JOURNAL OF MOLECULAR STRUCTURE
·
2018
·
IF 2.011
Guanfan Chen,Mengzhuo Tang,Xiufang Fu,Fenmin Cheng,Yunfei Long,Yuanyuan Li,Yinchun Jiao,Rongjin Zeng
Thiophenol and its derivatives easily cause damage to aquatic bioorganisms, animals and even human being, therefore, fluorescent probes for detecting thiophenol with sensitive and selective characters are highly popular. In this study, a highly sensitive and selective porphyrin-based fluorescent sensor ( M1 ) was reported for detection of thiophenol based on the steric hindrance effect, where the recognition unit, 7-nitrobenzo[ c ][1,2,5]oxadiazolyl group is linked to aromatic ortho -position in the porphyrin , and correspondingly the fluorescence of fluorescein is efficiently quenched. Its time of fluorescence response for thiophenol was only 60s, and its fluorescence responses for the other anions/molecules were all far lower than the relative fluorescence ratio values for thiophenol, which means that the porphyrin-based fluorescent sensor is rapid, sensitive and selective to detection of thiophenol. This approach offers some useful insights for designing sensitive and selective fluorescent turn-on sensors in the detection assays for other analytes.
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Jinze Wang,Lin Liu,Jie Chen,Mingxiao Deng,Xiagru Feng,Li Chen
In clinical cancer treatment, the combination therapy as new therapeutic strategy has attracted more concerns to feature stronger anticancer efficacy and fewer side effects. Herein, a kind of cationic nanoplatform was fabricated to co-deliver gene and photosensitizer based on the supramolecular interaction between β-cyclodextrin (β-CD) and tetraphenylporphyrin (TPP), in which cationic poly (L-lysine) as genes delivery was modified by β-cyclodextrin (β-CD-PLL) and PEGylated TPP was used as water soluble photosensitizer (TPP-PEG). The structures of β-CD-PLL and TPP-PEG were characterized by 1 H NMR. The host-guest recognition between β-CD-PLL and TPP-PEG was verified by DLS and TEM. In vitro data indicated that this platform showed high DNA transfection efficiency and photodynamic effect for the combination of genetic and photodynamic therapy.
✓ 已验证
产品关联
DOI
高影响因子
SOIL USE AND MANAGEMENT
·
2019
·Vol. 35
·期 4
·664-674
·
IF 1.958
Xuewei Wang,Yanju Gao,Baowei Hu,Guixin Chu
Polyphosphate is an alternative phosphorus (P) source which can substitute for orthophosphate-based P fertilizers in agriculture. In order to explore the effects of polyphosphate addition on soil P availability, and how pH and temperature affect polyphosphate hydrolysis, an aqueous and a soil incubation experiment were conducted at different pHs (5.0 and 8.2) and temperatures (15, 25 and 35°C); the influence of polyphosphate addition on soil available micronutrients (i.e., iron—Fe, manganese—Mn and zinc—Zn) was also studied. The experiments used three different polyphosphate fertilizers (solid and liquid ammonium polyphosphate and polyphosphoric acid) and two soil types (acid and alkaline). In aqueous incubation conditions, the average amount of phosphate ( ) released from polyphosphate fertilizers at 35°C was 2.7 times greater than at 25°C. The average Olsen P in polyphosphate-treated soil at 35°C was 1.12 times greater than at 25°C, indicating that higher temperature facilitates polyphosphate hydrolysis. Polyphosphate hydrolysis increased as the pH decreased in aqueous solution, but its hydrolysis rate was greater in calcareous soil than in acid soil. Moreover, polyphosphate significantly increased soil available Fe, Mn and Zn concentrations by an average of 14%, 16% and 20%, respectively, relative to orthophosphate fertilizer. In summary, high temperature and low pH favour the hydrolysis of short-chain polyphosphate (aqueous incubation experiment), and polyphosphate significantly increases soil P availability and mobilizes soil micronutrients. The application of polyphosphate can be recommended as a pragmatic P management strategy in agriculture: however, soil temperature and pH should be taken into account when using polyphosphate fertilizers.
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2019
·
IF 3.579
Ruiqiu Zhao,Ninghui Cheng,Paul A. Nakata,Liyan Zhao,Qiuhui Hu
The objective was to determine the contribution of A. auricular polysaccharides (AAP) in modulating the composition and diversity of the intestinal microbe in mice. AAP was extracted from A. auricula freeze-dried powder and different amounts of AAP (40, 80, 160 mg AAP/kg body weight) were administered to 6 week-old male ICR mice by gavage feeding over a five-week period. AAP feeding changed the intestinal environment in the mice. The pH value of the intestinal compartments decreased while SCFAs concentrations increased in AAP-fed groups, in a dose dependent manner, compared to the controls ( P < .05). High throughput sequencing revealed an enrichment in the diversity and an alteration in the composition of the fecal microbiota in the AAP fed mice with a significant decrease in the Firmicutes/Bacteroidetes ratio ( P < .05). The relative abundances of Porphyromonadaceae and Bacteroidaceae also increased in the AAP fed mice which positively correlated with an increase in serum IgA and IgG concentrations ( P < .05). The findings from this study show that AAP modulates the mouse gut microbiota and may contribute, at least in part, to some of the reported beneficial effects from the consumption of the mushroom, A. auricula .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHARMACOLOGICAL RESEARCH
·
2019
·
IF 5.574
Runzhi Chen,Ying Xu,Peng Wu,Hao Zhou,Yi Lasanajak,Yingying Fang,Lan Tang,Ling Ye,Xing Li,Zheng Cai,Jie Zhao
The gut microbiota and its short chain fatty acid (SCFA) metabolites have been established to play an important protective role against neurodegenerative diseases. Our previous study demonstrated that cerebral ischemic stroke triggers dysfunctional gut microbiota and increased intestinal permeability. In this study, we aimed to clarify the mechanism by which gut microbiota and SCFAs can treat cerebral ischemic stroke in rat middle cerebral artery occlusion models and use the information to develop new therapies. Our results show that oral administration of non-absorbable antibiotics reduced neurological impairment and the cerebral infarct volume, relieved cerebral edemas, and decreased blood lipid levels by altering the gut microbiota. We also found that ischemic stroke decreased intestinal levels of SCFAs. And that transplanting fecal microbiota rich in these metabolites was an effective means of treating the condition. Compared with other SCFAs, butyric acid showed the highest negative correlation with ischemic stroke. Supplementation with butyric acid treated models of ischemic stroke effectively by remodeling the gut microbiota, enriching the beneficial Lactobacillus , and repairing the leaky gut. In conclusion, interfering with the gut microbiota by transplanting fecal bacteria rich in SCFAs and supplementing with butyric acid were found to be effective treatments for cerebral ischemic stroke.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Solar RRL
·
2019
·Vol. 4
·期 1
·1900365
·
IF 0
Zi-Cheng Kong,Hong-Hong Zhang,Jin-Feng Liao,Yu-Jie Dong,Yong Jiang,Hong-Yan Chen,Dai-Bin Kuang
The excellent photoelectrical properties have rendered lead halide perovskites potential candidates for photocatalytic CO 2 reduction, but they still suffer from the low charge separation efficiency and slow catalytic reaction dynamics. To tackle these drawbacks, herein, a novel CsPbBr 3 -Re(CO) 3 Br(dcbpy) (dcbpy=4,4’-dicarboxy-2,2’-bipyridine) composite photocatalyst is elaborately designed and fabricated by anchoring the complex molecules onto the surface of CsPbBr 3 nanocrystal to work as co-catalyst. Owing to the robust interfacial interaction, effective electron extraction from CsPbBr 3 to complex molecules can be established, which enables the mutual synergetic action to get boosted visible-light-driven catalytic activity and product selectivity. As an encouraging result, a high electron consumption rate of 73.34 μmol g −1 h −1 is yielded for the optimized CsPbBr 3 -Re(600) sample, which is about 23-fold of that of pristine CsPbBr 3 . In addition, a praiseworthy CO selectivity of up to 95% is obtained. The composite catalyst also exhibits good catalytic stability, and a CO yield of 509.14 μmol g −1 is achieved after 15 h of continuous illumination. This result may provide a new strategy to design efficient lead halide perovskite-based heterogeneous photocatalysts.
✓ 已验证
产品关联
DOI
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Wangting Zhou,Yamei Yan,Jia Mi,Hongcheng Zhang,Lu Lu,Qing Luo,Xiaoying Li,Xiaoxiong Zeng,Youlong Cao
Digestion and fermentation in vitro of polysaccharides from bee collected pollen of Chinese wolfberry (WBPPS) were investigated in the present study. It was found that WBPPS mainly consisted of mannose, ribose, rhamnose, galacturonic acid, glucose, galactose, xylose, and arabinose in a molar ratio of 0.38:0.09:0.17:0.64:0.22:0.67:0.08:1.03, respectively. WBPPS was not affected by human saliva. The fraction A (molecular weight 1340 kDa) of WBPPS was not broken down in simulated gastric and small intestinal juices, while the small fraction B (molecular weight 523 kDa) of WBPPS was degraded. Moreover, fermentation in vitro revealed that WBPPS could significantly enhance the production of short-chain fatty acids and modulate gut microbiota composition via increasing the relative abundances of genera Prevotella, Dialister, Megamonas, Faecalibacterium, and Alloprevotella and decreasing the numbers of genera Bacteroides, Clostridium XlVa, Parabacteroides, Escherichia/Shigella, Phascolarctobacterium, Parasutterella, Clostridium sensu stricto, and Fusobacterium.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xiao Liu,Wei Qi,Yuefei Wang,Daiwu Lin,Xuejiao Yang,Rongxin Su,Zhimin He
A facile approach was reported to establish mimic multienzyme systems with hierarchically porous (HP) biomimetic metal–organic frameworks (MOFs) and natural enzymes for tandem catalysis. The hierarchically porous MOF HP-PCN-224(Fe) with peroxidase-like activity and tunable hierarchical porosity was synthesized via a modulator-induced strategy. HP-PCN-224(Fe) not only acts as the enzyme-immobilization matrix but also as an effective enzyme mimic, which could cooperate with the immobilized natural enzyme to catalyze the cascade reactions. The mimic multienzyme systems were used for the efficient colorimetric detection of a series of biomolecules, including glucose and uric acid. This work displays the great potential to construct highly functional biocatalysts by integrating the merits of both natural enzymes and MOF mimics, which are promising for applications in biosensing and biomimetic catalysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICAL ENTOMOLOGY
·
2018
·Vol. 55
·期 4
·787-794
·
IF 1.968
Tian Jiaxin,Mao Jie,Yu Baoting,Fouad Hatem,Ga’al Hassan,Mao Guofeng,Mo Jianchu
Efforts to develop mosquito attractants using vertebrate host volatiles have been well made under laboratory conditions but their attractiveness to mosquitoes in the wild still needs to be evaluated. In the present study, we evaluated the attraction of female Culex pipiens pallens Coquillett (Diptera: Culicidae) to 11 individual chemical compounds found in vertebrate host odors, and to synthetic blends, consisting of different combinations of the compounds. These tests were conducted under laboratory and field conditions using a Y-tube olfactometer and odor-baited traps, respectively. When delivered at concentrations ranging from 0.1 to 10.0 μg/kg, 9 of the 11 compounds were attractive to female mosquitoes under laboratory conditions. We developed 47 synthetic blends composed of the 6 most attractive compounds (propionic acid, hexanal, myristic acid, benzaldehyde, 1-octen-3-ol, and geranyl acetone) and 18 of them were significantly attractive to mosquitoes in the olfactometer. Most of the attractive blends contained two to four attractive compounds. In the field, 5 of the 18 blends captured significantly more mosquitoes than did control traps. The findings demonstrate that female mosquitoes can be attracted by single chemical compounds as well as some of their synthetic blends. The effectiveness of synthetic blends depended on specific combinations of several compounds, rather than simply increasing the number of attractive compounds in the blends. Synthetic blends may have potential for use in odor-baited traps for mosquito surveillance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2018
·
IF 1.911
Dailian Zhu,Cunqi Qin,Shanshi Ao,Qiuping Su,Xiying Sun,Tengfei Jiang,Kemei Pei,Huagang Ni,Peng Ye
Zinc porphyrin-based porous polymers (PPs-Zn) with different pore sizes were prepared by controlling the reaction condition of click chemistry, and the protein adsorption in PPs-Zn and the catalytic activity of immobilized enzyme were investigated. PPs-Zn-1 with 18 nm and PPS-Zn-2 with 90 nm of pore size were characterized by FTIR, NMR and nitrogen absorption experiments. The amount of adsorbed protein in PPs-Zn-1 was more than that in PPs-Zn-2 for small size proteins, such as lysozyme, lipase and bovine serum albumin (BSA). And for large size proteins including myosin and human fibrinogen (HFg), the amount of adsorbed protein in PPs-Zn-1 was less than that in PPs-Zn-2. The result indicates that the protein adsorption is size-selective in PPs-Zn. Both the protein size and the pore size have a significant effect on the amount of adsorbed protein in the PPs-Zn. Lipase and lysozyme immobilized in PPs-Zn exhibited excellent reuse stability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Guiqiang Pu,Dongxu Zhang,Xiang Mao,Zhen Zhang,Huan Wang,Xingming Ning,Xiaoquan Lu
We provide here, for the first time, a new interfacial electron-induced electrochemiluminescence (IEIECL) system, realizing bionic construction of bioluminescence (BL) by exploiting electrochemiluminescence (ECL) and ITIES (the interface between two immiscible electrolyte solutions). Significantly, the superiority of the IEIECL system is embodied with the solution of the two bottlenecks encountered in the conventional ECL innovation: that are (a) the applications of hydrophobic luminophores in more commonly used aqueous solution are inhibited tremendously due to the poor inherent solubility and the instability of radicals and (b) the analytes, insoluble in water, are hard to be discovered in an aqueous system because of too little content. More productive IEIECL radiation, analogous to BL, originates from the triplet excited state porphyrin in comparison to the homogeneous ECL. The mechanism of IEIECL, as well as the interaction mechanism between IEIECL and charge transfer (comprising electron transfer (ET), ion transfer (IT), and facilitated ion transfer (FIT)) at the ITIES, are explored in detail. Finally, we emphasize the actual application potential of the IEIECL system with the detection of cytochrome c (Cyt c); it is a key biomolecule in the electron transport chain in the process of biological oxidation and is also an intermediate species in apoptosis. Potentially, the IEIECL system permits ones to explore the lifetime and diffusion path of free radicals, as well as imparting a possibility for the construction of a bionic sensor.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Song-Tao Fan,Shao-Ping Nie,Xiao-Jun Huang,Sunan Wang,Jie-Lun Hu,Jun-Hua Xie,Qi-Xing Nie,Ming-Yong Xie
In vivo an ecological network of polysaccharides utilization by gut microbiota is not only an intense competition but also an impressive cooperation pattern. The present study evaluated the in vivo protective effect of combined fungal polysaccharides (CFP) from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction, induced by 150 mg/kg cyclophosphamide (CP). The results showed that C. sinensis polysaccharides (CSP) significantly promoted microbial-derived butyrate to improve histone h3 acetylation mediating regulatory T (Treg) cell specific Foxp3, as well as significantly restored CP-induced elevation of interleukin (IL)-17 and IL-21. Additionally, G. atrum polysaccharides (PSG) significantly down-regulated MyD88, as well as significantly increased IL-10 and TGF-β3. Furthermore, CFP balanced the disequilibrium of cytokines secretion and Foxp3/RORγt ratio related Treg/T helper 17 (Th17) balance, as well as down-regulated the TLR-mediated inflammatory signaling pathway and promoted secretory immunoglobulin A (sIgA) secretion to suppress colonic inflammation. Therefore, our results typically contribute to understand the in vivo immunoregulatory function of fungal polysaccharides compounds, involving microbial-associated inflammatory signals and specific metabolic products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）