BIOSENSORS & BIOELECTRONICS
·
2020
·
IF 10.257
Guojuan Zhang,Zhiguang Liu,Lifang Fan,Yujie Han,Yujing Guo
A dual signal and label-free electrochemical aptasensor for mucin 1 was constructed based on hemin/ [email protected] nanocomposite ( [email protected] ). Hemin attached on the graphene surface not only improves the solubility of graphene and acts as an in-situ electrochemical probe but also exhibits excellent peroxidase-like properties to electrocatalyze the reduction of H 2 O 2 . PdPtNPs also show outstanding catalytic capacity to the reduction of H 2 O 2 and provide numerous binding sites for loading dDNA (mucin 1 aptamer and cDNA) to form the sensing interface. In the presence of mucin 1, due to the specific affinity between aptamer and mucin 1, double helix would be induced dissociation and the aptamer would be pulled off from the electrode. As a result, the electrochemical signals of hemin and H 2 O 2 were recovered. Based on these properties, the label-free and sensitive dual signal electrochemical biosensor for mucin 1 detection has been developed. The one is differential pulse voltammetry (DPV) signal of hemin and the other is chronoamperometry signal arisen from the catalytic reduction of H 2 O 2 . The linear ranges for mucin 1 were 8.0 pg mL −1 to 80 ng mL −1 and 0.8 pg mL −1 to 80 ng mL −1 with the limit of detection 2.5 pg mL −1 and 0.25 pg mL −1 by DPV and chronoamperometry, respectively. The recovery of mucin 1 in human blood serum samples was from 95.0% to 104.2%. The detection platform does not need signal labeling which greatly reduced the sophisticated and expensive procedures. The aptasensor provide a promising strategy for the determination of mucin 1 in clinical diagnostics.
研究领域:
生物传感器
·
分析化学
·
癌症诊断
·
电化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2017
·
IF 6.844
Chenglong Wen,Shanlei Han,Jundong Xu,Yu Fan
The article proposes a novel and eco-friendly method for synthesizing SAPO-11 in ethylene glycol (EG) and supercritical carbon dioxide (ScCO 2 ). The method incorporates ScCO 2 into EG to decrease the solubility of SAPO-11 precursors in EG and thereby forms a highly supersaturated solution of SAPO-11 precursors. The as-synthesized SAPO-11 possesses smaller particles, a larger external surface area, and a larger number of acid sites than the SAPO-11 synthesized in EG and the SAPO-11 synthesized in water and ScCO 2 , respectively. These advantages of the as-synthesized SAPO-11 endow the corresponding catalyst with superior dibranched isomer selectivity and low cracking selectivity during 1-octene hydro isomerization.
研究领域:
化学工程
·
催化材料
✓ 已验证
DOI
高影响因子
POLYHEDRON
·
2022
·
IF 2.975
Shun-Ping Zhao,Qiang-hong Yu,Ping Yang,Yu Guo,Jie Wang,Heng Xu
Oriented design of crystal structures to obtain specific properties is one of the hot topics in the field of chemistry and materials. In this paper, three organic–inorganic hybrid crystals were synthesized by the reaction of 1-aminopyridinium salts with o -, m -, and p -cyanobenzaldehyde and PbBr 2 . The asymmetric unit of 1 ([1- aminopyridinium][Pb 2 Br 5 ], P 2 1 / m ) contains half of the 1-aminopyridinium cation and the anion forms a zig-zag shaped puckered sheet of [Pb 2 Br 5 ] ∞ ; while 2 ([ m -cyanobenzaldehyde-1-aminopyridinium][PbBr 3 ], Pna 2 1 ) includes a m -cyanobenzaldehyde-1-aminopyridinium Schiff base cation, and the anion forms a [PbBr 3 ] ∞ single chain. On the other hand, 3 ([ p -cyanobenzaldehyde-1- aminopyridinium][PbBr 3 ], P 2 1 / c ) consists of a p -cyanobenzaldehyde-1- aminopyridinium Schiff base cation, with the anion forming a [Pb 2 Br 6 ] ∞ double chain. Structural analysis and energy framework calculations show that 2 possesses stronger π-π stacking and hydrogen bonding interactions, and its lattice energy and thermal stability are higher than those of 1 and 3 . The combined use of CE and dielectric modulus analysis reveals a good correlation between multi-step dielectric relaxation and intermolecular forces. This strategy of modulating the crystal structure and dielectric properties by altering the position of the substituents provides useful assistance in the design of new relaxation dielectric materials.
研究领域:
材料化学
·
晶体工程
·
介电材料
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Bing Zhao,Zhiqiang Qian,Min Guo,Zhijian Wu,Zhong Liu
The improved adsorption capacities by increasing specific surface area methods are merely reached about 50% of H 4 Ti 5 O 12 ’s theoretical adsorption capacity, and the adsorption behavior and mechanism of lithium on special facets of H 4 Ti 5 O 12 remain unclear. In this study, a flower-shaped Li 4 Ti 5 O 12 and an octahedral Li 4 Ti 5 O 12 were prepared with the specific surface areas of 176.23 and 83.02 m 2 /g, and the corresponding adsorption behaviors of the obtained adsorbents exposed with (1 1 0) and (1 1 1) facets were investigated by using experimental and computational methods. The maximum Li + uptake values on H 4 Ti 5 O 12 (1 1 0) and H 4 Ti 5 O 12 (1 1 1) are 26.85 mg/g and 33.56 mg/g at 45 °C in 24 mM LiCl solutions, respectively. The fifth reuse ability of H 4 Ti 5 O 12 (1 1 1) still remains 88.9% of the original’s, which is higher than H 4 Ti 5 O 12 (1 1 0) (76.3%). Although with lower specific surface area, the octahedral H 4 Ti 5 O 12 have higher ions selectivity , greater adsorption capacity, and better reuse ability than flower-shaped H 4 Ti 5 O 12 , which may due to the special (1 1 1) facet exposed. Firstly, H 4 Ti 5 O 12 (1 1 1) owned small hole sizes can inhibit other ions diffusing into H 4 Ti 5 O 12 and improve the ion selectivity. Secondly, the immigration paths by the First-principles calculations revealed that the Li + migrate onto the Li 4 Ti 5 O 12 (1 1 1) is easier to than Li 4 Ti 5 O 12 (1 1 0) through 8a-16c-8a-16c sites. At last, [Li(H 2 O) 4 ] + can form the stable complexes and its adsorption energies on (1 1 1) are higher than on (1 1 0) facets, which may lead to larger adsorption capacity and better reuse ability. This work will help to understand the [Li(H 2 O) 4 ] + adsorption behavior and mechanism on different crystal facets by experiments and computations.
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产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2021
·Vol. 31
·期 4
·1125-1132
·
IF 2.217
Wu Chuqiao,Lin Xin,Wang Qianming
The new design strategy will provide the possibility for preparing a dynamic sensor by employing the inhibition of C = N isomerization. In this work, the functional probe 4-(1 H-imidazo [4,5-f] [1,10]-phenanthrolin-2-yl) benzaldehyde oxime (compound 4 ) has been synthesized and such molecule gives rise to blue emission. Due to the incorporation of hypochlorite, the oxime group can be oxidized to the structure of aldehyde. As a result, the molecular motif exhibits sharp emission change from blue to green due to the addition of hypochlorite with enough sensitivity and selectivity (detection limit = 53 nM, linear range 0.5-8.0 µM). It has also been used for monitoring ClO − by employing solution color change and the absorption signal difference could effectively rule out the effects of interference species. To our knowledge, it will be the first case of a highly selective hypochlorite sensor derived from oxime isomerization reaction based on phenanthroline backbone.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Alimujiang Yalikun,Yanhong Wang,Nian Shi,Yiwen Chen,Hao Huang,Hyun-Joo Koo,Zhongwen Ouyang,Zhengcai Xia,Reinhard K. Kremer,Myung-Hwan Whangbo,Hongcheng Lu
We prepared a new polar layered quantum magnet Ba2Cu3(SeO3)4F2, by a combined use of F– and pyramidal SeO32– anions, determined its crystal structure by X-ray diffraction, and characterized its magnetic properties by magnetization, electron spin resonance (ESR) and specific heat measurements, and by density functional theory calculations. The title compound has first experimentally reported bitriangular chains of Cu2+ ions aligned along the b direction to form layers parallel to the ab plane, and these layers are separated by Ba2+ ions. The magnetic susceptibility data reveal that, despite strong predominant antiferromagnetic intrachain interactions indicated by the large negative Weiss temperature θ of −143.9 K within bitriangular chains, no long-range order occurs down to 2 K. The latter, further confirmed by the specific heat measurements, is attributed to the extremely weak interlayer interaction. The spins in each bitriangular chain become ferrimagnetically ordered to exhibit a 1/3-magnetization plateau, which persists at least up to 30 T. This reveals that each bitriangular chain acts as an S = 1/2 entity at low temperatures, as observed from the decrease of the effective magnetic moment Peff from 3.67 μB in the high temperature range to 1.89 μB in the low temperature range, equivalently, from three free Cu2+ ions to only one effective Cu2+ ion per formula unit. In each layer of Ba2Cu3(SeO3)4F2, the interaction between adjacent ferrimagnetic chains is ferromagnetic rather than antiferromagnetic, contrary to the observations in other reported cases.
研究领域:
凝聚态物理
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量子磁性
·
晶体学
·
材料科学
·
固体物理
✓ 已验证
DOI
高影响因子
Protein & Cell
·
2024
·
IF 13.6
Ma Wei,Zhang Lu,Chen Weilong,Chang Zhaoxia,Tu Juchuanli,Qin Yuanyuan,Yao Yuwen,Dong Mengxue,Ding Jiajun,Li Siqin,Li Fengkai,Deng Qiaodan,Yang Yifei,Feng Tingting,Zhang Fanrong,Shao Xiying,He Xueyan,Zhang Lixing,Hu Guohong,Liu Quentin,Jiang Yi-Zhou,Zhu Shu,Xiao Zhi,Su Dan,Liu Tong,Liu Suling
Tumor-resident microbiota in breast cancer promote cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail. Here, we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to taxane-based neoadjuvant chemotherapy. ETBF, albeit at low biomass, secreted the toxic protein BFT-1 to promote breast cancer cell stemness and chemoresistance. Mechanistic studies showed that BFT-1 directly bound to NOD1 and stabilized NOD1 protein. NOD1 was highly expressed on ALDH+ breast cancer stem cells (BCSCs) and cooperated with GAK to phosphorylate NUMB and promote its lysosomal degradation, thereby activating the NOTCH1-HEY1 signaling pathway to increase BCSCs. NOD1 inhibition and ETBF clearance increases the chemosensitivity of breast cancer by impairing BCSCs.
研究领域:
肿瘤学
·
微生物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 60
·期 15
·2298-2308
·
IF 3.046
Zhaolai Huang,Jiaqi Li,Mengxiao Zhang,Weilin Feng,Chuanjie Fang,Liping Zhu
Polymers of intrinsic microporosity (PIMs) are promising materials for membrane separation because their special rigid and contorted structures contribute to high permeability. However, their chain rearrangement to fill excessive free volume makes the permeability stability a tough challenge. In this work, we report on a new use of rutile nano-TiO 2 to mitigate the physical aging of PIM-1 (a typical PIM) nanofilms for stable permeability by mixing matrix. It was shown that the PIM-1 membrane incorporated with nano-TiO 2 displayed remarkably higher aging resistance with a lower swelling degree in long-term ethanol soaking, having more stable ethanol permeance with only a 5% decrease after 35 days, lower than 25% of the pure one. The mechanism of anti-aging was revealed by molecular simulation, thermal, tensile mechanical, and dynamic mechanical analysis. It was found that nano-TiO 2 had good compatibility with PIM-1 due to strong coordination interaction, making its uniform dispersion in polymer. Additional solvent permeation channels were also created to increase solvent permeance without compromising solute rejection. Due to the reliable interaction of nano-TiO 2 , which makes particles serve as physical crosslinking points, the movement of PIM-1 chains was limited partially to mitigate aging, enabling PIM-1-based membranes to have robust solvent permeation. Graphical
研究领域:
材料科学
·
化学工程
·
高分子科学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Hao Lu,Yu Yang,Ruijue Chen,Wenyi Huang,Hao Cheng,Xueping Liu,Hongxing Kong,Lijun Li,Jun Feng
In this study, we synthesized gold nanoparticles (AuNPs) in situ on the surface of two-dimensional Cu-TCPP (meso-tetra(4-carboxyphenyl)porphine) metal– organic framework (MOF) nanosheets to produce AuNP@Cu-TCPP nanocomposites as surface-enhanced Raman scattering (SERS) substrates. The SERS signal was enhanced in two ways: aggregation of the AuNPs@Cu-TCPP near the SERS hotspot through the strong adsorption capacity of the MOF, and the synergistic effect between the charge-transfer enhancement of the Cu-TCPP MOF and the electromagnetic enhancement of plasmonic metal AuNPs. The SERS activity of AuNPs@Cu-TCPP was evaluated by the analysis of multiple model analytes; Rhodamine 6G (R6G) and benzidine were detected with detection limits below 10 –13 and 10 –12 mol·L –1 , respectively. We used AuNP@Cu-TCPP as a SERS substrate combined with an enzyme-linked immuno- sorbent assay (ELISA) to detect the tumor marker carboxylesterase 1 (hCE1) in human serum. The SERS signal of benzidine at 1609 cm −1 is linearly correlated with hCE1 in the concentration range of 0.1–120 ng·mL −1 . Owing to their high sensitivity and excellent SERS sensing capability, AuNPs@Cu-TCPP nanocomposites have potential applicability in the analysis of clinical samples.
研究领域:
生物医学工程
·
分析化学
·
肿瘤标志物检测
✓ 已验证
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Kaiwei Wang,Hao Ruan,Fumin Wang,Yi Zhai,Mingshuai Sun,Yan Chen,Jiaxing Zhang,Yihao Wang,Xuyang Zou,Xubin Zhang
The construction of abundant TiO 6 active sites within the zeolite framework is essential for further enhancing the catalytic performance of TS-1 zeolite. Here, we employ a strategy involving treatment with a mixture of amines and ammonium salts to generate abundant TiO 6 species within zeolites synthesized with the assistance of N,N-dimethylformamide (DMF). It was observed that during the post-treatment process, the presence of amines and ammonium salts plays a key role for the formation of highly active TiO 6 species. The incorporation of DMF can significantly enhance the TiO 6 content in the post-treated zeolite, increasing it to 61.5 % compared with 28.5 % in the zeolite synthesized without DMF. The effect of the DMF/SiO 2 ratio in the synthesized gel on the morphology and catalytic performance was also examined. It is noteworthy that the incorporation of DMF influences the microenvironment of the Ti active sites following post-treatment. 1 H MAS NMR analysis reveals that the characteristic peaks corresponding to Ti-OH and isolated Si-OH groups in the DMF-synthesized catalyst are significantly intensified after treatment with amines and ammonium salts. When H 2 O 2 is employed as an oxidant, the optimal catalytic performance achieves a cyclohexene conversion of 51.1 % and a cyclohexene oxide yield of 39.4 %, with a high TOF value of 92.77 h −1 . Notably, the catalyst exhibits a significantly conversion rate of 79.4 % and a yield of 72.7 % using O 2 as the oxidant.
研究领域:
催化化学
·
材料科学
·
无机化学
·
石油化工
·
绿色氧化
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2022
·
IF 3.322
Wei Sun,Jing Liu,Renhao Zhao,Teng Yang,Zhichen Zheng,Tongyu Zhang,Guofeng Wang
Background and Purpose: To investigate the biological role of interferon α/β receptor 2 (IFNAR2) in type 1 diabetes (T1D). Methods First, IFNAR2 mRNA and protein expression levels in serum of T1D patients and healthy controls were detected by RT-qPCR and Western blot . For experimental studies, 80 male C57BL/6 mice were randomly divided into 4 groups with 20 mice in each group: the control group, the T1D group, the T1D + ad-con group and the T1D + ad-si-IFNAR2 group. The T1D mouse model was generated by multiple intraperitoneal injections of small doses of streptozotocin (STZ). Body weight and blood glucose levels were measured weekly until 6 weeks. After 6 weeks, all mice were sacrificed and the levels of insulin (Ins), tumor necrosis factor α (TNF-α), interleukin 4 (IL-4), IL-6, and type I interferon γ (IFN-γ), IFNAR2 protein expression, the number of dendritic cells (DCs), and changes in islet β cells were assessed. Results IFNAR2 mRNA and protein expression levels in serum of T1D patients were significantly higher than those in healthy controls ( P < 0.05). Furthermore, IFNAR2 protein expression, number of DCs, and IFNAR2 mRNA, blood glucose, TNF-α, and IFN-γ levels were significantly upregulated in T1D mice compared with the control group ( P < 0.05), while weight, and Ins, IL-6, and IL-4 levels were decreased ( P < 0.05). However, knockdown of IFNAR2 reversed these trends. There was no significant difference in markers between the T1D + ad-con group and the T1D group ( P > 0.05). Conclusions Knockdown of IFNAR2 reduced the inflammatory response and improved islet function of T1D mice.
研究领域:
免疫学
·
糖尿病
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
·
2021
·Vol. 99
·期 12
·
IF 2.273
Weimin Xu,Peng Wang,Dalong Wang,Ke Liu,Shuaishuai Zhang,Wei Zhao,Guoqing Liu
The aim of the present study was to investigate the protective effect of S-ketamine (S-KET) against carbon tetrachloride (CCl4) – induced liver damage and oxidative stress, as well as to elucidate the related underlying mechanisms. Blood was collected to measure biochemical parameters (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TB) and γ-glutamyltransferase (γ-GT)) and the liver was harvested for histopathological analysis of enzymes related to the antioxidant response (malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-PX)). Liver cell apoptosis was evaluated using the TUNEL assay. In addition, the expression levels of apoptosis-related proteins and the nuclear factor erythroid 2–related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway were detected by Western blot analysis to explore potential mechanisms. S-KET protected the liver from CCl4-induced damage. The changes to the liver biochemical parameters (increased ALT, AST, ALP, TB, and γ-GT) and oxidative stress-related indicators (increased MDA; depleted SOD, GSH, and GSH-PX) induced by CCl4 were inhibited by S-KET. S-Ket also inhibited CCl4-induced cell apoptosis, the changes in expression of related proteins, and blocked CCl4-induced liver injury and oxidative stress via activation of the Nrf2/HO-1 signaling pathway. S-KET effectively protected the liver by inhibition of CCl4-induced damage via upregulation the Nrf2/HO-1 signaling pathway.
研究领域:
药理学
·
肝病学
·
分子生物学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
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