Food Production Processing and Nutrition
·
2025
·Vol. 7
·期 1
·1-14
·
IF 5.7
Sun Teng,Wang Zhaojun,Dai Yiqiang,Zhai Kang,Fang Xiangna,Chen Yitian,Zhao Baomin,Dong Mingsheng
In this study, Rhizopus oligosporus RT-3 was utilized to ferment soybean meal to obtain a tempe-like food with low fat and high bioactivity. To investigate the impact of fermentation on soybean meal’s nutritional value, we detected the protein-related indices and conducted a non-targeted metabonomic analysis on both fermented soybean meal (FSM) and soybean meal (SM) in order to explore changes in a certain type of metabolite and its corresponding metabolic pathways. The results showed a significant increase in crude protein, peptides and amino acids while getting porous after fermentation. A reduction of raffinose and stachyose to 18.1% and 8.5%, respectively, due to the action of α-galactosidase and β-furanofructosidase occurred. As to amino acid metabolites, essential amino acids for human bodily functions such as lysine, histidine, and threonine were significantly upregulated. Furthermore, nine peptide metabolites were identified as angiotensin-converting enzyme (ACE) inhibitors and dipeptidyl peptidase-4 inhibitors (DPP-IV). After feeding with different doses of FSM, levels of insulin-like growth factor-1 (IGF-1), hemoglobin (HB), albumin (ALB), and total protein (TP) of malnourished mice all returned to normal. In conclusion, fermentation with Rhizopus oligosporus RT-3 can improve the quality of SM by reducing the level of oligosaccharide anti-nutrition factors and increasing the contents of free amino acid and small bioactive peptides, which provide a theoretical basis and new ideas for the application of FSM. Graphical
研究领域:
食品科学
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代谢组学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2025
·
IF 1.6
Jiadi Zhou,Weilong Zhang,Shangkun Bai,Yinghui Shao,Yuanyuan Tang,Mengqian Jing,Zhiqun Yu
3-Amino-1-adamantanol (3AA) is an important intermediate of vildagliptin. In this work, a fully continuous flow synthesis of 3-amino-1-adamantanol has been proposed. Selecting amantadine sulfate (AS) as the starting material, the effects of process parameters were systematically investigated, such as the molar ratio of reactants, the amount of sulfuric acid and reaction temperature. The kinetics of nitration reaction were carried out in both batch and continuous flow processes to explain the relationship between the amount of sulfuric acid and the reaction rate constant. Based on the apparent reaction rate constants and thermodynamic parameters, a fully continuous flow synthesis of 3AA combining nitration, hydrolysis and neutralization reaction has been realized. Compared with the batch method, the reaction time was shortened from 8 h to 36 min, the side reactions were significantly inhibited, and the yield increased from 87.8 % to 95.2 % by continuous flow strategy.
研究领域:
有机化学
·
制药工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Zhaohong Su,Daili Tang,Junjie Liu,Xiaolan Yang,Siyu Xu,Wenjing Xu,Yuqing Zhou,Mingyang Xu,Jianlong Yi,Hongmei Jiang,Yuanhua Shao,Xiaoli Qin
A simple and rapid electrochemical synthesis strategy for in-situ fabrication of toluidine blue (TB)-functionalized metal organic framework (TB@MOFs) thin films via one-step reduction approach was reported. The TB@MOFs thin layer has been synthesized on the working electrode surface in different times at room temperature , and its morphology and thickness was characterized by varied instruments, including scanning electron microscope, transmission electron microscope, and scanning ion conductance microscope. The prepared TB@MOFs shows exceptional electrochemical activity and stability under mild conditions, and its electrochemical response is dependent on the amount of TB molecules which are encapsulated in the MOFs. Based on the TB@MOFs sensing platform, a sensitive label-free electrochemical immunosensor for the detection of Indole-3-acetic acid (IAA, a plant hormone) was developed with a wide linear range (2.5 pg mL −1 - 5 ng mL −1 ) and a low detection limit (1.4 pg mL −1 ). Moreover, this immune sensor shows good sensitivity and selectivity in real samples for IAA detection.
研究领域:
分析化学
·
植物学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·
IF 10.7
Jiarong Li,Shude Liu,Yuanzhao Xie,Fengluan Jiang,Xinyu Huang,Jianfeng Xia,Limin Wu,Yonghui Deng
Core–shell magnetic polymer microspheres with porous organic shells are highly desired for adsorption, separation, delivery/immobilization of guest objects in catalysis, and drug release. Herein, an amphiphilic block copolymer-directed interfacial assembly and polymerization strategy was reported to synthesize magnetic mesoporous 3-aminophenol–formaldehyde resin (MMAPF) microspheres. The uniform MMAPF microspheres exhibit well-defined core–shell structures, controllable porous shell thickness, high magnetization, and superparamagnetic properties. The abundant hydroxyl and amino groups in the porous shell offer the exceptional capability for stable immobilization of ultrafine Au nanoparticles, which can serve as a magnetically recoverable heterogeneous catalyst for catalyzing the hydrogenation of 4-nitrophenol with a fast reaction rate constant (0.59 min−1) and conversion rate (99%) at room temperature and good recycling stability.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 31
·10918-10926
·
IF 4
Yu Zhang,Xia Liu,Qian-Yan Liu,Jian-Hua Wang,Ting Hu,Yan-Mei Lin,Jian-Han Zhang
Two novel alkaline-earth zincophosphites, namely CaZn(HPO3)2 and Ba2Zn(HPO3)3, were successfully synthesized under hydrothermal conditions. CaZn(HPO3)2 exhibits a three-dimensional (3D) anionic framework with a 6-connected uni-nodal pcu α-Po primitive cubic topology, constructed by unique Zn2O8 dimers and HPO3 pseudo-tetrahedra, while Ba2Zn(HPO3)3 displays one-dimensional (1D) [Zn(HPO3)3]4− anionic chains. It is worth mentioning that CaZn(HPO3)2 represents the first example of an alkaline-earth zincophosphite compound with a 3D framework structure. Our research also revealed the importance of both alkaline earth cation sizes and Zn/P ratios in anionic open-framework formation. The crystal structures of both compounds were further verified by energy dispersive spectroscopy, IR spectroscopy and Raman spectroscopy. Optical diffuse reflectance spectra, coupled with Tauc's fitting, revealed direct bandgaps with energy values of 4.33 and 4.48 eV for CaZn(HPO3)2 and Ba2Zn(HPO3)3, respectively, which differ from the prediction of theoretical calculations. Density of states calculations were conducted to reveal the origin of the bandgaps and bond interactions. Both compounds exhibited moderate birefringence values. This work may have implications for the design and synthesis of novel metal phosphites with desired properties.
研究领域:
无机化学
·
材料科学
·
固体化学
✓ 已验证
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2024
·
IF 4.1
Yonghua Wang,Yujia Shang,Xiaodan Liu,Xi Chen,Guanhua Xu,Guanghua Lu
Benzophenone-3 (BP-3) is a commonly used ultraviolet absorber that has the potential to accumulate in organisms, leading to toxicity. Benzophenone-8 (BP-8) is one of the major metabolites of BP-3. In this study, zebrafish were exposed to different concentrations of BP-3 and BP-8 (1 μg/L, 30 μg/L, and 300 μg/L) to investigate their accumulation and toxic effects in various tissues, including zebrafish brain, gut, and liver. The analysis focused on neurotoxicity, oxidative damage, inflammation, and gene expressions. The results showed that both BP-3 and BP-8 accumulated in the tissues, with the highest concentration observed in the gut, followed by the liver and brain. BP-8 exhibited a stronger ability to accumulate. In the brain, exposure to 1 μg/L of BP-3 and BP-8 promoted cortisol production, while higher exposures (30 μg/L and 300 μg/L) inhibited acetylcholinesterase activity and suppressed cortisol production. In the gut, both BP-3 and BP-8 exposures disrupted oxidative stress, inflammatory immunity, and apoptosis functions. In the liver, BP-3 and BP-8 affected hepatic metabolism, oxidative stress, apoptosis, and inflammatory immunity. Comparing gene expression in the brain, gut, and liver, it was found that BP-3 and BP-8 had a lower effect on gene expression in the brain, while the effect on the gut and liver was significantly higher. BP-8 generally had a higher effect than BP-3, which aligns with the observed accumulation pattern. These findings provide valuable insights for the risk assessment of BP-3 and BP-8 in the aquatic environment.
研究领域:
环境毒理学
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水生毒理学
·
分子生物学
·
生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
·
2025
·
IF 2.5
Xiaoli Liu,Shan Wang,Chuangfu Kuang,Yuwen Deng,Shuaicai Yuan,Juying Zou
We aim to explore the key metabolic components and underlying mechanisms of the Bushen Huoxue Formula (BH) in treating Osteoarthritis (OA). The mouse knee OA model was constructed using the destabilization of the medial meniscus method. OA mice were orally administered the BH. Mouse cartilage damage was assessed. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS), network pharmacology analysis and molecular docking were employed to analyze the serum metabolite components and target protein of BH. After lipopolysaccharide (LPS) treatment, different concentrations of β-Estradiol 3-acetate were added to primary chondrocytes. Flow cytometry was utilized for detecting cell apoptosis. The Ubiquitin-Specific Protease 13 (USP13)/Toll-like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response Protein 88 (MYD88)/NF-κB pathway and the TLR4 ubiquitination levels were assessed using immunological quantification and biochemical methods. Relative to normal mice, OA mice exhibited decreased knee joint cartilage thickness and increased inflammatory damage. BH treatment reversed these effects. Furthermore, BH enhanced TLR4 ubiquitination. Estradiol acetate was identified as the metabolic component of BH that alleviates OA. Estradiol acetate and its subtype molecule β-Estradiol 3-acetate could bind to the USP13 protein. The β-Estradiol 3-acetate concentration-dependently decreased the elevated levels of USP13, TLR4, MYD88, p-p65/p65 in chondrocytes induced by LPS, while increasing the TLR4 ubiquitination. β-Estradiol 3-acetate reversed LPS-induced chondrocyte apoptosis and elevation of inflammatory factors. Moreover, USP13 overexpression abolished the protective effects of BH and β-Estradiol 3-acetate against LPS-induced chondrocytes. In Conclusion, the BH metabolite β-Estradiol 3-acetate promotes TLR4 ubiquitination to relieve inflammation and apoptosis in OA chondrocytes by inhibiting USP13.
研究领域:
药理学
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中医中药
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分子生物学
·
风湿病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Qian Yu,Xian Qiu,Jing Zhong,Chao Cao,Yuechan Liao,Zhiwei Zeng,Dawei Zhang,Chunyan Yan
Acorus tatarinowii , a famous traditional Chinese medicine, is used for the clinical treatment of memory impairment and dementia. In this research, AT50, the crude polysaccharide extracted from A. tatarinowii rhizome, significantly improved the memory and learning ability of mice with Alzheimer's disease (AD) and exerted excellent anti-neuroinflammatory effects. More importantly, AT50 returned the levels of NO, TNF- α , IL-1 β , PGE-2, and IL-6 in AD mouse brains to normal levels. To identify the active ingredients in AT50, a heteropolysaccharide ATP50–3 was obtained from AT50. Structural analysis indicated ATP50–3 consisted of α -L-Ara f -(1→, →2)- α -L-Ara f -(1→, →3)- α -L-Ara f -(1→, →5)- α -L-Ara f -(1→, α -D-Xyl p -(1→, →3,4)- β -D-Xyl p -(1→, →3)- α -D-Gal p -(1→, →3,6)- α -D-Gal p -(1→, →6)-4-OAc- α -D-Gal p -(1→, →3,4,6)- α -D-Gal p -(1→, →4)- α -D-Glc p -(1→, →2,3,6)- β -D-Glc p -(1→, →4,6)- α -D-Man p -(1→, →3,4)- α -L-Rha p -(1→, →4)- α -D-Gal p A-(1→, and →4)- α -D-Glc p A-(1 → residues and terminated with Xyl and Ara. Additionally, ATP50–3 significantly inhibited the release of proinflammatory factors in lipopolysaccharide-stimulated BV2 cells. ATP50–3 may be an active constituent of AT50, responsible for its anti-neuroinflammatory effects, with great potential to treat AD.
研究领域:
药理学
·
神经科学
·
传统中药
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Yuansong Luo,Han Gao,Xiujian Zhao
The NASICON-type Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) is considered to be one of the most promising solid electrolytes because of its excellent chemical stability against moisture and considerable total ionic conductivity . Nevertheless, the poor sinterability and low grain boundary ionic conductivity of LATP limit its practical commercial applications. Herein, Li 2 CO 3 ·Bi 2 O 3 (abbreviated as LB), as a sintering aid, was introduced into LATP to improve its sinterability and ionic conductivity. It was demonstrated that the addition of LB promoted the liquid phase sintering of LATP by forming the secondary phases with a low melting point, thereby promoting the growth of grains and making the contact between the grains closer. With the help of LB, the sintering temperature of LATP was reduced to about 900 °C. A series of comparative investigations indicated that the LATP-2LB ceramic pellets sintered at 900 °C exhibited the highest total ionic conductivity of 0.673 mS/cm. Meanwhile, the relative density and grain boundary ionic conductivity of LATP-2LB ceramic pellets sintered at 900 °C reached 95.28% and 3.835 mS/cm, respectively, which is much higher than 77.16% and 0.264 mS/cm of LATP-0LB ceramic pellets sintered at the same temperature. Obviously, LB can effectively improve the sinterability of LATP while increasing its ionic conductivity, providing a new strategy for preparing LATP ceramics with excellent properties.
研究领域:
材料科学
·
电化学
·
固体化学
✓ 已验证
DOI
高影响因子
POLYMER COMPOSITES
·
2013
·Vol. 34
·期 11
·1801-1808
·
IF 1.482
Jie Zhao,Yu Xie,Zhanggao Le,Yan Luo,Yunhua Gao,Rong Zhong,Yuancheng Qin,Jianfei Pan,Yan Huang
The BaFe 12 O 19 /multiwall carbon nanotubes/poly(3-methyl-thiophene) (BaFe 12 O 19 /MCNTs/P(3MT)) composites were synthesized through an in situ chemical polymerization of 3-methyl-thiophene (3MT) in the presence of BaFe 12 O 19 /MCNTs composite powders. The BaFe 12 O 19 /MCNTs/P(3MT) composites were characterized by the fourier transform infrared spectrometry (FTIR) and X-ray diffraction (XRD). The morphologies of the composites were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The electric conductive properties were tested by a four-probe conductivity tester and the magnetic properties were measured by vibrating sample magnetometer (VSM). The electromagnetic performance tests showed that when the mass ratio of BaFe 12 O 19 to MCNTs was 0.4, and the BaFe 12 O 19 /MCNTs to P(3MT) was 0.15, the conductivity, saturation magnetization ( M s ) and residual magnetization ( M r ) of the BaFe 12 O 19 /MCNTs/P(3MT) composites achieved 166.740 S/m, 29.884 emu/g, and 17.581 emu/g, respectively. POLYM. COMPOS., 34:1801–1808, 2013. © 2013 Society of Plastics Engineers
研究领域:
材料科学
·
电磁材料
·
聚合物复合材料
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Mengli Wang,Xinjing Li,Foxin Zhang,Heping Cui,Khizar Hayat,Xiaoming Zhang,Chi-Tang Ho
Extra-added l- cysteine effectively inhibited the browning of Maillard peptides (MPs) derived from Lentinus edodes . Meanwhile, an unsaturated fatty acid (UFA) was introduced to increase the content of 1-octen-3-ol (mushroom alcohol) to enhance the mushroom aroma of the MPs. Among the three UFAs tested, linoleic acid (LA) exhibited the strongest promoting effect on 1-octen-3-ol, resulting in a 1-octen-3-ol content of 74.57 ± 1.48 μg/L in MPs. When LA was co-heated with l- cysteine and/or xylose, a synergistic effect was observed between LA and l- cysteine, leading to the highest 1-octen-3-ol content of 211.29 ± 3.62 μg/L in LA- l- cysteine-xylose system. The enzymatic hydrolysate of commercial safflower seed oil was further used as an alternative source of LA to fortify the typical mushroom flavor. The incorporation of 25 % safflower seed oil hydrolysate was recommended to enhance the 1-octen-3-ol production (133.09 ± 8.74 μg/L) in MPs. These findings provide new ideas for enhancing the mushroom aroma, offering potential applications in flavor design and food processing.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Danyang Liu,Yiming Song,Bing Zheng,Jianhua Xie,Yi Chen,Jiayan Xie,Xinyi Chen,Qiang Yu
This study aimed to investigate the mitigation effect of epigallocatechin gallate (EGCG) on aging induced by 3-monochloropropane-1,2-diol (3-MCPD) in Caenorhabditis elegans, evaluate health indicators during the process, and reveal the underlying mechanism through transcriptomics and identification of mutants. The results showed that EGCG alleviated the declined fertility, shortened lifespan, reduced body size, weakened movement, increased reactive oxygen species and lipofuscin, and damaged antioxidative stress response and excessive heat shock proteins caused by 3-MCPD. Transcriptomics study indicated that treatment with 3-MCPD and EGCG altered gene expression, and gene mutants confirmed the involvement of insulin/IGF-1 signaling pathway in mediating the process that EGCG alleviated the aging toxicity induced by 3-MCPD. The study showed that EGCG alleviated the aging toxicity induced by 3-MCPD.
研究领域:
分子生物学
·
毒理学
·
遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）