POLYHEDRON
·
2022
·
IF 2.975
Yan-Ling Deng,Wei Li,Chun-Yang Pan
Two new metal hybrid borates , Na[Ni(py) 2 ] 2 ·[(C 4 H 2 O 6 ) 2 B]·H 2 O (py = pyridine) ( 1 ) and [Cu(H 2 O) 2 (1-EI) 4 ]·[B 5 O 6 (OH) 4 ] 2 ·H 2 O (1-EI = 1-ethylimidazole) ( 2 ), have been successfully synthesized. 1 features an interesting structure based on mixed borate-tartrate motifs. Two tartrate anions are condensed with one BO 4 to form the hybrid anionic group [(C 4 H 2 O 6 ) 2 B] 5− . The structure of 2 is composed of [B 5 O 6 (OH) 4 ] − clusters and [Cu(H 2 O) 2 (1-EI) 4 ] 2+ complexes, which exhibits hydrogen-bonded network formed by [B 5 O 6 (OH) 4 ] − clusters. These compounds are further confirmed by FTIR, PXRD and UV–vis. In addition, the catalyst prepared from 2 shows excellent electrocatalytic oxygen reduction reaction (ORR) activity.
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Materials Research Express
·
2014
·Vol. 1
·期 1
·015033
·
IF 0
Yanyan Chen,Shenjie Li,Lijian Huang,Daocheng Pan
Au+ ions have been successfully incorporated into the lattice of ZnxCd1−xS quantum dots as luminescent centers via an aqueous method. The dopant emission can be tuned in the range of 445 to 570 nm, and the highest quantum yield can reach as high as 30%. Our results showed that Au+ ions can be used as an excellent luminescent dopant in doped quantum dots. Finally, these water-soluble quantum dots can be used directly in PL imaging of HepG2 cells without conjugating any biological targets, indicating a high potential application in bio-labeling.
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Journal of Diabetes Investigation
·
2023
·Vol. 14
·期 3
·364-375
·
IF 3.2
Ji Chen,Peng Guo,Xinxin Liu,Huizhi Liao,Kemin Chen,Yuxia Wang,Jie Qin,Fengrui Yang
Introduction We tried to show the effect of sinomenine (SIN) in diabetic peripheral neuropathic pain (DPNP) and the related underlying mechanism. Methods Network pharmacological analysis and bioinformatics analysis were carried out for identification of the active ingredients of Sinomenium acutum and the related genes. The DPNP rat model was constructed and primary rat spinal cord microglial cells were isolated for in vitro cell experiments. The therapeutic role of SIN in DPNP was determined in vivo and in vitro through analysis of microglial cell activation and inflammatory response. Results Therapeutic role of S. acutum in DPNP was mainly achieved by regulating 14 key genes, among which the target gene prostaglandin-endoperoxide synthase 2 ( PTGS2 ) of SIN might be the key gene . An in vivo experiment showed that SIN inactivated the inositol-requiring enzyme 1 alpha–X-box binding protein 1 pathway by downregulating PTGS2 , which relieved pain symptoms in DPNP rats. It was confirmed in vivo that SIN inhibited the pathway through PTGS2 to alleviate the activation of spinal cord microglial cells and inflammatory response . Conclusion SIN decreases the expression of PTGS2 to inactivate the inositol-requiring enzyme 1 alpha–X-box binding protein 1 signaling pathway, which inhibits microglial activation, as well as the release of inflammatory factors, thus alleviating DPNP.
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高影响因子
TALANTA
·
2023
·
IF 6.1
Fatemeh Maleki,Mohammad-Reza Rashidi,Habib Razmi,Marjan Ghorbani
A novel electrochemical immunosensor was developed for ultrasensitive determination of the hormone insulin-like growth factor 1 (IGF-1) based on immobilization of a specific monoclonal antibody on the electrospun nanofibers of Polyacrylonitrile (PAN)/Zein-reduced graphene oxide (rGO) nanoparticle . The nanofibers deposited on glassy carbon electrode (GCE) showed good electrochemical behaviors with synergistic effects between PAN, Zein, and rGO. PAN/Zein nanofibers were used due to flexibility, high porosity, good mechanical strength, high specific surface area, and flexible structures, while rGO nanoparticles were used to improve the detection sensitivity and anti-IGF-1 immobilizing. Different characterization techniques were applied consisting of FE-SEM, FT-IR, and EDS for the investigation of morphological features and nanofiber size. The redox reactions of [Fe(CN) 6 ] 4−/3− on the modified electrode surface were probed for studying the immobilization and determination processes, using differential pulse voltammetry (DPV) and cyclic voltammetry (CV). Under optimal conditions, LOD (limit of detection) and LOQ (limit of quantification) were obtained as 55.72 fg/mL and 185.73 fg/mL respectively, and sensitivity was acquired 136.29 μA/cm 2 .dec. Moreover, a wide linear range was obtained ranging from 1 pg/mL to 10 ng/mL for IGF-1. Furthermore, the proposed method was applied for the analysis of IGF-1 in several human plasma samples with acceptable results, and it also exhibited high selectivity, stability, and reproducibility.
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RSC Advances
·
2023
·Vol. 13
·期 20
·13824-13833
·
IF 3.9
Yani Zheng,Yin Dai,Junqiang Hong,Huizhu Fan,Qing Zhang,Wei Jiang,Wei Xu,Jianwen Fei,Junli Hong
The compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), one of the tobacco specific nitrosamines (TSNAs), is widely recognized as a major carcinogen found in tobacco products, environmental tobacco smoke and wastewater. Thus, a selective enrichment and sensitive detection method for monitoring the risk of NNK exposure is highly desirable. In this study, a magnetic molecularly imprinted polymer (MMIP) functionalized with dendritic nanoclusters was synthesized to selectively recognize NNK via the dummy template imprinting strategy, aiming to avoid residual template leakage and increase the imprinting efficiency. The nanocomposites were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, as well as vibrating sample magnetometry (VSM) and nitrogen adsorption/desorption analysis. The resulting MMIPs exhibited high adsorption capacity, fast binding kinetics and good selectivity for trace amounts of NNK. A rapid, low cost and efficient method for detecting NNK in tobacco products was established using magnetic dispersive solid-phase extraction coupled with HPLC-DAD with a good linear range of 0.1–250 μg mL−1. The limit of detection (LOD) and limit of quantification (LOQ) of NNK were 13.5 and 25.0 ng mL−1, respectively. The average recoveries were 87.8–97.3% with RSDs lower than 3%. The results confirmed that the MMIPs could be used as an excellent selective adsorbent for NNK, with potential applications in the pretreatment of tobacco products.
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高影响因子
JOURNAL OF POWER SOURCES
·
2019
·
IF 7.467
Zeyi Yao,Wu Tang,Xinxin Wang,Chuan Wang,Chuluo Yang,Cong Fan
The organic cathodes with high specific capacity are highly desirable to fabricate high-specific-energy-density organic Li-ion full cells. Herein, we initially propose the long-term plan for the systematic synthesis of the oligomer family of 1,4-benzoquinone (BQ), which can possess theoretical specific capacity above 500 mA h g −1 . As a start, the dimer of 1,4-benzoquinone (2,2′-bis-(1,4-benzoquinone), BBQ) is synthesized, which can realize the specific capacity of 501 mA h g −1 and the average discharge potential of ~2.5 V (vs. Li + /Li). Even facing the dissolution problem, BBQ can deliver average specific capacities of ~190 mA h g −1 during 3000 cycles at 500 mA g −1 and ~120 mA h g −1 during 8000 cycles at 2 A g −1 in Li-ion half cells. Afterwards, the all-organic Li-ion full cells are fabricated by using the reduced state (Li 4 TP) of lithium terephthalate (Li 2 TP) as the starting anode and BBQ as the starting cathode. Delightfully, the resulting Li 4 TP-BBQ Li-ion full cells can realize the specific capacity of 316 mA h g −1 cathode in the 1st cycle (500 mA g −1 ). Meanwhile, average specific capacities of ~98 mA h g −1 during 1000 cycles can be fulfilled (500 mA g −1 ). The results of the Li 4 TP-BBQ Li-ion full cells are among the best all-organic Li-ion full batteries reported to date.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Han Zhang,Heping Cui,Xue Xia,Shahzad Hussain,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
Lysine (Lys) glycated by xylose (Xyl) at α-NH2 [Nα(1-deoxy-D-xylulos-1-yl)lysine (Nα-Xyl-Lys ARP)] or ε-NH2 [Nε-(1-deoxy-D-xylulos-1-yl)lysine (Nε-Xyl-Lys ARP)] significantly impacted the thermal degradation pathways of Amadori rearrangement products (ARPs). Nα-Xyl-Lys ARP was found to undergo retro-aldolization on the sugar fragment more readily to form glyoxal/methylglyoxal than Nε-Xyl-Lys ARP. Furans and pyrazines formation during the degradation of the diglycated lysine [Nα,Nε-di(1-deoxy-d-xylulos-1-yl)lysine (Nα,Nε-di-Xyl-Lys ARP)] was delayed at 120 °C relative to Nε-Xyl-Lys ARP. This was attributed to the complex degradation of Nα,Nε-di-Xyl-Lys ARP, which slowed the substantial formation of deoxypentosones and the effective release of Lys. At 140 °C, the dual glycated Nα,Nε-di-Xyl-Lys ARP was more conducive to promoting the redistribution of electrons and facilitating molecular rearrangement. This accelerated the efficient decomposition of dual glycated groups in Nα,Nε-di-Xyl-Lys ARP and enabled glyoxal to actively participate in Strecker degradation. Thus, the production of furans and pyrazines was substantially increased, and the variety of pyrazines was expanded from three types to eight types. An appropriate increase to pH 7.5 effectively avoided the overprotonation of hydroxyl and amino groups (pH 5.5), simultaneously enhancing furans and pyrazines yield while minimizing the formation of pyridines under alkaline conditions.
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高影响因子
SYNTHESIS-STUTTGART
·
2025
·Vol. 57
·期 16
·2490-2495
·
IF 2.3
Lin-Gen Zhang,Wen Yuan,Shunsheng Yan,Ke Cao
An efficient and environmentally friendly protocol for the synthesis of 1-(α-hydroxyindole)-o-carboranes has been developed via Friedel–Crafts reaction of C3-H of indoles with 1-formyl-o-carborane in the absence of Lewis acid and solvent. The intermolecular σ-π interaction between indole and B–H bonds of o-carborane was proposed for promoting the Friedel–Crafts reaction of the C3-H of indole.
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CERAMICS INTERNATIONAL
·
2020
·Vol. 46
·期 14
·22221-22229
·
IF 3.83
S. Huang,R. Jiang,J.Y. Wei,J. Yang,J.Y. Ge,D.X. Yang,D.X. Huo
The (La 0.3 Pr 0.7 ) 1- x Ca x CrO 3 ( x = 0, 0.1, 0.3 and 0.5) ceramics have been synthesized by a sol-gel method. The compounds crystalize in orthorhombic structure with space group Pnma at room temperature . The magnetic measurements confirm that the materials form canted antiferromagnetic (AFM) ordering from 254.1, 231.2, 118.5, 49.3 K for the samples of x = 0, 0.1, 0.3 and 0.5, accompanied by a spin reorientation transition at 191.4, 145.1, 55.8, 38.9 K because of the Pr 3+ -Cr 3+ interaction. Meanwhile, a positive exchange bias effect is observed due to the antiparallel coupling between the Pr 3+ and the canted AFM structure of Cr 3+ . The Néel temperature , compensation temperature as well as the coupling strength of Pr 3+ -Cr 3+ monotonously decrease with the increase of Ca 2+ concentration. For the samples of x = 0.1 and 0.3, there exists a field induced Pr 3+ -Pr 3+ AFM ordering. By means of dielectric measurements, large permittivity at room temperature and dielectric relaxation are observed in all the samples. The permittivity is decreased and dielectric relaxation moves to low temperature range with the increase of Ca 2+ concentration. A relaxor-like ferroelectric transition is observed in the measuring temperature range in Ca 2+ doped samples.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2017
·Vol. 24
·期 5
·1080-1087
·
IF 5.317
Chengli Wang,Yingchun Su,Xiaole Zhao,Shanshan Tong,Xiaojun Han
A novel MoS 2 -based flower-like nanohybrid for hydrogen evolution was fabricated through coating the Cu-containing metal-organic framework (HKUST-1) onto MoS 2 nanosheets. It is the first time that MoS 2 @HKUST-1 nanohybrids have been reported for the enhanced electrochemical performance of HER. The morphologies and components of the MoS 2 @HKUST-1 flower-like nanohybrids were characterized by scanning electron microscopy, X-ray diffraction analysis and Fourier transform infrared spectroscopy. Compared with pure MoS 2 , the MoS 2 @HKUST-1 hybrids exhibit enhanced performance on hydrogen evolution reaction with an onset potential of −99 mV, a smaller Tafel slope of 69 mV dec −1 , and a Faradaic efficiency of nearly 100 %. The MoS 2 @HKUST-1 flower-like nanohybrids exhibit excellent stability in acidic media. This design opens new possibilities to effectively synthesize non-noble metal catalysts with high performance for the hydrogen evolution reaction (HER). Graphical Surprise HER with flowers : A novel MoS 2 -based flower-like nanohybrid for hydrogen evolution was fabricated through coating the Cu-containing metal-organic framework (HKUST-1) onto MoS 2 nanosheets (see figure). This design opens new possibilities to effectively synthesize non-noble metal catalysts with high performance for the hydrogen evolution reaction (HER).
研究领域:
材料科学
·
电化学
·
纳米技术
·
能量转换
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Catalysts
·
2018
·Vol. 8
·期 4
·146
·
IF 3.465
Xiong Wang,Xiaoyu Han,Feng Ren,Renwei Xu,Yongxiao Bai
Porous organic polymers (POPs) have received much attention in adsorption, separation, and catalysis. In this paper, porous organic polymers with different pore structure were used as metallocene catalyst supports, and ethylene/1-hexene copolymerizations were conducted using the POPs-supported metallocene catalyst. The pore structure of the prepared POPs and the supported metallocene catalyst were characterized by nitrogen sorption porosimetry and non-local density functional theory simulation, and the molecular chain structure of the produced ethylene/1-hexene copolymers were investigated through gel permeation chromatography (GPC), IR analysis, differential scanning calorimetry (DSC), and temperature rising elution fractionation (TREF). The results show that the loading amount of active sites varied with different pore structures of the POP supports, and the active species scattered in different pore sizes had a moderate impact on the molecular chain growth and the molecular weight distribution. The IR, DSC, and TREF analysis revealedthat different branching degree, double bond content, and chemical composition distributions were detected from the molecular chain structure of the ethylene/α-olefin copolymers from different POPs and silica-supported metallocene catalysts, despite their similar IR, DSC, and TREF curves due to the same active species. Scanning electron microscopy (SEM) showed that porous ethylene/α-olefin copolymers with varied surface morphology were obtained from the POPs-supported metallocene catalysts with different pore structure.
研究领域:
高分子化学
·
催化化学
·
材料科学
·
有机-无机杂化材料
·
聚烯烃合成
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Translational Psychiatry
·
2026
·
IF 7.5
Ye Tao,Lv Xinhuang,Fang Zheyu,Li Qiyao,Chen Feichi,Dong Yiyao,Xiang Kun,Yang Yao,Dai Conghui,Do Quang Le,Sun Jing,Su Kuan-Pin,Liu Jiaming
Recent evidence suggests that microglial activation, driven by a metabolic shift towards glycolysis, was involved in the pathogenesis of Alzheimer’s disease (AD). Although sphingolipid (SL) dysregulation has been linked to AD, the role of 1-deoxysphinganine (deoxySO), an atypical and neurotoxic SL, on microglial glycolytic reprogramming remains unclear. We measured serum deoxySO levels in AD patients and evaluated their association with cognitive performance. In APP/PS1 mice, we examined cerebral deoxySO level and the effects of deoxySO supplementation on cognitive function, neuropathology, and microglial activation. In vitro, BV2 microglia were used to assess inflammatory and metabolic changes via qPCR, western blot, ELISA, and RNA-seq analyses. The serum deoxySO levels were significantly elevated in AD patients, which was positively correlated with cognitive impairment. APP/PS1 mice exhibited increased cerebral deoxySO level, and supplementation with deoxySO could exacerbate cognitive deficits and Aβ plaque accumulation. Moreover, deoxySO supplementation increased microglial activation and enhanced inflammation in vivo and in vitro AD models. qPCR analysis identified disease-associated microglia (DAM) as a key deoxySO-responsive subpopulation, while RNA-seq revealed significant enrichment of genes related to glycolytic metabolism and inflammatory responses. Subsequently, qPCR confirmed that deoxySO promoted glycolytic metabolic reprogramming, which promoted DAM activation, thereby aggravating AD pathology. These findings identify deoxySO as a critical metabolic driver that links to microglial glycolytic activation and neuroinflammation, suggesting that targeting deoxySO-mediated metabolic pathways may offer a novel therapeutic strategy for AD.
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