Journal of Functional Foods
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2019
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IF 3.197
Junlei Liu,Huarong Huang,Zebin Huang,Yuran Ma,Lanyue Zhang,Yan He,Dongli Li,Wenfeng Liu,Susan Goodin,Kun Zhang,Xi Zheng
Eriocitrin is a flavonoid that is isolated from orange peel. Resveratrol is a polyphenol compound, which is present in various fruits, such as grapes. The aim of the present study was to investigate both in vitro and in vivo anti-inflammatory effects of eriocitrin combined with resveratrol using lipopolysaccharide (LPS)-induced RAW264.7 cells and a mouse model of ear edema. The results showed that eriocitrin combined with resveratrol strongly inhibited LPS-induced secretion of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and Interleukin-1β (IL-1β). Moreover, Eriocitrin combined with resveratrol potently inhibited nuclear factor-κB (NF-κB), phosphor-STAT3, and phosphor-AKT, which was accompanied by inhibition of phosphorylation in mitogen-activated protein kinase (MAPK) signaling pathways . Treatment with eriocitrin combined with resveratrol alleviated edema and subcutaneous tissue inflammation caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vivo . This study also demonstrated that treatment with eriocitrin and resveratrol decreased the levels of the pro-inflammatory cytokines TNF-α and IL-1β. The results of the present study indicate that eriocitrin combined with resveratrol effectively inhibits inflammatory responses both in vitro and in vivo .
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2018
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IF 2.297
Hao Liu,Xuemei Zhou,Yingying Wang,Menglu Yang,Xiaohui Xu,Ailing Wu
Etomidate is one of the first-line general anesthetic agents , with distinguished properties such as rapid onset, excellent cardiovascular stability, minimal impact on respiratory system, etc . However, the clinical application of etomidate preparation is often confined by the notable defects of both the drug and its current formulations. Previously, we reported a new etomidate formulation based on Pluronic F108 micelle which demonstrated improved anesthetic effects. Nevertheless, the micellar encapsulation of etomidate was limited using only one kind of Pluronic, which required organic solvents to modulate the hydrophobicity . Besides, the biocompatibility of this formulation was not yet clear. Herein, we reported that mixed nanomicelles consisting of different Pluronic could make full advantage of each loading material, which led to improved physicochemical properties for the delivery of etomidate. Moreover, in vivo studies demonstrated that, the etomidate-loaded mixed micelle (Eto-PFM) maintained the anesthetic effects and rapid onset property of etomidate, with a broad safe dose range. The potential mechanisms of the acute toxicity were also discussed. The results suggest that Eto-PFM is a promising etomidate preparation with the potential to further develop as an alternative to the current etomidate preparations.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2018
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IF 2.891
Xing Du,Weixin Li,Lei Zhao,Xuan He,Hui Chen,Wei Fang
A facile in-situ modification of photoanode is proposed to construct a unique hierarchical TiO 2 /ZnO structure with the aim at suppressing charge recombination rate and enhancing light harvest efficiency. Foam is not only employed as the soft template to fabricate hierarchical porous TiO 2 films but also as the carrier to realize in-situ growth of one dimensional ZnO nanowires among the TiO 2 nanoparticles. The results revealed that the hierarchical porous TiO 2 nanoparticles could provide both large surface areas and suitable porosity for the loading of quantum dots. In the meantime, ZnO nanowire can act as scattering centers for light absorption and offer direct pathways for electron transportation, thus decreasing the undesired charge recombination process. Consequently, the novel ZnO nanowires in-situ modified hierarchical porous TiO 2 photoanode are used as photoanode material to boost the performances of CdSe sensitized solar cells by virtue of controlling the moderate growth of ZnO nanowires. As a result, a power conversion efficiency of 3.07% is obtained based on this modified photoanode, which manifests 39.5% improvement compared to that of the cells based on bare TiO 2 hierarchical porous films (2.20%) due to the improved interconnections between TiO 2 nanoparticles and FTO substrate caused by ZnO nanowires.
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Journal of Physical Chemistry C
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2019
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IF 4.309
Caiju Chen,Mengling Liao,Beibei Shan,Ming Li
A fundamental understanding of the thermal stability of vacancy-doped cuprous telluride nanocrystals (Cu2–xTe NCs) will be conductive to their exploitation in plasmon-related applications. However, the thermally induced structural and Raman spectral changes of Cu2–xTe NCs have remained fairly unexplored so far. Here, temperature-induced structural transitions of Cu2–xTe nanowires (NWs) are studied by in situ Raman spectroscopy from −190 to 530 °C. Results reveal a dramatic temperature dependence of Raman signatures of Cu2–xTe NWs, serving as a potent indicator for their structures and structural transitions. The hexagonal weissite-to-orthorhombic phase transition takes place in the cooling process from 25 °C to −190 °C. An intermediate state of high degree of disorder with featureless Raman spectra is observed before its dissociation into the elemental Cu and the high-temperature phase above 480 °C. This work provides fundamental insights into the thermally induced structural stability of Cu2–xTe NWs and will further stimulate new exploration of their plasmon-related practical applications.
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RSC Advances
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2018
·Vol. 8
·期 16
·8805-8812
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IF 2.936
Pengfei Wu,Yuanyuan Tang,Zongwei Cai
Coal fly ash is usually used as a cost-effective adsorbent for heavy metal removal, accumulating large amounts of spent coal fly ash that requires further disposal. In this study, fly ash that adsorbs copper with a maximum copper adsorption capacity of 48.8 mg g−1 was further sintered at 900–1050 °C, and it was found that the copper is thermally incorporated in a spinel structure in aluminum- and iron-containing ceramic matrices provided by the fly ash. To further explore the immobilization mechanisms of copper in both aluminum- and iron-containing ceramic matrices like those in fly ash, two systems were prepared from CuO + Fe2O3 + kaolinite and CuO + Fe2O3 + Al2O3. A CuAlxFe2−xO4 spinel solid solution was formed, the peak intensity of which was found to increase upon an increase in the sintering temperature until a maximum amount was reached at 1150 °C. In the CuO + Fe2O3 + Al2O3 system, the 2θ value of the CuAlxFe2−xO4 peaks was found to increase due to the continuous engagement of aluminum in the spinel structure. However, iron was found to be more likely to react with the copper in CuO + Fe2O3 + kaolinite during the formation of CuAlxFe2−xO4. Through effective adsorption of copper on coal fly ash and the subsequent copper stabilization in the spinel, this study found a dual role for fly ash in copper immobilization and further confirmed the potential to recycle waste coal fly ash as a marketable ceramic material.
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ANALYTICAL CHEMISTRY
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2018
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IF 6.042
Xilin Bai,Suying Xu,Leyu Wang
The sensitive and selective detection of hydrogen sulfide is of great importance due to its crucial role in pathological and physiological processes. Herein, we report a novel fluorescent platform, AuNCs@GC, for selective detection of hydrogen sulfide in living cells by impregnating the Au nanoclusters (AuNCs) into a biocompatible cationic polymer matrix, glycol-chitosan (GC) nanogel. The confinement effect significantly increased the emissive Au(I) units, resulting in a 6-fold enhancement of quantum yield (from 6.38% to 36.42%). In addition, the prepared positively charged AuNCs@GC nanogel exhibits excellent selectivity and improved sensitivity to aqueous sulfides. Moreover, the as-fabricated AuNCs@GC showed very good biocompatibility and super fluorescence stability across the full pH range and good salt tolerance, which demonstrated excellent adaptability toward intracellular sulfide imaging.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
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2018
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IF 3.616
Linlin Zhang,Huizong Su,Yue Li,Yujuan Fan,Qian Wang,Jian Jiang,Yiyang Hu,Gaofeng Chen,Bo Tan,Furong Qiu
The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) on the alpha-naphthylisothiocyanate (ANIT)-induced acute and recovery stage of cholestasis model mice. In the acute stage of model mice, pretreatment with UDCA (25, 50, and 100 mg·kg −1 , ig) for 12 days prior to ANIT administration (50 mg·kg −1 , ig) resulted in the dramatic increase in serum biochemistry, with aggrevation of bile infarcts and hepatocyte necrosis. The elevation of beta-muricholic acid (β-MCA), cholic acid (CA), and taurocholic acid (TCA) in serum and liver, and reduction of these bile acids (BAs) in bile was observed. In contrast, in the recovery stage of model mice, treatment with UDCA (25, 50, and 100 mg·kg −1 , ig) for 7 days after ANIT administration (50 mg·kg −1 , ig) resulted in the significant decrease in levels of serum alanine aminotransferase (ALT) and total bile acid (TBA). Liver injury was attenuated, and the levels of TBA, CA, TCA, and β-MCA in the liver were significantly decreased. Additionally, UDCA can upregulate expression of BSEP, but it cannot upregulate expression of AE2. UDCA, which induced BSEP to increase bile acid-dependent bile flow, aggravated cholestasis and liver injury when the bile duct was obstructed in the acute stage of injury in model mice. In contrast, UDCA alleviated cholestasis and liver injury induced by ANIT when the obstruction was improved in the recovery stage.
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DIGESTIVE DISEASES AND SCIENCES
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2018
·Vol. 63
·期 12
·3329-3338
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IF 2.819
Lin Meng-juan,Yu Bao-ping
Background Irritable bowel syndrome (IBS) is a common disease with intestinal dysmotility, whose mechanism remains elusive. TMEM16A is a calcium-activated chloride channel (CaCC) involved in intestinal slow-wave generation. Aims To investigate whether TMEM16A is involved in colonic dysmotility in IBS. Methods A rat model of IBS was established by chronic water avoidance stress (WAS). Colonic pathological alterations were evaluated histologically, and intestinal motility was assessed by intestinal transit time (ITT) and fecal water content (FWC). Visceral sensitivity was determined by visceromotor response (VMR) to colorectal distension (CRD). TMEM16A expression was evaluated by RT-PCR, Western blot, and immunofluorescence. Colonic muscle strip contractility was measured by isometric transducers, and the effect of niflumic acid (NFA), a CaCC antagonist, on colonic motility was examined. Results After 10 days of WAS exposure, ITT was decreased and FWC was elevated. Furthermore, VMR magnitude of WAS rats in response to CRD was significantly enhanced. Protein and mRNA levels of TMEM16A in colon were considerably increased after WAS. The percentage of TMEM16A-positive neurons in myenteric plexus (MP) of WAS rats was significantly higher than controls. Pharmacological blockade of TMEM16A activity by NFA considerably enhanced ITT, with concentration-dependent declines in FWC and VMR magnitude in NFA-treated rats. Further, spontaneous contraction of colonic strips of NFA-treated rats was significantly ameliorated in a concentration-dependent manner in vitro. Conclusions Upregulation of TMEM16A in MP neurons may play an important role in chronic stress-induced colonic hypermotility, making CaCC-blocking drugs a putatively effective treatment method for colonic hypermotility in IBS.
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Journal of Materials Chemistry B
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2018
·Vol. 6
·期 22
·3655-3664
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IF 4.776
Yijia Tang,Siming Huang,Jianqiao Xu,Gangfeng Ouyang,Yuan Liu
Nanomaterials have shown great potential for application in microextraction due to their distinguishing nanoscale architectures and superior physicochemical properties. Herein, novel poly(lactic-co-glycolic acid) (PLGA) solid-phase microextraction (SPME) fibers, which were incorporated with a self-assembled graphene oxide (GO)-coated γ-Al2O3 composite (Al2O3@GO), were fabricated on stainless steel wires via an electrospinning method. The as-spun nanofibers were further sheathed through the self-polymerization of noradrenaline (NA), an agonist found in oysters, to provide a compatible biointerface and antifouling capacity. Acting as the coating substrate of the as-prepared fibers, PLGA is known for its prominent biocompatibility and biodegradability, while the adsorptive Al2O3@GO particles helped to increase their loading capacity. The modified PLGA-based electrospun nanofibers exhibited much higher extraction efficiency compared with the thicker polydimethylsiloxane (PDMS) coatings (165 μm) and polyacrylate (PA) coatings (85 μm). Due to the fine biointerface of the PLGA-based nanofibers, a rapid extraction equilibrium was observed and sampling with the custom-made Al2O3@GO–PLGA@PNA fibers could be accomplished within 15 min. The fibers were then successfully employed for simultaneous in vivo sampling of tetrodotoxin (TTX) and sulfonamides (SAs) in the dorsal–epaxial muscle of living pufferfish (Takifugu obscurus), and satisfactory sensitivities with limits of detection (LODs) in the range of 0.52–2.30 ng g−1 and comparable accuracies to the conventional liquid extraction (LE) method were achieved. In vivo sampling of target pharmaceuticals with the modified nanofibers showed their feasibility for further metabolomics and pharmacokinetics studies in biotissues.
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Nano Energy
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2018
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IF 13.12
Qiuyan Jin,Bowen Ren,Dongqi Li,Hao Cui,Chengxin Wang
Carbon-encapsulated 3d-transition metal (TM) hybrid structure (denoted as M@C) have been considered as a promising candidate for HER . In recent years, the Co@C composites have exhibited effective HER catalytic performance in acidic media. However, the catalytic performance of Co@C in alkaline media is still unsatisfactory because of the sluggish water dissociation in Volmer step. In this work, by using carbon encapsulated metal Co nanoparticles hybrid structure (CoNP@C) as precatalyst, we firstly demonstrate that the HER activity of Co-based precatalysts could be unprecedentedly promoted through a simple in situ electrochemical activation process . Compared with initial CoNPs@C precatalyst, the activated catalyst realizes about 3.5-fold improved activity and the overpotential greatly decreases from 191 mV to 58 mV at 10 mA cm −2 . Specially, the remarkable reduced Tafel slope (from 113 mV dec −1 to 51 mV dec −1 ) indicates that the sluggish kinetics of the water dissociation step (Volmer step) is effectively speeded up by in situ electrochemical activation. Such a highly enhanced catalytic performance is mainly due to the in situ introduction of cobalt hydroxides NPs as water dissociation promoter and the synergetic effects among core Co NPs, middle layered carbon structure and outer cobalt hydroxides NPs. Our study offers a generic strategy for development of high-performance 3d-transition metal hybrid based HER catalysts in alkaline media.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2018
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IF 3.141
Pan Sun,Kun Huang,Jieyuan Lin,Huizhou Liu
PEG-based aqueous two-phase systems (ATPS) for extraction and removal of metal ions from industrial wastewaters is a promising strategy to replace traditional organic-aqueous two phase systems, due to its environmentally friendly advantages and excellent separation efficiency from controllable phase structure and physicochemical properties. However, controversy still remains about the partitioning mechanism of metal ions into the PEG-rich phase in ATPS. The present contribution revealed that a specific hydrophobic interaction was a main driving force for the transferring of Cr(VI) ions into the PEG-rich phase in ATPS. The properties of aqueous media around the PEG molecules and Cr(VI) ions also played a crucial role in the partitioning of Cr(VI) ions in the PEG-base ATPS. The PEG-rich phase in the ATPS exhibited a specific affinity toward poorly hydrated HCrO4– ions, compared to the strongly hydrated CrO42– ions. The difference in the properties of aqueous media in the coexisting liquid phases was response for the partitioning of Cr(VI) ions in the PEG-base ATPS. It was confirmed by combined application of UV–vis spectroscopy and molecular dynamics simulations. The present work provides a new understanding into the microscopic mechanism of the partitioning of metal ions in the polymer-based ATPS.
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CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Zheng-Nan Cai,Wan Li,Shomaila Mehmood,Wen-Juan Pan,Ya Wang,Fan-Ju Meng,Xiao-Fang Wang,Yong-Ming Lu,Yan Chen
This study aimed to investigate the structural features, in vitro and in vivo antioxidant activities of a heteropolysaccharide from the fruiting bodies of Morchella esculenta (FMP-1). FMP-1 had an average molecular weight of 4.7 × 10 3 Da and consisted of mannose, glucose and galactose. By methylation and NMR analysis, the backbone of FMP-1 was deduced to be made up of 1,4-linked Glc p and 1,6-linked Gal p . Hydroxyl, DPPH and superoxide radicals could be efficiently scavenged by FMP-1, with IC 50 values of 74.26, 119.32 and 161.49 μg/mL, respectively. Furthermore, FMP-1 could significantly protect zebrafish embryos against AAPH-induced oxidative damage. Decrease in malformations and mortalities was observed along with the reduction of ROS production, NO production and cell death. The protective effects were by decreasing MDA content and increasing SOD, CAT and GSH-Px levels. The current work provided a good suggestion of the potential utilization of FMP-1 as an attractive natural antioxidant.
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