxy-imide resin based on diglycidyl ether of bisphenol-A and N-(4-hydroxyphenyl) terahydrophthalic anhydrideimide (HTAM) was synthesized. The structural characterization of the epoxy-imide resin was conducted by FT-IR spectra. 4,4’-diaminodiphneylmethane (DDM) was used as a curing agent for the epoxy-imide resin. The thermal properties of the cured resin were evaluated with dynamic mechanical analyses (DMA) and thermogravimetric analysis (TGA). The results showed that the cured resin exhibited a high glass transition temperature ( T g ) of 186 °C when the molar amount of HTAM was 0.04 mol in the resin. The yields of the cured resin at 800 °C raised from 16.45% to 19.41%. The flexural properties were also measured, the flexural strength raised from 79.4 to 95.7 MPa, and the flexural modulus exhibited from 2.6 to 3.0 GPa.
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
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2018
·Vol. 41
·期 9
·1347-1354
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IF 2.139
Tang Xiao-Ling,Liu Xiao,Suo Hui,Wang Zhi-Chao,Zheng Ren-Chao,Zheng Yu-Guo
The tyrosine phenol lyase (TPL) catalyzed synthesis of L-DOPA was regarded as one of the most economic route for L-DOPA synthesis. In our previous study, a novel TPL from Fusobacterium nucleatum ( Fn -TPL) was exploited for efficient biosynthesis of L-DOPA. However, the catalytic efficiency decreased when the reaction system expanded from 100 mL to 1 L. As such, the bioprocess for scale-up production of L-DOPA was developed in this study. To increase the stability of substrate and product, as well as decrease the by-product formation, the optimum temperature and pH were determined to be 15 °C and pH 8.0, respectively. The initial concentration of pyrocatechol, pyruvate and ammonium acetate was fixed at 8, 5 and 77 g/L and a fed-batch approach was applied with sodium pyruvate, pyrocatechol and ammonium acetate fed in a concentration of 5, 5 and 3.5 g/L, respectively. In addition, L-DOPA crystals were exogenously added to inhibit cell encapsulation by the precipitated product. The final L-DOPA concentration reached higher than 120 g/L with pyrocatechol conversion more than 96% in a 15-L stirred tank, demonstrating the great potential of Fn -TPL for industrial production of L-DOPA.
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高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 6
·1-9
·
IF 5.705
Wang Yong,Cao Wei,Wang Luyao,Zhuang Qianfen,Ni Yongnian
A metal organic framework (MOF) of the type copper(II)-1,3,5-benzenetricarboxylic acid (Cu-BTC) was electrodeposited on electroreduced graphene oxide (ERGO) placed on a glassy carbon electrode (GCE). The modified GCE was used for highly sensitive electrochemical determination of 2,4,6-trinitrophenol (TNP). The fabrication process of the modified electrode was characterized by scanning electron microscopy and electrochemical impedance spectroscopy. Differential pulse voltammetry (DPV) demonstrates that the Cu-BTC/ERGO/GCE gives stronger signals for TNP reduction than Cu-BTC/GCE or ERGO/GCE alone. DPV also shows TNP to exhibit three reduction peaks, the first at a potential of −0.42 V (vs. SCE). This potential was selected because the other three similarly-structured compounds (2-nitrophenol, 4-nitrophenol, 2,4-dinitrophenol) do not give a signal at this potential. Response is linear in the 0.2 to 10 μM TNP concentration range, with a 0.1 μM detection limit (at S/ N = 3) and a 15.98 μA∙μM −1 ∙cm −2 sensitivity under optimal conditions. The applicability of the sensor was evaluated by detecting TNP in spiked tap water and lake water samples. Recoveries ranged between 95 and 101%.
Schematic presentation of an electrochemical sensor that was fabricated by electrodeposition of the metal-organic framework (MOF) of copper(II)-1,3,5-benzenetricarboxylic acid (Cu-BTC) onto the surface of electroreduced graphene oxide (ERGO) modified glassy carbon electrode (GCE). It was applied to sensitive and selective detection of 2,4,6-trinitrophenol (TNP).
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2018
·Vol. 20
·期 6
·1-9
·
IF 2.127
Wu Xiang-Feng,Li Hui,Su Jun-Zhang,Zhang Jia-Rui,Feng Yan-Mei,Pan Jun-Cheng,Zhang Ying,Sun Li-Song,Zhang Wei-Guang,Sun Guo-Wen
The In 2.77 S 4 microspheres had been firstly fabricated by using polyethylene glycol (PEG) as the morphological modifier and then used to hybridize with In(OH) 3 nanocubes by a simply depositional method. The structure, optical properties, morphology, chemical compositions, and charge carrier behaviors of the as-prepared In 2.77 S 4 /In(OH) 3 composites were characterized, respectively. The methyl orange, tetracycline, rhodamine B, and Cr(VI) dilute solution were selected to evaluate their photocatalytic activities. Experimental results showed that In(OH) 3 nanocubes could improve the photocatalytic activity and recyclability of the In 2.77 S 4 microspheres under the visible light irradiation. With the usage of In(OH) 3 increased, the photocatalytic efficiency of the hybrids was firstly increased and then decreased. When the mass ratios of In 2.77 S 4 to In(OH) 3 were 6:2, it reached the maximum of 100% in 15 min for methyl orange, obviously higher than 67.4% of In 2.77 S 4 and 1.1% of In(OH) 3 . Meanwhile, it could also oxidize 85.6% of tetracycline in 20 min, 97.8% of rhodamine B in 7.5 min, and reduce 92.9% of Cr(VI) in 30 min under the visible light irradiation. Moreover, it could still degrade 91.7% of methyl orange solution after 3 cycles, which was much higher than 40.7% of In 2.77 S 4 microspheres. In addition, the possible mechanism of enhancing photocatalytic properties was proposed.
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高影响因子
CELLULOSE
·
2018
·Vol. 25
·期 6
·3189-3196
·
IF 3.809
Lv Pengfei,Zhou Huimin,Zhao Min,Li Dawei,Lu Keyu,Wang Di,Huang Jieyu,Cai Yibing,Lucia Lucian Amerigo,Wei Qufu
A simple, rapid method for developing conductive, ultrafine, and high aspect ratio silver nanowires (AgNWs) is reported. Transparent and flexible nanocomposites were fashioned from bacterial cellulose (BC) and AgNWs in a very straightforward and direct manner without the addition of materials or the need for specific facilities. The as-prepared BC/AgNWs composite thin films were able to demonstrate acceptable transparency (near 80% at 550 nm), high flexibility, good mechanical strength (18.95 MPa) and stable conductivity (7.46 Ω sq −1 ) under various bending states.
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高影响因子
CELLULOSE
·
2018
·Vol. 25
·期 6
·3533-3544
·
IF 3.809
Yang Jin,Xia Yunfei,Xu Peng,Chen Beibei
Abstract To overcome the poor mechanical properties of biomass aerogels in oil/water separations, three different freeze-casting methods were used including direct freezing, unidirectional freezing, and bidirectional freezing with sodium alginate (SA) aerogels reinforced with cellulose nanofibrils (CN). After chemical crosslinking and silane modification, compression testing revealed that the SA/CN aerogels with parallel lamellar microstructures prepared by bidirectional freezing exhibited super-elasticity with the minimal energy dissipation of ~ 0.04 in each cycle, a maximum compressive stress of 80.4 kPa, and minimal plastic deformation at ~ 4.15%. Additionally, the water and oil contact angle of the surface of the lamellar SA/CN aerogel was 148.7° and 0°, respectively. By combining the super-elasticity and hydrophobicity/superoleophilicity, the lamella SA/CN aerogels could be reused for the separation of oil/water mixture with oil absorption capacities up to 34 times its weight. Furthermore, the lamellar SA/CN aerogel could continuously separate oil/water mixtures with the assistance of a pump. Therefore, the present study offers a simple and environmentally friendly method for fabrication of super-elastic and hydrophobic/superoleophilic biomass aerogels that are applied to continuous removal of oil from water. Graphical Abstract
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高影响因子
IONICS
·
2018
·Vol. 24
·期 12
·4055-4061
·
IF 2.347
Wu Kezhong,Zhao Jiajing,Xiong Yuanyuan,Ruan Bei,Wu Mingxing
Pt-free composite counter electrode (CE) composed of La 2 O 3 was successfully synthesized by a simple pyrolysis of Lanthanum acetate hydrate (La(CH 3 COO) 3 ·xH 2 O) in a high-temperature solid phase. Furthermore, three proportion composite catalysts of La 2 O 3 @MWCNTs based on La 2 O 3 and multiwall carbon nanotubes (MWCNTs) were prepared and characterized as Pt-free catalysts for CE in dye-sensitized solar cells (DSSCs). The morphology and structure of La 2 O 3 @MWCNT composites were determined by scanning electron microscopy and X-ray diffraction. The electrochemical performance of La 2 O 3 @MWCNT composite catalysts for CEs was determined by photocurrent-voltage measurements, cyclic voltammetry, electrochemical impedance spectroscopy, and Tafel polarization. The experimental results showed that the power conversion efficiencies of 5.20, 5.12, and 4.70% were obtained for La 2 O 3 : MWCNTs with mass ratios of 5:1, 3:1, and 1:1 as counter electrode towards the reduction of I 3 − /I − ions respectively in the encapsulation of DSSC batteries, which were higher than that of MWCNTs (3.94%) and La 2 O 3 (0.77%) electrode under the similar conditions. The enhanced electrode performance was attributed to relatively larger surface area and higher conductivity of La 2 O 3 @MWCNT composite catalysts.
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COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 2
·249-260
·
IF 1.906
Zou Hongyun,Tang Dongyan,Wang Ning,Jia Shuyue,Sun Zhaojie,Yang Xu,Peng Jing
Molybdenum oxide, as one of the important transition metal semiconductor materials with photothermal property, has received increasing attention in the field of catalysis, sensing, energy storage, and clinical biomedicine. To improve its certain limitations such as poor biocompatibility and easy agglomeration during application as biomaterials and promote its performance as photothermal agent in biomedical fields, polyethylene glycol (PEG)–modified molybdenum oxide was synthesized and the synthesis conditions during the hydrothermal process, including the pH values and the amount of PEG added, were adjusted. Owing to the reduction function of PEG, as-obtained PEG-MoO x showed good photostability and colloidal stability, which were beneficial to its application in long-term clinical photothermal therapy. In addition, cell experiments indicated that PEG-MoO x particles exhibited low cytotoxicity and ability of photothermal killing for HeLa cells. With the increase PEG-MoO x particles in solution, the photothermal ablation ability of PEG-MoO x particles for the HeLa cells was enhanced under an 808-nm NIR laser irradiation. Hence, PEG-MoO x particles have great potential in the photothermal treatment of diseases.
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CELLULOSE
·
2019
·Vol. 26
·期 4
·2715-2728
·
IF 3.917
Huang Shuo,Zhong Ling,Li Shengnan,Liu Mingsheng,Zhang Zhao,Zhang Fengxiu,Zhang Guangxian
Abstract A novel bio-based flame retardant ammonium salt of sodium glutamate tetramethylenephosphonic acid (ASGTMPA) was synthesized for cotton. The structure of ASGTMPA was characterized by nuclear magnetic resonance. When the concentration of ASGTMPA was 30%, the limit oxygen index of treated cotton fabric reached 39.5% and was 26.3% after 50 laundering cycles. TG and TG-IR results suggested that ASGTMPA-treated cotton remarkably promoted dehydration of cellulose to form char and reduced production of flammable volatiles. Cone calorimetry and thermogravimetry tests indicated that the ASGTMPA-treated cotton fabric had a lower decomposing temperature and promoted char formation, with peak heat release rate and total heat release lower than those of unfinished cotton fabrics. In a vertical flammability test, the treated cotton fabric showed no after-flame or after-glow, and the char length was 35 mm. The Fourier-transform infrared spectra showed that ASGTMPA combined with cellulose through P–O–C and –COOC– covalent bonds. SEM images revealed that the morphologies of the original and treated cotton fibers were similar. Graphical abstract
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高影响因子
危险品化学品经营许可证（带存储）