Journal of Neuroinflammation
·
2024
·Vol. 21
·期 1
·1-18
·
IF 9.3
Su Xi,Wang Guanyu,Liu Senqi,Li Jinming,Shao Minglong,Yang Yongfeng,Song Meng,Han Yong,Li Wenqiang,Lv Luxian
Autophagy is crucial for synaptic plasticity and the architecture of dendritic spines. However, the role of autophagy in schizophrenia (SCZ) and the mechanisms through which it affects synaptic function remain unclear. In this study, we identified 995 single nucleotide polymorphisms (SNPs) across 19 autophagy-related genes that are associated with SCZ. Gene Set Enrichment Analysis (GSEA) of data from the Gene Expression Omnibus public database revealed defective autophagy in patients with SCZ. Using a maternal immune activation (MIA) rat model, we observed that autophagy was downregulated during the weaning period, and early-life activation of autophagy with rapamycin restored abnormal behaviors and electrophysiological deficits in adult rats. Additionally, inhibition of autophagy with 3-Methyladenine (3-MA) during the weaning period resulted in aberrant behaviors, abnormal electrophysiology, increased spine density, and reduced microglia-mediated synaptic pruning. Furthermore, 3-MA treatment significantly decreased the expression and synaptosomal content of complement, impaired the recognition of C3b and CR3, indicating that autophagy deficiency disrupts complement-mediated synaptic pruning. Our findings provide evidence for a significant association between SCZ and defective autophagy, highlighting a previously underappreciated role of autophagy in regulating the synaptic and behavioral deficits induced by MIA.
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高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
·
2024
·
IF 2.4
Li Jingzhe,Zhang Jiaxin,Ling Yikai,Long Min,Tian Rui,Liang Ti,Nong Guangzai
Pt counter electrodes are essential components of dye-sensitized solar cells (DSSCs). However, their high cost and poor stability limit the development of these cells. In the quest for alternative materials to replace Pt, this study utilized sodium lignosulfonate as the primary raw material and successfully prepared N, S co-doped hierarchical porous carbon by adjusting the ratio of thiourea. This carbon was then fabricated into a counter electrode to replace Pt. The results showed that the N, S co-doped hierarchical porous carbon exhibited superior electrochemical performance compared to single-atom doped carbon. When used as the counter electrode in DSSCs, it achieved a power conversion efficiency of 8.62%, which is higher than the 7.98% efficiency of Pt. Furthermore, it demonstrated greater stability than Pt in stability tests. These findings confirm that N, S co-doped hierarchical porous carbon could replace Pt, thereby advancing the scientific understanding of DSSCs and promoting their application and development. Graphical Abstract
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2019
·Vol. 92
·期 3
·618-627
·
IF 1.986
Zhu Hongyu,Zhu Meng,Shuai Shirong,Zhao Cong,Liu Yu,Liu Yuan,Li Xiaohong,Rao Zikun,Li Yang,Hao Jianyuan
The delicacy of nature prompted scientists to create functional or responsive biomaterials using existing natural components. Here we reported novel thermo-gelling hydrogels based on methyl poly (ethylene glycol)-poly (L-valine) (mPEG-L-PV) diblock copolymer solutions, which exhibited well-defined sol–gel transition at a temperature range from 10 °C to 40 °C. The β-sheet was the dominant secondary structure for poly(L-PV) block when the molecular weight of the polypeptide ranged from 277 Da to 1138 Da. The formation of mPEG–L-PV clear sol solutions was related to the stable nanostructures that were aggregated clusters of poly(L-PV) β-sheet filaments and stabilized by the hydrophilic PEG segments. The block length of poly(L-PV) significantly affected the secondary structures of polypeptide and the morphology of assembled filaments, which resulted in different thermo-gelling behavior of the copolymer solutions. The occurrence of sol–gel transition with temperature was primarily due to the dehydration effect of PEG block, whereas in the case of the copolymer with a lower molecular weight of poly(L-PV) block, the change of polypeptide secondary structures also contributed to the formation of the gel. This paper provides fundamental information about the strong dependence of polypeptide block length on the nano-assembly morphology as well as thermosensitive behavior of polypeptide-based hydrogels.
The block length of poly(L-PV) significantly affected the secondary structures of polypeptide and the morphology of assembled filaments, which resulted in different thermo-gelling behavior of the copolymer solutions.
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Microsystems & Nanoengineering
·
2024
·Vol. 10
·期 1
·1-14
·
IF 7.3
Zhang Jianpeng,Wei Song,Liu Caichao,Shang Chao,He Zhaoqiang,Duan Yu,Peng Zhengchun
In this work, we propose porous fluororubber/thermoplastic urethane nanocomposites ( PFTNs ) and explore their intrinsic piezoresistive sensitivity to pressure. Our experiments reveal that the intrinsic sensitivity of the PFTN-based sensor to pressure up to 10 kPa increases up to 900% compared to the porous thermoplastic urethane nanocomposite ( PTN ) counterpart and up to 275% compared to the porous fluororubber nanocomposite ( PFN ) counterpart. For pressures exceeding 10 kPa, the resistance-pressure relationship of PFTN follows a logarithmic function, and the sensitivity is 221% and 125% higher than that of PTN and PFN, respectively. With the excellent intrinsic sensitivity of the thick PFTN film, a single sensing unit with integrated electrode design can imitate human skin for touch detection, pressure perception and traction sensation. The sensing range of our multimodal tactile sensor reaches ~150 Pa, and it exhibits a linear fit over 97% for both normal pressure and shear force. We also demonstrate that an electronic skin, made of an array of sensing units, is capable of accurately recognizing complex tactile interactions including pinch, spread, and tweak motions.
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JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Guan Lijiao,Wang Wenxian,Zhang Xianfen,Zhang Yuding,Wu Jiyong,Xue Weiming,Huang Saipeng
Intracellular copper ion (Cu 2+ ) is irreplaceable and essential in regulation of physiological and biological processes, while excessive copper from bioaccumulation may cause potential hazards to human health. Hence, effective and sensitive recognition is urgently significant to prevent over-intake of copper. In this work, a novel highly sensitive and green carbon quantum dots (Green-CQDs) were synthesized by a low-cost and facile one-step microwave auxiliary method, which utilized gallic acid, carbamide and PEG400 as carbon source, nitrogen source and surface passivation agent, respectively. The decreased fluorescence illustrated excellent linear relationship with the increasing of Cu 2+ concentration in a wide range. Substantial surface amino and hydroxyl group introduced by PEG 400 significantly improved selectivity and sensitivity of Green-CQDs. The surface amino chelation mechanism and fluorescence internal filtration effect were demonstrated by the restored fluorescence after addition of EDTA. Crucially, the nanosensor illustrated good cell permeability, high biocompatibility and recovery rate, significantly practical application in fluorescent imaging and biosensing of intracellular Cu 2+ in HepG-2 cells, which revealed a potential and promising biological applications in early diagnosis and treatment of copper ion related disease. Graphical
The carbon quantum dot backbone is formed by a facile one-step microwave auxiliary method, gallic acid was used as a carbon source, and carbamide was added as a nitrogen source. Copper was added to Green-CQDs solution and the fluorescence intensity of Green-CQDs was significantly reduced, indicating that Copper had a quenching effect on the fluorescence of carbon quantum dots, and that is the basis and focus of the detection of Copper.
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2024
·Vol. 28
·期 7
·2473-2481
·
IF 2.6
Gao Ziang,Wang Huihui,Cui Xia,Shi Hongchao
The metal-organic framework-derived sulfate hydrates exhibit exceptional energy storage performance due to their remarkable synergistic effect. In this study, the volcanic rock-like structure of nickel and cobalt sulfates hydrates (VNCSH) was derived in situ using a nickel-cobalt metal-organic framework as a substrate by a solvothermal method. Through the characterization analysis, the structure continues the porous structural characteristics of MOF materials with abundant active sites and prominent crystal morphology, which is conducive to the full contact with the electrolyte, accelerates the ion transfer, and improves the stability of the material. The VNCSH as an electrode has a high specific capacity of 1418.2 F g −1 at a current density of 2 A g −1 and maintains a high capacity of 870.9 F g −1 when the current density is increased to 10 A g −1 . Furthermore, the assembled VNCSH//AC asymmetric supercapacitor device demonstrated a remarkable energy density of 146.2 Wh kg −1 at a power density of 725.8 W kg −1 , while maintaining a capacity retention of 66.2% after undergoing 6000 cycles at a current density of 10 A g −1 . These results indicate that VNCSH with volcanic rock-like morphology holds significant promise for advanced supercapacitor applications.
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CHEMICAL PAPERS
·
2024
·Vol. 78
·期 6
·3773-3786
·
IF 2.1
Wu Jianying,Dong Yalin,Mao Yonglu
Chinese Nuo mask is made up of wooden substrate and colorful paint, in which wooden substrate exhibits high hydrophilicity and paint cannot show a hydrophobicity. To achieve long-term non-destructive hydrophobic protection of Nuo mask surface, here, epoxy-based nanohybrid coatings were prepared. Poly(glycidyl methacrylate) (PGMA) matrix was used for strong interfacial adhesion and good transparency. Silica nanofiller was used for good weather resistance and high surface roughness. Here, PGMA/silica composite coatings on Nuo mask surfaces were prepared. The reduced water wettability and well-maintained color of coating/mask composite surfaces were verified. Strong abrasion and ultraviolet (UV) resistances of optimal coating/mask composite surface were found. Optimal PGMA/silica composite (2 wt% silica) has high light transmittance (> 89%), and hydrophobicity is achieved on optimal coating/mask composite surface with water static contact angle (SCA) of 93.1° ± 1.1°. This surface displays color difference (Δ E ) of 1.9 ± 0.1. This surface after 50 abrasion cycles (Δ E of 2.4 ± 0.1) still exhibits higher SCA (65.5° ± 1.1°) than untreated Nuo mask surface without abrasion (~ 32°). This surface after 24 h of UV exposure possesses SCA of 85.2° ± 1.3° with Δ E of 0.2 ± 0.1. This work enables long-lasting hydrophobic protection of traditional mask surfaces.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 7
·10950-10966
·
IF 0
Xue Wenjing,Chen Xinyu,Liu Hongdou,Li Jun,Wen Siqi,Guo Jiaming,Shi Xiaoyu,Gao Yang,Wang Rongzhong,Xu Yiqun
The pollution of antibiotics, specifically ciprofloxacin (CIP), has emerged as a significant issue in the aquatic environment. Advanced oxidation processes (AOPs) are capable of achieving stable and efficient removal of antibiotics from wastewater. In this work, biochar-supported sulfidized nanoscale zero-valent iron (S-nZVI/BC) was adopted to activate persulfate (PS) for the degradation of CIP. The impacts of different influencing factors such as S/Fe molar ratios, BC/S-nZVI mass ratios, PS concentration, S-nZVI/BC dosage, CIP concentration, initial pH, coexisting anions, and humic acid on CIP degradation efficiency were explored by batch experiments. The results demonstrated that the highest degradation ability of S-nZVI/BC was achieved when the S/Fe molar ratio was 0.07 and the BC/S-nZVI mass ratio was 1:1. Under the experimental conditions with 0.6 g/L S-nZVI/BC, 2 mmol/L PS, and 10 mg/L CIP, the degradation rate reached 97.45% after 90 min. The S-nZVI/BC + PS system showed significant degradation in the pH range from 3 to 9. The coexisting anions affected the CIP degradation efficiency in the following order: CO 3 2− > NO 3 − > SO 4 2− > Cl − . The radical quenching experiments and electron paramagnetic resonance (EPR) revealed that oxidative species, including SO 4 •− , HO • , • O 2 − , and 1 O 2 , all contribute to the degradation of CIP, in which • O 2 − plays a particularly prominent role. Furthermore, the probable degradation pathway of CIP was explored according to the 12 degradation intermediates identified by LC-MS. This study provides a new idea for the activation method of PS and presents a new approach for the treatment of aqueous antibiotics with highly catalytic active nanomaterials. Graphical Abstract
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Journal of the Iranian Chemical Society
·
2023
·Vol. 20
·期 5
·1095-1105
·
IF 2.4
Liu Kejun,Luo Rui,Fu Jiaxu,Bao Lijian,Xue Yafei,Gu Qiang,Zhang Yumin,Lin Feng
An efficient synthesis of 1,2,5-trisubstituted benzimidazoles was explored under microwave irradiation. Twenty novel 1,2,5-trisubstituted benzimidazoles were prepared using K 2 CO 3 as an acid-binging agent starting from 2-substituted benzimidazoles and 4-substituted benzyl chloride. This method revealed broad substrate adaptability and provided the target products in moderate to excellent yield within 15 min. The effect of different substituents on the yield was investigated under the obtained optimal reaction conditions. Besides, the crystal structure of compound 4c in the orthorhombic space group P 2ac 2ab was presented. Also, the antibacterial activity of the synthesized compounds against Mycobacterium smegmatis in vitro at the cellular level was evaluated using rifampicin as a positive control. Product 4s had the best antibacterial activity among the synthesized compounds and was superior to rifampicin.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·Vol. 333
·期 3
·1333-1341
·
IF 1.5
Wang Jiahong,Ji Gangchuan,Luo Fen,Yuan Beilong,Shu Xiaoyan,Tang Hexi,Lu Xirui
To investigate the irradiation resistance of the microwave sintered contaminated soil samples, the samples were irradiated with 0.5 MeV He 2+ ions. The property changes of the irradiated samples were investigated. After irradiation, the Vickers hardness values of the samples showed a relatively low degree of decrease, with a maximum reduction of 1.36%. The magnitude of NL Ce of samples before and after irradiation was in the order of 1 × 10 –5 g·m −2 ·d −1 . This result will provide a useful reference for the treatment of the contaminated soil. Graphical Abstract
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 29
·1-12
·
IF 2.8
Zhang Zeqing,Liu Wei,Li Lin,Li Huan,Zhang Zhijun,Cheng Shuai,Rao Guanghui,Zhao Jingtai
In recent years, materials exhibiting multimodal luminescence properties from deep red to near-infrared (NIR) wavelengths have been a focal point of research, particularly in the exploration of applications within the realms of stress sensing and dynamic signature anti-counterfeiting. A pyroxene-type layered crystal structure compound, CaMgGe 2 O 6 : Mn 2+ , has been reported as a mechanoluminescent (ML) material. Upon incorporation into the host, Mn 2+ ions preferentially substitute for Mg 2+ ions, emitting deep red to near-infrared light (600–800 nm) within this six-coordinated [MgO 6 ] octahedral environment. The congruence of photoluminescence and ML spectra indicates that both types of luminescence originate from the same emissive center. The doping of Mn 2+ ions introduces impurity band, effectively reducing the optical band gap, as evidenced by ultraviolet diffuse reflectance measurements. Thermoluminescence results reveal three defect centers within the phosphor, whose concentrations decrease with Mn 2+ doping, correlating with a reduction in ML intensity. The ML mechanism of the phosphor is elucidated through the analysis of local piezoelectric properties within the crystal. Overall, this study may pave new pathways for the development of efficient near-infrared mechanoluminescent materials, showcasing potential applications within the biological domain.
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高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-12
·
IF 3.8
Yin Jinpeng,Wang Guanqin,Kong Dongqing,Li Chuang,Zhang Qiang,Xie Dongbai,Yan Yangyang,Li Ning,Li Qiang
To enhance the volumetric energy density and initial coulombic efficiency (ICE) of titanium oxide (TiO 2 ) as anode electrode material for lithium-ion batteries (LIB), this study employed a surface-confined in-situ inter-growth mechanism to prepare a TiO 2 embedded carbon microsphere composite. The results revealed that the composite exhibited a highly integrated structure of TiO 2 with oxygen vacancies and carbon, along with an exceptionally small specific surface area of 11.52 m 2 /g. Due to its unique microstructure, the composite demonstrated remarkable lithium storage properties, including a high ICE of 75%, a notable capacity of 426.8 mAh/g after 200 cycles at 0.2 A/g, superior rate performance of 210.1 mAh/g at 5 A/g, and an outstanding cycle life, with a capacity decay rate of only 0.003% per cycle over 2000 cycles. Furthermore, electrochemical kinetic studies further validated the advantages of this microstructure.
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