JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2020
·Vol. 97
·期 2
·466-478
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IF 2.008
Ma Haohua,Wang Jianqiang,Zhang Wenpei,Guo Cheng
To allay concerns that sunscreen ingredients are harmful to skin health, we have developed phenylalanine (Phe) and leucine (Leu) dipeptide functionalized silica-based nanoporous material (Phe-Leu-OMe-Meso) as a safe ultraviolet filter for skin protection from UVA/UVB sun irradiation. The selected peptide-based functional molecules are composed of natural amino acids, which have obvious advantages compared with other biological molecules and organic molecules, such as low toxicity and high stability. Octyl salicylate (OS) is adopted as the drug molecule to observe the adsorption behavior of the nanoporous materials. The results confirm that Phe groups effectively improve the OS loaded capacity of Phe-Leu-OMe-Meso by aromatic π – π stacking interaction, and the experimental data obey the pseudo-second-order kinetic model and the Langmuir, Freundlich, Temkin isotherm model. Moreover, in vitro evaluation of the spectrophotometric sun protection factor indicates that Leu groups make Phe-Leu-OMe-Meso possess an excellent sunscreen efficacy close to that of mesoporous TiO 2 and exhibit a synergistic effect with OS on sun protection. In summary, the dipeptide functionalization of silica-based nanoporous material has an excellent prospect in the application of sunscreen.
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International Journal of Peptide Research and Therapeutics
·
2020
·Vol. 26
·期 4
·2457-2464
·
IF 1.5
Yang Shi-Zhong,Quan Hong-Zhi,Liu Jin-Feng,Gang Hong-Ze,Mu Bo-Zhong
Lipopeptides have potential applications in many industries. It is challenging to quantitatively determine low concentration of lipopeptide. In this paper a highly sensitive and quantitative method for determination of lipopeptide concentration is described. Fatty acids and surfactin were labelled with naphthalene ethylenediamine (NEDA). LC–MS and HPLC with fluorescence detection analyses shown that the surfactins with 2 free carboxyl groups were wholly labelled by 2 NEDA. Linear relationships were found between molar concentration of fatty acids and peak area of labelled fatty acids. Different fatty acids share the same quantitative regression equation and slope of equation due to the reason that each fatty acid was labelled by 1 NEDA. The relationship between surfactin molar concentration and peak area was obtained based on the concentration of the photoluminescent molecule. This method can detect concentrations as low as 3.1 nmol/L, which is less than the limits of the most sensitive method reported for the surfactins previously. The method can also be used to determine other lipopeptides with carboxyl groups.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-12
·
IF 5.3
Guo Chunyan,Miao Pandeng,Yan Yifan,Li Xiaoqi,Du Shuaijing,Du Yingxiang
A capillary coating column was prepared for capillary electrochromatography (CEC) using a novel nanomaterial synthesized by chiral metal–organic frameworks (CMOFs) (Co 2 (L-Trp)(INT) 2 (H 2 O) 2 (ClO 4 ) and chiral molecularly imprinted polymers (CMIPs) as the stationary phase for enantioseparation of amlodipine. The rigid skeleton of CMOFs can be used as a support to reduce the deformation and collapse of CMIPs pores, the high specific surface area of CMOFs can increase the loading of molecular imprinting, while the viscosity of CMIPs improves the stability of stationary phases connected to the inner wall of capillaries. Compared with the capillary-coated columns with CMOFs and CMIPs as stationary phases alone, the novel capillary-coated columns utilizing the synergistic effect of CMIP@CMOF stationary phases showed a greatly improved chiral recognition (resolution: 0/0 → 5.79). The new nanomaterials synthesized by CMOFs and CMIPs as the stationary phase of CEC chiral resolution system show broad application prospects and potentials in the field of chiral drug/compound separation. Graphical
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Science China-Materials
·
2025
·
IF 7.4
Zhang Tao,Wang Xin,Song Wanqing,Feng Jiahui,Yang Xinyi,Wang Haozhi,Ding Jia,Hu Wenbin
Alloying Pt with non-noble metals is effective for optimizing the activity of Pt-based electrocatalysts. However, the development of high-activity and stable hydrogen electrocatalysts remains challenging owing to the random elemental distribution and weak interatomic bonding in alloys. Herein, we reported a Pt 2 CoNi intermetallic nanocatalyst rich in surface microstrain for high-performance hydrogen electrocatalysis. The superlattice ordering crystalline structure ensures the specific positions of atoms in this nanocatalyst, resulting in the alternating arrangement of Pt and Co/Ni atoms. In one nanoparticle, multiple Pt 2 CoNi grains are arranged along different grain orientations, which generates abundant surface microstrain due to the discrepancy of intermetallic lattice parameters. The unique crystal structure effectively modulates the electron distribution of Pt 2 CoNi intermetallic nanocatalyst. The active sites of this nanocatalyst exhibit downshifted d-band centers, leading to accelerated hydrogen adsorption/desorption behavior. Resultantly, the Pt 2 CoNi intermetallic nanocatalyst demonstrates impressive bifunctional hydrogen electrocatalytic capabilities for hydrogen evolution reaction (mass activity of 1.02 A/mg Pt and η 10 variation of 3.7 mV after 10,000 cycles) and hydrogen oxidation reaction (kinetic mass activity of 4.08 A/mg Pt and 97.3% activity retention after 12 h operating at 0.1 V vs. RHE). This work provides a promising route for the development of efficient nanocatalysts with ingenious crystal structures.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Li Rui,Xu Kaiqi,Wen Shenhao,Tang Xiaohan,Lin Zheyu,Guo Xia,Avdeev Maxim,Zhang Zhizhen,Hu Yong-Sheng
Halides are promising solid electrolytes due to their high ionic conductivity and high oxidation potential. Here we report a superionic chloride material, NaTaCl 6 , which exhibits a high ionic conductivity of 3.3 mS cm −1 at 27 °C, being two-orders of magnitude higher than that of NaNbCl 6 (0.01 mS cm −1 ). The considerably higher conductivity exhibited by NaTaCl 6 vs. NaNbCl 6 arises from the more facile rotational/reorientational dynamics of the [TaCl 6 ] polyanions in comparison to the [NbCl 6 ] anions. [TaCl 6 ] polyanion rotation is readily activated while [NbCl 6 ] polyanion reorientation is hindered at room temperature but can be turned on as the temperature increases or under prolonged mechanical milling. The higher degree of structural disorder exhibited by NaTaCl 6 compared to NaNbCl 6 —likely attributed to its greater mechanical and phonon softness—is found to contribute to the more pronounced [TaCl 6 ] anion rotation. Anion rotation is coupled with, and facilitates, macroscopic Na + -ion diffusion. As a result, enhanced rotational dynamics are directly correlated with the higher Na + -ion conductivity observed in NaTaCl 6 . The high ionic conductivity, combined with its electrochemical stability against positive electrode materials, enables good rate capability and long-term cycling performance in solid-state cells. These findings provide insights into ion transport mechanism in the newly emerging halide solid electrolytes.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Xu Junling,Xie Fuqiang,Huang Lipeng,Li Nana,Peng Shang,Ma Wensheng,Zhang Kai,Wu Yanxue,Shao Lianyi,Shi Xiaoyan,Chen Jizhang,Tao Li,Zhang Kai,Zhang Zhonghua,Wang Yonggang,Sun Zhipeng
Doping is an important approach to tailor materials’ properties, yet the success of doping can depend on factors such as ionic radii similarities. For materials like silicon or perovskite, doping is not only facile to implement but can also enhance material properties. However, for host lattice structures like Nb 2 O 5 , doping without causing phase change is challenging. Here, we introduce a high-entropy-doping effect in Nb 2 O 5 . Unlike traditional doping approaches, high-entropy-doping minimizes the chemical properties of doping elements and focuses solely on their quantities. By high-entropizing the doping elements (selecting 10–15 from Mg, Ca, Sr, Ba, Cr, Mn, Fe, Co, Ni, Cu, Zn, Al, Ga, In, Sn, Sb, Y, Mo, La, Ce) and keeping them within a certain range of doping concentrations (1–3 mol %), a successful high-entropy-doping is achieved for Nb 2 O 5 without phase change. The obtained high-entropy-doped (HED) Nb 2 O 5 exhibits rapid-charging capabilities. At a rate of 40 A g −1 , the HED-Nb 2 O 5 delivers a capacity of 80 mAh g −1 , whereas the undoped Nb 2 O 5 fails to exceed 25 mAh g −1 .
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Wang Ran,Qi Yilin,Liu Jinjin,Li Yang,An Hongde,Wang Heping,Song Jie,Hu Wenzhuo,Wu Shaochun,Yu Leqian,Chen Yao,Xue Xue
Embryonic stem cells (ESC) are pluripotent, with the potential to differentiate into multiple cell types, making them a valuable tool for regenerative medicine and disease therapy. However, common culture methods face challenges, including strict operating procedures and high costs. Currently, Leukemia inhibitory factor (LIF), an indispensable bioactive protein for ESC culture, is typically applied to maintain self-renewal and pluripotency, but its instability and high cost limit its effectiveness in stable culture conditions. Hence, we have developed an innovative strategy using a soluble nanomaterial, metal-organic polyhedra (MOPs), to effectively maintain the self-renewal and pluripotency of ESC. The selected amino-modified vanadium-based MOP not only exhibits excellent biocompatibility and high stability but also possesses similar or even superior biological functions compared to commercial LIF. Due to the precise structure of MOPs, the active site responsible for maintaining ESC pluripotency has been identified and regulated at the molecular level. The new ESC culture method significantly reduces costs, simplifies preparation, and enhances the practicality of biopharmaceutical preparation and storage. This represents the first case of using MOPs to maintain self-renewal of ECS, opening an avenue for introducing advanced materials into the development of innovative ESC culture methods.
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MRS Communications
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2025
·
IF 2.3
Tan Jing Er,Liu Shengnan,Bai Jun,Yu Bingbing,Chen Kuntao,Sheng Xing,Yin Lan
Wet-adhesive hydrogels hold significant promise for biomedical applications, yet achieving long-term adhesion remains a major challenge in biodegradable systems. Here, we present a biodegradable hydrogel incorporating a water-absorbent layer to regulate swelling behavior and water content. Comprising a poly(ethylene glycol) diacrylate (PEGDA)–gelatin matrix with a starch-based absorbent layer, the hydrogel exhibits high wet adhesion energy, elevated burst pressure, effective in vivo hemostasis, and mechanical compatibility with soft tissue. This water-absorbent strategy provides a new avenue for achieving sustained and stable wet tissue adhesion in biodegradable hydrogel systems. Graphical abstract
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Nature Photonics
·
2026
·
IF 38.1
Qiu Jian,Huang Yuling,Wong Pui Ying,Chang Kin Ting,Xue Jie,Chen Zhongwei,Wang Zhiyu,Yao Jingwen,Yu Zhi-Gang,Chen Xihan,Lu Haipeng
The promises of halide perovskites for chiroptical and spintronic applications hinge largely on how long their spin coherence can last. Recent demonstrations of spin injection from chiral single quantum wells to achiral semiconductors have enabled a variety of spin functionalities. However, their spin polarization at the device level remains limited due to rapid interfacial and bulk spin losses. Here we demonstrate a spin cascade strategy by constructing oriented perovskite chiral multiple quantum wells to extend the spin lifetime. In chiral multiple quantum wells, quantum wells with varying well widths exhibit intrinsic and continuous chirality across all quantum-well phases with an average circular dichroism dissymmetry factor of 1.5 × 10 −2 . In this system, slowly energy-varying and spatially coupled chiral multiple quantum wells establish consecutive intermediate polarization states for spin cascade, thereby extending the spin coherence lifetime to ~5 ns at room temperature. The long-lived spin coherence yields circularly polarized luminescence with a luminescence dissymmetry factor (| g lum |) of 1.4 × 10 −2 and spin-dependent charge transport with a polarization degree of over 80%, enabling efficient X-ray-triggered dissymmetric photopolymerization and high-performance circularly polarized light photodetectors. This work opens the way to long-lived spin coherence in halide perovskites, promoting their use in chiroptical and spintronic devices.
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MOLECULAR BIOLOGY REPORTS
·
2026
·Vol. 53
·期 1
·1702
·
IF 3.2
Lan Xiaoxu,Sun Hang,Mu Yulong,Hou Xiaoqing,Ti Chenhui,Sun Weimiao,Xie Shuyang,Li Youjie,Sun Yunxiao
Background Imatinib (IM) resistance poses a major unresolved clinical challenge in chronic myeloid leukemia (CML) treatment, significantly compromising patient prognosis. This study aims to elucidate the role of cell division cycle-associated protein 4 (CDCA4) in IM resistance and the underlying molecular mechanisms in CML. Methods and Results Pan-cancer analysis revealed that high CDCA4 expression was significantly associated with shorter overall survival in multiple cancer types. Quantitative real-time PCR demonstrated upregulated CDCA4 expression in both peripheral blood samples from CML patients and IM-resistant cell lines. CCK-8 assays showed that CDCA4 overexpression markedly enhanced IM resistance and promoted cell proliferation in CML cells. Mechanistic investigations indicated that CDCA4 is associated with hyperactivation of the AKT-mTOR signaling axis and concurrent suppression of basal autophagy, a phenotype that correlates with imatinib chemoresistance in CML cells. Subsequent molecular profiling identified a circ_0029325-dependent regulatory circuit that governs CDCA4 expression levels. Conclusions Our findings clarify the critical function of CDCA4 in CML IM resistance via the AKT-mTOR/autophagy axis and reveal its upstream circ_0029325 regulatory mechanism. This work provides promising potential biomarkers and therapeutic targets for improving CML treatment outcomes.
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Journal of Soil Science and Plant Nutrition
·
2026
·
IF 3.6
Qin Haohui,Dong Xinjiao,Xiao Yanping,Dai Anni,Zhou Jiacheng,Song Yongsheng,Shang Yuemei,Wang Chengxian,Du Linna,Li Gang
Soil salinization severely constrains agricultural productivity worldwide. This study aimed to evaluate the effectiveness of a nano-superhydrophobic material (NSHM) in enhancing leaching desalination and to elucidate its effects on soil microstructure and microbial communities in saline-alkali soil and sand. A gradient concentration experiment (0.0001‰-10‰, w : w ) combined with controlled leaching was conducted. Soil physicochemical properties, aggregate structure, and desalination efficiency were measured. Microstructural changes were characterized using scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM–EDS) and Fourier transform infrared spectroscopy (FTIR). Bacterial and fungal communities were analyzed using 16S rRNA gene and internal transcribed spacer (ITS) sequencing. NSHM exhibited a non-linear dose effect, with an optimal concentration of 0.01‰, increasing desalination rates by 10.09% in soil and 16.21% in sand. NSHM significantly improved pore connectivity and permeability without altering mineral composition. Bacterial communities were strongly reshaped, with increased diversity and enrichment of beneficial taxa in soil, whereas diversity decreased in sand. Fungal communities were more stable, but pathogenic guilds were reduced. Microbial responses were closely associated with changes in soil properties. NSHM enhances desalination primarily through microstructural optimization that improves water-salt transport, thereby indirectly regulating microbial community assembly. Its effects are soil type-dependent, highlighting the need for tailored management strategies. This study provides a mechanistic basis for applying nanomaterials in saline-alkali land remediation. Graphical
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JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Ullah Najiy,Sun Jiaxiao,Duan Mengqi,Deng Haoyu,Ning Jinli,Zheng Haotian,Yan Yongjie
Flexible carbon nanotube fiber-based neural electrodes offer significant advantages for neural interface applications; however, their practical implementation is limited by relatively low electrical conductivity, insufficient mechanical strength, and challenges in implantation. In this study, we present a synergistic strategy to address these inherent challenges through structural densification combined with metal nanoparticle integration. Continuous CNTF ribbons were fabricated by the floating chemical vapor deposition method and subsequently transformed into twisted fibers (T-CNTF) to reduce inter-tube voids and examine the mechanical response. Gold nanoparticles (Au NPs) were then electrochemically deposited onto the surfaces of T-CNTF, yielding metal-enhanced fibers (T-CNTF-Au) with improved electrical conductivity, achieving a maximum value of 2.90 × 10 5 S/m at a nominal Au deposition thickness of 100 nm. A systematic investigation demonstrated a strong structure–property relationship, where a sample prepared at a nominal Au deposition thickness of 50 nm increased fracture elongation to approximately 28%. The fabricated electrode maintained electrical continuity during 5000 bending cycles with relative resistance change below 11%. Electrochemical impedance spectroscopy and cyclic voltammetry revealed mixed capacitive-resistance interfacial behavior and repeatable voltammetric response across cycles 22–25, during which cathodic charge-storage capacity declined from approximately 95.5 to 81 mC cm⁻ 2 . The optimized fibers were integrated into multi-channel neural electrode arrays and implanted into the hippocampal region of mice using stereotaxic techniques. Electrophysiological recordings were acquired over a 2-h acute session, from which a continuous 41.7-min epoch was quantitatively analyzed using four validated contacts. The resulting median impedance magnitude at 1 kHz, spike-free RMS noise, negative-event amplitude, and signal-to-noise ratio were 13.13 kΩ, 6.45 μV, 45.97 μV, and 6.86 (16.73 dB), respectively. Overall, this study demonstrates that metal-enhanced CNTF electrodes, combining high electrical conductivity with mechanical flexibility, constitute a promising platform for next-generation neural interfaces. The proposed approach provides valuable insights into the rational design of high-performance, flexible neural electrodes for advanced neuroscience applications.
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