Exposure and Health
·
2026
·Vol. 18
·期 3
·35
·
IF 3.5
Liu Ruyun,Li Xun,Xue Yilin,Wang Xuanxuan,Wang Cheng,Yang Shulin,Zhang Tao,Hu Dan,Liu Si,Yue Jing,Jin Lei,Gao Ke,Lu Liping
Minimal studies focused on the association of mixed neonicotinoids (NEOs) exposure in seminal plasma with semen quality parameters, and further mixed effects on male reproductive health. In this study, we analyzed the concentrations of 6 parent neonicotinoids (p-NEOs) and 8 metabolite neonicotinoids (m-NEOs) using 155 male seminal plasma samples collected in Wuhan, China. Imidacloprid-olefin (IMI-olefin, 87.1%), acetamiprid-n-desmethyl (ACE-n-des, 74.2%), and 5-hydroxy-imidacloprid (IMI-5-OH, 80.0%) were dominant compounds, with median concentrations of 0.474, 0.294, and 0.277 ng/mL, respectively. Multivariate linear regression, and three mixture statistical models, including weighted quantile sum regression, quantile g-computation, and Bayesian kernel-machine regression models, were applied to explore the single and mixed effects of p-NEOs and m-NEOs exposure on semen quality. In the multivariate linear regression model, IMI-5-OH and thiacloprid-amide (TCP-Amide) were both significantly negatively associated with sperm concentration (β=-8.67, 95% CI = -16.26, -1.07, p = 0.026; β=-7.85, 95% CI = -14.64, -1.05, p = 0.024) and total sperm count (β=-17.32, 95% CI = -32.51, -2.13, p = 0.026; β=-15.17, 95% CI = -28.77, -1.57, p = 0.029). Similar results were observed in the mixture statistical models. These findings demonstrated a significantly detrimental impact of the NEOs mixture on both sperm concentration and total sperm count, with thiacloprid (TCP), IMI-olefin, IMI-5-OH, and TCP-Amide identified as the primary contributors. This study provided valuable insights into the potential mixed negative impacts of p-NEOs and m-NEOs on semen quality and offered a more comprehensive assessment of the reproductive health effects for p-NEOs and m-NEOs in the human body.
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Nature Communications
·
2026
·
IF 18.1
Ye Daoping,Wu Zihe,Feng Yifan,Lei Jiwei,Niu Jin,Wu Hao,Cheng Chong,Tang Shengwei,Li Shuang
Among CO 2 emission mitigation strategies, the reverse water-gas shift (RWGS) reaction represents a promising route for selective CO 2 -to-CO conversion, enabling subsequent valorization. However, designing selective and stable non-noble metal catalysts for RWGS remains a persistent challenge. In this study, we report a Ni site-induced localized accelerated carbonization process to produce noble metal-like active Ni-WC nano-islands for high-performance RWGS catalysis. Benefiting from the unique structures, the Ni 0.02 WC/WO 2 -NIs catalyst exhibits exceptionally high RWGS activities, with a CO production rate of 2340 mol CO ·mol WC -1 ·h -1 and over 97% CO selectivity. Even after 100 hours of continuous testing at 500 °C, the activity loss of Ni 0.02 WC/WO 2 -NIs was only 0.5%. Unlike the conventional catalyst structure in the RWGS reaction, we demonstrate that the nano-island WC structure with stretch strain ensures the space limitation of electron-rich Ni sites for CO desorption and H 2 dissociation. Integrated in-situ DRIFTS, Raman spectroscopy, and DFT calculations reveal that dual-functional WC/WO x interfaces enhance catalyst activity through bidentate carbonate formation and intensified hydrogen spillover. We suggest that the design of new, efficient, and selective Ni-based noble-metal-like catalysts with nano-island structure through interface synergistic effects offers a promising path to engineering superior RWGS catalysts for CO 2 reduction.
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Scientific Reports
·
2026
·
IF 4.9
Han Ying,Yang Xinyao,Jia Yuhao,Liu Mingying,Sun Xinglin,Yu Dan,Zhang Dayi
Salmonella is a Gram-negative bacterium causing intestinal infections. Polymyxin B (PMB) is an effective antibiotic against Salmonella , but the emergence of antibiotic resistance poses a growing concern. To address this challenge, this study synthesized a new nanocarrier by functionalizing nano-montmorillonite (NMMT) with PMB by adsorption, namely NMMT@PMB. PMB adsorption on NMMT followed the Langmuir isotherm and pseudo‑first‑order kinetics, and its release kinetics followed a diffusion-controlled mechanism. Although the minimum inhibitory concentration (MIC) of NMMT@PMB (2.78 and 44.54 µg/mL) was slightly higher than that of free PMB (2 and 32 µg/mL) for PMB-sensitive (S AT ) and resistant (S AT−P ) Salmonella typhimurium , the nanocarrier demonstrated sustained long‑term antibacterial activity over time. The antibacterial mechanism was the disruption of bacterial membrane integrity. Additionally, ex vivo results demonstrated that NMMT@PMB regulated the microbial community composition, increasing the relative abundance of probiotic bacteria (from 72.34% to 75.20%) and inhibiting pathogenic bacteria (from 8.54% to 2.36%), thereby facilitating its return toward the original state. These findings suggest that NMMT@PMB is a promising nano-delivery system that may support sustained antibacterial action and microbiota homeostasis, offering a potential strategy for improved management of Salmonella infections.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Guo Zhiliang,Chen Song,Dong Shengting,Lu Kai,Shi Jiaxu,Chen Weicheng,Liu Dachuan,Fu Jianlong,Zhu Caihong,Li Bin,Long Xianming
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition, epithelial barrier failure, and pathological remodelling of the alveolar mucus layer, which together limit the effectiveness of inhaled therapeutics. Here, we report a dual-mechanism inhalable system, CL-Shell/PF-µGel, designed to restore the dysfunctional mucus barrier while delivering antifibrotic agents into deep fibrotic lesions. The platform integrates calcium phosphate-shell coated celastrol-loaded liposomes (CL-Shell) with pirfenidone-loaded gelatin microgels (PF-µGel). The calcium phosphate shell is generated through a layer-by-layer mineralization process that produces a stable, uniformly charged coating capable of traversing diseased mucus and protecting the liposomal core from enzymatic degradation, thereby enabling efficient intracellular delivery of celastrol to activated myofibroblasts. Concurrently, microscale PF-µGels (1-5 μm) deposit along airway and alveolar surfaces, regulate local hydration to normalize abnormal mucus rheology, and release pirfenidone in a sustained manner to support epithelial repair and suppress profibrotic signalling. In vitro and in vivo studies revealed that CL-Shell/PF-µGel enhances pulmonary retention and attenuates fibroblast activation. This work establishes a biomimetic inhalation strategy that couples barrier repair with targeted deep-lesion therapy, offering a promising and clinically translatable approach for IPF and other chronic respiratory diseases. Graphical The alternative text for this image may have been generated using AI.
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WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2026
·Vol. 42
·期 5
·213
·
IF 4.7
Huan Tong,Zhang Jing-Yi,Huang Jia-Ying,Si Wen-Jie,Wu Yue,Zhang Ye-Wang
Chondroitinase ABC (ChSase ABC), which can digest chondroitin sulfate (CS), has been utilized for the analysis of CS glycan structure and the preparation of low-molecular-weight chondroitin sulfate. However, the catalytic activity of most ChSase ABCs remains insufficient for industrial or large-scale applications. Previous structure studies of ChSase ABCs indicate that the N-terminal domain is typically involved in substrate recognition and binding. Furthermore, the N-terminal domain of the ChSase ABC from Bacteroides thetaiotaomicron ( Bt ChSase ABC) also exhibits similarity with the carbohydrate-binding module of other glycosidases. In the present work, the N-terminal of Bt ChSase ABC was chosen for engineering. Through multiple sequence alignment, 9 non-conserved residues were selected as candidate mutation sites, and a mutant library containing 20 variants was constructed by single-point and combinatorial mutations. Among them, the catalytic activity of 13 mutants showed varying degrees of improvement. The mutant L137V showed 79.29% and 84.49% increases in specific activity and V max , respectively, compared to the wild type. SAX-HPLC analysis of enzymatic hydrolysates confirmed that the mutation retained the enzyme’s substrate recognition and cleavage mechanism. Kinetic parameters revealed that the enhanced catalytic activity of the mutants was mainly attributed to an increased turnover number ( k cat ), indicating that the rate-limiting step of catalysis was effectively accelerated.
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JOURNAL OF PEST SCIENCE
·
2026
·Vol. 99
·期 2
·73
·
IF 4.4
Cui Chenglong,Xia Xiwei,Wang Zhimin,Li Ertao,Dong Huanhuan,Shen Jiaan,Sun Yujun,Peng Yu,Li Kebin,Yin Jiao
Plant-derived semiochemicals underpin the push–pull strategy, yet their widespread agricultural adoption is limited by the land requirements, growth dependence and inconsistent field performance of companion plants. Here we develop a fully plant-free push–pull system for managing the white grub Holotrichia parallela in peanut agroecosystems, achieved by embedding optimized PVOC blends into biodegradable electrospun fibers composed of an 8% PHB/2% PCL polymer matrix (PHB 8 /PCL 2 ). The attractant mixture (1-heptanol and (Z)-3-hexenyl acetate) and repellent mixture (1,8-cineole and 2-ethylhexanol) were efficiently encapsulated (45–53%) within uniform fibers (1.24 ± 0.03 μm), which released volatiles following first-order kinetics for more than 56 days. Electroantennography confirmed sustained antennal detectability, with > 60% of initial response retained at day 14 and measurable activity through day 42. Behavioral assays showed that attractant-loaded fibers elicited ~ 65% attraction and maintained > 50% activity for 35 days, while repellent-loaded fibers induced 53–66% deterrence over the same period. In field trials conducted in peanut fields, the plant-free system reduced grub density by 73%, matching the efficacy of plant-based push–pull plots while outperforming commercial dispensers. The PHB 8 /PCL 2 matrices degraded by > 50% within 60 days, avoiding environmental persistence. These results establish electrospun biodegradable fibers as a scalable semiochemical platform and a viable plant-free alternative for sustainable behavioral pest manipulation.
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Nature Water
·
2026
·
IF 30.7
Xuan Qize,Yu Xinyu,Feng Yifan,Qiao Xinchi,Gao Yuan,Cai Jiazhe,Peydayesh Mohammad,Zhan Lijian,Jin Tonghui,Hu Qian,Lin Xinrong,Feng Yifan,Yang Zhiyuan,Ren Xinlei,Zhou Jiangtao,Barceló Damià,Chen Chao,Li Hui,Mezzenga Raffaele
Nanoplastics (NPs), as persistent and unregulated aquatic contaminants, evade conventional removal technologies, posing severe health risks and urgently demanding innovative, effective solutions. Here we introduce recyclable magnetic biohybrid nanonets (LAF-IONPs), engineered through in situ growth of iron oxide nanoparticles (IONPs) on lysozyme amyloid fibrils (LAFs). Stabilized by synergistic interfacial interactions, LAF-IONPs efficiently capture NPs over a wide range of sizes (30–1,000 nm) and chemical compositions across environmentally relevant concentrations and conditions (pH 7–9, high salinity and co-existing pollutants). The superior removal efficiency arises from magnetic active motion and abundant fibril binding sites. Remarkably, LAF-IONPs achieved 98.0–99.9% NPs removal from various real water samples and maintained >95% efficiency over 100 recycling cycles when using a custom alternating magnetic field system. Critically, LAF-IONPs treatment reduced in vivo NPs bioaccumulation by 91.5%. This work establishes a blueprint for designing recyclable biohybrid adsorbents for active, efficient and sustainable removal of NPs and potentially other emerging contaminants.
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Drug Delivery and Translational Research
·
2026
·
IF 6.9
Cao Ruijie,Zhou Rongwei,Wang Chuancui,Shen Meizhu,Yu Jiangyue,Xu Hao,Guo Zhong
Acute lung injury (ALI) is characterized by uncontrolled inflammation and oxidative stress, driven largely by macrophage dysregulation. Despite their anti-inflammatory potential, flavonoids like quercetin (Qu) are limited by poor solubility and systemic toxicity. To address these challenges, this study developed a “bioactive co-assembly” nanomicelle platform (Qu@PSA-VES/diT-VES) based on polysialic acid (PSA) and a novel dimerized taurine-vitamin E succinate (diT-VES). Molecular docking simulations demonstrated that quercetin (Qu) exhibits an exceptionally high binding affinity for the VES hydrophobic core. Furthermore, the incorporation of diT-VES significantly enhanced the colloidal stability of the micelles through strengthened non-covalent interactions, effectively preventing disassembly during physiological circulation. Hydrophobic interactions and hydrogen bonding were identified as the primary driving forces for micellar stability. The carrier leverages PSA to specifically target the overexpressed Siglec-1 receptor on the surface of inflammatory macrophages, thereby mediating receptor-dependent endocytosis. Within the acidic and enzyme-enriched lysosomal environment, the micelles undergo pH/enzyme dual-responsive dissociation, facilitating the escape of the drug from the lysosomal barrier and its subsequent diffusion into the cytoplasm for pharmacological action. Additionally, the carrier components VES and taurine provide antioxidant and mitochondrial protection, respectively, synergizing with Qu to significantly induce the reprogramming of M1 macrophages toward the M2 phenotype in vitro. In a murine ALI model, the system demonstrated superior lung-targeting ability, significantly reducing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in bronchoalveolar lavage fluid and alleviating pulmonary edema and neutrophil infiltration. Experimental results indicated that under a lethal ALI challenge, the 72-h survival rate of mice in the treatment group was significantly increased from 16.7% to 83.3%, while maintaining excellent in vivo biocompatibility. This integrated "targeting-stabilization-synergy" nanoplatform provides a promising translational strategy for the treatment of macrophage-driven inflammatory disorders.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Zhu Linao,Gao Hanbing,Shen Min,Huang Kuanxin,Tang Yongqun,He Lele,Huang Jing,Zhao Cheng,Xiong Weiping,Ni Xiaoli,Wu Honghui,Li Shikai,Guo Zhaohui,Cao Jie,Xue Wenjing,Xu Rui
Antimony contamination in mining-impacted river basins poses persistent environmental risks, yet the microbial processes governing antimony redox transformation under anoxic sediments remain poorly understood. Here, we report that photoelectrons generated by naturally occurring dissolved organic matter can support microbial antimonate reduction. Natural dissolved organic matter exhibits sustained photocurrent responses under illumination. In anoxic microcosms, indigenous sediment communities achieve 50–70% antimonate reduction with photoelectron supply, thereby constraining purely abiotic reduction or alternative electron-donor explanations under our experimental conditions. Multi-omics further identify non-phototrophic taxa (e.g., Sphingomonas and Bosea ) with elevated antimony reduction/detoxification pathways and respiratory electron-transfer components under photoelectron exposure. The consistent presence of photosensitive dissolved organic matter and candidate taxa across mining-impacted sediments suggests broader environmental relevance. These findings indicate that photosensitive dissolved organic matter may provide a photoelectron flux that influences microbial antimony redox transformations in anoxic sediments.
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European Journal of Wood and Wood Products
·
2026
·Vol. 84
·期 3
·59
·
IF 2.7
Bi Zhenju,Guo Dongyou,Gao Yufa,Zhao Yan,Ding Qun
Eco-friendly small-molecule natural products hold great potential for improving wood properties; however, their application is limited by susceptibility to leaching and restricted functionality. To improve the fixation of these compounds within wood and achieve a synergistic improvement in both antifungal performance and dimensional stability, cinnamaldehyde was grafted onto the cell wall of poplar ( Populus × euramericana ‘I-69’) wood via a one-pot process mediated by (3-aminopropyl)triethoxysilane (APTES). The retention of cinnamaldehyde in modified poplar wood was evaluated based on its leached and volatile mass. The mold resistance was assessed according to anti-mold efficacy following leaching tests. The dimensional stability was assessed by measuring moisture content and dimensional changes during hygroscopic and drying processes. Additionally, the modified wood was characterized using the Fourier transform infrared spectrometer (FTIR), X-ray photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM). The results demonstrated a significant improvement in the leaching resistance of cinnamaldehyde and the anti-mold stability of the modified wood. The leached and volatile mass of cinnamaldehyde were reduced by more than 90%. Consequently, the anti-mold efficacy of modified wood after leaching was more than 70%. Dimensional stability of modified wood was significantly improved, manifested by a reduction of over 40% in the volumetric swelling coefficient (VSWC). The moisture exclusion efficiency (MEE) and anti-swelling efficiency (ASE) reached 25.9% and 56.0% under air-dried conditions, and 8.1% and 41.1% under water-saturated conditions, respectively. The characterization confirmed that cinnamaldehyde was grafted onto wood hydroxyl groups via Schiff base and condensation reactions mediated by APTES. This study achieved a synergistic improvement in mold resistance, leaching resistance, and dimensional stability, thereby extending the potential application of small-molecule aldehyde natural products in wood modification.
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高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2026
·
IF 4.7
Li Qianyu,Wang Huiyue,Chen Nan,Liu Xue,Li Yongle,Chen Lei,Gan Lu,Luan Yong
Postoperative cognitive dysfunction (POCD) is a common complication following surgery, particularly in elderly patients, and is closely linked to neuroinflammation driven by microglial activation. While dexmedetomidine (Dex) has shown neuroprotective potential in clinical settings, the molecular mechanisms underlying its beneficial effects—particularly in relation to RNA epigenetic regulation and metabolic reprogramming in microglia—remain poorly understood. Here, we uncover a novel mechanism by which Dex alleviates POCD through modulation of N6-methyladenosine (m 6 A)–dependent post-transcriptional regulation of pyruvate kinase M2 (PKM2). We demonstrate that Dex enhances the expression of the m 6 A reader protein YTHDF2, which recognizes m 6 A-modified PKM2 mRNA and promotes its degradation, thereby suppressing microglial glycolysis and neuroinflammation. In both in vitro and in vivo models, Dex treatment reversed surgery- or LPS-induced cognitive deficits, reduced pro-inflammatory cytokine production, and normalized metabolic shifts in microglia—effects that were dependent on YTHDF2-mediated PKM2 downregulation. Our findings uncovered a novel epigenetic mechanism by which Dex exerts neuroprotection and highlight YTHDF2-mediated PKM2 regulation as a potential therapeutic target for POCD.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2026
·Vol. 34
·期 5
·98
·
IF 5.6
Qi Chao,Jia Jun,Zhang Ning,Qin Yi,Li Haiyang,Feng Jingyuan,Hu Jing
Bio-based poly(butylene 2,5-furandicarboxylate) (PBF) has high tensile strength, but low elongation at break. To improve the toughness, this study employed 1,5-glutaric acid (GA) to synthesize poly(butylene 2,5-furandicarboxylate-co-glutarate) (PBFG). The impact of GA on PBF’s composition and properties was investigated in detail. The thermal decomposition temperature exceeded 350 °C, and as the concentration of GA rose, the thermal decomposition behavior gradually grew closer to poly(butylene glutarate) (PBG). In accordance with DMA, GA enables PBF’s glass transition temperature to fall from 44.4 °C to -52.7 °C. The copolyester’s toughness is substantially improved by adding a portion of GA. PBFG25 with high tensile strength of 61.5 MPa and high elongation at break of 856% combines exceptional toughness and high tensile strength. After the tensile test, the transparency of PBFG25 and PBFG50 increased, the melting enthalpy of DSC decreased, and they rebounded after the fracture. The above results support the mesophase hypothesis of furan-based polyesters. This paper presents the theoretical foundations for the controlled structure and property enhancement of bio-based polyesters.
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