Processes
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2026
·Vol. 14
·期 12
·1998
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IF 3.4
Zhuangzhuang Zhang,Lingling Ma,Yang Shao,Diandou Xu,Min Luo
To tackle the environmental challenges associated with industrial oily wastewater discharges and recurrent marine oil spill incidents, developing high-efficiency oil–water separation technologies represents a pressing environmental challenge. This research presents a novel design approach comprising the deposition of a stable SiO2anchoring layer followed by the fabrication of a PDA/CS crosslinked coating, thereby achieving successful construction of a superhydrophilic/underwater superoleophobic (SH/UWSO) coating on stainless steel meshes (SSM). In the first step, SiO2microspheres were deposited via vapor deposition to create a micro-rough surface architecture. Subsequently, a dopamine/chitosan (DA/CS) reaction solution was introduced to form a Polydopamine/chitosan (PDA/CS) coating, yielding a SiO2@PDA/CS-SSM separation membrane. The resulting membrane exhibited separation efficiencies surpassing 99% for various oil–water mixtures, achieving a flux of 1.24 × 105L·m−2·h−1in petroleum ether systems. Notably, the membrane maintained high efficiency and structural stability even after 25 separation cycles, immersion in strong acid and base solutions for 72 h, and 100 abrasion tests. The rational design of the anchoring and crosslinking layers endows SiO2@PDA/CS-SSM with high efficiency and stability, making it an effective oil–water separation material.
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高影响因子
JOURNAL OF LIPOSOME RESEARCH
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2026
·
IF 4.7
Li Zhang,Yize Lv,Xuedi Weng,Yan Gao,Jie Gao,Xia Cao,Michael Adu-Frimpong,Qilong Wang
Chitosan-polyethylene glycol (CS-PEG)-modified long-circulating liposomes were developed and loaded with tanshinone I (TaI@CS-PEG-L) to overcome its poor solubility and low bioavailability, as well as enhance the lipid-lowering efficacy of atorvastatin (At) and mitigate its tissues toxicity. After synthesis of CS-PEG copolymer, it was characterized with infrared and proton nuclear magnetic resonance. Thin-film hydration was used to prepare TaI@CS-PEG-L before optimization was performed using Box-Behnken design. Optimal liposomal formulation was obtained when mass ratio of lecithin:cholesterol:TaI mass ratio was 12:1:1 along with 0.2% CS-PEG, which displayed appropriate particle size (117.41 nm), polydispersity index (0.182), zeta potential (+17.31 mV), encapsulation efficiency (93.15%), and drug loading (5.19%). Besides, the liposomal preparation exhibited good long-term storage stability (over 30 days at 4 °C and 25 °C) and satisfactory gastrointestinal stability in simulated gastric (pH 1.2) and intestinal (pH 6.8) fluids for 4 h. TaI@CS-PEG-L displayed increased cellular uptake and in vitro release compared with free TaI and unmodified liposomes. Regarding pharmacokinetic studies, TaI@CS-PEG-L increased AUC0-ₜ, t1/2, and Cmax in rats by 7.26-fold, 2.43-fold, and 3.12-fold, respectively, which indicates significantly enhanced oral bioavailability. TaI@CS-PEG-L monotherapy markedly lowered serum lipid levels in hyperlipidemic mice, thereby improving liver function indices, and alleviating pathological liver injury. TaI@CS-PEG-L demonstrated synergistic lipid-lowering effects and efficiently reversed At-induced hepatic and pancreatic injuries after combination with At, thus outperforming free TaI and TaI@L. Therefore, CS-PEG-modified long-circulating liposomes could efficiently address delivery challenges of TaI, thereby yielding a formulation that could potently lower serum lipid levels and protect liver against injury. The findings of this study offer a promising ‘efficacy-enhancing and toxicity-reducing’ strategy for potential treatment of hyperlipidemia in the clinics.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2021
·
IF 3.498
Yanping Wang,Kexin Li,Dezhen Fang,Xiushen Ye,Haining Liu,Xiaoli Tan,Quan Li,Jun Li,Zhijian Wu
A new composite adsorbent (AMP@MOF-76(Sm)) grafted ammonium molybdophosphate onto MOF-76(Sm) was synthesized via a solvothermal method and well-characterized by SEM-EDS, particle size analysis , N 2 adsorption-desorption isotherms, TG, FT-IR, XRD and XPS analysis . The adsorption behaviors of Rb + and Cs + on synthesized AMP@MOF-76(Sm) were investigated depending on the parameters of solution pH, ionic strength, contact time, ion concentration and temperature. The adsorbent can adsorb Rb + and Cs + from the solution when the solution pH ranged from 4.0 to 10.0 and the coexisted ion (Na + ) has little effect on the adsorption amounts of both Rb + and Cs + . The adsorption kinetic data fitted well with pseudo-second order kinetic models . The adsorption equilibrium of Rb + and Cs + on AMP@MOF-76(Sm) is better explained by the Langmuir isotherm model and the maximum adsorption amounts for Rb + and Cs + are 0.490 mmol g −1 and 0.434 mmol g −1 , respectively. Furthermore, the AMP@MOF-76(Sm) could be easily reused at least four times using 3.0 mmol L −1 ammonia nitrate as the eluent . The mechanism of the adsorption of Rb + and Cs + is proposed to be a combination of electrostatic attraction and ion exchange mechanism.
研究领域:
环境科学
·
材料科学
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DRUG DELIVERY
·
2023
·
IF 6
Xiaoyan Xu,Tianhao Zhou,Xudong Wei,Xuelian Jiang,Jiyan Cao
Although surgery-based comprehensive therapy is becoming the main approach to treat laryngeal cancer, recurrence, metastasis, radiotherapy resistance and chemotherapy tolerance are still the main causes of death in patients. Targeted inhibition of laryngeal cancer stem cells has been considered as the consensus to cure laryngeal cancer. Our previous study has confirmed proto-oncogene Bmi-1 as a key regulator for self-renewal of laryngeal cancer stem cells. Targeted knockdown of Bmi-1 gene effectively inhibited the self-renewal and differentiation of laryngeal cancer stem cells, leading to the promoted sensitivity to chemotherapy including paclitaxel. However, due to off-target effects and quick degradation of the naked Bmi-1-RNAi small RNA oligo by nuclease in body fluids, it is urgently needed to develop a tumor-targeted delivery system with a protective shell. In this study, we designed and synthesized cRGD peptide-modified chitosan-polyethylene glycol slow-release nanoparticles (mPEG-CS-cRGD/Bmi-1RNAi-PTX) containing Bmi-1RNAi siRNA oligo and paclitaxel, which showed spherical in shape, 200 nm diameter in size, low cytotoxicity, strong DNA wrapping, resistance to nuclease degradation and high transfection efficiency to cells. Functional analysis indicated significant suppression of cell proliferation and migration and induction of apoptosis by the nanocomplex in laryngeal cancer cells in vitro. By application to the mouse model with laryngeal cancer, the nanocomplex inhibited tumor growth significantly in vivo. In addition, cRGD peptide, paclitaxel and Bmi-1 siRNA in the nanoparticles showed synergistic effects to suppress laryngeal cancer stem cells. In conclusion, this study not only developed a laryngeal tumor-targeted chemotherapeutic system, but also demonstrated a Bmi-1 RNAi-based chemotherapeutic strategy to inhibit cancer stem cells, having strong potential to treat laryngeal cancer patients suffering therapy resistance and/or tumor recurrence.
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高影响因子
FUEL
·
2023
·
IF 7.4
Kaiwen Zheng,Qiliang Gao,Chao Li,Guojie Zhang,Qingde Zhang,Junfeng Zhang,Yizhuo Han,Yisheng Tan
The production of high value-added oxygenated chemicals from methanol and its derivatives is one of the important ways of coal conversion and clean and efficient utilization. Herein, a series of environmentally-friendly Cs-modified NASICON materials were applied to catalyze the aldol condensation of acetic acid (HAc) and formaldehyde (FA) to acrylic acid (AA) and methyl acrylate (MA). Encouragingly, the selectivity of target products (AA + MA) was highly up to 92.2%, corresponding to the space–time-yield more than 48.0 μmol·g cat - 1 ·min - 1 over the 2Cs/NSC catalyst, achieving the synchronization of good selectivity and productivity for the target products. Characterization results demonstrated that the acid-base modulation by Cs was responsible for catalyst supremacy. The weak basic sites on catalyst surface were efficient in adsorbing and activating HAc. Plenty of acidic sites especially the medium-strong and strong acidic sites were more favorable for the AA formation.
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-13
·
IF 6.408
Chen Jing,Li Shuying,Chen Ying,Yang Jiao,Dong Jianbin
Adenine (A) and guanine (G) are mainly found in deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and play a crucial role in genetic information transfer and protein synthesis. In this study, NH 2 -MIL-53(Fe)/CS/MXene nanocomposites were prepared for detecting guanine and adenine. With high specific surface area, excellent water dispersion, and numerous active sites, MXene (transition metal carbides, nitrides, and carbonitrides) provides a good platform for loading primitive metal-organic frameworks (MOFs). At the same time, the problem of poor conductivity and dispersion of MOFs is solved. The electrochemical catalytic oxidation of adenine and guanine of NH 2 -MIL-53 (Fe)/CS/MXene nanocomposites was carried out by differential pulse voltammetry (DPV). Operating voltage of DPV: 0.7–0.9 V (vs. Ag/AgCl) for G, 1.0–1.2 V (vs. Ag/AgCl) for A, 0.8 V (vs. Ag/AgCl), and 1.1 V (vs. Ag/AgCl) for G and A. The concentration ranges for detecting A and G were 3–118 μM and 2–120 μM with detection limits of 0.57 μM and 0.17 μM (S/N = 3), respectively. The nanocomposite was used for detecting G and A in herring sperm DNA, and the content of G and A was found to be about 9 and 11 μM; the RSD values were 3.4 and 1.3%, respectively. Graphical abstract
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CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Jing Duan,Huiping Shao,Jialei Wu,Hongyuan Liu,Siqi Wang,Tao Lin
The design of magnetic composite scaffolds with superior properties has the potential to construct a targeted delivery platform with hyperthermia. In this study, strontium hexaferrite (SrFe 12 O 19 , SrM) magnetic nanoparticles (MNPs) were obtained by the chemical precipitation method. Non-toxic cross-linked biogels were prepared for adhesive ceramic scaffolds, and chitosan/polyvinylalcohol (CS/PVA)-bonded SrM magnetic nanoscaffolds were successfully prepared by 3D gel printing (3DGP) method. The effects of PVA physical cross-linking and in situ formed SiO 2 on the properties of CS-bonded scaffolds were evaluated, and the compressive strengths were increased from 6.13 ± 2.45 MPa to 8.80 ± 2.02 MPa and 17.18 ± 2.15 MPa, respectively. The results showed that the saturation magnetization of SiO 2 /CS/PVA/SrM composite scaffolds was 59.96 emu/g. In vitro immersion experiments showed that the degradation rates of SiO 2 /CS/PVA/SrM scaffolds were 4.90% after 28 days, and the in situ SiO 2 improved the deposition of calcium salts on the scaffolds. The experiments showed that the SrM magnetic scaffolds could not only concentrate magnetic fields to improve the efficiency of targeting deposition but also achieve a weak targeting process without external magnetic field assistance. In vitro cell proliferation test showed that MC3T3-E1 cells had good adhesion and proliferation on the surface of SiO 2 /CS/PVA/SrM scaffolds, which indicated that the scaffolds may be used for bone repairing.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Zihao Xu,Meng Rong,Shan Ni,Qiyu Meng,Liyan Chen,Huizhou Liu,Liangrong Yang
Hypercrosslinked polymers (HCPs) with synergistic effect of ether oxygen and phenolic hydroxyl groups was designed and fabricated for Cs + isolation in the salt lake system. The separation factors (S.F.)(Cs + /K + ) of the adsorbents were significantly increased through regulating the content of the ether oxygen group in the frameworks. The S.F. of PO-HCPs-6 was increased by nearly 5 times to an ultra-high value (S.F. = 57) compared with the Cs + adsorbents reported in the literature. Moreover, the mild and sufficient polymerization process endowed PO-HCPs-6 with an extremely fast kinetic adsorption rate. PO-HCPs-6 could quickly reach 90% of the equilibrium adsorption capacity in just 1 min . Finally, after 5 times adsorption–desorption experiments, the remarkable elution rate (>92%) and reusability adsorption capacity (>91%) of PO-HCPs-6 proved it has inspiring application potential for the Cs + isolation in the salt lake brine system.
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Journal of Environmental Sciences
·
2023
·
IF 6.9
Mei Du,Jingzhang Liu,Qiong Wang,Fengbang Wang,Lei Bi,Chunyan Ma,Maoyong Song,Guibin Jiang
Endocrine disruptors such as bisphenol A (BPA) adversely affect the environment and human health. Laccases are used for the efficient biodegradation of various persistent organic pollutants in an environmentally safe manner. However, the direct application of free laccases is generally hindered by short enzyme lifetimes, non-reusability, and the high cost of a single use. In this study, laccases were immobilized on a novel magnetic three-dimensional poly(ethylene glycol) diacrylate (PEGDA)–chitosan (CS) inverse opal hydrogel (LAC@MPEGDA@CS@IOH). The immobilized laccase showed significant improvement in the BPA degradation performance and superior storage stability compared with the free laccase. 91.1% of 100 mg/L BPA was removed by the LAC@MPEGDA@CS@IOH in 3 hr, whereas only 50.6% of BPA was removed by the same amount of the free laccase. Compared with the laccase, the outstanding BPA degradation efficiency of the LAC@MPEGDA@CS@IOH was maintained over a wider range of pH values and temperatures. Moreover, its relative activity of was maintained at 70.4% after 10 cycles, and the system performed well in actual water matrices. This efficient method for preparing immobilized laccases is simple and green, and it can be used to further develop ecofriendly biocatalysts to remove organic pollutants from wastewater.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Tao Huang,Dongping Song,Lulu Zhou,Hui Tao,Aiyin Li,Shu-wen Zhang,Long-fei Liu
The natural ecosystem will continually deteriorate for decades by the leakage of Cs and Sr isotopes. The exploration of the new materials or techniques for the efficient treatment of radioactive wastewater is critically important. In this study, a dielectric barrier discharge (DBD) configuration was constructed to operate the non-thermal plasma (NTP). The NTP was incorporated into the synthesis of polyaluminum chloride (PAC) in two different procedures to intensify the synthesis of PAC (NTP-PAC) and enhance the further removal of Cs and Sr from wastewater. The employment of NTP in two procedures both had significantly changed the physicochemical characteristics of PAC materials, which facilitated the further adsorption application of NTP-PAC on the treatment of Cs + and Sr 2+ . Different molecular, morphological, and adsorption characteristics were confirmed to the NTP-PAC materials. The heterogeneous adsorption of the NTP-PAC can be appropriately fitted by both the pseudo-first-order kinetic model and the Elovich model. Both physisorption and chemisorption reaction mechanisms were ensured for the heterogeneous adsorption of the NTP-PAC material towards Cs + and Sr 2+ , which guaranteed the excellent adsorption performance of NTP-PAC materials compared to PAC. The electron collisions caused by NTP with alum pulp created highly reactive growth precursors and intensified the nucleation and hydrolysis polymerization of PAC. The employment of NTP explicitly broadens the reaction pathways between PAC and cationic contaminants in the aqueous environment, which expands the application area of PAC materials in environmental sustainability.
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ACS Omega
·
2020
·
IF 2.87
Hongjie Zhao,Ran Wang,Huizhen Deng,Lijun Zhang,Lili Gao,Lexin Zhang,Tifeng Jiao
In this work, a new nanocomposite based on octa-amino polyhedral oligomeric silsesquioxanes (POSS), carbon nanotubes (CNTs), and chitosan (CS) was synthesized and used for wastewater treatment. The properties and morphologies of the prepared composite were analyzed by X-ray diffraction, scanning electron microscopy, transmission electron microscope, thermogravimetric, and atomic force microscopy. The results showed that POSS, CNTs, and CS formed a stable composite through intermolecular forces, and the modification of CS by POSS and CNTs improved its stability. In addition, the obtained composite showed good adsorption performance for the degradation of methyl orange and Congo red dyes. The pseudo-first-order model and pseudo-second-order model were used to analyze the adsorption data, and the results showed that the adsorption process conforms to the kinetic model. Moreover, the maximum adsorption capacity of the composite to methyl orange and Congo red reached 63.23 and 314.97 mg/g, respectively. This work provides new ideas for the preparation of self-assembled multi-composite and their potential applications in wastewater treatment.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2018
·
IF 3.235
Xiaofang Ma,Jing Chen,Yali Wu,Samrat Devaramani,Xiaoyan Hu,Qixia Niu,Caizhong Zhang,Duoliang Shan,Huan Wang,Xiaoquan Lu
The RGO/AuNPs/CS/ZnTCPP nanocomposites were successfully prepared with reduced graphene oxide (RGO) loaded with Au nanoparticles (AuNPs) existed in chitosan (CS) and water-soluble zinc meso-tetra (4-carboxylphenyl) porphyrin (ZnTCPP) by π-π nanoassembly method and were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), 1 H NMR spectra and UV–vis absorption spectroscopy. The most important advantage of the RGO/AuNPs/CS/ZnTCPP nanocomposites was environmentally friendly. Indium tin oxide (ITO) electrode surface was modified with the RGO/AuNPs/CS/ZnTCPP nanocomposites exhibited a good photocurrent response at −0.2 V under whitelight of Xenon lamp illumination. The photocurrent response could be greatly increased by adding hydroquinone (HQ) to the solution. Electrons of ZnTCPP were excited from HOMO to LUMO by irradiating light. The photoexcited electrons injected into the RGO , and then transferred to AuNPs further to the ITO. Addition of HQ resulted in the enhanced photocurrent signal by acting as a sacrificial electron donor ; Thereby scavenged the photogenerated holes of the excited ZnTCPP and oxidized to benzoquinone (BQ). Based on the above interaction, detection of HQ was developed by a novel photoelectrochemical (PEC) sensor (S/N = 3) with a linear range from 5 to 300 nmol/L (r = 0.997) and detection limit of 0.5 nmol/L. Proposed biosensor is simple, rapid and this was successfully applied for the quantification HQ in the real sample matrices.
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