JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2024
·
IF 1.5
Xu Xiang,Mao Yiyin,Zhou Peng,Wu Yujing,Liu Yaling,Wang Hongyong,Lu Chunxiong,Zou Pei
In this study, a 99m Tc-labeled small molecule imaging probe [ 99m Tc]Tc-PG3C-CBM for PD-L1 imaging was designed. It showed a radiochemical yield of > 97% and good in vitro stability. Uptake in A375-hPD-L1 cells (17.07 ± 1.40%) was 4.5 times higher than in A375 cells (3.81 ± 0.19%). The probe demonstrated moderate PD-L1 affinity (K D : 11.6 ± 2.57 nM; IC 50 : 59.2 ± 2.40 nM). Additionally, SPECT/CT imaging and biodistribution results indicated that [ 99m Tc]Tc-PG3C-CBM was mainly metabolized by the liver and showed some accumulation at the tumor site. These results suggest that [ 99m Tc]Tc-PG3C-CBM could potentially target PD-L1 at tumor sites.
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高影响因子
Frontiers of Materials Science
·
2024
·Vol. 18
·期 4
·1-14
·
IF 2.5
Rong Xinshan,He Yuqing,Gao Ping,Sun Ting,Zhou Xiangtong,Wu Zhiren
The utilization of photocatalytic nitrogen fixation, a process celebrated for its environmental friendliness and sustainability, has emerged as a promising avenue for ammonia synthesis. The rational design of photocatalysts containing single atoms and heterojunctions has been a long-standing challenge for achieving efficient nitrogen fixation. This study innovatively constructs composite catalysts integrating single-atom copper within metal–organic frameworks (Fe-MOF, NH 2 -MIL-101) and carbon nitride nanosheet (CNNS). The nitrogen fixation efficiency of the Cu@MIL-CNNS heterojunction was 8 and 12 times those of the original MOF and CNNSs, respectively. Through detailed characterization, we unveil a unique charge transfer pathway facilitated by the synergy between single-atom copper and heterojunctions, highlighting the critical function of copper centers as potent active sites. Our findings underscore the transformative potential of single atomic sites in amplifying charge transfer efficiency, propelling advancements in the photocatalyst design.
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NEUROCHEMICAL RESEARCH
·
2024
·Vol. 50
·期 1
·1-15
·
IF 3.7
Luo Yuanfei,Yuan Linying,Liu Zhihui,Dong Weichen,Huang Li,Liao Anyu,Xie Yi,Liu Rui,Lan Wenya,Cai Yulong,Zhu Wusheng
Proprotein convertase substilin/kexin type 9 (PCSK9), a pivotal protein regulating lipid metabolism, has been implicated in promoting microthrombotic formation and inflammatory cascades, thereby contributing to cardiovascular ischemia/reperfusion (I/R) injury. However, its involvement in cerebral I/R injury and its potential role in microcirculation protection remain unexplored. In this investigation, we utilized a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model to simulate ischemic stroke. Different concentrations of evolocumab (1, 5, 10 mg/kg, i.v.), a PCSK9 inhibitor, were administered to assess its impact. Immunofluorescence staining was employed to analyze changes in the expression of occludin, claudin-5, thrombocyte, ICAM-1, VCAM-1, and CD45, providing insights into blood-brain barrier integrity, platelet adhesion, and immune cell infiltration. Moreover, the Morris water maze and elevated plus maze were utilized to evaluate neurological and behavioral functions in MCAO/R mice, shedding light on the effects of PCSK9 inhibition. Our findings revealed a surge in plasma PCSK9 levels post-MCAO/R, peaking at 24 h post-reperfusion. Evolocumab (10 mg/kg) treatment significantly mitigated brain infarction and neurological deficits, evidenced by enhanced locomotor function and reduced post-stroke anxiety. However, it did not ameliorate cognitive impairment following MCAO/R. Additionally, evolocumab administration led to diminished leakage of evans blue solution and upregulated expression of occludin and claudin-5. Thrombocyte, ICAM-1, VCAM-1, and CD45 levels were notably reduced in the penumbral area post-evolocumab treatment. These protective effects are speculated to be mediated through the inhibition of the ERK/NF-κB pathway. The PCSK9 inhibitor evolocumab holds promise as a therapeutic agent during the acute phase of stroke, exerting its beneficial effects by modulating the ERK/NF-κB signaling pathway.
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高影响因子
Frontiers of Environmental Science & Engineering
·
2025
·Vol. 19
·期 3
·1-15
·
IF 6.4
Zhang Xiang,Tian Jian,Hu Tanghui,Yue Guangyong,Liu Xianlong,Zhou Wen,Liu Xiaohong,Wang Xinye
Combining pulverized coal gasifiers with cement kiln production is promising for application in low-cost and efficient NO reduction. This paper presents a pulverized coal gasifier catalytic denitration technique and investigates the homogeneous reduction (by CO and CH 4 ) and heterogeneous catalytic reduction (by coke, CaO, MgO, and Fe 2 O 3 ) of NO. A combination of Chemkin simulations and fixed-bed experiments is used to elucidate the reaction pathways and key intermediates of NO reduction by carbon-based gases. In addition, the activation energies for different catalyst combinations were analyzed via reaction kinetics. The results demonstrate that the presence of small amounts of O 2 inhibits NO reduction by CO but promotes NO reduction by CH 4 . The NCO• radical is essential for the NO reduction process, and the generation of this radical depends on the CH 4 cleavage intermediate and O• radical. CaO and Fe 2 O 3 exhibit more significant catalytic effects on NO reduction by carbon-based gases than the other catalysts tested. The presence of a small amount of O 2 in the reacting gas mixtures facilitates the NO reduction reaction. The activation energy is reduced to 1.02 kJ/mol, and the NO conversion reaches 99.80% when the catalyst is C + CaO + MgO + Fe 2 O 3 and the gas composition is CO + CH 4 + O 2 . This work provides theoretical support and data recommendations for the use of pulverized coal gasifiers for the denitrification of cement kilns.
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高影响因子
IONICS
·
2023
·Vol. 30
·期 2
·1075-1087
·
IF 2.8
Zhou Jingkai,Xiao Lijuan,Zhou Song,Liu Jiaqin,Huang Lvhang,Chen Yan
Obtaining electrode materials with excellent electrochemical properties is always a challenge in the research of new energy materials. This paper presents a novel composite material prepared using a simple method, which involves embedding core–shell Co 3 O 4 @SiO 2 nanoparticles onto highly conductive reduced graphene oxide (rGO) with excellent electrochemical performance. The results indicate that the encapsulation of the polymer with the core–shell material enhances the electrochemical performance. In this process, graphene oxide is reduced to reduced graphene oxide (rGO) by the hydrothermal method, and then the prepared core–shell Co 3 O 4 @SiO 2 nanoparticles are embedded into the network structure of reduced graphene oxide (rGO). In addition, we investigate the optimal mass ratio of the core–shell material Co 3 O 4 @SiO 2 and rGO in the Co 3 O 4 @SiO 2 /rGO composite. We prepare composites with different ratios of 4:1, 2:1, 4:3, 1:1, and 4:5, Co 3 O 4 @SiO 2 /rGO. The experimental results illustrate that when the current density is 0.4 A/g, the specific capacitance of the composite Co 3 O 4 @SiO 2 /rGO (1:1) is up to 216 F/g, and the volumetric capacitance is 372 F cm −3 , which is more than fivefold higher than that of the core–shell material Co 3 O 4 @SiO 2 . Such large performance improvement is mainly attributed to the addition of rGO which can improve the conductivity of the entire composite material and the aggregation of Co 3 O 4 @SiO 2 , thus providing more active sites. This study confirms that the electrochemical properties of graphene oxide can be greatly improved by the combination of hydrothermal reduction graphene oxide with core–shell material Co 3 O 4 @SiO 2 , which provides a certain reference value for the further research of high-performance electrode materials.
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高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1915-1925
·
IF 1.282
Gao Y.,Hou D.,He D. X.,Jiang M.,Yang X. C.,Liao S.,Zhang W.,Yan X. M.,Tan N.
The grafted mangrove endophytic fungus Fusarium sp. #ZZF51 by phytic acid with polyphosphate groups (PA-ZZF51) was successfully synthesized by esterification reaction, and its uranium(VI) biosorption conditions, models, mechanism and regeneration property were also obtainted. The uranium(VI) removal from aqueous solution by PA-ZZF51 was optimized at pH (5.0), S/L ratio (0.2 g L −1 ), time (45 min), and the initial uranyl ions concentration (100 mg L −1 ) with 453.70 mg g −1 of biosorption capacity and 90.74% of removal percentage, respectively. Kinetic and equilibrium biosorption studies showed pseudo-second-order equation and Langmuir isotherm model could better fit with the experiment data. FTIR and SEM of the prepared material indicated the various functionalities on the mycelium surface including hydroxyl, carboxyl, phosphate groups and so on were responsible for the binding of uranyl ions.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 2
·1-9
·
IF 2.6
Yue Mengjie,Pu Zejun,Wu Fang,Zhu Rongli,Wang Xu,Yu Dayang,Zhong Jiachun
In this study, h-BN-OH was obtained by hydroxylating h-BN and subsequently KH560 was grafted onto the surface of h-BN-OH, resulting in h-BN-KH560. The h-BN-KH560 was then dispersed in an epoxy resin (EP) to create an EP/h-BN-KH560 adhesive solution, with the content of h-BN-KH560 being varied. Graphene oxide (GO) was dispersed in PMIA precipitated fibers to produce PMIA/GO composite paper. Finally, the surface of the composite paper was evenly coated with the EP/h-BN-KH560 adhesive solution, and then PMIA/EP/GO/h-BN composites with different h-BN-KH560 contents and good thermal conductivity were prepared by hot pressing. The FTIR analysis confirmed the successful grafting of KH560 onto the surface of h-BN-OH. By utilizing h-BN-KH560 and GO as thermal conductive fillers, we achieved a higher thermal conductivity in the composite material, creating a “dual thermal conductivity network” compared to using a single filler. Additionally, the thermal conductivity increased as the content of h-BN-KH560 increased. At h-BN-KH560 contents of 20 wt%, 40 wt%, and 60 wt%, the thermal conductivities of the prepared PMIA/EP/GO/h-BN composites were 0.661 Wm −1 K −1 , 1.082 Wm −1 K −1 , and 1.206 Wm −1 K −1 , respectively. Importantly, the addition of the thermal conductive filler did not significantly affect the thermal stability of the composites.
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高影响因子
Cell Communication and Signaling
·
2024
·Vol. 22
·期 1
·1-13
·
IF 8.2
Zhao Changrui,Bo Jiaqiang,Li Tianyu,Tian Jiameng,Long Tian,He Yingying,Chen Siyu,Liu Chang
Background Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a rising incidence. Traditional treatments, such as thyroidectomy and radiotherapy, often lead to significant side effects, including impaired thyroid function. Therefore, there is an urgent need for non-invasive therapeutic approaches. This study aims to explore the potential of photobiomodulation therapy (PBMT), a non-invasive treatment using specific wavelengths of light, in the management of PTC. Methods We investigated the effects of blue light PBMT on PTC cells, focusing on the Retinal-OPSIN 3 (OPN3) complex’s role in mediating cellular responses. Blue light exposure was applied to PTC cells, and subsequent changes in cellular proliferation, cell cycle progression, and protein expression were analyzed. Statistical tests, including one-way ANOVA and t-tests, were used to evaluate the significance of the findings. Results Blue light exposure led to the dissociation of 11-cis-retinal from OPN3, resulting in the accumulation of all-trans retinal. This accumulation disrupted cellular proliferation pathways and induced G0/G1 cell cycle arrest in PTC cells. The Retinal-OPN3 complex was found to be a key mediator in these processes, demonstrating that thyroid cells can respond to specific light wavelengths and utilize their photoreceptive potential for therapeutic purposes. Conclusions Our findings suggest that PBMT, through the modulation of the Retinal-OPN3 complex, offers a promising non-invasive approach for treating PTC. This study highlights the therapeutic potential of light signal transduction in non-ocular tissues and opens new avenues for non-invasive cancer therapies.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 15
·1-11
·
IF 2.8
Tan Jie,Gao Xiuying,Huang Xiaolin,Wangyang Peihua,Sun Hui,Yang Dingyu,Zeng Tixian
A self-powered X-ray detector based on CH 3 NH 3 PbI 3 thick film with both electron and hole transport layers has been prepared by a facile and low-cost solution method. The CH 3 NH 3 PbI 3 thick film has a compact structure and a thickness of 16.5 μm processed by the doctor-blade method. The structure and thickness of CH 3 NH 3 PbI 3 thick film are helpful to improve its efficiency of directly converting X-ray photons into electron-hole pairs. The photoelectric characteristics and operation mechanism with ions migration of the detector were systematically investigated. Meanwhile, the influence of the migration ions on the performance of the X-ray detector was studied by controlling the poling time of ions migration. After poling process, the sensitivity of the self-powered detector enhanced from 65 to 127 µC Gy air −1 cm − 2 under an irradiation dose rate of 0.1584 mGy air s − 1 . Noticeably, with the blade-coating Carbon electrode on the surface of CH 3 NH 3 PbI 3 , the device without encapsulating showed good stability after being exposed to ambient air for two months.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 18
·5709-5717
·
IF 4.478
Yu Ying,Hu Jiaju,Zhao Xinyi,Liu Jiangchuan,Gao Ying
Photochemical vapor generation (PVG) of germanium (Ge) was first reported in this work. The synergistic effect from cobalt/chloride ions and air-liquid interfaces was found for the PVG of Ge. No obvious signal response was observed from the standard solution of Ge in 10% (v/v) formic acids (FAs) under UV irradiation. The addition of 300 mg L −1 of Co 2+ and 30 mmol L −1 of Cl − resulted in enhanced photochemical reduction for Ge, and the introduction of air-liquid interfaces proceeding and succeeding the sample solution caused another 4.6 folds of enhancement in signal response of Ge. Under the selected condition, the limit of detection (LOD, 3σ, n = 11) was obtained to be 0.008 ng mL −1 with inductively coupled plasma mass spectrometry (ICP MS) measurement. A good precision, expressed as a relative standard deviation (RSD, n = 7) of 2.0%, was found from replicated measurements of 2 ng mL −1 of Ge. The generation efficiency was found to be no better than 9 ± 2%. The PVG mechanism of Ge was investigated in this work. The new finding is useful for understanding the principle of PVG, and further exploring the analytical and environmental application of PVG. Graphical abstract
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2021
·Vol. 35
·期 6
·1031-1037
·
IF 0.957
Cao Yaoqin,He Qianglong,Wang Weimin
B 4 C-TiB 2 -SiC composites with excellent properties were prepared by reactive hot-pressing using B 4 C, TiC, and Si powders as the raw materials. The phase transition process was investigated by heating the powder mixture to different temperatures and combined with XRD tests. TiB 2 and SiC phases were synthesized through an in situ reaction, and the mechanical and thermal properties were improved simultaneously. Microstructure and mechanical properties were also studied, and the 60wt% B 4 C-21.6wt% TiB 2 -18.4wt% SiC composite showed a relative density of 99.1%, Vickers hardness of 34.6 GPa, flexural strength of 582 MPa, and fracture toughness of 5.08 MPa·m 1/2 . In addition, the values of thermal conductivity and thermal expansion coefficient were investigated, respectively.
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高影响因子
CATALYSIS LETTERS
·
2024
·
IF 2.3
Mei Mingjie,Zhao Jiangui,Fang Hu,Sun Zuowei,Xue Weichao,Fu Haiyan,Li Ruixiang,Chen Hua,Li Chen,Yang Chunji,Zheng Xueli,Yuan Maolin
1,4-Butanediol, an important chemical raw material, especially as the monomer of engineering plastic polyethylene terephthalate (PBT), plays a pivotal role in contemporary chemicals. A promising parallel approach is the linear-selective hydroformylation of inexpensive allyl acetate, which is economical yet challenging. Herein, we describe an atom-economic approach characterized by high selectivity for synthesizing 4-oxobutyl acetate through rhodium-catalyzed hydroformylation using allyl acetate. This protocol affords the intermediate of valuable 1,4-butanediol in excellent yield (up to 95%) and exhibits excellent regioselectivity (linear/branched up to 164) under mild conditions (60 °C, 10 bar of syngas), effectively minimizing the formation of decomposed byproducts. The success of this protocol hinges on the use of a "Rh/POP-type ligand" in combination with either acetic acid or bulky anionic salts as additives. Preliminary mechanism studies show that the use of CH 3 COOH facilitates the formation of a tridentate κ 3 -P,O,P-coordination, which prevents the coordination of carbonyl with the Rh center, leading to the relatively high linear selectivity of 4-oxobutyl acetate. Furthermore, the successful application of this protocol in synthesizing 4-oxobutyl acetate at a scale of 3.8 g, employing low Rh-loading (0.05 mol%), highlights its potential for industrial applications. Graphical Abstract
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