MOLECULES
·
2025
·Vol. 30
·期 7
·1625
·
IF 4.6
Qing Tang,Qi Fan,Lei He,Ping Yu,Qing Huang,Yuanming Chen,Bingbing Fan,Kun Liang
MXene is widely used in the fields of microwave absorption and electromagnetic shielding to balance electromagnetic pollution with the development of communication technologies and human health, due to its excellent surface functional groups and tunable electronic properties. Although pure multilayered MXene has an excellent accordion-like structure, the weak dielectric loss and lack of magnetic loss result in poor microwave absorption performance. Here, we propose a strategy for the catalytic growth of CNTs by the electrophoretic deposition of adsorbed metal ions, leading to the successful preparation of Ni-MWCNTs/Ti3C2Txcomposites with a “layer-by-layer” structure, achieved through in situ regulated growth of CNTs. By introducing dielectric–magnetic synergy to improve the impedance matching conditions, and by regulating the diameter of the CNTs to alter the electromagnetic parameters of Ni-MWCNTs/Ti3C2Tx, the 2-Ni-MWCNTs/Ti3C2Txcomposite achieves the best reflection loss (RL) value of −44.08 dB and an effective absorption bandwidth of 1.52 GHz at only 2.49 mm thickness. This unique layered structure and the regulation strategy provide new opportunities for the development of few-layered MXene composites.
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Advanced Science
·
2025
·Vol. 12
·期 21
·2412158
·
IF 14.1
Lei Ren,Yangnan Hu,Xiaoqiong Ding,Menghui Liao,Tian Shen,Sixing Cao,Hui Zhang,Hong Cheng,Yanru Qi,Pan Feng,Xinyi Pang,Ling Lu,Huan Wang,Wenwen Liu,Renjie Chai,Lin Cheng
Severe to profound sensorineural hearing loss seriously affects the communication and cognitive ability of the patients. Cochlear implantation (CI) is currently the most effective treatment, while it may damage the remaining inner ear function due to its poor biocompatibility and the resultant fibrosis. Herein, a porous methacrylated poly(dimethylsiloxane) (MA-PDMS)-coated cochlear electrode is presented for CI and hearing protection. The porous MA-PDMS is filled with a hybrid hydrogel system made of dexamethasone sodium phosphate (Dex), Ti 3 C 2 T x MXene (MXene), and methacrylate gelatin (GelMA). The coating shows good biocompatibility and drug loading and release capacity in vitro, protective effects on hair cells (HCs) and spiral ganglion neurons (SGNs) of the inner ear, as well as the residual hearing protection and the effective fibrosis reduction in vivo. It is anticipated that this porous electrode drug-loading coating may provide a valuable reference strategy for the future cochlear electrode transplantation system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ling Zhou,Ao Chen,Zhenzhen Liu,Chong Tao,Jing Ding,Jieru Guo,Hao Wu,Weiyi Zhou,Xipo Zhao
Long-term protection of skin-defect wounds is challenging for the common wound dressings cotton gauze due to its weak skin adhesion, limited drug-loading capacity and frequent replacement. Hydrogels are considered as the promising wound dressings benefiting by their good mechanical compatibility and biocompatibility. Nevertheless, the hydrogels always suffer from the drawbacks of fast water evaporation, lack of antibacterial ability and uncontrollable drug release, which greatly shorten their long-term wound protection duration. Herein, a novel and multifunctional phase change gel (PCG) combining flexibility of hydrogel and release-controllable ability of phase change materials (PCMs) was fabricated through a facile solvent-exchange strategy. Specifically, the bacterial cellulose (BC)/polyethylene glycol based phase change gels (BC/PEG PCGs) were prepared by direct impregnation of BC hydrogel into massive PEG melts. The solvent-exchange mechanism between BC hydrogel and PCM melts was firstly studied based on the impregnation experiments of BC gels into various PCMs. The as-prepared BC/PEG PCGs were then characterized in terms of structure, mechanical, phase change and wound dressing properties, subsequently. This work provides a comprehensive understanding of the structure relationship on their excellent flexibility, good adhesive, skin-cooling, antibacterial and controllable drug-release functions of BC/PEG PCGs, extending their potential in the long-term protection of skin-defect wounds.
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CARBON
·
2025
·
IF 11.6
Jin Wang,Qiankun Sha,Xiangyuan Yan,Changhui Ma,Chang Ma,Wei Li,Xingxiang Zhang,Na Han
Phase change materials (PCM) have great potential in storing and releasing thermal energy, but the poor light absorption, low thermal conductivity, and weak shape stability severely restrict the absorption, conversion, and utilization of solar energy. In this study, inspired by the articular structure, we prepared cyclized polyacrylonitrile@carbon nanotubes (CPAN@CNT)/graphene hybrid aerogel (CPAN@CNT/GA). The introduction of CPAN@CNT enhanced the mechanical properties and thermal conductivity of the aerogels, establishing continuous and stable heat transfer pathways and ensuring stable encapsulation of PCMs in the following step. Under a compressive strain of 50%, the compressive strength of CPAN@CNT/GA increased to 7.8 kPa, demonstrating stable compression resilience. Paraffin wax (PW) as the PCM was integrated into CPAN@CNT/GA by vacuum impregnation to fabricate PW/CPAN@CNT/GA shape-stabilized phase change materials (SSPCMs). PW/CPAN@CNT/GA exhibited a high latent heat (190.1 J g -1 ), a high thermal conductivity (0.764 W m -1 K -1 ), and exceptional photothermal conversion efficiency (93.7%). PW/CPAN@CNT/GA also showed its advanced solar-thermal-electric energy conversion potential. The output voltage was sufficient to power the electronic devices with a rated voltage of 2V under simulated sunlight (2 kW m -2 ), and provided additional operating time even in the absence of light. This study presents a feasible and effective method for fabricating SSPCMs with high latent heat retention, possessing efficient solar-thermal-electric energy conversion.
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ENERGY
·
2025
·
IF 9.4
Xiaokai Zhang,Zhaoda Zhang,Shuai Li,Guanghan Yan,Hongyang Li,Hongsheng Dong,Mingrui Sun,Yi Zhang,Yongchen Song
Triply periodic minimal surface (TPMS) lattices offer great design flexibility. A well-designed lattice effectively enhances the effective thermal conductivity of TPMS composite phase change materials, thereby improving the efficiency of latent heat thermal energy storage systems. In this study, four anisotropic Primitive structures (γ-10, γ-2.5, β-10, and β-2.5) were obtained by varying cell sizes along the heat flux direction (γ) and perpendicular to it (β). Computational fluid dynamics (CFD) simulations were used to investigate the effective thermal conductivity and melting behavior of these structures under isothermal and isoflux conditions. Results indicated that, due to the shortened heat transfer path along the TPMS, γ-10 and β-2.5 enhanced effective thermal conductivity by24.8 % and 10.5 %, respectively, compared to the original Primitive. This enhancement led to a 12.5 % reduction in the complete melting time for γ-10 under isothermal conditions, while maintaining excellent temperature uniformity under isoflux conditions. However, β-2.5's significant suppression of convective heat transfer offset the increase in effective thermal conductivity, resulting in no reduction in complete melting time. Furthermore, as γ increased, the complete melting time under isothermal conditions gradually decreased (by 8.0–14.5 %), while temperature uniformity under isoflux conditions improved. These findings provide a promising approach for efficient thermal energy storage applications.
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Journal of Extracellular Vesicles
·
2025
·Vol. 14
·期 9
·e70162
·
IF 14.5
Bin Liu,Yansi Xian,Tao Shen,Yu Ben,Wenshu Wu,Yong Shi,Xueying An,Rui Peng,Wentian Gao,Wang Gong,Xiang Chen,Baosheng Guo,Qing Jiang
Osteoarthritis (OA), the prevalent debilitating joint disorder, is accelerated by dysregulated intercellular crosstalk, yet the role of fibroblast-like synoviocyte (FLS)-derived extracellular vesicles and particles (EVPs) in disease progression remains to be elucidated. Here, integrative analysis of clinical specimens, animal models, and publicly available datasets revealed significant alterations in exosomal pathways within OA synovium. Proteomic profiling revealed distinct molecular signatures in EVPs derived from inflammatory and senescent FLSs, reflecting the pathophysiological status of their parent cells. We demonstrated that FLSs under inflammatory and senescent states in OA secreted pathogenic EVPs that propagated joint degeneration by disrupting chondrocyte homeostasis, polarizing macrophages towards a pro-inflammatory phenotype, and impairing chondrogenesis of mesenchymal stem cells. To therapeutically target these pathogenic EVPs, we engineered an adeno-associated virus 9 (AAV9) vector fused with a synovium-affinity peptide (HAP-1) to deliver shRNA against Rab27a , a key regulator of EVP secretion. Intra-articular administration of the engineered AAV9 in a murine OA model induced by destabilization of the medical meniscus significantly reduced synovial hyperplasia, cartilage degradation and inflammatory responses, while demonstrating satisfactory systemic biosafety. Our findings establish FLS-derived EVPs as critical mediators of OA pathogenesis and propose a targeted strategy to block their secretion, offering a promising disease-modifying therapeutic avenue for OA. Graphical Osteoarthritis (OA) progression involves pathogenic extracellular vesicles and particles (EVPs) from inflamed/senescent fibroblast-like synoviocytes (FLSs). Proteomic profiling revealed that pathogenic EVPs contribute to OA progression by disrupting the homeostasis of macrophages, chondrocytes and mesenchymal stem cells. Targeted inhibition of FLS-derived exosomes effectively alleviated OA progression with good biosafety.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Zhanlin Zhang,Kun Wei,Jie Meng,Junwu Wei,Yupeng Su,Huan Tan,Xiaohong Li
Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation therapy is constrained by insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling piezoelectric potential-amplified enzyme activities and synergistic PEDT-starvation tumor therapy. Here hollow barium titanate (hBT) NPs are synthesized using SiO 2 templates, followed by partial Au deposition via the Pickering emulsion-masking method to create Janus hBT@Au NPs, which are then conjugated with GOx and CAT on opposing sides to yield C-hBT@Au-G NPs. The hollow structure of hBT enhances flexibility and deformation under ultrasonication, while Schottky heterojunctions with Au layers promote charge carrier transfer, amplifying piezoelectric effects and free electron transfer to boost GOx activities. Piezoelectric field-enhances selective tumor cell internalization of NPs and PEDT generation of reactive oxygen species (ROS), coupled with self-propagated GOx/CAT cascades, intensify tumor cytotoxicities and deplete intracellular adenosine triphosphate. The Janus architecture, ultrasonic cavitation, and O 2 generation collaboratively drive robust propulsion for efficient NP accumulation and deep ROS penetration into tumor tissues, thereby achieving full tumor suppression with negligible systemic toxicity. This design overcomes delivery barriers of tumor accumulation, intratumoral penetration, and cellular uptake and synergizes PEDT-starvation tumor therapy.
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Waste and Biomass Valorization
·
2024
·
IF 2.6
Luo Bo,Liu Huiyu,Shan Rui,Zhang Jun,Yuan Haoran,Chen Yong
Purpose This work aims to investigate the thermal behavior and kinetic characteristics of polyethylene (PE) pyrolysis over Cu/Ce modified ZSM-5. The influences of metal types, particles size of active center and interaction of Cu–Ce species on products distribution are elucidated. Methods Metal-modified ZSM-5 catalysts were prepared by negative pressure impregnation method. Catalytic fast pyrolysis and thermogravimetric experiments were conducted using Py–GC/MS and TG/MS for the qualitative and quantitative analysis of pyrolysis products. Results Morphology characterization indicated the interaction of Cu–Ce species facilitated the regulation of active center size into a nanoparticle scale. The final products were restricted to a carbon number of less than 9 over CuCe/ZSM-5. Cu–Ce modification increased the aliphatic content from 58.5 to 76.1%. Kinetic analysis revealed a remarkable reduction in activation energies during both the intermediate and final stages, where an average decrease of 30% was achieved. Conclusion The synergistic effects of Cu 0 and CeO x facilitated the formation of more short chain olefins by enhancing C–C bonds cleavage activity. Undesired polycyclic aromatic hydrocarbons (PAHs) were avoided by the optimal steric hindrance of CuCe/ZSM-5. Graphical Abstract
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Clinics
·
2025
·
IF 2.4
Shan Xu,Xuming Lin,Fengling Jia
Objective Retinoblastoma (RB) is a type of intraocular tumor in childhood with a high lethality rate. N4-acetylcytosine (ac 4 C) modification is known to regulate multiple cancers, which is mediated by the only known ac 4 C writer N-Acetyltransferase 10 (NAT10). In this study, the authors aimed to reveal the mechanism of RB progression regulated by ac 4 C modification. Method Phenotypically, dot blot assay and quantitative real-time PCR were used to detect the ac 4 C levels and NAT10 expression in clinical samples and RB cell lines. Then, NAT10 was knocked down to assess its effect on glycolysis. Mechanically, RNA immunoprecipitation assay, immunofluorescence assay, and dual luciferase report were used to explore the mRNA modified by NAT10-mediated ac 4 C modification. Mice xenograft model was used to determine the effect of NAT10 on tumor growth in vivo . Results The present results demonstrated that the levels of ac 4 C and NAT10 were increased in cancer tissues and RB cell lines. Furthermore, NAT10 knockdown inhibited the glycolysis in RB cell lines. Moreover, the authors revealed that NAT10 knockdown decreased the ac 4 C modification and mRNA stability of HK1, while the inhibition of glycolysis by NAT10 knockdown was reversed by HK1 overexpression. Finally, NAT10 knockdown relieved the growth of tumors in mice models. Conclusion The authors illustrated that NAT10 plays an important role in the progression of RB by regulating the ac 4 C modification on HK1 mRNA and affects its stability, which may provide a novel theoretical basis for the treatment of RB.
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ACS Applied Bio Materials
·
2025
·
IF 4.7
Ji Xia,Jin Huang,Yixiao Yan,Chenxin Jian,Jiansheng He,Nisha Wang,Lei Shi,Qiyang Ding,Hao Tian,Wei Gao
Mitochondrial damage occurs as an initial event following ischemic onset, and the extent of mitochondrial dysfunction is highly correlated to the severity of ischemia-induced cell death. Once appropriate therapeutic interventions are provided, the ischemic tissue can be salvaged, which is of great significance in achieving better neurological outcomes. Herein, we developed a nanosized starch as a targeting nanoplatform, featuring effective blood-brain barrier (BBB) penetration through lactoferrin-mediated transcytosis. Notably, the nanostarch-based delivery of Mdivi-1 and Alda-1 enables controlled release in the acidic lysosome of neurons, effectively inhibiting the pathological mitochondrial fission and metabolizing toxic aldehydes, thereby creating protective effects on maintaining mitochondrial function. Moreover, we demonstrated that mitochondrial protection induces a transition from activated pro-death responses to a pro-survival state by reducing the release of pro-apoptotic proteins, significantly contributing to the long-term recovery of neurological function. Overall, our nanostarch provided an in-depth understanding of the delivery of mitochondrial protectants and underscored the potential and utility of mitochondrial protection for ischemic stroke via minimizing neuronal apoptosis.
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ACS Nano
·
2025
·
IF 16
Hengdong Ren,Chensi Zhou,Ka Wang,Ximing Zhang,Lei Feng,Wenqing Wei,Yuqing Sun,Yukang Liu,Jun Dai,Xiaobing Xu,Zhiyong Zhang,Xinglong Wu
Interface polarization (one of the slow polarizations) is considered the primary mechanism driving microwave absorption (MA), but limitations in material composition and microstructure design often lead to weak interfacial polarization relaxation. In this work, we developed an interesting heterostructure consisting of carbon nanotube-encapsulated α-Fe2O3 nanocolumns (CNTs@α-Fe2O3). The curvature effects of CNTs induce a built-in electric field between CNTs and α-Fe2O3 nanocolumns, facilitating effective interface polarization. Under microwave irradiation, electron accumulation at the interfaces, driven by the energy-level mismatch between the two materials, further strengthens interface polarization, leading to a highly efficient MA performance. This heterostructured material achieves a minimum reflection loss of −74.1 dB at a thickness of 1.8 mm and an effective absorption bandwidth (reflection loss ≤ −10 dB) of 5.2 GHz (11.9 ∼ 17.1 GHz) at a thickness of only 1.5 mm. X-ray photoelectron spectroscopy and Raman scattering show a distinct blueshift in the Fe 2p binding energy and the A1g mode energy (exclusively associated with Fe atom vibrations), suggesting substantial charge transfer and redistribution at the interface associated with enhanced interface polarization. This work provides insights into interface polarization through the strategic design of energy levels and materials.
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高影响因子
MOLECULES
·
2025
·Vol. 30
·期 11
·2429
·
IF 4.6
Wei Wang,Xiangyao Chen,Wen-Can Huang,Simiao Di,Jie Luo
This study presents a multilayer magnetic Janus sub-micrometric particle (MMJSP) as a nanoreactor for lipase catalysis. The core of the nanoparticle is constructed from a core-shell Fe3O4@SiO2framework, which serves as a precursor for the sequential amino and aldehyde modifications using 3-aminopropyltriethoxysilane and benzaldehyde. Following localized etching and subsequent modification with N,N-dimethyldodecylamine, a Janus nanoparticle with distinct hydrophilic and hydrophobic domains is synthesized. The resulting MMJSP demonstrates a stable attachment to the reaction interface and significantly enhances lipase performance, exhibiting 1.4-fold and 1.6-fold enhancements in activity after immobilization during 1 h hydrolysis and 24 h esterification reactions, respectively. Additionally, the storage stability of the immobilized lipase is improved by 100% over a period of 30 days. Reusability assessments reveal that the immobilized enzyme retains 80.7% activity after 10 cycles of esterification and 80.6% after 50 cycles of hydrolysis, with the magnetic properties allowing for rapid separation and recovery of the immobilized enzyme.
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