MEDICINAL CHEMISTRY RESEARCH
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2019
·Vol. 28
·期 8
·1212-1222
·
IF 1.72
Sheng Li-xin,Huang Jia-yan,Liu Chun-mei,Zhang Ju-zheng,Cheng Ke-guang
A total of 25 targeted hydrogen sulfide donor–pentacyclic triterpene hybrids were designed, synthesized and evaluated on the basis of inspiring reports about hydrogen sulfide donor molecules and oleanolic acid derivatives on anti-tumor activity. The results revealed that only some hybrids ( 10a , 10b , 12a , 12b , 13a , and 15b ) showed moderate anti-proliferation activity against K562 cell line. It indicated that oleanane-type, ( R )-lipoic acid and TBZ groups were much more favorable to the anti-proliferation activity. Furthermore, C-3 OH was more beneficial than C-28/29 COOH in the oleanane-type to the antitumor activity of the batch of ( R )-lipoic acid derivatives. And among them, only compound 13a exhibited moderate anti-proliferation activity against both K562 and K562/ADR cell lines, while it exhibited no anti-proliferation activity against BEL-7402 and L-O2 cell lines. Therefore, it suggested that it was not suitable for hybridization of hydrogen sulfide donors attached to oleanolic acid, ursolic acid and glycyrrhetinic acid in the field of anti-tumor.
研究领域:
药物化学
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肿瘤学
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分子生物学
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药理学
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天然产物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2018
·Vol. 22
·期 12
·3977-3983
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IF 2.509
Li Kaidi,Zhang Fangfang,Wu Haoran,Wang Yina,Du Jimin,Lu Yayun,Wang Weimin,Zhao Guoyan,Kang Dae Joon
Here, we demonstrate the synthesis of sheet-shaped Co 2 P grown on carbon cloth (sheet-shaped Co 2 P-CC) through a facile route. Electrochemical measurements indicated that sheet-shaped Co 2 P-CC with a loading of 0.6 mg cm −2 Co 2 P (denoted Co 2 P-CC-0.6) exhibits exceptional electrocatalytic activity in the hydrogen evolution reaction (HER), with an overpotential of 94 mV at a current density of 10 mA cm −2 and a small Tafel slope of 80 mV decade −1 in 1 M KOH. Similarly, sheet-shaped Co 2 P-CC-0.6 was also found to be an excellent electrocatalyst for the HER in 0.5 M H 2 SO 4 and in 0.5 M phosphate buffer solution (PBS), with overpotentials of 95 and 231 mV at a current density of 10 mA cm −2 , respectively. Sheet-shaped Co 2 P has a large surface area, meaning that it can provide a relatively large number of active sites on its surface, and CC is an highly conductive substrate that, when used in conjunction with Co 2 P, can enhance the conductivity of the electrocatalyst. These outstanding results show that sheet-shaped Co 2 P-CC could be an excellent candidate for a highly efficient electrocatalyst.
研究领域:
电化学
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材料科学
·
能源催化
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纳米技术
·
表面科学
✓ 已验证
DOI
高影响因子
Catalysis Science & Technology
·
2017
·Vol. 7
·期 21
·5055-5068
·
IF 5.773
Pengyu Niu,Hongjuan Xi,Jun Ren,Minggui Lin,Qiang Wang,Litao Jia,Bo Hou,Debao Li
Highly siliceous ZSM-22 was synthesized under hydrothermal conditions with ZSM-22 seeds. Characterization by FT-IR and 1H and 29Si NMR spectroscopy confirms that due to the existence of defective sites in the siliceous ZSM-22, acidic silanol groups including vicinal silanol and silanol nests are detected. Acidic silanol groups are considered as the acid sites of siliceous ZSM-22. As a result, siliceous ZSM-22 shows much lower acid site density and lower acid strength than silica–alumina ZSM-22 which contains hydroxyl groups bridging Si and Al as acid sites. In n-dodecane isomerization, Pt/siliceous ZSM-22 shows much higher isomer selectivity than Pt/silica–alumina ZSM-22. Furthermore, a lower loading amount of Pt on siliceous ZSM-22 (about 0.2 wt% Pt) can lead to high isomer selectivity. Owing to the acidic silanol groups and the low acid site density of siliceous ZSM-22, a good balance between metal and acid function in Pt/siliceous ZSM-22 is achieved, which results in a lower allowable Pt loading value and higher isomer selectivity.
研究领域:
催化化学
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材料科学
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石油炼制
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表面化学
✓ 已验证
DOI
高影响因子
Systems Microbiology and Biomanufacturing
·
2021
·Vol. 2
·期 3
·473-486
·
IF 0
Wu Aiai,Bai Yajun,Fan TaiPing,Zheng Xiaohui,Cai Yujie
l -Lactate dehydrogenases can reduce alpha-keto carboxylic acids asymmetrically and generally have a broad substrate spectrum. l -Lactate dehydrogenase gene (LF- l -LDH0845) with reducing activity towards 3,4-dihydroxyphenylpyruvate and phenylpyruvate was obtained from Lactobacillus fermentum JN248. To change the substrate specificity of LDH0845 and improve its catalytic activity towards large substrates, site-directed mutation of Tyr221 was performed by analyzing the amino acids in the active center. Kinetic parameters show that the k cat values of Y221F mutant on 3,4-dihydroxyphenylpyruvate, 4-methyl-2-oxopentanoate, and glyoxylate are 1.21 s −1 , 1.35 s −1 , and 0.72 s −1 , respectively, which are 420%, 150% and 130% of the wild-type LDH0845. This study shows that the mutations of Y221 can significantly change the substrate specificity of LDH0845, making it become a potential tool enzyme for the reduction of alpha-keto carboxylic acids with large functional groups.
研究领域:
生物化学
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分子生物学
·
酶工程
✓ 已验证
DOI
JOURNAL OF POWER SOURCES
·
2017
·
IF 6.395
Lan Sun,Tao Wang,Long Zhang,Yunjin Sun,Kewei Xu,Zhengfei Dai,Fei Ma
The rational design and preparation of earth-abundant, stable and efficient electrocatalysts for hydrogen production is currently the subject in extensive scientific and technological researches toward the future of a clean-energy society. Herein, a mace-like MoS 2 /NiCo 2 S 4 hierarchical structure is designed and synthesized on carbon fiber paper via a facile hydrothermal method , and evaluated as electrocatalyst for hydrogen evolution reaction . In the MoS 2 /NiCo 2 S 4 /carbon fiber paper hierarchical structures, MoS 2 nanosheets are dispersively distributed on the surface of NiCo 2 S 4 nanowires, which provides an enlarged surface area , abundant interfaces and catalytic active sites. As for hydrogen evolution reaction , such MoS 2 /NiCo 2 S 4 /carbon fiber paper heterostructures give rise to a hydrogen evolution reaction catalytic current density of 10 mA cm −2 with a lower overpotential of 139 mV and a smaller Tafel slope of 37 mV·dec −1 than those of MoS 2 /carbon fiber paper and NiCo 2 S 4 /carbon fiber paper counterparts, exhibiting a prominent electrocatalytic performance. Moreover, the electrocatalytic properties change little after 5000 CV cycles and continual electrolysis for 12 h without obvious decay, respectively, demonstrating high durability and stability. The excellent hydrogen evolution reaction performances endow the hierarchical configuration MoS 2 /NiCo 2 S 4 /carbon fiber paper with promising alternative in HER and other related renewable energy fields.
研究领域:
材料科学
·
能源化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Guojun Weng,Xinju Zhao,Jing Zhao,Jianjun Li,Jian Zhu,Junwu Zhao
The plasmonic spectral sensing method based on the etching of gold nanorods has been a powerful tool in the field of biomedical detection. Among the plasmonic etching sensors, the most popular sensing strategy is the “positive oxidative etching” plasmonic sensor that is based on plasmon blue-shifting due to nanorod shortening. In this study, we proposed a nanoplasmonic detection of dihydronicotinamide adenine dinucleotide (NADH) based on negative oxidative etching: NADH-mediated inhibition of H 2 O 2 induced gold nanorods etching. In the presence of NADH, the bromine intermediates (Br 3 − and Br 2 ) used for etching gold nanorods were reduced and consumed, inhibiting the etching rate and resulting in a small blue-shift of the longitudinal plasmon band (LPB). This shift can be utilized to sense the presence of NADH. Under the optimal reaction conditions, the LPB difference (Δλ) of etched gold nanorods and the concentration of NADH had a good linear relationship in the range of 0–4.9 × 10 −6 mol/L. The nanoplasmonic sensing showed a satisfactory preference for NADH over other common substances tested. It was successfully applied to the detection of NADH in PBS solution. This system provides a platform for the detection of targets in NADH-generated enzyme catalysis.
研究领域:
生物医学检测
·
纳米技术
·
分析化学
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2016
·
IF 4.803
Zhicai Xing,Qun Li,Dewen Wang,Xiurong Yang,Xuping Sun
ABSTRACT Transition metal nitrides (TMNs) attract a lot of attention due to their excellent catalytic activities for energy related applications, although TMN catalysts developed as HER catalysts in alkaline environment are limited. Herein, we report a very simple and straightforward method to fabricate self-supported nickel nitride film on nickel foam (Ni 3 N/NF) via direct nitridation of NF under NH 3 atmosphere. The Ni 3 N/NF, as an efficient 3D hydrogen-evolving cathode, needs overpotentials of 121, 177, and 254 mV to attain current densities of 10, 20, and 100 mA cm −2 , respectively, and it maintains its catalytic activity for at least 32 h in alkaline media. Additionally, this electrode is also highly efficient under neutral and acidic conditions. The scalable fabrication approach reported here can be extended to synthesize other self-supported transition metal nitride HER cathodes.
研究领域:
材料科学
·
能源化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2017
·
IF 6.035
Jinqiang Cui,Jiuqing Liu,Chunfeng He,Jie Li,Xiufeng Wu
As an important component of the lithium ion batteries, the separator has attracted much attention by researchers. In this paper, a polymer electrolyte separator based on the blended polymer of polyvinylidene fluoride and cellulose acetate was obtained via non-solvent induced phase separation (NIPS), meanwhile, the Al(OH) 3 particles was used as the addition doping into the blended polymer matrix. The structure, for example, pore size, porosity and the crystallization of the resulting separators were characterized. The thermal stability, ionic conductivity and electrochemical performance were also investigated. The results indicated that the PVDF-CA/Al(OH) 3 separator presented high porosity (68.6%), high electrolyte uptake (403.9%), especially superior thermal stability (thermal shrinkage ratio was 4.6% at 160 °C) and excellent ionic conductivity (2.85 mS cm −1 ). In addition, the rate capability (128.28 mA h g −1 at 8 C) and cycle performance (151.97 mA h g −1 after 100 cycles at 1 C) were also superior to those of the commercial polypropylene separator, demonstrating that the PVDF-CA/Al(OH) 3 separator can be a promising separator for the high-safety and high-rate dischargeable lithium ion battery.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Jie Han,Xin Wen,Hongchao Wang,Tianren Wang,Yuzhen Sun,Luis Ricardez-Sandoval,Guoyi Bai
Selective semi-hydrogenation of alkynes plays a pivotal role in the field of chemical production but still suffers from low selectivity and catalyst stability. Herein, an aminoclay-derived nickel catalyst was constructed by replacing part of Mg 2+ by Ni 2+ in the skeleton and coordinating Ni 2+ with aminopropyl groups via a self-assembly synthetic strategy. The introduction of Ni 2+ facilitated the exfoliation of lamellar structure, resulting in highly exposed and uniformly dispersed Ni nanoparticles. The optimal catalyst showed an excellent catalytic performance with 99.9 % conversion and 98.9 % regio- selectivity to alkene ( cis / trans = 94:6) in diphenylacetylene semi-hydrogenation. Experimental data and theoretical calculations validated that the aminopropyl groups on NiMg-AC improved the activity and selectivity to alkene by tuning the adsorption/desorption energies of substrate/product. Furthermore, this non-precious metal catalyst showed stable activity and selectivity during cyclic testing, thanks to the strong interaction between Ni and the aminopropyl groups. This "self-assembly" synthetic strategy provides valuable guidance for the preparation of aminoclay-derived Ni catalysts for selective semi-hydrogenation.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2025
·
IF 13.5
Fanpeng Meng,Fei Zhao,Jingkai Lin,Jinsheng Zhao,Huayang Zhang,Shaobin Wang
Designing heterojunctions based on carbon nitride offers a promising pathway for enhancing photocatalytic efficiency. This study develops an all-organic S-scheme metal-free heterojunction uniquely composed of carbon nitride nanosheets (GCNNS) and a donor–acceptor conjugated polymer, poly p-aminobenzylidene-so-aniline (PASO), synthesized through a simple yet effective ball-milling technique. This heterojunction demonstrates excellent photocatalytic efficiency for hydrogen (H 2 ) evolution. The optimized GCNNS/PASO-10 sample attains an H 2 evolution rate of 10.12 mmol∙g −1 ∙h −1 , which is about 5.9 times and 19.5 times greater than those of pure GCNNS and PASO, respectively. This improvement is due to the unique interfacial bonding, increased visible-light absorption, and efficient charge carrier separation facilitated by a strong internal electric field within the S-scheme. Theoretical calculations and characterization reveal that this heterojunction’s S-scheme mechanism optimally aligns energy bands and promotes spatial charge separation, driving superior photocatalytic activity. This work presents the unique advantage of all-organic materials for heterojunction construction and provides insights into designing advanced S-scheme systems for sustainable energy conversion.
研究领域:
材料科学
·
能源化学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2020
·
IF 7.489
Yaoning Chen,Ziping Zeng,Yuanping Li,Yihuan Liu,Yanrong Chen,Yanxin Wu,Jiachao Zhang,Hui Li,Ran Xu,Sha Wang,Zhen Peng
In this work, iron-manganese binary oxides (FMO) modified with different proportions of glucose addition (FMOCx) by co-precipitation method showed good activity in activating hydrogen peroxide (H 2 O 2 ) for tetracycline degradation. The structure and surface characterizations of the FMO and FMOCx were measured by XRD, FTIR , TEM , BET and XPS . With increased glucose addition, FMOCx has more surface functional groups such as –OH and –COOH, particle size decreases, surface area gradually increases, and the ratio of high valence iron and manganese also increases. In addition, the glucose might be oxidized by KMnO 4 to form amorphous carbon on the catalyst surface . Glucose modified iron-manganese binary oxides FMOC3 (with 0.003 mol glucose added) showed the highest efficiency removal capability for tetracycline up to 85%, which attribute to it has a larger surface area, more surface functional groups and higher surface active Mn(IV) site content. The results also demonstrated that FMOC3 could efficiently activate hydrogen peroxide. This study proves that glucose modified iron-manganese binary oxides (FMOCx) can offered a possibility of degradation of refractory organic pollutants as an environmentally friendly catalyst in the absence of H 2 O 2 or not.
研究领域:
环境科学
·
催化材料
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Yuan Zhou,Zhanfang Ma
Gold nanoclusters (AuNCs), due to their enzyme-like activity, can catalyze the decomposition of hydrogen peroxide (H 2 O 2 ), which can be used to reduce HAuCl 4 into gold nanoparticles (AuNPs). Hg 2+ effectively decreases the catalytic ability of AuNCs to decompose H 2 O 2 by the interactions between Au + on surface of AuNCs and Hg 2+ . In a system containing AuNCs, H 2 O 2 , and HAuCl 4 , increasing the Hg 2+ concentration prompts a color change from purple to red of the solution of as-synthesized AuNPs, which results from the increase in residual H 2 O 2 after decomposition by AuNCs. Based on this principle, a novel colorimetric method for ultrasensitive detection of mercury ions was developed in this work. AuNPs synthesized by a one-step method without modification were used to directly detect mercury ions in lake and river water samples. The detection limit of the present method was determined to be 8:9 pM with a linear response range of 0.1 nM–10 μM, which is much lower than the standard value defined by the Environmental Protection Agency (EPA). The method not only possesses advantages of convenience and simplicity, but also is promising for application in real samples.
研究领域:
分析化学
·
环境科学
·
纳米技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）