CHEMBIOCHEM
·
2024
·
IF 2.6
Xiang Zhu,Weizhe Luo,Donghui Zhang,Runhui Liu
With the increasing use of polyethylene glycol (PEG) based proteins and drug delivery systems, anti-PEG antibodies have commonly been detected among the population, causing the accelerated blood clearance and hypersensitivity reactions, poses potential risks to the clinical efficacy and safety of PEGylated drugs. Therefore, vigilant monitoring of anti-PEG antibodies is crucial for both research and clinical guidance regarding PEGylated drugs. The enzyme-linked immunosorbent assay (ELISA) is a common method for detecting anti-PEG antibodies. However, diverse coating methods, blocking solutions and washing solutions have been employed across different studies, and unsuitable use of Tween 20 as the surfactant even caused biased results. In this study, we established the optimal substrate coating conditions, and investigated the influence of various surfactants and blocking solutions on the detection accuracy. The findings revealed that incorporating 1% bovine serum albumin into the serum dilution in the absence of surfactants will result the credible outcomes of anti-PEG antibody detection.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Ni Cheng,Qi Kang,Jianhong Xiao,Na Du,Li Yu
Studies on supramolecular gel aggregates via supramolecular interactions are very fascinating and impressive. The interactions of gelator with solvent and inorganic salt can functionalize, activate, or control the properties of supramolecular gels. A lot of work on this area has been done, but all these contributions are only at an early stage. In this work, we tuned the gel formation conditions and properties by using low-molecular-weight gelator (LMWGs), amide-functionalized imidazolium-based surfactant , viz., N-cetyl-N′-acetamido imidazolium bromide ([N-C 16 , N′-CONH 2 -Im]Br), in different solvents and with inorganic salt additives. Under chemical (Cu 2+ /H 2 O 2 ) and physical (temperature) stimuli, gel-sol phase transition occurred in the gel formed from 2 wt% [N-C 16 , N′-CONH 2 -Im]Br in the solvent formamide (FM). Accompanied with increased mechanical strength of the gels, morphology alternation from initial straight stripe-shaped structures to curly belt-like textures was observed in the addition of CuBr 2 . From Small-angle X-ray scattering (SAXS) measurements, bilayer units with interdigitated hydrocarbon tails of the gelator were testified to appear in the gels. Comparative experiments demonstrate that the π-π interaction, H-bonding, and hydrophobic interaction between the gelator molecules are the main driving forces for the gelation . The low-cost gelator, facile preparation, and coordination-driven assembly process make the robust gel a good candidate in various applications, such as material templates and drug deliveries.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Rui Zhou,Huasheng Tian,Hongyang Zhao,Li Ke,Haoyu Wu,Yaqing Liu,Jingcheng Hao
The increasing significance of data security promotes the development of multilevel information encryption and decryption techniques. However, the realization of logical outputs modulated by multiple stimuli is challenging in the design of advanced functional materials. Herein, a multilevel information decryption system with a combination of visual and digital outputs that responds to dual-optical inputs is developed based on a hydrogel-based synaptic device. ammonium molybdate nanoparticles and calcium alginate supramolecular networks is incorporated into a polyacrylamide hydrogel to enable optically regulated color change and ionic conductivity. Under UV irradiation, the reduction of the nanoparticles allows the hydrogel to change color as visual outputs. Meanwhile, the ionic conductivity of the hydrogel can be modulated by near-infrared (NIR) optical pulses to emulate the synaptic plasticity of biological synapses, producing NIR-mediated digital outputs. As a demonstration, a multilevel decryption strategy is provided using a hydrogel array that combines digital information decoding with visual information camouflage. Moreover, the short-term plasticity of the hydrogel synapse endows the system with time-dependent decryption, which improves information security and reduces the risk of data leakage. This study contributes to advancing multilevel decryption systems by providing an effective technique for integrating digital and visual decryption in hydrogel materials.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 10
·100541
·
IF 3.721
Zhaohui Han,Yang Xu,Shenggang Zhou,Lei Xu,Peixian Zhu
In this study, an Al-0.08Sn-0.08Ga-0.5Mg alloy was annealed at 200 °C–400 °C for 10 h. The microstructure and corrosion morphology of the Al anode were observed by scanning electron microscopy (SEM), and the effects of different annealing temperatures on the electrochemical properties of the Al anodes were studied by the hydrogen evolution rate, open circuit potential, Tafel curves, EIS and constant current discharge. The results show that the annealing treatment had a certain effect on the number and size of precipitates on the alloy surface, which improved the electrochemical activity and corrosion resistance of the Al alloy. Additionally, the Al–Sn–Ga–Mg alloy anode material has an excellent discharge performance in the actual use process when the annealing temperature is 350 °C, the related performance parameters were greatly improved compared with other annealing temperature conditions. The capacity density is 2670.99 mAh·g−1, and the energy density is 3379.15 mWh·g−1.
研究领域:
材料科学
·
电化学
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2018
·
IF 3.927
Guoqiang Cui,Xuebing Yang,Tingting Liu,Zaizhi Liu,Lei Yang
An efficient approach for enzyme-enhanced extraction using an ionic liquid solution (ILEEE) of the major alkaloidal components camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) from the samara of Camptotheca acuminata is presented. The enzyme pretreatment in an aqueous ionic liquid (IL) media was used for the enhancement of extraction yield. The activity of hemicellulase was investigated in various ILs with imidazolium-based cations ([C 2 MIM] + , [C 4 MIM] + , [C 6 MIM] + , [C 8 MIM] + , [C 10 MIM] + ) and anions (Br − , Cl − , Ac − , HSO 4 − , NO 3 − ). The optimal ionic liquid for the hemicellulase extraction process was found to be a 0.75 M [C 8 MIM]Br aqueous solution. Single factor experiments and Box–Behnken design found the optimal operational parameters for ILEEE to be an incubation temperature of 40 °C, incubation time of 12 h, extraction phase of pH 4, liquid-solid ratio of 30 mL/g, 0.75 M [C 8 MIM]Br and a hemicellulase concentration of 0.441 mg/mL. Under these optimized extraction conditions, the total yield of CPT and HCPT was 1043 ± 51.2 μg/g. SEM images of the samples revealed that hemicellulases hydrolyze the cell wall, leading to structure breakdown, which enabled [C 8 MIM]Br to have a high dissolving power for the targeted components. These factors are the main causes for the increasing in the total yield of the CPT and HCPT when using the ILEEE extraction method.
研究领域:
药学
·
化学工程
·
生物技术
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xiaohan Liu,Qi Wang,Minzhi Chen,Juya Zhu,Guohang Zhang,Xiaoyan Zhou
Modifications to wood adhesives to improve flame resistance are often accompanied by undesirable properties, such as reduced bonding strength, increased moisture absorption, color changes, and increased toxicity. Herein, a highly reactive hyperbranched flame retardant (HBFR) was synthesized via polymerization of biphenyl tetracarboxylic dianhydride (BPDA) and tris(2-hydroxyethyl)isocyanurate (THEIC). Consequently, HBFR was treated with urea-formaldehyde (UF) to form a covalently crosslinked HBFR–UF resin network. Compared with UF resin, the char residue of HBFR-UF increases from 8% to 25% at 800 °C, and the limiting oxygen index (LOI) improves to 28.8%. The peak heat release rate (HRR) of HBFR-plywood was 27.5% lower than that of plywood. Furthermore, the shear strength, flexural strength, and impact toughness of HBFR-plywood increase by 37.5%, 37.5%, and 36.1% respectively, compared to the plywood. This study elucidates the intrinsic reaction pathway between HBFR and resin molecules, revealing the synergistic mechanisms that enhance flame retardancy and mechanical strength. The findings provide a theoretical basis for advancing flame-retardant UF resins.
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Advanced Intelligent Systems
·
2021
·Vol. 3
·期 4
·2000090
·
IF 0
Shengnan Chen,Heng Zhang,Xiangfei Yang,Xiaoguang Shao,Taihao Li,Na Chen,Zhenyi Chen,Wei Xue,Jiahua Pan,Shupeng Liu
Early diagnosis of prostate cancer (PCa) is always a great challenge in clinical practice, especially in distinguishing benign prostatic hyperplasia (BPH) from early cancer, due to the high similarity in pathology from the prostate-specific antigen (PSA) test and radiological detection. The conventional diagnostic methods are often less efficient in specificity and accuracy, leading to quite a few unnecessary biopsies. This work establishes a noninvasive diagnostic method for PCa by investigating urine samples using Raman spectroscopy and convolutional neural network (CNN) algorithm. The results of urine Raman spectra show the intensities of characteristic peaks for lipids, nucleic acids, and some amino acids are distinguishable between PCa and BPH, suggesting an abnormal metabolism caused by PCa, which can be detected by Raman spectroscopy. These data are then used to train an intelligent diagnostic model with CNN algorithm. The cross-validation results show the mean diagnostic accuracy, sensitivity, and specificity for PCa are 74.95%, 77.32%, and 72.46%, respectively. This noninvasive diagnostic method is a promising method for the early diagnosis of PCa, and the idea of using urine Raman spectroscopy with deep learning techniques for diagnosing PCa provides a reference for the application of artificial intelligence in the field of clinical medicine research.
研究领域:
肿瘤学
·
泌尿科学
·
分子诊断学
·
转化医学
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生物光子学
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临床化学
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人工智能医学
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuexi Zheng,Pengfei Shang,Feng Pei,Guang Ma,Zhiguo Ye,Xinyuan Peng,Duosheng Li
Electrochemical water splitting powered by green electricity generated from intermittent geothermal, wind and solar power is a promising approach to realize large-scale hydrogen production owing to its sustainable and clean characteristics. Developing electrocatalysts with high electrocatalytic activity and long-term stability for the hydrogen evolution reaction (HER) at an ultrahigh current density (>1000 mA cm −2 ) still needs a breakthrough. Here, a bicontinuous nanoporous PtNiMg alloy with an ultralow noble metal content for the HER is fabricated by a facile high-temperature sintering method based on the nanoscale Kirkendall effect. A bicontinuous nanoporous alloy electrode with an ultralow content of approximately 1 at % Pt for the HER in an alkaline medium achieves an extremely low overpotential of 22 mV at a current density of 10 mA cm −2 and a Tafel slope (30.9 mV dec -1 ) of the Volmer-Tafel mechanism. The alloy electrode for the HER at a wide current density of 1–2000 mA cm −2 displays superior stability in alkaline media. The 3D bicontinuous nanoporous structure, perfect synergistic effect of Ni and Pt species, high structural stability and excellent conductivity of the 1-PtNiMg-900 alloy achieve outstanding electrocatalytic activity and long-term stability at an ultrawide range of HER current densities. This study greatly improves the electrochemical performance of Pt-based electrocatalysts for the HER via a novel fabrication approach and provides the possibility of large-scale industrial application for H 2 production.
研究领域:
材料科学
·
电化学
·
纳米科技
·
能源化学
·
催化化学
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INORGANIC CHEMISTRY
·
2022
·
IF 5.436
Cuilan Tang,Jinglin Huang,Yansong Liu,Xiaoshan He,Guo Chen,Zhibing He
The design of electrocatalysts with high activity and the understanding of the reaction mechanism for the ethanol oxidation reaction (EOR) are pivotal for commercializing direct ethanol fuel cells (DEFCs). Herein, island-like nanoporous gold/palladium (INPG/Pd) is designed as a highly efficient EOR electrocatalyst. For a better understanding of the reaction mechanism, in situ surface-enhanced Raman spectroscopy (SERS) in conjunction with H–D isotope replacement is used to investigate the dissociation and oxidation of CH3CH2OH on the INPG/Pd electrode, with a focus on identifying significant intermediate species in the reaction process. The results show that INPG/Pd has a higher electrocatalytic performance than INPG and indium–tin oxide (ITO) glass/palladium (Pd) due to the synergistic effect of NPG and Pd. INPG/Pd-10 shows the highest specific activity, the strongest charge-transfer ability, and relatively good stability. INPG/Pd presents better SERS sensitivity than ITO glass/Pd because of the plasma enhancement effect of nanoporous Au. The in situ Raman spectral results suggest that the oxidation of ethanol proceeds via a dual-pathway (C1 and C2) reaction mechanism. Dehydrogenation of ethanol can form acetaldehyde (CH3CHO) at −0.4 V. Meanwhile, the adsorbed acetaldehyde is oxidized to acetate from approximately −0.4 V, with the potential moving positively, which is the so-called C2 pathway. Alternatively, in the C1 pathway, CH3CHO and CH3CH2OH decomposed to intermediate species (adsorbed CO) on the INPG/Pd electrode due to C–C bond breaking at potentials of approximately −0.2 V. Subsequently, the CO species is oxidized to CO2 at more positive potentials.
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RSC Advances
·
2023
·Vol. 13
·期 38
·26528-26543
·
IF 3.9
Asma Zaka,Muhammad Waqas Iqbal,Amir Muhammad Afzal,Haseebul Hassan,Hira Rafique,Saikh Mohammad Wabaidur,Ahmed M. Tawfeek,Eshan Elahi
In this work, a novel bimetallic Fe–Mg/MOF was synthesized through a cost-effective and rapid hydrothermal process. The structure, morphology, and composition were examined using X-ray diffraction (XRD), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy. Further, the Brunauer–Emmett–Teller (BET) measurement showed a 324 m2 g−1 surface area for Fe–Mg/MOF. The Fe–Mg/MOF achieved 1825 C g−1 capacity at 1.2 A g−1 current density, which is higher than simple Fe-MOF (1144 C g−1) and Mg-MOF (1401 C g−1). To assess the long-term stability of the asymmetric device, the bimetallic MOF supercapattery underwent 1000 charge/discharge cycles and retained 85% of its initial capacity. The energy and power densities were calculated to be 57 W h kg−1 and 2393 W kg−1, respectively. Additionally, Fe–Mg/MOF showed superior electrocatalytic performance in hydrogen evolution reaction (HER) by demonstrating a smaller Tafel slope of 51.43 mV dec−1. Our research lays the foundation for enhancing the efficiency of energy storage technologies, paving the way for more sustainable and robust energy solutions.
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ENERGY & FUELS
·
2021
·
IF 3.605
Ruiqin Gao,Mengfei Yu,Hui Xu,Lichun Li,Meng Deng,Yuxue Wu,Zhengfei Chen
Two-dimensional Ti2(PO4)2F nanosheets were synthesized with an ionic liquid (IL) containing PF6 ([Bmim]PF6) via a hydrothermal method. In comparison, only anatase titanium dioxide (TiO2) nanoparticles were obtained when changing the type of anion ([Bmim]Br or [Bmim]BF4) under the same conditions, suggesting that the anion type could greatly affect the crystalline phase, particle size, specific surface, and morphology of the final products; two-dimensional nanosheets were obtained in [Bmim]PF6, whereas nanocrystals with a relatively large surface were formed in the latter two ILs, as revealed by X-ray diffraction, nitrogen gas sorption, scanning electron microscopy, and transmission electron microscopy measurements. 1H and 19F nuclear magnetic resonance examinations of the fresh and recycled ILs suggest that the IL with the PF6 anion experienced complete hydrolysis, which could be the key factor for the formation of such unique Ti2(PO4)2F nanosheets. The electrochemical performances of such Ti2(PO4)2F nanosheets were evaluated as anode materials in lithium-ion batteries (LIBs) in comparison to TiO2 nanomaterials. The rate capability and cycling performance of the Ti2(PO4)2F electrode outperformed the other two electrodes studied, as illustrated by cyclic voltammetry curves, charge/discharge behavior, and long cycling test, which is mainly due its unique layered structure and low surface area, which resulted in low volume change. The Ti2(PO4)2F electrode derived from [Bmim]PF6 displays a steady reversible capacity of 170 mAh/g and high cycling stability with over 70% capacity retention after 100 cycles. The synthesis of the controllable crystalline phase and morphology of Ti2(PO4)2F nanomaterials with such ILs paves a useful route to prepare such alternative anode materials for LIBs.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Nuerbiya Yalikun,Xamxikamar Mamat,Yongtao Li,Xun Hu,Thomas Wågberg,Yemin Dong,Guangzhi Hu
In this study, we developed a sensitive electrochemical sensor for the detection of chloramphenicol (CAP). An iron-nitrogen co-doped ordered mesoporous carbon-silicon nanocomposite (Si-Fe/NOMC) was prepared as follows. First, an SBA-15 surface was treated with an iron and nitrogen co-doped carbon framework obtained from the polymerization of ethylenediamine and carbon tetrachloride via the hard templating method. The mixture was then carbonized at a high temperature (900℃). Finally, the Si-Fe/NOMC modified electrode was fabricated, and employed as a high-performance electrochemical sensor to trace the CAP in drug samples using the large surface area of the hetero-atoms iron, nitrogen and silicon co-doped in the porous structure. Cyclic voltammetry and differential pulse voltammetry tests were determine to assess the efficiency of the sensor. Under optimized conditions, the sensor exhibited rapid current response for CAP in a phosphate buffer solution PBS with pH 7.5. The linear concentration of CAP ranged from 1 μM to 500 μM, with a limit of detection of 0.03 μM (S/N = 3). Furthermore, the electrochemical sensor was used to detect CAP in eye drop samples with satisfactory results.
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