JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Haiyan Huang,Rui Zhang,Yu Luo,Kexin Zhang,Bingbing Duan,Gulizhaer Ainiwa,Yiting Ma,Yamei Miao,Lingxiao Zhang,Xiaofeng Zhu,Xiang Li,Kaiyang Wang
Modulating intratumoral copper homeostasis to trigger cuproptosis is a promising copper‑based anticancer strategy, but its clinical translation is hindered by the absence of precise spatiotemporal control over intracellular copper levels and ATP7A‑mediated active copper efflux. Here we report an ultrasound-activated copper molybdate nanoregulator, HCu 1.5 MoO 5 (HCMO), that releases copper on demand and reprograms copper flux in tumor cells under ultrasound. Once internalized, ultrasound activates HCMO to release copper ions, providing a sustained intracellular copper supply. In parallel, HCMO also generates reactive oxygen species that impair mitochondrial function and depress cellular ATP, thereby attenuating the activity of the ATP-dependent exporter ATP7A and narrowing copper efflux. This dual-axis imbalance, in situ copper supplement, and efflux limitation significantly disrupt cellular copper homeostasis, interrupt the tricarboxylic-acid cycle, induce mitochondrial dysfunction, further enhance copper accumulation, and eventually cause irreversible cuproptosis. Together with apoptosis and necroptosis, the coordinated damage releases damage-associated molecular patterns and induces immunogenic cell death. Overall, this spatiotemporally programmable strategy links materials, physical fields, and immunity in a closed framework to coordinately disrupt copper homeostasis, offering a generalizable route to on-demand cuproptosis therapy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Shilu Zhang,Hai Li,Faguo Li,Jiayi Wu,Fengwei Shi,Jianglei Hu
A novel composite aerogel adsorbent, calcium alginate-tris(hydroxymethyl) aminomethane hydrochloride (CA-Tris), was synthesized through amidation reaction between sodium alginate (SA) and tris(hydroxymethyl) aminomethane hydrochloride (Tris) followed by Ca 2+ cross-linking, and further applied for removing Cu 2+ and Pb 2+ ions from aqueous solutions. Results illustrated that, compared with calcium alginate (CA), the particle compression strength and the total pore surface area of CA-Tris aerogel were increased to 16.8 kg·cm −2 and 10.51 m 2 ·g −1 , respectively. In addition, CA-Tris demonstrated exceptional adsorption performance for heavy metal ions, with maximum adsorption capacities of 278.03 mg·g −1 for Cu 2+ and 354.69 mg·g −1 for Pb 2+ through a spontaneous monolayer chemisorption process that fitted Langmuir isotherm model and pseudo-second-order kinetic model. X-ray photoelectron spectrometer (XPS) and density functional theory (DFT) calculations revealed that ion exchange, electrostatic attraction and coordination complexation were the dominant mechanisms. Notably, CA-Tris maintained stable removal efficiencies of 77.14% for Cu 2+ and 75.65% for Pb 2+ after 10 successive adsorption-desorption cycles. The exceptional adsorption performance of this functionalized SA aerogel positioned it as a promising candidate for industrial wastewater remediation.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Haixia Wu,Sai Li,Dongyuan Yang,Yuhang Wang,Shuoshuo Wang,Yameng Ma,Zekai Ma,Na Liu,Kui Zhang,Haiyan Zhu,Shaobo Jia,Peng Ren,Qing Feng,Rui Tan,Zhiming Feng
Flexible zinc-air batteries (FZABs) hold great promise for powering next-generation wearable electronics, yet their advancement is hindered by sluggish oxygen electrocatalysis and poor cycling stability. Here, we employ a dielectric barrier discharge (DBD) plasma-assisted approach to modify CuO x /activated carbon (CuO x /AC) composite catalysts, offering a facile and scalable route to simultaneously tailor surface chemistry and nanostructure. The plasma treatment generates abundant oxygen vacancies and stabilizes mixed Cu + /Cu 2+ valence states, thereby accelerating both oxygen reduction and evolution reaction (ORR/OER) kinetics. It also produces a three-dimensional porous architecture of vertically aligned nanosheets with uniformly dispersed CuO x nanoparticles, enabling rapid electron/mass transport. When applied in FZABs, the CuO x /AC-DBD catalyst achieves a high peak power density (226 mW cm −2 ), an open-circuit voltage of 1.37 V, and remarkable cycling stability with 95% capacity retention. Compared with untreated catalysts, it exhibits a much lower charge-transfer resistance (12 Ω cm 2 ) and superior durability. This study demonstrates that DBD plasma engineering is an effective and low-cost strategy for designing high-performance bifunctional catalysts, paving the way for flexible and wearable energy storage devices.
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APPLIED OPTICS
·
2025
·Vol. 64
·期 19
·5593-5601
·
IF 1.7
Chenxi Wang,Siyu Wan,Deen Wang,Ruoyu Li,Zhiyang Jin,Alan R. Kost,Xiaolan Sun
Copper ions (${{\rm Cu}^{2 +}}$) play critical roles in biological systems but induce toxicity at elevated concentrations. This study, to our knowledge, reports a novel ratio-metric fluorescence sensor based on near-infrared (NIR)-emissive PbS quantum dot (QD)-doped hydrogel fiber sensor for real-time, selective detection of ${{\rm Cu}^{2 +}}$. The sensor employs a biocompatible and mechanically flexible HF with a core-cladding structure to confine light within the core for efficient transmission. Densely silica-coated PbS QDs (Si-QDs, emission at 1000 nm) serve as a stable reference signal, while copolymer-functionalized PbS QDs (P-QDs, emission at 1300 nm) exhibit ${{\rm Cu}^{2 +}}$-specific fluorescence quenching via photoinduced electron transfer. By ratiometrically monitoring the dual emission intensities (${F} = {{I}_{1300}}/{{I}_{1000}})$, the sensor achieves quantitative ${{\rm Cu}^{2 +}}$ detection with a linear range of ${0 {-} 100}\;\unicode{x00B5}{\rm M}$ and a limit of detection of 1.57 µM, effectively mitigating environmental interference. This work synergistically integrates the biocompatibility of hydrogels with the deep tissue penetration advantages of the NIR window. It has been preliminarily tested in laboratory environments, establishing a foundational platform for future-deep tissue implantable sensors.
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JOURNAL OF HAZARDOUS MATERIALS
·
2015
·
IF 4.529
Ping Tan,Jian Sun,Yongyou Hu,Zheng Fang,Qi Bi,Yuancai Chen,Jianhua Cheng
Novel, highly ordered layered graphene oxide (GO) membranes with larger interlayer spacing were prepared by induced directional flow and were used as adsorbents for the removal of Cu 2+ , Cd 2+ and Ni 2+ from aqueous solutions. The effects of pH, ionic strength, contact time, metal ion concentration and cycle time on Cu 2+ , Cd 2+ and Ni 2+ sorption were investigated. The results indicated that the adsorption of Cu 2+ , Cd 2+ and Ni 2+ onto GO membranes was greatly influenced by the pH and weakly affected by the ionic strength. The adsorption isotherms for Cu 2+ , Cd 2+ and Ni 2+ were well fitted by the Langmuir model. The maximum adsorption capacities of the GO membranes for Cu 2+ , Cd 2+ and Ni 2+ were approximately 72.6, 83.8 and 62.3 mg/g, respectively. The adsorption kinetics of Cu 2+ , Cd 2+ and Ni 2+ onto GO membranes followed the pseudo-second-order model. The adsorption equilibrium was reached in a shorter time. The GO membranes can be regenerated more than six times based on their adsorption/desorption cycles, with a slight loss in the adsorption capacity. The results demonstrated that the GO membranes can be used as effective adsorbents for heavy metal removal from water.
研究领域:
环境科学
·
材料科学
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Materials Today Bio
·
2025
·
IF 10.2
Xiaohuan Guo,Bingbing Cai,Qi Fang,Yanyan Chen,Yuzhu Zhou,Zhixing Liang,Changchun Wen,Yan-Cheng Liu,Hong Liang
The high level of glutathione (GSH) in tumor cells can consume reactive oxygen species (ROS), seriously affecting the efficacy of chemodynamic therapy (CDT). Although it took a great deal of effort, developing a tumor-specific CDT that efficiently depletes GSH remains a formidable challenge. Herein, we propose a pH-responsive nanocatalyst containing the active molecule norcantharidin (NCTD) and Cu 2+ for dual GSH depletion, achieving efficient GSH depletion. Due to the weakly acidic tumor microenvironment (TME), the catalyst releases NCTD and Cu 2+ in a pH-responsive manner for the synergistic therapy of chemotherapy (CT) and CDT. Both components consume GSH and subsequently produce ROS, reducing the antioxidant capacity of cancer cells while increasing oxidative stress. This disrupts cellular redox homeostasis, leading to mitochondrial dysfunction and inducing tumor cell apoptosis. This work not only develops nanomaterials with dual GSH depletion capabilities for high-efficiency CDT but also achieves synergistic CT and CDT tumor therapy with the addition of NCTD, an active ingredient of traditional Chinese medicine.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2018
·
IF 4.005
Chirag B. Godiya,Ma Liang,Sayed Mir Sayed,Dawei Li,Xiaolin Lu
Heavy metal ion pollution leads to severe health risk to human beings. Herein, a natural and highly efficient sodium alginate (ALG)/polyethyleneimine (PEI) composite hydrogel was designed and fabricated for the removal of heavy metal ions from wastewater. The adsorption of heavy metal ions on the ALG based, 3D composite hydrogel were thoroughly investigated in this study. Furthermore, the in situ reduced metal nanoparticle-loaded ALG/PEI composite hydrogel provided us a sustainable utilization route of the heavy metal ion with a promising adsorption-catalysis ability. In general, this research will present an effective and practical paradigm for the cascaded treatment and recycling of heavy metal ions in wastewater.
研究领域:
环境科学
·
材料科学
·
生物学
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Jiali Jiang,He Li,Tao Fu,Bing-Joe Hwang,Xue Li,Jinbao Zhao
In this work, nonstoichiometric Cu2–xSe fabricated by a facile water evaporation process is used as high-performance Al-ion battery cathode materials. Cu2–xSe electrodes show high reversible capacity and excellent cycling stability, even at a high current density of 200 mA g–1, the specific charge capacity in the initial cycle is 241 mA h g–1 and maintains 100 mA h g–1 after 100 cycles with a Coulombic efficiency of 96.1%, showing good capacity retention. The prominent kinetics of Cu2–xSe electrodes is also revealed by the GITT, which is attributed to the ultrahigh electronic conductivity of the Cu2–xSe material. Most importantly, an extensive research is dedicated to investigating the detailed intercalation and de-intercalation of relatively large chloroaluminate anions into the cubic Cu2–xSe, which is conducive to better understand the reaction mechanism of the Al/Cu2–xSe battery.
研究领域:
材料科学
·
电化学
·
能源存储
·
纳米材料
·
电池技术
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·830
·
IF 5.3
Hou Hongming,Long Jiajun,Li Xianglong
The chelation interaction between sodium lignosulfonate (SLS) and Cu 2+ is exploited to construct an enzyme-free creatinine sensing electrode (SLS-Cu/SPCE) via one-step electrodeposition on screen-printed carbon electrodes (SPCE). SLS chelation moderates Cu 2+ electro-reduction kinetics, resulting in finely structured Cu particles with a uniform and dense distribution. These Cu particles, with abundant unsaturated coordination sites, enhance creatinine adsorption and promote specific complexation with Cu 2+ , thereby increasing the oxidation current response for sensitive detection. The SLS-Cu/SPCE achieved a 0.12 µM detection limit, a 10–300 µM linear range, high reproducibility, and long-term stability over 28 days. Tests in human urine samples showed good agreement with enzymatic assays (relative error < 16%). The SLS-Cu 2+ coordination strategy offers a novel approach for optimizing Cu-based enzyme-free electrochemical creatinine sensors. Graphical A sodium lignosulfonate-Cu 2+ chelation strategy produces refined copper particles on SPCE with abundant unsaturated sites. These sites enhance creatinine adsorption and Cu 2+ complexation, enabling highly sensitive non-enzymatic detection (0.12 μM LOD, 10-300 μM range) with strong anti-interference and excellent stability.
研究领域:
电分析化学
·
生物传感器
·
纳米材料
·
环境与临床监测
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OPTICAL MATERIALS
·
2020
·
IF 2.779
Zhenhua Li,Guotao Sun,Christopher D. Snow,Yanan Xu,Yao Wang,Dan Xiu,Yu Zhang,Zhijun Zhu,Laurence A. Belfiore,Jianguo Tang
DNA-based high-performance rare-earth materials were synthesized for the first time to enhance the near-infrared fluorescence of Yb 3+ and to provide a sensory response to Cu 2+ and Fe 3+ . Yb 3+ , TTA, phen and DNA were coordinated in an ethanol solution. The mixture produced a stable DNA material under the action of stirring and ultrasound. By changing the ratio, the morphology and luminous properties of the product were controlled. The addition of DNA increased the luminescent intensity of Yb 3+ complexes three folds. Earlier reports investigated Yb 3+ complexes fluorescence in the visible range or reported weak near-infrared emission. The rare-earth materials we synthesized herein have significantly increased near-infrared fluorescence intensity of Yb 3+ , and significantly improved biocompatibility. Potential applications for DNA-coordinated Yb 3+ complexes include the detection of Cu 2+ and Fe 3+ in vitro and in vivo , taking advantage of good penetration of IR through human tissue in the window 950 nm to 1050 nm.
研究领域:
材料科学
·
分析化学
·
生物化学
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Xiong-Xin Peng,Guang-Ming Bao,Yu-Fei Zhong,Jia-Xin He,Lintao Zeng,Hou-Qun Yuan
In this work, a metal−organic framework UiO-66-(COOH) 2 has been synthesized and is further functionalized with Tb 3+ through coordination interactions. The functionalized MOF, denoted as Tb 3+ @UiO-66-(COOH) 2 , is fully characterized and further developed as an excellent fluorescent probe to monitor Cu 2+ ions in aqueous media by fluorescence quenching effect. Tb 3+ @UiO-66-(COOH) 2 exhibits high selectivity and sensitivity, broad linear concentration range (0–200 μM), low detection limits (0.23 μM), fast response speed (within 1 min), as well as in situ naked eye observation under UV light for sensing Cu 2+ ion. Furthermore, this probe was successfully employed to detect Cu 2+ ion in real water with good recovery. Hence, this work developed a very excellent fluorescent sensor with high potential practical applications for detection of Cu 2+ ion in environmental water samples.
研究领域:
材料科学
·
环境科学
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INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Ning Li,Wenwen Zhao,Linping Li,Yangqin Gao,Lei Ge
Photocatalysts with hollow structures have drawn great interest owing to their high specific surface area, which can enhance the photocatalytic performance. Herein, we designed the hollow cubic Cu2–xS@Ni–Mo–S nanocomposites by vulcanizing from the Cu2O template and loading the Ni–Mo–S lamellas. The Cu2–xS@Ni–Mo–S composites greatly improved the photocatalytic hydrogen performance. Among them, Cu2–xS–NiMo-5 achieved the optimal photocatalytic rate of 1326.07 μmol/g h, which is approximately 3.85 times higher than that of hollow Cu2–xS (344 μmol/g h) and had good stability for 16 h. The enhanced photocatalytic property was attributed to the metallic behavior of bimetallic Ni–Mo–S lamellas and the LSPR (localized surface plasmon resonance) effect of Cu2–xS. The bimetallic Ni–Mo–S can effectively capture the photogenerated electrons and quickly transfer-diffuse to produce H2. Meanwhile, the hollow Cu2–xS not only provided many more active sites to take part in the reaction but also introduced the LSPR effect to increase the solar utilization. This work provides valuable insights into the synergistic effect of using non-precious metal co-catalysts and the LSPR materials to assist in the photocatalytic hydrogen evolution.
研究领域:
材料化学
·
光催化
·
能源科学
·
纳米材料
·
半导体物理
·
可再生能源
·
表面科学
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