ACS Applied Nano Materials
·
2023
·
IF 5.9
Junru Li,Yunqi Huang,Yanli Zhou,Hui Dong,Haoyuan Wang,Haoran Shan,Yifei Li,Maotian Xu,Xiaobing Wang
The conductive metal–organic framework (CMOF) is a promising application nanomaterial for the construction of electrochemical sensors. Three two-dimensional conductive M3(HHTP)2 materials with larger aspect ratios were prepared by a one-pot method using acetate-based metals (Cu, Ni, Co) and 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) with the introduction of N,N-dimethylformamide (DMF) as the limiting reagent. Compared with Ni3(HHTP)2 and Co3(HHTP)2, Cu3(HHTP)2 had a larger double capacitance, pore size, specific surface area, and smaller resistance. As a result, Cu3(HHTP)2 provided greater catalytic oxidation active surface area and charge transfer efficiency for malachite green (MG) detection. Hence, Cu3(HHTP)2 efficiently catalyzed MG oxidation and significantly improved the sensitivity of MG detection. Meanwhile, the oxidation current signal from the copper of Cu3(HHTP)2 was used as an internal reference signal to form a ratiometric electrochemical sensor with an MG oxidation current signal, which effectively reduced the external interference. The constructed electrochemical assay for MG detection displayed broad linearity (5–1000 nM) with a detection limit of 1.34 nM. In the meantime, MG residues in fish was evaluated and high reliability was obtained, confirming the feasibility of this valuable method for food safety and health evaluation of aquatic products.
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BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Aijin Fang,Qiongqiong Wu,Qiujun Lu,Hongyu Chen,Haitao Li,Meiling Liu,Youyu Zhang,Shouzhuo Yao
A new upconversion colorimetric and ratiometric fluorescence detection method for uric acid (UA) has been designed. Yb 3+ , Er 3+ and Tm 3+ co-doped NaYF 4 nanoparticles (UCNPs) was synthesized. The co-doped NaYF 4 nanoparticles, emit upconversion fluorescence with four typical emission peaks centered at 490 nm, 557 nm, 670 nm and 705 nm under the 980 nm near-infrared (NIR) irradiation. The ZnFe 2 O 4 magnetic nanoparticles (MNPs) possessing excellent peroxidase-like activity was prepared and used to catalyze oxidation the coupling of N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt (TOPS) and 4-amino-antipyrine (4-AAP) in the presence of H 2 O 2 to form purple products (compound 1) which has a characteristic absorption peak located at 550 nm. The upconversion fluorescence at 557 nm was quenched by the compound 1 while the upconversion emission at 705 nm was essentially unchanged, the fluorescence ratio (( I 557 / I 705 ) 0 /( I 557 / I 705 )) is positively proportional to UA concentration in existence of uricase. More importantly, colorimetric signal can be easily observed and applied to directly distinguish the concentration of UA by the naked eye. Under the optimized conditions, the linear range of colorimetric and ratiometric fluorescence sensing towards UA was 0.01–1 mM, the detection limits were as low as 5.79 μM and 2.86 μM (S/N=3), respectively. The proposed method has been successfully applied to the analysis of UA in human serum. These results indicate that the colorimetric and ratiometric fluorescence dual-readout assay method has great potential for applications in physiological and pathological diagnosis.
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高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 22
·4233-4238
·
IF 4.543
Qi Wang,Sisheng Hu,Tian Yang,Shangshang Ma,Yuhong Liu,Chunxue Ma,Mimi Wan,Chun Mao
To detect hydrogen peroxide (H2O2) that is released in situ by cells is a challenge because of its high activity and short life time. Here, a new type of H2O2 biosensor was reported based on three-dimensional (3D) micro/nano-biointerfaces as an amicable platform to promote cell adhesion, and which can directly grow living cells on manganese dioxide (MnO2) immobilized onto a novel hollow horn-like morphology polypyrrole (hPPy) film. The composite MnO2/hPPy array films were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and elemental mapping. Further, the results of a cell adhesion test indicated that the as-obtained 3D micro/nano-array films had good cell adhesion. This proposed sensing platform provided high electroactivity and excellent electron transport with a lower detection limit, a higher sensitivity and a short diffusion distance to reaction sites by electrochemical study. The new design strategy we proposed can expand the bioapplication of 3D micro/nano-biointerfaces that can guide cell fate and electrochemical detection in cell biology.
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高影响因子
JOURNAL OF FOOD BIOCHEMISTRY
·
2022
·Vol. 46
·期 2
·e14049
·
IF 3.654
Rui Sun,Juan Kan,Huahao Cai,Jinhai Hong,Changhai Jin,Man Zhang
In the present study, the ameliorative effects of polyphenols from purple potato leaves (PSPLP) on hyperuricemia were investigated. HPLC-MS analysis showed that PSPLP was mainly composed of caffeoylquinic acid derivatives (84%). PSPLP inhibited the levels of cytokines (IL-1β, IL-6, and TNF-α) in monosodium urate-induced RAW264.7 cells. In vivo, PSPLP significantly inhibited the level of uric acid in hyperuricemia mice from 209.6 to 166.6 μM, and significantly interfered with the activities of xanthine oxidase (XOD) and adenosine deaminase in liver, the activity of XOD decreased from 13.5 to 11.6 U/gprot. PSPLP can decrease serum creatinine level from 105 to 59 μM, and urea nitrogen level from 21.9 to 14.1 mM, which can effectively protect kidney. These results provide a reference for future research and application of PSPLP as a functional food to intervene hyperuricemia and associated inflammation. Practical applications This study evaluated the effect of polyphenols from purple potato leaves (PSPLP) on hyperuricemia. The results suggested that PSPLP has an important role in the intervention of hyperuricemia and hyperuricemic-related inflammation or renal injury, and can be used in the application of functional foods. These results provided a basis for further study on the biological activities of polyphenols from purple sweet potato leaves.
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ACS Sensors
·
2022
·
IF 9.618
Mei Zhao,Limei Luo,Yongxian Guo,Binglu Zhao,Xiangfeng Chen,Xingang Shi,Mashooq Khan,Jin-Ming Lin,Qiongzheng Hu
α-Amylase (AMS) in human serum is a critical biomarker for the early diagnosis of pancreatic damage. In addition, the inhibition of α-amylase has long been thought to decrease the occurrence of diabetes. Thus, it is critical to construct a facile and convenient method for the determination of AMS and its inhibitor. In this study, we demonstrate a novel amylase sensor based on translating the viscosity change of the aqueous solution into the difference of the water diffusion length on a pH paper strip. AMS can be quantitatively detected by measuring the viscosity change of the amylopectin solution in the presence of AMS with different concentrations. The paper-based AMS sensor has a very high sensitivity with a detection limit of 0.017 U/mL and also shows excellent specificity. In addition, the inhibitory effect of acarbose on AMS is demonstrated with the IC50 value determined to be 21.66 ± 1.13 μg/mL. Furthermore, it is also evaluated for the detection of AMS in human serum samples of healthy people and acute pancreatitis patients. The difference in amylase levels between the two groups is unambiguously distinguished. Overall, this study provides a very simple, cost-effective, equipment-free, high-throughput, and label-free method for rapid and quantitative detection of α-amylase and may have significant applications in the diagnosis of acute pancreatitis and the screening of AMS inhibitors.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2026
·
IF 4.6
Zhouchao Wang,Yuchen Zhang,Lin Xu,Baolong Niu
This study synthesized a novel pNiPc-COF via low-temperature molten salt method and composited it with GO. The synergy between them overcomes the conductivity bottleneck of pure COFs. • The electrochemical sensor based on this composite shows exceptional glucose detection performance, with a sensitivity of 875.71 μA·mM −1 ·cm −2 and a detection limit of 0.103 μM. • The sensor shows over 90% selectivity for glucose amid common interferents, along with excellent long-term stability and high repeatability. • The sensor's linear range is 0.15–9.45 mM, covering the physiological glucose window (3–6 mM) and extending to higher concentrations. Glucose electrochemical sensors underpin clinical diagnosis, biomanufacturing, food quality control and environmental surveillance. Covalent organic frameworks (COFs) are attractive for electroanalysis, yet nearly all COF glucose sensors require glucose oxidase immobilization, limiting long-term stability and scalability. Herein, we fabricate an enzyme-free glucose electrocatalyst: nickel phthalocyanine COF (pNiPc-COF) hybridized with graphene oxide (GO) via one-pot solvothermal treatment. XRD, SEM, FTIR, TGA and XPS confirm uniform pNiPc-COF/GO heterostructures; electroanalytical tests reveal strong synergistic glucose oxidation from dense Ni catalytic sites and fast charge transport in GO. At +0.65 V vs. SCE, the sensor achieves 5 s response over 0.15–9.45 mM glucose, with sensitivity of 875.71 μA mM −1 cm −2 and LOD = 0.103 μM (S/N = 3). It also exhibits strong anti-interference capability, offering a stable, high-performance enzyme-free platform for clinical glucose quantification. Download: Download high-res image (114KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Yujing Nie,Yijiang Li,Junwei Li,Leniu Chen,Xudong Wang,Tao Chen,Zhixiong Cai
Metal-organic frameworks (MOFs) exhibit structural diversity and functional tunability, rendering them a versatile platform for a wide range of applications. Specifically, defects or function groups induced by exotic ligands is an efficient strategy to adjust the catalytic performance. In this study, we explore the impact of incorporating ferrocene derivatives into two Ni-based MOFs and examine their suitability as potential glucose sensors. One strategy involves introducing bidentate 1,1′-ferrocenedicarboxylic acid (1,1′-Fc) into the 3D Ni-1,4-benzenedicarboxylic acid MOF (Fc-Ni-BDC) using a simple single-step hydrothermal method . Another approach involves encapsulating ferrocenemethylamine (Fc-NH 2 ) inside the cavity of 2D conductive Ni-HHTP MOF (HHTP=2,3,6,7,10,11-hexahydroxytriphenylene) driven by electrostatic attraction to form Fc-Ni-HHTP. On account of the synergy between ferrocene derivatives and MOFs, the hybrid MOFs demonstrated remarkable electrochemical performance , characterized by pronounced electrocatalytic reactivity towards glucose oxidation . It is showed that the doped ferrocene derivatives act as electron donors to the MOF active sites, modifying the electronic structure and facilitating the kinetics of the reactions, then an augmentation in the catalytic efficiency has been achieved. This work demonstrates a simple strategy to improve MOF-based electrochemical sensors by incorporating metallocene ligands.
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RSC Advances
·
2023
·Vol. 13
·期 46
·32558-32566
·
IF 3.9
Jialei Zhu,Fuqin Wang,Jiaying Chen,Chang Liu
Glucose detection with small and micro volume sampling has recently received increasing attention in monitoring personal health. Herein, a cauliflower-type cluster of Cu2O nanoparticles (NPs) was directly deposited on the tip surface of a stainless steel acupuncture needle electrode (ANE) by electrochemical deposition, and then this pre-formed cuprous basis was used to further prepare the neatly arranged CoCu-layered double hydroxide (CoCu-LDH) nanosheets that interconnected to form nano-sized pores in the range from 100 to 500 nm. The microstructure and spectral characteristics of the surface modification materials were comprehensively characterized by FE-SEM, EDS, XRD, FT-IR and TEM. Cu2O-based CoCu-LDH composites with special morphology had been proven to accelerate the rate of electron transport and provide more available active centers, and moreover, the mixed valence of Cu/Co induced an excellent synergism for the electrocatalytic oxidation of glucose. As a result, CoCu-LDH/Cu2O/ANE as a sensitive glucose probe exhibited two wider linear ranges of 0.03–0.40 mM and 0.40–6.00 mM, with sensitivities of 116.13 μA mM−1 and 52.08 μA mM−1, respectively, and the detection limit as low as 0.46 μM (S/N = 3). The response time only took 3 s and it kept working stably in the interference of ascorbic acid (AA), dopamine (DA), uric acid (UA), and Cl−. In the stability test, the CoCu-LDH/Cu2O/ANE sensor exhibited a stable monitoring sensitivity after 15 days. Finally, the CoCu-LDH/Cu2O/ANE sensor had been successfully applied to glucose analysis in human serum, proving that our design was an attractive strategy for developing a portable, minimally invasive, and low-cost non-enzymatic electrochemical glucose sensing platform.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Shaoming Yang,Jiayi Chen,Long Yan,Yongxin Liu,Wenlin Zha,Zhili Fang,Jiali Zhang
A molecularly imprinted photoelectrochemical sensor was successfully designed for sensitive detection of norfloxacin (NOR) based on poly ( o -phenylenediamine) (PoPD) sensitized g-C 3 N 4 /Zr-MOFs(Fe) composite. Herein g-C 3 N 4 /Zr-MOFs(Fe) heterojunction composite was explored as photoresponsive oxidase mimic and photoactive material for the purpose of enhancing photoelectrochemical performances. In addition, PoPD molecularly imprinted polymers (MIPs) were introduced not only to act as the recognition element for selective performance, but also to possess photosensitive effect, which enhanced the photocurrent of sensor. SEM, element mapping method, XRD, UV–Vis and electrochemical impedance spectroscopy were employed for the characterization of the structural, chemical composition, optical and electrical properties of g-C 3 N 4 /Zr-MOFs(Fe) composite. Thanks to the photoresponsive oxidase mimic property and the selectivity of MIPs, the as-prepared sensor presented a good linear range of from 1.0 × 10 −8 mol/L to 2.0 × 10 −6 mol/L with NOR and a limit of detection of 5.7 × 10 −9 mol/L. Moreover, the sensor platform has been proved to have excellent selectivity and real sample application.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Ziyin Yang,Zhigao Tian,Chengcheng Qi
The development of a high-performance electrocatalyst is the key to the construction of highly sensitive electrochemical sensing methods. In this work, we design Ru nanoclusters supported on MnO2 nanotubes (c-Ru/MnO2) as an electrocatalyst for boosting electrochemical nonenzymatic hydrogen peroxide (H2O2) sensing. c-Ru/MnO2 is synthesized based on a facile hydrothermal method, followed by cation exchange and calcination. The obtained c-Ru/MnO2 nanocomposite is characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and electrochemical methods. Electrochemical studies and theoretical calculations reveal that the anchoring of Ru nanoclusters not only makes MnO2 nanotubes exhibit higher electrochemical surface area and faster electron transfer rate but also promotes the strong adsorption of H2O2 and optimizes the interactions with the key intermediates OOH*/OO*. Thanks to the synergistic effect between Ru nanoclusters and MnO2 nanotubes, the sensor based on c-Ru/MnO2 exhibits a low anode peak potential of 0.42 V and an extremely high sensitivity of 2967.9 μA mM–1 cm–2 toward H2O2. Therefore, c-Ru/MnO2 is demonstrated to be an advanced electrocatalyst for sensitive electrochemical sensing of H2O2.
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Materials
·
2023
·Vol. 16
·期 22
·7154
·
IF 3.4
Minggang Zhao,Yichang He,Xiaotong Dong,Kun Pang,Qian He,Ye Ma,Hongzhi Cui
Detecting heavy metals in seawater is challenging due to the high salinity and complex composition, which cause strong interference. To address this issue, we propose using a multistage energy barrier as an electrochemical driver to generate electrochemical responses that can resist interference. The Ni-based heterojunction foams with different types of barriers were fabricated to detect Cr(VI), and the effects of the energy barriers on the electrochemical response were studied. The single-stage barrier can effectively drive the electrochemical response, and the multistage barrier is even more powerful in improving sensing performance. A prototype Ni/NiO/CeO2/Au/PANI foam with multistage barriers achieved a high sensitivity and recovery rate (93.63–104.79%) in detecting seawater while resisting interference. The use of multistage barriers as a driver to resist electrochemical interference is a promising approach.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2023
·Vol. 25
·期 11
·1-12
·
IF 2.5
Li Fangyuan,Yao Niu,Yuan Huiyu,Cui Junyan,Jia Quanli
The redox properties of electrode materials play a vital role in electrochemical performance. Fabrication of electrode materials with multiple oxidation species is highly desired for ultrasensitive glucose sensing. Herein, multivalent Cu/Cu 2 O/CuO/C (Cu/C) nanocomposites were successfully prepared for non-enzymatic glucose sensing by in situ pyrolysis of Cu metal-organic framework (Cu 3 (BTC) 2 ·3H 2 O, Cu-BTC) at a critical temperature. Structure characterizations showed that the nanocomposites maintained the original morphology of Cu-BTC crystals and exhibited mesoporous structures. Meanwhile, multiple Cu species containing Cu, Cu 2 O and CuO were generated simultaneously, which were tightly pinned on the ligand-derived carbon layers. Thus, under the synergistic effect of multivalent Cu species, mesoporous structure and intense interface contact, the sensing platforms based on Cu/C nanocomposites exhibited good glucose detection performance with a wide linear range of 0.005-2.0 mM, ultrasensitivity of 147.65 μA mM -1 cm -2 , low detection limit of 6.31 μM (S/N = 3), and favorable anti-interference properties and stability. Especially, the Cu/C sensing platform showed excellent recoveries of glucose when used to monitor glucose in real sample of honey. The good electrochemical activities of Cu/C nanocomposites render them promising candidates for sensors and other applications. Graphical abstract
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危险品化学品经营许可证（带存储）