INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
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2026
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IF 4.6
Rongrong Dong,Yifei Wang,Lei Song,Jiayin Wang,Chun Yang,Xufeng Ji,Qi Zhou,Hao Wang,Xinhua Guo,Jiancheng Xu
Background Carbapenem-resistant Escherichia coli (CREC) producing New Delhi metallo-beta-lactamase (NDM) poses a substantial threat to global public health. Prompt detection of CREC is essential for effective patient management and to curb the spread of resistance. Objective This study aims to establish a rapid and reliable detection method for NDM-producing CREC using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in conjunction with machine learning (ML) techniques. Methods Clinical isolates of E. coli were collected from the First Hospital of Jilin University’s clinical laboratory from August 2018 to December 2022. PCR was employed to detect 23 prevalent resistance genes in the isolates. Protein profiles were analyzed by MALDI-TOF MS with a cooperative matrix consisting of (E)-propyl α-cyano-4-hydroxylcinnamylate (CHCA-C3) and α-cyano-4-hydroxycinnamic acid (CHCA). By comparative analysis of nine ML algorithms, the optimal Random Forest (RF) algorithm was identified and used to find the NDM specific ion peaks. Furthermore, the NDM gene was cloned into the standard E. coli strain ATCC 25922 to verify the reliability of these specific peaks. Results A total of 154 E. coli strains were categorized into three groups: 45 CREC strains, 58 extended-spectrum beta-lactamase (ESBL)-producing strains, and 51 non-CREC, non-ESBL strains. PCR amplification identified 12 resistance genes. The established ML model with RF algorithm exhibits excellent discriminative ability, achieving an AUC of 0.993 and an AP of 0.997. Four specific peaks ( m/z 5132, m/z 5209, m/z 6350, and m/z 6371) of NDM were identified using the cooperative matrix. In contrast, the traditional CHCA matrix revealed no specific peaks. Furthermore, the specific peaks at m/z 5132 and m/z 5209 were detected in the MALDI-TOF MS spectra of the recombinant E. coli strain ATCC 25922-PZY01/NDM, which directly correlated with the expression of the NDM gene. Conclusion The integration of MALDI-TOF MS with ML techniques, facilitated by the cooperative matrix approach, has enabled the swift and precise identification of NDM-producing CREC. This advancement significantly enhances the effectiveness of clinical management and the control of hospital-acquired infections.
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Materials Today Bio
·
2026
·
IF 10.2
Xiaofei Zheng,Tiaotiao Zhu,Xuanyu Lin,Pengjing Chen,Baiwei Ma,Juanfang Zhu
s Periodontitis, a widespread inflammatory disease, is difficult to treat effectively due to incomplete mechanical cleaning and increasing antibiotic resistance. To overcome this, we developed a new covalent organic framework, THP-PE-COF, which combines aggregation-induced emission (AIE) with local asymmetric electron distribution (LAED) to enhance photodynamic therapy (PDT). The AIE unit prolongs fluorescence lifetime and inhibits charge recombination, while the electron-donating triphenylthiophene (THP) induces LAED to form local dipoles that promote oxygen adsorption and charge separation. Compared with control THP-PB-COF and THP-BPE-COF, THP-PE-COF exhibited improved light absorption, charge dynamics, and reactive oxygen species (ROS) generation. It showed strong antibacterial activity against Porphyromonas gingivalis and Fusobacterium nucleatum in vitro and demonstrated effective periodontitis treatment with decreased inflammatory responses in vivo . This work pioneered the integration of AIE and LAED in COFs, providing a promising antibiotic-free strategy for periodontal therapy.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2026
·
IF 2.9
Shi Huang,Qianqian Guo,Jiancong Ni,Zhenyu Lin,Xiaoping Chen
Using indium tin oxide (ITO) substrates as bottom and eutectic gallium and indium (EGaIn) as top electrodes, we successfully formed alkyl phosphate self-assembled monolayers (SAMs) on ITO and molecular junctions in the form of ITO-PO3(CH2)nH//GaOx/EGaIn (n=8, 10, 12, 14, or 16). The tunneling decay coefficient (β, decay of charge transport rate vs. n) of junctions obtained from direct current (DC) characterization is 0.90 n-1 with a log-injection current density (log10|J0|) of 1.87 A/cm2 at an applied bias of 0.5 V, which is confirmed by the impedance spectroscopy results from the resistance of SAM (RSAM), indicating the evolution of RSAM with molecular length is the main origin of decay of charge transport rate in the phosphate junctions. The dielectric constant (εr) values of PO3(CH2)nH SAMs measured in junctions are 2.28-2.60, indicating the semiconductor of ITO substrates do not affect the dielectric and electrical responses of junctions. This work provides a compatible platform for studying the interfacial charge transport, dielectric responses, and even possible optical properties of a hybrid electronic system of organic molecules with phosphonic acid anchoring group, semiconductor and metallic electrodes.
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DESALINATION
·
2026
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IF 9.8
Huazhen Rong,Jiashun Mao,Yue Ma,Xiaohui Yan,Min Luo,Handan Wen,Tao Liu,Yihui Yuan,Ning Wang
Uranium-contaminated water streams associated with nuclear fuel cycle operations represent an emerging challenge in water purification, combining radiological risk with the opportunity for resource recovery. Developing sustainable uranium removal technologies that operate under mild conditions while minimizing chemical inputs remains a critical task, particularly for integration into advanced water treatment systems. Herein, we report a donor-acceptor covalent organic framework (DANT-TFPT) featuring an in-framework coupled H 2 O 2 production and consumption (IFC-HPC) architecture for photocatalytic uranium removal. By co-localizing oxygen reduction reaction catalytic sites and uranyl-binding pockets within a single scaffold, photogenerated H 2 O 2 is produced and consumed in-situ, minimizing diffusion losses and nonproductive decomposition. Together with strong donor-acceptor coupling and abundant N/O-rich coordination domains, the DANT-TFPT exhibits a high H 2 O 2 evolution rate under ambient air to achieve an exceptional U(VI) uptake capacity of 745.7 mg g −1 with a fast removal rate of 67.8 mg g −1 h −1 without sacrificial reagents in uranium-contaminated wastewater. This study demonstrates a chemical-efficient and environmentally benign strategy for the removal and recovery of uranium from contaminated waters, highlighting the potential of integrated photocatalytic-sorptive materials for emerging contaminant control and resource recovery in water purification and desalination-related treatment processes.
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Frontiers in Plant Science
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2026
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IF 4.8
Hongjun Chen,Xing Tang,Long Xiao,Xiu Liu,Chenzhong Jin
In this study, the crude extract of natural Loropetalum chinense (LoE) was prepared using a simple ethanol leaching approach. Preliminary evaluations of the safening effect of LoE in both agar and soil media demonstrated its ability to protect rice seedlings from damage induced by the herbicide pretilachlor (Pre). Specifically, treatment with LoE at 50 mg/L resulted in a 40.35% increase in root length and a 25.11% increase in plant height. In contrast, treatment at 100 mg/L led to a 36.85% increase in fresh weight, demonstrating effectiveness comparable to that of the commercial safener fenclorim (Fen). Moreover, compared to rice seedlings treated with Pre alone, LoE significantly increased the levels of glutathione (GSH) and enhanced the activities of several important enzymes: glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT). The mechanism of action for LoE appears to involve enhancing GST activity to accelerate the metabolism of Pre and improving herbicide tolerance by activating antioxidant enzymes. Overall, LoE shows promise as a potential eco-friendly, plant-derived herbicide safener candidate for pretilachlor. For practical commercial application, further efforts should focus on (i) clarifying the phytochemical profile of LoE extracts, and (ii) conducting in-depth assessments of LoE’s mechanisms of action, including studies on degradation kinetics and metabolite formation.
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FOOD CHEMISTRY
·
2026
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IF 9.8
Shui Jiang,Xiangyuan Li,Lexin Zhao,Shuang Bai,Danni Zhang,Hengli Meng,Zhiyong Cui,Xiaoming Wang,Bo Yu,Yuan Liu
Soft-boiled chicken, a traditional Chinese delicacy renowned for its distinct umami and overall taste, was investigated to identify key taste-active compounds and potential umami peptides. Using taste recombination combined with omission/addition tests, six compounds (sodium ion, chloride ion, inosine-5′-monophosphate (IMP), lactic acid, succinic acid and glutamic acid) were identified as key taste-active compounds. Through the mass spectrometry and virtual screening 14 potential umami peptides were identified, with 13 being reported for the first time. Molecular docking analysis revealed that amino acid residues including 277_ARG, 151_ARG, 220_TYR, 276_SER and 107_SER on T1R1/T1R3 receptor are critical for umami perception. Sensory evaluation and electronic tongue results confirmed that the recombination taste solution effectively mimics the taste characteristic of Tuer soft-boiled chicken. This study advances the understanding of the taste mechanisms underlying soft-boiled chicken and provides valuable technical support for optimizing the industrial production and flavor development.
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Theranostics
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2026
·Vol. 16
·期 7
·3616
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IF 13.3
Pan-Miao Liu,Yu-Ge Wang,Ting-Ting Zhu,Ji-Chun Zhang,Han-Wen Gu,Hui-Juan Li,Wei-Tong Pan,Yan-Bo Zhou,Kui-Cheng Zhu,Kenji Hashimoto,Jian-Jun Yang
Altered dopamine (DA) neurotransmission in key brain circuits underlies cognitive deficits across psychiatric and neurological disorders by disrupting working memory, attention, and executive function. Here, we introduce a novel, carrier-free nanotherapeutic approach using polydopamine nanoparticles (PDA NPs)—synthesized via oxidative self-polymerization of DA hydrochloride—for targeted DA supplementation and cognitive rescue. Uniform, spherical PDA NPs (~250 nm) exhibit excellent biocompatibility and cross the blood-brain barrier via endocytosis. In acidic environments, they degrade to release DA, which is internalized by endothelial and neuronal cells and subsequently converted into downstream catecholamines. In a mouse model of lipopolysaccharide-induced cognitive impairment, PDA NP treatment fully restored performance in Y-maze and novel-object recognition tests. Biochemical analyses showed that short-term administration elevated hippocampal DA, norepinephrine, and tyrosine, while prolonged treatment markedly increased acetylcholine levels. This long-term cholinergic enhancement was mediated by activation of septo-hippocampal projections via DA D2 receptor signaling in the medial septal nucleus. Together, these results establish PDA NPs as an effective, carrier-free platform for targeted DA delivery that not only replenishes catecholamines but also engages cholinergic circuits to ameliorate cognitive impairments.
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Food Bioscience
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2026
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IF 5.9
Ge Xu,Longbin Tan,Jiewen Tan,Wenzhu Zhao,Zhipeng Yu
Tilapia skin collagen peptides possess multiple biological functions, yet their potential value remains underdeveloped and underutilized. This study investigated the efficacy and mechanisms of tilapia skin collagen peptides (TSCPs) in mitigating aging. TSCPs significantly delayed aging progression in H 2 O 2 - and glucose-induced zebrafish models. Three tyrosinase-inhibitory peptides and five antiglycation peptides were identified in TSCPs through targeted screening. Specifically, peptides Ser-Glu-Gly-Lys (SEGK) and Asp-Asp-Asp (DDD) exhibited the strongest in vitro tyrosinase-inhibitory and antiglycation activity, respectively. Molecular dynamics simulations revealed that both peptides bound more stably to anti-aging targets (tyrosinase and receptor for advanced glycation end products (RAGE)) through hydrogen bonds and electrostatic interactions. Moreover, SEGK and DDD reduced reactive oxygen species (ROS), malondialdehyde (MDA), and advanced glycation end products (AGEs) levels in zebrafish models, thereby contributing to the preferable aging mitigation effects. These findings provide in-depth insights into the mechanisms by which TSCPs mitigate aging from the perspectives of antioxidation, antiglycation, and tyrosinase inhibition, offering a theoretical basis for the development of TSCPs-based functional foods.
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POLYMER
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2026
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IF 4.5
Yanhong Zeng,Weitao Tang,Chao Ji,Jingchao Geng,Xinwang Li,Qiang Zhang
Soft capacitive pressure sensors have been widely utilized in the fields of flexible electronics and smart devices. While expanding its pressure sensing range, enhancing the sensitivity of sensors has attracted attention. Currently, the problems that need further solution also include improving the pressure sensing linearity and force detection resolution, enabling sensors to identify tiny pressure changes under high pressure. To address this issue, this study presents a strategy utilizing direct ink writing (DIW) 3D printing technology to construct a double-sided sawtooth structure, which can significantly enhance sensitivity while improving pressure resolution. Traditional flexible dielectric layers are mostly bulk polymer. As the applied pressure increases, the compression of the dielectric layer reduces the distance change between the electrode plates under the same pressure, making it difficult to achieve linear variation of capacitance. This paper designs a double-sided sawtooth structure, which squeezes out the air in the dielectric layer with the increase of pressure to realize linear detection of a wide range of pressures. The thermal expansion microspheres (TEM) introduces micro-pores in PDMS to further expand the linear detection range. In addition, the interfacial polarization effect of CB is utilized and improve the sensitivity. Comparing the double-sided sawtooth structured sensors based on PDMS, PDMS&TEM and PDMS&TEM&CB, the results show that the PDMS&TEM&CB sensor exhibits the highest sensitivity (6.8 × 10 −3 kPa −1 ), excellent linear response across a wide pressure detection range of up to 150 kPa, ultra-low detection limits (∼3.2 Pa), and outstanding dynamic response and repeatability (over 8000 cycles). Additionally, the high pressure resolution of the sensor renders it exceptionally suitable for various applications, including minute pressure detection, spatial pressure mapping, Braille recognition, and mapping changes in object curvature.
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Journal of Energy Storage
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2026
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IF 9.8
Ting Liu,Menghui Yin,Beibei Li,Salifu Nasir,Qiang Chen
The accelerating demand for sustainable, high-rate, and durable energy storage underscores the need for carbon electrodes that simultaneously offer balanced micro–mesoporosity for rapid ion transport and robust heteroatom functionalities for enhanced interfacial chemistry. In the present work, we convert bitumen asphaltenes and recycled cellulose acetate into N/S co-doped hierarchical carbons via ammonium persulfate-assisted co‑carbonization and KOH activation. The optimized carbon combines an ultrahigh specific surface area of 3527 m 2 g −1 , balanced micro–mesoporosity, and uniformly distributed electroactive N/S species (pyridinic/pyrrolic N, C S, SO x ), enhancing conductivity and pseudocapacitance. In three-electrode tests, the electrode delivered 382.5 F g −1 at 0.5 A g −1 with 74% retention at 10 A g −1 . The symmetric aqueous device achieved a specific capacitance of 288.2 F g −1 at 0.5 A g −1 , energy densities of 10.01 Wh kg −1 at 257.4 W kg −1 and 5.42 Wh kg −1 at 6728.3 W kg −1 , and 108.7% capacitance retention after 10,000 cycles at 5 A g −1 . This study advances sustainable energy storage by enabling low-cost, high-performance supercapacitors and promoting solid-waste recycling.
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Food Bioscience
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2026
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IF 5.9
Shijin Huang,Ganggang Zhang,Zongyou Chen,Jiawei Chen,Xiaocui Lai,Weihua Lai
Chlortetracycline (CTC), a broad-spectrum veterinary antibiotic, poses serious risks to human health through bioaccumulation due to excessive use. To address the critical need for CTC monitoring, we developed a fluorescence quenching lateral flow immunoassay (FQ-LFIA) employing black bimetallic hollow nanoparticles (BBHNPs) as quencher. BBHNPs were engineered with a unique dual-advantage architecture: an internal hollow structure for enhanced light capture capability and an external polydopamine layer for higher spectral overlap with fluorophores. This design resulted in exceptional photophysical characteristics, including a remarkable molar extinction coefficient (2.18×10 12 L mol -1 cm -1 ) and an unprecedented fluorescence quenching constant (5.20×10 13 L mol -1 ). BBHNP-based FQ-LFIA achieved a limit of detection (LOD) of 0.32 ng mL -1 , representing a 6.91-fold improvement over conventional gold nanoparticle-based lateral flow immunoassay (LFIA). Validation studies in spiked milk samples showed excellent recovery rates (87.73-118.09%) with high precision (coefficient of variation < 10.36%). Method comparison with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis confirmed the reliability of BBHNP-FQ-LFIA for real-world applications.
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Journal of Agriculture and Food Research
·
2026
·
IF 6.2
Yiting Yang,Mailin Gan,Yuanyuan Wu,Huiling Zhang,Haifeng Dan,Yu Zou,Tianci Liao,Yuhang Lei,Lili Niu,Ye Zhao,Lei Chen,Yan Wang,Li Zhu,Linyuan Shen
In this study, metabolomics (MET) and flavoromics (FLA) were used to comprehensively characterize the meat quality indicators, metabolites and flavor compounds of two muscles of Wuhuang (WH) pig, a newly recognized local breed in China. The results showed that the pH value of WH pork was in the range of 5.57–6.17 with the pH of the longissimus dorsi muscle (LDM) decreasing rapidly, while that of the psoas major muscle (PMM) remained stable. At the same time, the two meats showed obvious differences in meat color, with a higher Lightness ( L∗ ) value of LDM, a higher a value of PMM, and a stronger sweetness and citrus flavor of LDM. 1-hydroxy-2-Propanone; L-valine ethyl ester; L-Leucine ethyl ester were the main differentiating compounds between the two meats. Phosphatidyl acids, sphingolipids, nucleosides, nucleotides and their analogues were significantly different in the two muscles. Correlation analysis reveal a close association between the above metabolites, flavor compounds, pH value, and meat color. WH pork has excellent quality traits, unique flavor characteristics and high flavor genetic stability. This study provides a theoretical basis for the research, development and utilization of WH pork quality.
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危险品化学品经营许可证（带存储）