JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2016
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IF 2.687
Yi Tao,Xi Chen,Hao Cai,Weidong Li,Baochang Cai,Chuan Chai,Liuqing Di,Liyun Shi,Lihong Hu
Fu-Zhu-Jiang-Tang tablet, a six-herb preparation, was proved to show beneficial effects on type II diabetes patients in clinical. This study aims to optimize the component proportion of the six-herb preparation and explore the serum metabolic signatures of type II diabetes rats after treatment with Fu-Zhu-Jiang-Tang tablet and its optimal combination. The component proportion of the preparation was optimized using uniform experimental design and machine learning techniques. Untargeted GC–MS metabolomic experiments were carried out with serum samples from model group and treatment groups. Data were normalized, multivariate and univariate statistical analysis performed and metabolites of interest putatively identified. 23 metabolites were significantly changed by Fu-Zhu-Jiang-Tang tablet treatment and the majority of these were decreased, including various carbohydrates (glucose, mannose, fructose, allose and gluconic acid), unsaturated fatty acids (palmitic acid, 9-octadecenoic acid, oleic acid, arachidonic acid), alanine, valine, propanoic acid, 3-hydroxybutyrate, along with pyrimidine and cholesterol. Increased concentrations of oxalic acid, leucine, glycine, serine, threonine, proline, lysine and citrate were observed. In the optimal combination-fed group, 21 metabolites were significantly affected and strikingly, the magnitudes of changes here were generally much greater than that of Fu-Zhu-Jiang-Tang tablet treated rats. 18 metabolites affected in both groups included various carbohydrates (mannose, glucose, allose, fructose and gluconic acid), unsaturated fatty acids (palmitic acid, 9-octadecenoic acid, oleic acid and arachidonic acid), short-chain fatty acids (oxalic acid, 3-hydroxybutyrate), and amino acids (alanine, valine, leucine, glycine, proline and lysine), as well as pyrimidine. Metabolites exclusively affected in optimal combination treated rat included succinic acid, cysteine and phenylalanine, whilst four metabolites (propanoic acid, citrate, serine and threonine) were only altered in Fu-Zhu-Jiang-Tang tablet treated rat. Our investigation demonstrated Fu-Zhu-Jiang-Tang tablet and its optimal combination treatments were able to ameliorate impaired glucose and lipid metabolism, down- regulate the high level of glucose to a lower level and reverse abnormal levels of metabolites in serum of type II diabetes rats. However, the optimal combination treatment was able to maximize the magnitudes of changes in some metabolites. These findings may be helpful in clarifying the anti-diabetic mechanism of FZJT tablet and its optimal combination.
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PubMed
高影响因子
CATALYSIS COMMUNICATIONS
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2015
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IF 3.699
Xiao-dong Tang,Yong-fen Zhang,Jing-jing Li
Deep eutectic solvents (DESs), which were prepared by using AlCl 3 and acetamide or urea, show excellent catalytic performance for the olefin alkylation thiophenic sulfur (OATS) in 3-methylthiophene (3-MT) model oil and real gasoline within 40 min at 50 °C. The addition of toluene and benzene increases the conversion of thiophenic compounds and decreases the conversion of olefin. Then the mechanism of OATS with modified catalyst was discussed.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2015
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IF 2.679
Fufeng Cai,Guomin Xiao
In this work, the feasibility of ionic liquids (ILs), 1,3-dimethylimidazolium dimethylphosphate ([MMIM][DMP]), 1-ethyl-3-methylimidazolium diethylphosphate ([EMIM][DEP]), and 1-butyl-3-methylimidazolium dibutylphosphate ([BMIM][DBP]), as solvents for the extraction of methanol from its mixtures with hexane and heptane was analyzed. The knowledge of (liquid + liquid) equilibria (LLE) of these mixtures is necessary for the design of the extraction separation process. Hence, the LLE data for the ternary systems, {methanol + hexane + ([MMIM][DMP], or [EMIM][DEP], or [BMIM][DBP])}, and {methanol + heptane + ([MMIM][DMP], or [EMIM][DEP], or [BMIM][DBP])}, were measured at T = 298.2 K and atmospheric pressure. The experimental results were correlated with the thermodynamic nonrandom two-liquid (NRTL) model. The solute distribution ratios of methanol and methanol/alkane selectivities, derived from the experimental LLE data, were calculated and analyzed to evaluate the capability of the studied ILs to accomplish the separation target. Meanwhile, these capabilities were also compared with that of other ILs obtained from the literature.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2015
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IF 2.037
Xiong Zheng,Ying Zhang,Maogang He
The speed of sound in hexane and heptane (mass purity > 0.990, GC) was measured using the Brillouin light scattering method at T = (300.15 to 506.15) K for hexane, (302.15 to 536.15) K for heptane), and p = (1.0 to 8.5) MPa, including saturated liquid, saturated vapor, and compressed liquid. The expanded relative uncertainty (k = 2) of the speed of sound was estimated to be less than 1.0% over the whole investigated range of states. Polynomial representations for the speed of sound in hexane and heptane were fitted to the experimental results. A comparison of the speed of sound data with the correlation shows that, for hexane, the AAD is 0.67% for the saturated liquid, 0.36% for the saturated vapor and 0.57% for the compressed liquid respectively, and for heptane, the AAD is 0.46% for the saturated liquid, 0.38% for the saturated vapor and 0.41% for the compressed liquid, respectively.
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高影响因子
FLUID PHASE EQUILIBRIA
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2014
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IF 2.241
Fufeng Cai,Guomin Xiao
This work demonstrates the capabilities of three phosphoric-based ionic liquids (ILs) as solvents for the extraction of ethanol from its mixture with heptane. The knowledge of liquid–liquid equilibria (LLE) of this mixture is essential for the design of the extraction separation process. For this reason, the experimental LLE data were measured for the ternary systems, {ethanol + heptane + 1,3-dimethylimidazolium dimethylphosphate ([MMIM][DMP]), or 1-ethyl-3-methylimidazolium diethylphosphate ([EMIM][DEP]), or 1-butyl-3-methylimidazolium dibutylphosphate ([BMIM][DBP])}, at T = 298.2 K and atmospheric pressure. The thermodynamic nonrandom two-liquid (NRTL) model was used to correlate the experimental results for the studied ternary systems. The extraction capabilities for the studied ILs were evaluated by solute distribution ratios of ethanol and ethanol/heptane selectivities. Moreover, this extraction capability was also compared with other ILs obtained from the literature. The experimental results show that the studied ILs can be suitable to act as solvents for the separation of the ethanol and heptane in the extraction process. The extraction capabilities for the studied ILs decrease in the following order [MMIM][DMP] > [EMIM][DEP] > [BMIM][DBP].
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高影响因子
FOOD CHEMISTRY
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2025
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IF 9.8
Wen Li,Jintao He,Qijue Chen,Feng Bao,Yinqiang Huo,Jing Deng,Qinlu Lin,Feijun Luo
Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate Oryzanol. Polycaprolactone-chitosan (PCL-CS) and IC were prepared into a fiber membrane (PCL-CS-IC) using an electrostatic spinning technique and applied to wound healing and grape preservation. The results showed that the prepared ICs had a drug loading rate of 43.18 % with good antimicrobial, wettability, and air permeability properties. The PCL-CS-IC effectively reduced the inflammation of mouse wounds, with obvious re-epithelialization and inflammatory factors reduction in skin tissues. Meanwhile, the PCL-CS-IC delayed the decay process of grapes and extended shelf life. In conclusion, this study effectively improved the utilization of oryzanol and provided potential ideas for wound dressing preparation and food packaging materials development.
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PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
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2024
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IF 4.1
Min Han,Lexuan Zhao,Hongye Cheng,Zhiwen Qi
Efficient deterpenation of essential oils is crucial for obtaining high value-added products. In this work, a biphasic extraction system integrated with associative extraction was utilized to enhance fractionation of terpenoids and terpenes, where organic salt and organic solvent were employed as extractants in each phase. Ten different organic solvents were evaluated in terms of their phase behavior, extraction performance, and EHS-related properties. The positive or negative effect of organic solvents on biphasic extraction performance was elucidated through molecular dynamics simulations and FT-IR spectra analysis. The results indicate that an organic solvent lacking hydrogen bonding ability can reduce its interaction with organic salt or terpenoids, thereby exerting a positive contribution to biphasic extraction. For crude orange sweet essential oil, the biphasic system containing tetrabutylammonium chloride and n-hexane achieves a 6.2-fold concentration of terpenoids, demonstrating its effectiveness in enhancing extractive deterpenation of essential oil.
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ACS Omega
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2024
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IF 3.7
Xiujun Wang,Jian Zhang,Qian Xu,Ming Duan,Chunsheng Zhang,Shenwen Fang
In this work, the empirical relationship among three apparent parameters in the hydrophilic–lipophilic deviation (HLD) equation was studied to provide help in using the HLD equation to design a block polyether water clarifier for treating produced water in an oilfield. Ten block polyethers (including six linear polyethers and four branched polyethers) were prepared, and their HLD equations were measured. By curve fitting, the empirical relationship among apparent hydrophobicity characteristic (K), apparent characteristic curvature (Ccn), and apparent temperature coefficient (ct) of block polyether were obtained: K = 9.32ct, Ccn = 18e–24.5K (for linear polyether), and Ccn = 3.7e–20.8K (for branched polyether). By introducing these relationships into the HLD equation and combining an empirical relationship between propylene oxide/ethylene oxide (mole ratio) in a block polyether and K/Ccn, a new block polyether was designed to treat the produced water. The treatment result confirmed the reliability of these empirical relationships. The results expand the practical application of HLD theory and are useful for the development of a block polyether water clarifier.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Wenchen Ren,Huanxi Wang,Qianlin Zhang,Mengchi Chen,Zhongrui Li,Huan Guo,Jing Bai,Xiaomin Dai,Santosh Kumar Verma,Yunhua Xu
In this paper, petal sheet layered Co-Al bimetallic hydroxides were prepared using the hydrothermal method using methanol as a solvent. Pt/Co-Al-O catalysts were produced after the impregnation method and H 2 reduction. This catalyst was applied to the dehydrogenation reaction process of methylcyclohexane to toluene. A fixed-bed reaction device carried out comparative tests of this series of catalysts, and the effect of Co addition on the performance of Pt/Co-Al-O catalysts was investigated in detail. Among them, the Pt/Co 3 -Al 1 -O catalyst showed the best performance with high toluene selectivity throughout the dehydrogenation process. The MCH conversion started to be greater than 90% at 330 °C, and the hydrogenolysis rate was 262.7 mmol/g Pt /min. The conversion gradually increased with the reaction temperature, and the conversion could reach 99.5% at 410 °C. The appropriate introduction of Co element can reduce the excessive strong acidic sites of Al 2 O 3 itself and retain a certain number of weak acidic sites, while the bimetallic hydroxide carrier improves the dispersibility of the active component, reduces its particle size, and forms a certain strong interaction between the carrier and Pt. The final conversion of the catalyst decreased by about 2% in the 100 h stability test at 380 °C, which indicated that the Pt/Co 3 –Al 1 –O catalyst had strong coking resistance and good stability. These results indicate that the Pt/Co–Al–O series catalysts have potential industrial applications in hydrogen energy utilization.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Huan Sun,Shen Yan,Chaojie Wu,Jingye Ma,Kangwei Lu,Xi Cheng,Wenqi Yan,Shengyu Zhang,Xiao Dong Chen,Winston Duo Wu
Active pharmaceutical ingredient (API) embedded dry powder for inhalation (AeDPI) shows higher drug loading and delivery dose for directly treating various lung infections. Inspired by the dandelion, we propose a novel kind of AeDPI microparticle structure fabricated by spray freeze drying technology, which would potentially enhance the alveoli deposition efficiency. When inhaling, such microparticles are expected to be easily broken-up into fragments containing API that acts as ‘seed’ and could be delivered to alveoli aided by the low density ‘pappus’ composed of excipient. Herein, itraconazole (ITZ), a first-line drug for treating pulmonary aspergillosis, was selected as model API. TPGS, an amphiphilic surfactant, was used to achieve stable primary ITZ nanocrystal (INc) suspensions for spray freeze drying. A series of microparticles were prepared, and the dandelion-like structure was successfully achieved. The effects of feed liquid compositions and freezing parameters on the microparticle size, morphology, surface energy, crystal properties and in vitro aerosol performance were systematically investigated. The optimal sample (SF (-50) D-INc 7 Leu 3 -2) in one-way experiment showed the highest fine particle fraction of ~ 68.96% and extra fine particle fraction of ~ 36.87%, equivalently ~ 4.60 mg and ~ 2.46 mg could reach the lung and alveoli, respectively, when inhaling 10 mg dry powders. The response surface methodology (RSM) analysis provided the optimized design space for fabricating microparticles with higher deep lung deposition performance. This study demonstrates the advantages of AeDPI microparticle with dandelion-like structure on promoting the delivery efficiency of high-dose drug to the deep lung.
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PubMed
高影响因子
Geoenergy Science and Engineering
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2024
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IF 0
Shuai Liu,Yuan Geng,Chao Li,Min Hu,Jiang Liu,Qi Gao,Xingguang Xu
Enhancing oil recovery (EOR) from sandstone reservoirs with high formation salinity and high temperature has gained prominence as most of the easy-to-produce oil has already been produced.It has been approved that the surfactants-assisted nanofluids (SAN) perform well as a viable EOR technique. Most of the studies have macroscopically presented that surfactants-assisted nanofluids (SAN) can enhance oil recovery by reducing interfacial tension and wettability alteration. The effect of nanoparticles on the phase behaviour of microemulsions and the mechanism of surfactants-assisted nanofluids (SAN) to enhance oil recovery at the micro-scale are not clear. In this study, the performance in EOR of alcohol ethoxylate (AEO-15)/sodium alpha-olefin sulfonate (AOS) and hydrophobic nanoparticles (S16) was analysed. 2D visualization experiments systematically elucidated the mechanism of surfactants-assisted nanofluids (SAN) mobilisation of residual oil in the pores. Dynamic light scattering and zeta potential measurements showed that when the S16 concentration was less than 0.1 wt%, the SAN remained stable at 70 °C with a particle size of 64.27 nm and a zeta potential of −30.88 mV.Contact angle and adsorption experiments demonstrated that the addition of 0.1 wt% S16 decreased the contact angle by 21.72°, making the rock surface more water wet and the surfactants adsorption on the sample surface was decreased by 16.9%. The microemulsion induced by the SAN had lower interfacial tension (IFT) and exhibited wider “salinity window” compared to the surfactants-induced microemulsions, which might make the proposed SAN more applicable in reservoirs with high salinity and residual oil saturation. Furthermore, spontaneous swelling of trapped oil in the dead end and elongation of oil droplets were clearly observed in 2D visual microscopic model during the SAN flooding, which somehow explained the exceptional EOR performance of the developed SAN in the core flooding experiment at 70 °C and 80 g/L of salt. This study is expected to provide useful insights into the development of SAN involving hydrophobic nanoparticles and deepen the EOR mechanism of SAN at the microscopic scale.
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FUEL
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2025
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IF 7.5
Hang Ye,Qi Liu,Tong Wu,Wanzhen Xue,Chunkai Wang,Kai Cheng,Tiong Michelle,Dan Luo,Chenggang Xian,Yiqun Liu
Asphaltene deposition is a significant issue in CO 2 -EOR, leading to reservoir damage and reduced efficiency. In this study, oil-soluble carbon quantum dots (CQDs) were synthesized to address asphaltene deposition issues, evaluating the inhibitory performance through laboratory experiments and molecular dynamics (MD) simulations. Experimental results demonstrated that CQDs effectively delayed the onset of asphaltene deposition from 45 vol% to 55 vol%, reduced the average particle size of asphaltene aggregates from 1200 nm to approximately 600 nm, and achieved an inhibition rate of 52.7 %. MD simulations revealed that CQDs reduced the mobility of asphaltene molecules and decreased the number of stacked asphaltene model molecules in aggregates from four to two, thereby lowering the risk of aggregation and subsequent deposition. Furthermore, the study showed that CQDs primarily inhibit asphaltene aggregation and deposition by weakening T-shaped or offset stacking interactions between asphaltene molecules. This effect was attributed to the strong interactions between CQDs and asphaltenes, with stabilization energies reaching up to −90 kcal/mol. Asphaltene molecules formed π-π interactions with CQDs through π-electron cloud overlap, dispersing the π-π interactions originally occurring between asphaltene molecules. This ultimately suppressed asphaltene aggregation. These characteristics suggested that CQDs offer a promising new approach to mitigate asphaltene deposition and have the potential to enhance oil recovery in low-permeability reservoirs.
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高影响因子
危险品化学品经营许可证（带存储）