Marine Drugs
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2026
·Vol. 24
·期 4
·125
·
IF 5.7
Zi-Han Xu,Zheng-Biao Zou,Chun-Xiu Wang,Chen Li,Xian-Wen Yang,Jun-Song Wang
Inhibition of inflammation and oxidative stress is increasingly recognized as a promising therapeutic strategy for neurodegenerative diseases. In this study, we isolated two new dimeric naphtho-γ-pyrone (aS)-fonsecinones B and D (1and2) and 14 known compounds (3–16) from the deep-sea-derived fungusAspergillus niger3A00562. Their structures were unambiguously determined through integrated physicochemical and spectroscopic analyses. Screening for neuroinflammatory inhibitors using a BV2 microglial cell model identified TMC 256 A1 (10) as the most potent candidate. Compound10significantly suppressed LPS-induced inflammation in BV2 cells without cytotoxicity. It concurrently inhibited LPS-triggered ROS overproduction and neutrophilic infiltration in zebrafish. Subsequent proteomics revealed that10targets NOS2 to modulate Alzheimer’s disease (AD)-associated pathways and the KEAP1-NRF2 axis. Molecular docking and dynamics simulations demonstrated that10occupies the NOS2 heme-binding pocket, thereby preventing dimerization and inhibiting enzymatic activity. Finally,10ameliorated locomotor deficits in an AD zebrafish model. Collectively, these findings highlight compound10as a candidate compound for preventing inflammatory and oxidative stress damage during treatment of neurodegenerative diseases, particularly AD.
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高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2026
·
IF 3.6
Lin Zhou,Zhanghong Guo,Haining Cui,Jinxin Ma,Chan Wang,Qijun Song
Direct transformation of biomass-derived platform compound 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) represents a highly attractive route with significant environmental and economic benefits. The nanozymes with oxidase-like (OXD-like) activity hold great promise for the green oxidation of HMF to FDCA. Herein, an iridium-coated γ-Fe 2 O 3 core-shell nanozyme (γ-Fe 2 O 3 @Ir) was prepared by the reduction of Ir 3+ with glycerol on the surface of γ-Fe 2 O 3, and the structure of the γ-Fe 2 O 3 @Ir nanozyme was confirmed by XRD, HAADF-STEM image, and elemental line-scan analyses results. The magnetic property of the nanozyme not only facilitates its recovery but also effectively enhances its affinity to oxygen. By employing γ-Fe 2 O 3 @Ir nanozyme as the catalyst and atmospheric oxygen as a green oxidant, a near-quantitative conversion (98.5%) of molar level HMF to FDCA was achieved.
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DOI
PubMed
高影响因子
Nanoscale
·
2026
·
IF 5.2
Zewen Shen,Tao Jiang,Gehong Liu,Jiayi Liu,Yezi Hu,Haotian Zhang,Huihui Jin,Bingfeng Li,Shuxian Hu,Xiangke Wang,Guixia Zhao,Xiubing Huang
Nuclear energy has emerged as a vital clean energy source with super-high energy density. As a representative of fourth-generation nuclear reactors, High-Temperature Gas-Cooled Reactor (HTGR) generates substantial amounts of tetrahydrofurfuryl alcohol (THFA)-containing wastewater, for which effective treatment methods are rarely explored. Here, we present a selective and efficient approach employing anatase TiO2 as a photocatalyst to upcycle THFA into γ-hydroxybutyric acid (GHB), which can be used as a valuable bifunctional monomer to successful synthesize biodegradable poly(4-hydroxybutyrate). With optimized TiO2 catalyst, a THFA conversion of 87.6% and a GHB yield of 0.198 g/h/m2 were achieved. It was further elucidated that the •OH radicals generated by UV-excited TiO2 initiate the rapid transformation of THFA into GHB through two parallel pathways and the sluggish oxidation of GHB thereby facilitates its accumulation. The developed flow reactor could lead to the total conversion of THFA with GHB as main product that can be purified and separated, demonstrating the practical feasibility of the proposed strategy. This approach showcases the potential for converting THFA-containing wastewater into high-value chemicals through photocatalysis, offering an eco-friendly solution for THFA-containing wastewater treatment.
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PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Shasha Fang,Ran Hao,Wenjiong Li,Yixin Luo,Fu Li,Qingxin Guan,Jia Wang,Wei Li,Daniel C.W. Tsang
The conversion of biomass-derived levulinic acid (LA) to γ-valerolactone (GVL) offers a sustainable route for chemical production. Achieving efficient and selective electrocatalytic hydrogenation in aqueous media remains challenging due to limited supply of active hydrogen (H*) and selectivity–efficiency trade-off. Herein, we propose an electrochemical reconstruction strategy to generate Pb/PbO nanosheet electrocatalysts that can enable efficient aqueous-phase electrocatalytic hydrogenation of LA to GVL at room temperature, achieving a Faradaic efficiency of 59.2% and a yield rate of 22.2 mg h −1 cm −2 at –1.1 V vs. RHE, outperforming most previously reported aqueous LA-to-GVL systems. In-situ experiments reveal that the superior performance resulted from the synergy of Pb/PbO heterostructures and oxygen vacancies: heterostructures facilitated efficient electron transfer, oxygen vacancies optimized LA adsorption and H* activation, and a high surface area exposed additional active sites. Integration of a flow electrolyzer with an extraction–distillation unit provided continuous LA conversion and high-purity GVL recovery, demonstrating practical feasibility. This work provides a rational design of efficient electrocatalysts for hydrogenation of biomass-derived platform molecules.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Xuan Wang,Xu Meng,Tao Liang,Jiachun Song,Kamal Eldin Afaf,Hong Duan,Lingyan Zheng,Gang Chen
γ-Cyclodextrin (γ-CD) is one of the most widely used materials for encapsulating hydrophobic functional molecules due to its distinctive structural features, especially an internal hydrophobic cavity surrounded by external hydrophilic surface. However, its limited loading capacity, adsorption efficiency, and poor stability hinder its broader applications. To address this issue, γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) was formed by anchoring potassium ions with γ-CD through hydrothermal self-assembly. After loading different hydrophobic small molecule active substances, a multifunctional composite coating was prepared by embedding them into the chitosan (CS) matrix. The release kinetic model analysis confirmed that the release behavior of Cinnamaldehyde (Cia), 2-methoxycinamaldehyde (2-MCA), and Curcumin (Cur) from γ-CD-MOFs conformed to the Ritger-Peppas equation. Compared with CS, CS/γ-CD-MOF@Cia has a strong inhibitory effect on E. coli O157: H7 and S. aureus . Sprayed on green grapes, the shelf life is extended to 21 days. CS/γ-CD-MOF@2-MCA can significantly reduce the spoilage of milk caused by photooxidation. Furthermore, compared with CS, the oxidation and browning of banana peels were effectively delayed by CS/γ-CD-MOF@Cur, and complete blackening is not observed even after 11 days of storage. By combining the advantages of chitosan and γ-CD-MOF, the active molecules with different functions were encapsulated on the platform of γ-CD-MOF to achieve antibacterial, light-blocking, and antioxidant effects on food. The novel functional coating materials presented in this work offer a promising approach to effectively prolonging the shelf life of fresh foods products.
研究领域:
食品科学与技术
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材料科学
·
纳米技术
·
活性包装
·
控释
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Sujie Shan,Wei Wang,Dongmei Liu,Zhiwei Zhao,Wenxin Shi,Fuyi Cui
Owing to the twin problems of eutrophication and global phosphorus (P) scarcity, the removal and recovery of phosphate from water and wastewater have received increasing attention. Herein, magnetically recyclable La 2 O 2 CO 3 /γ-Fe 2 O 3 adsorbents were rationally designed by derivation from La/Fe binary metal organic framework (MOF) precursors via calcination treatment. Based upon preliminary screening of as-prepared La 2 O 2 CO 3 /γ-Fe 2 O 3 nanocomposites with different La-to-Fe molar ratios in terms of phosphate sorption capacity and magnetic property as well as La content, La 2 O 2 CO 3 /γ-Fe 2 O 3 nanocomposite with a La-to-Fe molar ratio of 2:1 was selected for further characterization and adsorption performance evaluation. Batch adsorption experiments showed that La 2 O 2 CO 3 /γ-Fe 2 O 3 (2:1) adsorbent exhibited a remarkable phosphate sorption capacity of 134.82 mg P/g, a fast sorption kinetic, strong selectivity for phosphate in the presence of co-existing anions, and a wide applicable pH range of 3−9. Furthermore, La 2 O 2 CO 3 /γ-Fe 2 O 3 (2:1) sorbent displayed an excellent sorption performance for low-concentration wastewater, a low dosage of 0.1 g/L was sufficiently enough for reducing P-concentration from 0.5 mg P/L to below 10 μg P/L within 20 min. In a real sewage of 2.68 mg P/L, 0.2 g/L of sorbent could reduce the concentration of phosphate to <0.01 mg P/L within 50 min. Moreover, over 83.1 % of original sorption capacity could be retained after 5 consecutive regeneration cycles, showing great regenerative performance of the adsorbent. These development is expected to be meaningful for practical water purification.
研究领域:
环境科学
·
材料科学
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Xianghai Li,Xiaxia Yang,Shiyu Yan,Xiangyue Liu,Gang Yang
In recent years, the synthesis of inorganic materials and their morphology–property relationships have emerged as prominent research topics in the field of materials chemistry. This study employed a hydrothermal method to synthesize γ-AlOOH nanorods and nanosheets, which were subsequently coated onto Celgard 2325 separators. The effects of different morphologies of γ-AlOOH coatings on separator performance were analyzed comparatively. Compared to the Celgard 2325 separator, the γ-AlOOH-coated separator exhibited enhanced properties, with the Celgard 2325-nanorod separator demonstrating the best results, achieving an electrolyte uptake of 190.8%, a thermal shrinkage rate of only 1.7% at 160 °C, and an ionic conductivity of 0.75 mS cm−1. The assembled battery maintained a discharge specific capacity of 107.8 mA h g−1 at a rate of 5C, and after 300 cycles at 1C, the capacity retention was 79.6%, significantly outperforming the Celgard 2325 separator (66.1%) and the Celgard 2325-nanosheet separator (71.4%). These results elucidate the mechanism by which the γ-AlOOH morphology regulates the structural and electrochemical properties of composite separators, offering valuable insight for the design of next-generation, high-performance lithium-ion battery separators.
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BIOCATALYSIS AND BIOTRANSFORMATION
·
2026
·
IF 1.9
Zulekha,Beibei Fang,Kaixuan Liu,Ahmer Jalal,Chengli Yang,Dali Li
Glutamate decarboxylase (GAD) catalyzes the conversion of L-glutamate to γ-aminobutyric acid (GABA), a bioactive compound of therapeutic relevance. In this study, GAD was recombinantly expressed in Escherichia coli BL21 (DE3) (pET30a-GAD) and immobilized via entrapment in alginate gel with nano-calcium carbonate (nano-CaCO3) synthesized in a green deep eutectic solvent. The entrapment immobilization enhanced the nano-CaCO3 immobilized GAD catalytic properties, operational stability, and reusability. The immobilized GAD displayed optimal activity at 50 °C and pH 4, retained 42% activity after 3 h at 80 °C, and maintained 85% activity after 1 h at pH 3. The non-nano-CaCO3 immobilized GAD retained 21% activity after 3 h at 80 °C and 58% after 1 h at pH 3. The Km and Vmax of free GAD were 0.03 mM and 765.1 µmol·L−1·min−1. After immobilization, the Km and Vmax of non-nano-CaCO3 were 2.85 mM and 0.30 µmol⋅L−1 min−1, and the Km and Vmax of nano-CaCO3 were 1.37 mM and 0.48 µmol·L−1·min−1 respectively. Long-term storage and reusability assessments showed 52% retained activity after 40 days at 4 °C and over 90% after 8 cycles, compared to 27% and under 70% for the non-nano-CaCO3 immobilized GAD. The scanning electron microscopy (SEM) image confirmed the successful incorporation of nano-CaCO3 particles within the immobilized GAD beads. These results demonstrate that the nano-CaCO3 assisted alginate entrapment immobilization offers a robust and sustainable strategy for enhancing GAD stability and functionality in biocatalytic applications.
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高影响因子
JOURNAL OF POWER SOURCES
·
2013
·
IF 4.675
Xiaoling Cui,Hongming Zhang,Shiyou Li,Yangyu Zhao,Liping Mao,Wei Zhao,Yongli Li,Xiushen Ye
To seek the promising candidate for 5 V electrolytes, fluorine-free lithium bis(oxalato)borat (LiBOB) is chosen as the lithium salt , γ-butyrolactone (GBL) as well as sulfolane (SL) with the property of stability against oxidative decomposition is chosen as supporting electrolyte solvents, and linear diethyl carbonate (DMC) is chosen as the third supporting electrolyte solvent to lower viscosity. After systematical analytical studies, it indicates that SL solvent is the main and key reason for the improvement of electrochemical performance , which not only improves the stability of electrolyte system against oxidative decomposition, but also decreases the electrode polarization resistance . More than that, 1.0 mol L −1 LiBOB–SL/GBL/DMC electrolyte shows good compatibilities with both intercalation hosts as LiNi 0.5 Mn 1.5 O 4 cathode and carbonaceous anode. It suggests that this novel electrolyte would be an alternative electrolyte for 5 V high-voltage rechargeable lithium-ion batteries based upon LiNi 0.5 Mn 1.5 O 4 cathode.
研究领域:
电化学
·
能源材料
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锂离子电池
·
高电压电解质
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高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Zhengli Liang,Haitao Zhou,Yuchao Li,Maxim S. Molokeev,Mikhail Plyaskin,Youquan Liu,Rui Wu,Xingxing Jiang,Changlong Zhang,Zheshuai Lin
Negative-thermal-expansion (NTE) materials violate the common knowledge of “thermal expansion and cold contraction” in solids and embrace various physical mechanisms. In most phonon-driven NTE materials, an open-framework structure is necessary to accommodate the spatially anisotropic phonon excitations of the bridged atoms, but such a structural feature may result in structural instability at a high temperature. Herein, we focus on γ-LiBO2 with a closed-framework diamond-like structure and identify its uniaxial NTE behavior over the largest temperature range (100−850 K) among this structural family. As the temperature increases, the synergetic structural modification of the constituent structural groups, i.e., the stretching and bending of the Li−O bonds in floppy [LiO4] and the tension or rotation in the [BO4] group, accounts for NTE along the c-axis. Our study unveils that, apart from the anisotropic phonon excitations of individual atoms, the preferred phonon excitations of structural groups are also able to generate NTE, which would update the understanding of the NTE mechanism and guide the further exploration of phonon-driven NTE materials.
研究领域:
材料科学
·
固体物理
·
材料热学性能
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晶体学
·
声子动力学
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高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Wenquan Sun,Biao Ma,Yongjun Sun,Huaili Zheng,Genchao Ma
In this work, the degradation of tetracycline (TC) in wastewater was investigated using the γ-Al 2 O 3 – Bi–(Sn/Sb) particle electrodes. Parameters affecting the degradation efficiency and energy consumption of the γ-Al 2 O 3 –Bi–(Sn/Sb) particle electrodes, such as electrical conductivity, initial pH, air flow, current intensity, plate distance, filling ratio, and initial wastewater concentration, were systematically investigated. Results showed that the optimal conditions were 4000 mS·cm - 1 conductivity, pH 6, 15 mL·min - 1 air flow, 0.1 A current intensity, 4 cm plate distance, 0.05 g·mL - 1 filling ratio, and 100 mg·L -1 wastewater concentration. More than 90% and 70% of TC and total organic carbon were degraded, respectively, under the optimal conditions. In addition, the γ-Al 2 O 3 –Bi–(Sn/Sb) particle electrodes had good stability and reproducibility.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Yue Fang,Xianqi Zhu,Na Wang,Xuan Zhang,Dongzhi Yang,Jun Nie,Guiping Ma
The repair process in wound healing is vital and complicated, which brings great challenge to researchers. Tissue engineering scaffolds provide a realizable approach for wound repair. In this study, nanofibers with Poly(γ-glutamic acid) (γ-PGA) as the core and Polylactic acid (PLA) as the shell materials were prepared via coaxial electrospinning. The effect of flow rate on the structure and diameter of the core-shell nanofibers was investigated. The microstructure and morphology of the core-shell nanofibers were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). In laser scanning confocal microscopy experiments (LSCM), core-shell nanofibers loaded with rhodamine and coumarin-6 were excited with red and green light respectively to further investigate the structure of core-shell nanofibers. The hydrophobicity and degradation of core-shell nanofibers were studied by water contact angle test and degradation performance test experiments. The in vitro cell culture study showed favorable biocompatibility of nanofibers. The in vivo animal experiment showed that PLA/γ-PGA core-shell nanofiber membrane was conducive to wound repair, where more than 90% re-epithelialization was observed. It suggested a promising and dependable material for tissue engineering and wound healing.
研究领域:
生物材料
·
组织工程
·
纳米技术
·
伤口愈合
·
高分子科学
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高影响因子
危险品化学品经营许可证（带存储）