Progress in Biomaterials
·
2023
·Vol. 12
·期 2
·75-86
·
IF 4.9
Jafarimanesh Mohammad Amin,Ai Jafar,Shojaei Shahrokh,Khonakdar Hossein Ali,Darbemamieh Goldis,Shirian Sadegh
Hydrogels have been increasingly applied in tissue regeneration and drug delivery systems (DDS). In this study, the capacity of valproic acid (Val) encapsulated within hybrid of alginate (Alg)-chitosan (Cs) (Alg-Cs) hydrogel containing Cs nanoparticle (Npch) with/without human endometrial stem cells (hEnSC) was initially examined for regeneration of spinal cord injury (SCI). To evaluate the stability of the synthesized hydrogels zeta potential necessary measurements were made. Physicochemically, the developed hydrogels were evaluated using Fourier-transform infrared (FTIR) spectroscopy. The physical properties including degradation rate, swelling ability, and tunability of the synthesized hydrogels were studied. To evaluate the nerve regeneration ability of the synthesized hydrogels, 35 Sprague–Dawley rats were undergone SCI. The spinal cords were exposed using laminectomy in T9-T10 area and the hemi-section SCI model was made. The rats were then randomly divided into 5 groups ( n = 7) including, Alg-Cs/Npch, Alg-Cs/Npch/hEnSCs, Alg-Cs/Npch/Val, and Alg-Cs/Npch/hEnScs/Val, and the control groups without any intervention. The FTIR spectra showed band frequencies and assignments of Val, Alg-Cs, and alginate. Nanoparticles were formulated with a mean diameter of 187 and 210 nm, for Val/Alg-Cs and Alg-Cs, respectively. The loading of Val into Alg-Cs led to its reduced size by about 40 nm. The Cs-Npch/Val hydrogels degraded faster than the Alg-Cs-/Npch/Val hydrogel specifically in extended time of incubation. A higher swelling capacity of Alg-Cs/Npch hydrogel, compared to Cs/Npch/Val and Alg-Cs/Npch/Val hydrogels, was found. The Cs-Npch/Val hydrogels degraded faster than Alg-Cs-/Npch/Val hydrogel. The Alg-Cs/Npch/hEnSCs/Val could regenerate the damaged nerve fibers and histologically prevent the SCI-induced vacuolization spaces. The prepared Alg-Cs/Npch/Val could be a suitable polymeric carrier for taurine drugs as bioactive substrate in nerve tissue engineering (NTE) and DDS.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2023
·Vol. 13
·期 1
·1-16
·
IF 4.6
Shen Shaohang,Wei Hua,Pan Yu,Hu Pan,Yang Hu
Coagulation/flocculation is one of the most widely used and cost-effective pretreatment methods for improving the dewaterability of sludge. In this study, a cationic modified starch-based flocculant (St-CTA) in conjunction with a popular clay, attapulgite (ATP), was used for the conditioning of waste-activated sludge. The dewatering properties, including the filter cake moisture content, filtration specific resistance, capillary suction time, filtration rate and compressibility coefficient, were measured and compared by varying the doses of St-CTA and ATP. By combination of the apparent dewatering performance and the changes in the contents and distributions of the extracellular polymeric substance (EPS) fractions and components, sludge flocs, and microstructures of sludge cakes, the dewatering mechanisms were discussed in detail. St-CTA in conjunction with ATP can exhibit an enhanced dewaterability of sludge and the water content in final sludge cake can be stably reduced below 80% owing to the synergistic effects of St-CTA and ATP. In addition to the efficient charge neutralization of St-CTA, ATP not only acts as a skeleton builder in the sludge dewatering process which makes the sludge flocs more compact and improves the filterability and permeability, but also tightly interacts with the proteins in EPS of the sludge which reduces the protein content and further enhances the dewatering effect. This study provides an economical, green, and effective way to further improve the dewaterability of sludge.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2023
·Vol. 153
·期 12
·3724-3733
·
IF 2.8
Tan Xiao,Chen Hao,Shi Libin,Lu Qinghua,Qi Suitao,Yi Chunhai,Yang Bolun
Hydroxyapatite (HAP) supported Rh, Fe, and Rh-Fe catalysts were prepared by impregnation, and the synergy effects between the catalyst and NTP (non-thermal plasma) on N 2 O catalytic decomposition were also investigated. CO 2 -TPD results show that HAP synthesized at high pH have a greater number of surface alkaline sites and promoted the adsorption of N 2 O. RhFe/HAP-11 catalyst exhibited 95.9% activity for the direct catalytic decomposition of N 2 O at 350 °C. Combining NTP with the RhFe/HAP-11 catalyst can significantly enhance the catalytic decomposition of N 2 O and greatly reduce the reaction temperature. The one-stage combination method enables the radicals generated by the plasma to participate in the reaction immediately on the catalyst surface, so it is more conducive to the N 2 O catalytic decomposition in the range of 150–200 °C. When NTP is applied, N 2 O conversion on RhFe/HAP-11 at 200 °C increases a lot from 7.1 to 90.0%. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
PSYCHOPHARMACOLOGY
·
2023
·Vol. 240
·期 4
·881-897
·
IF 3.4
Chen Yanming,Xiao Xinyi,Huang Chaonan,Zhu Jin,Zhou Huiling,Qin Huimin,Bao Yu,Zhuang Tao,Zhang Guisen
Rationale Drug combinations are commonly used in pain management, which can produce potent analgesic effects with reduced dosage and adverse effects. Objective This study was designed to evaluate the anti-nociceptive effects and adverse effects of new combinations of flupirtine (a Kv7 potassium channel opener) and antihistamines (promethazine, fexofenadine) on acute and chronic pain in mice, and the possible mechanisms behind the synergistic analgesic effects were preliminarily investigated. Methods In acetic acid writhing test, carrageenan-induced inflammatory pain model, and paclitaxel-induced neuropathic pain model, the interaction indexes ( γ ) between flupirtine and antihistamines were determined by isobolographic analysis. Furthermore, the Kv7 channel blocker XE991 was used to determine whether the effects of single agents and drug combinations on paclitaxel- and carrageenan-induced mechanical allodynia were mediated by Kv7 channels. Finally, hepatotoxicity markers, liver histopathology, and the rotarod test were used to investigate the adverse effects of drugs in combination doses. Results The interaction indexes of flupirtine-promethazine and flupirtine-fexofenadine in all the above three pain models were lower than 1. The analgesic effects of flupirtine (13 mg/kg), promethazine (5 mg/kg), fexofenadine (20 mg/kg), and their combinations were antagonized significantly by XE991 (3 mg/kg). And the adverse effects of flupirtine and antihistamines in combination doses were not significantly different from the vehicle group. Conclusions Flupirtine and antihistamines produced synergistic analgesic effects in all the above pain models. The analgesic effects of antihistamines were partially mediated by Kv7/M channels, and the activation of Kv7/M channels may be partly responsible for the synergistic analgesic effects between flupirtine and antihistamines.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Jia Mutian,Wang Yuanyuan,Wang Jie,Qin Danhui,Wang Mengge,Chai Li,Fu Yue,Zhao Chunyuan,Gao Chengjiang,Jia Jihui,Zhao Wei
Stimulator of interferon gene (STING)-triggered autophagy is crucial for the host to eliminate invading pathogens and serves as a self-limiting mechanism of STING-induced interferon (IFN) responses. Thus, the mechanisms that ensure the beneficial effects of STING activation are of particular importance. Herein, we show that myristic acid, a type of long-chain saturated fatty acid (SFA), specifically attenuates cGAS-STING-induced IFN responses in macrophages, while enhancing STING-dependent autophagy. Myristic acid inhibits HSV-1 infection-induced innate antiviral immune responses and promotes HSV-1 replication in mice in vivo. Mechanistically, myristic acid enhances N-myristoylation of ARF1, a master regulator that controls STING membrane trafficking. Consequently, myristic acid facilitates STING activation-triggered autophagy degradation of the STING complex. Thus, our work identifies myristic acid as a metabolic checkpoint that contributes to immune homeostasis by balancing STING-dependent autophagy and IFN responses. This suggests that myristic acid and N-myristoylation are promising targets for the treatment of diseases caused by aberrant STING activation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 2
·1-10
·
IF 2.8
Guan Yeqing,Zhang Jinxian,Wang Fenglin,Li Wei,Mao Haijun,Liu Zhuofeng,Zhang Weijun,Chen Xingyu
The Ca 0.245 Li 0.325 Nd 0.395 Ti 1− x Sn x O 3 ( x = 0–0.12) ceramics were prepared by the traditional solid-state reaction method. The effects of Sn 4+ substitution for Ti 4+ on the phase composition, microstructure, and microwave dielectric properties of Ca 0.245 Li 0.325 Nd 0.395 Ti 1− x Sn x O 3 (CLNTS x ) were investigated in this work. The X-ray diffraction results showed that the ceramics had a single orthorhombic perovskite structure when x = 0–0.09. However, a secondary phase SnO 2 was observed with x > 0.09. The SEM micrographs indicated that the proper Sn 4+ substitution for Ti 4+ promoted the grain growth and homogenization. The analysis results of Raman spectroscopy revealed the correlation between vibration modes and microwave dielectric properties of CLNTS x ceramics with different Sn 4+ contents. The degree of cation order was related to the full width at half maximum (FWHM) of the Raman spectrum, and a lower FWHM value indicates higher cationic order and Q × f 0 value. The excellent microwave dielectric properties with ε r = 98, Q × f 0 = 3320 GHz, and τ f = 2.6 ppm/°C were obtained in the ceramics with x = 0.09 sintered at 1350 °C for 4 h.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 4
·1523-1537
·
IF 4.5
Zhang Dongqing,Yu Xiaoguang,Zhang Feng,Liu Wenqi,Miao Jiyuan,Li Xiaojin
High-temperature proton exchange membranes (HTPEMs) based on arginine-modified phosphoric acid-doped polybenzimidazole (Arginine-PBI-PA) and poly(tetrafluoroethylene) phosphoric acid-doped polybenzimidazole (PTFE-Arginine-PBI-PA) were fabricated and characterized for fuel cell applications. Arginine as filler was used to prepare HTPEMs for the first time, and the Arginine-PBI-PA membrane exhibited an excellent proton conducting ability with 24.1 mS cm −1 at 160 °C while maintaining mechanical strength. Furthermore, Arginine-PBI-PA composite membrane was also appropriate for membrane electrode assemblies (MEAs), and it exhibited better fuel cell performances (0.68 V@400 mA cm −2 ) compared with the PBI-PA membranes prepared. Molecular dynamics (MD) simulation revealed that the better electrochemical properties of Arginine-PBI-PA membranes over PBI-PA membranes were ascribed to the strong interactions between the basic sites and carboxyl groups of arginine and PA molecules, respectively. In addition, the higher proton conductivity for Arginine-PBI-PA membranes was attributed to the formation of a tighter H-bonding network and the interaction between arginine non-protonated oxygen (O) and PA protons (HPA). Graphical Abstract
Experimental investigation and molecular dynamics simulation of novel arginine/PBI composite membranes for high temperature PEM fuel cells
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 2
·1-10
·
IF 2.8
Gao Lingxiang,Zhang Hao,Liu Wen,Zhang Shulong,Xie Zunyuan
In this study, electro and magneto dual response of TiO 2 @Fe 3 O 4 composite nanoparticles is realized by situ-generating Fe 3 O 4 , which was synthesized by FeCl 3 and FeSO 4 , on rose-like TiO 2 pore in virtue of facile hydrothermal reaction. Morphology, structure and physical properties, such as dielectric constant and magnetic conductivity, of the TiO 2 @Fe 3 O 4 composite particles were characterized. The particles were dispersed in hydrous elastomer to measure their electro and magneto responsive property by the scanning electron microscopy of micro structure of hydrous elastomer and dynamic mechanical analysis that reflected by the sensitivity of the increase in storage modulus ( f = ∆ G / G ) of the hydrous elastomer cured in the absence/presence of external field. The one of the TiO 2 @Fe 3 O 4 particles consisting of the ratio of TiO 2 :Fe 3 O 4 to 2:1 has the highest electro and magneto dual responsive effect that reaches 62%, which is far higher than TiO 2 with only 15%. This work provides a new substance shows the excellent performance of electro and magneto dual response to applied in smart material field.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2022
·Vol. 6
·期 1
·1-10
·
IF 11.806
Ye Mengting,Wang Shengdan,Ji Xingxiang,Tian Zhongjian,Dai Lin,Si Chuanling
Superhydrophobic coatings have been widely developed to endue the materials with antibacterial, self-cleaning, antiseptic, and some other multifunctionalities. Fluorochemicals are the most commonly used superhydrophobic coatings; however, the released toxic substances from fluorinated polymers are a significant source of water pollution and even a threat to human health. With the increasingly great attention to the environment, it is imperative to exploit green and effective hydrophobic coatings. Here, a nanofibrillated cellulose-based multifunctional superhydrophobic coating (NMSC) was fabricated by using an efficient silylation process from cellulose, tetraethyl orthosilicate, and cetyl trimethoxysilane. Microscopic, chemical structural, and thermal properties analyses revealed that the NMSC has nanoroughness, low surface energy, and good thermal stability. More importantly, the NMSC displayed an unprecedented hydrophobic and self-cleaning performance (water contact angle ~ 165°). The NMSC superhydrophobic coating can realize long-term effective barriers to many fluids, including strong acid (pH 1), strong alkali (pH 13), alcohols, alkanes, esters, and some other organic solvents. Moreover, the NMSC also exhibited a certain degree of antibacterial performance. This work provides a good approach for not only the high-value application of cellulose but also the development of ecological and sustainable multifunctional coatings. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2022
·Vol. 33
·期 2
·487-495
·
IF 2.525
Chen Biru,Li Lei,Yang Qianqian,Liu Bolin,Hu Yue,Zhang Mingcui
Carbon dots as new nanomaterials, have been widely used in rapid detection because of their nondestructive, real-time detection characteristics. Improving the sensitivity and selectivity of the method in complex real samples is new challenge and requirement for sensing technology. Here, we report an ultrasensitive fluorescence immunoassay (FIA) for trace diethyl phthalate (DEP) using red carbon dots@SiO 2 (R-CDs@SiO 2 ) as tags. SiO 2 as a nanocarrier can effectively improve the bio-functionalization and utilization rate of carbon dots. Moreover, several R-CDs embedded in SiO 2 nanospheres can magnify the fluorescence signal and improve sensitivity. R-CDs@SiO 2 conjugate anti-DEP antibody (Ab) as fluorescent immunosensor, which can specifically recognize DEP. Under optimization conditions, the detection limit (LOD) of this FIA was calculated as 0.0011 ng/mL. In addition, the recoveries of this established FIA ranged from 96.8 to 108.5%, showing satisfactory accuracy. Compared with GC-MS/MS (LOD µg/mL), the sensitivity of the FIA was significantly improved. As a result, the FIA developed using R-CDs@SiO 2 as tags has a high potential for determining trace DEP.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Liu Zhankai,Liu Ziyi,Fan Jie,Lu Wen-Duo,Wu Fan,Gao Bin,Sheng Jian,Qiu Bin,Wang Dongqi,Lu An-Hui
Oxidative dehydrogenation (ODH) of alkane over boron nitride (BN) catalyst exhibits high olefin selectivity as well as a small ecological carbon footprint. Here we report an unusual phenomenon that the in-situ formed olefins under reactions are in turn actively accelerating parent alkane conversion over BN by interacting with hydroperoxyl and alkoxyl radicals and generating reactive species which promote oxidation of alkane and olefin formation, through feeding a mixture of alkane and olefin and DFT calculations. The isotope tracer studies reveal the cleavage of C-C bond in propylene when co-existing with propane, directly evidencing the deep-oxidation of olefins occur in the ODH reaction over BN. Furthermore, enhancing the activation of ethane by the in-situ formed olefins from propane is successfully realized at lower temperature by co-feeding alkane mixture strategy. This work unveils the realistic ODH reaction pathway over BN and provides an insight into efficiently producing olefins.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2022
·Vol. 15
·期 1
·1-16
·
IF 23.655
Wang Chenxi,Liu Yue,Jia Zirui,Zhao Wanru,Wu Guanglei
Heterogeneous interface engineering is designed by electrospinning.
The introduction of Co 3 SnC 0.7 nanoparticles increased the loss mechanism.
Enhanced electromagnetic loss and improved impedance matching are achieved.
The absorbers exhibit high-efficient electromagnetic wave absorption performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）