DYES AND PIGMENTS
·
2016
·
IF 4.055
Jia-Xiang Cheng,Zu-Sheng Huang,Lingyun Wang,Derong Cao
Four novel D–π–A–π–A metal-free organic dyes Q1-Q4 were synthesized and the impacts of the auxiliary acceptors on the photovoltaic performances were studied. Q2 with quinoxaline as the auxiliary acceptor exhibited the best photovoltaic performance due to its highest short-circuit photocurrent density (17.22 mA cm −2 ), leading to a power conversion efficiency of 7.42% under simulated AM 1.5 G illumination. Q1 with the strongest electron withdrawing group (pyrazino[2,3- g ]quinoxaline) as the auxiliary acceptor showed the weakest performance, which can be attributed to electron trap and mismatch of energy-level. The results showed that the different electron-withdrawing property of auxiliary units significantly influenced the absorption, energy levels and photovoltaic performance. Incorporating auxiliary acceptor with moderate electron-deficient ability can extend the absorption range and adjust the molecular orbital energy levels, resulting in better photovoltaic performance.
✓ 已验证
DOI
高影响因子
Applied Materials Today
·
2026
·
IF 7
Siqi Zhan,Chihao Gao,Junyi Yan,Xiaoli Lin,Xu Yan,Yaohui Fan,Zongrui Zhang,Xinyu Wang
Improve the sterile inflammation caused by soft tissue fillers. • Reduce inflammatory mediators and ROS levels. • Promoted cell migration and orderly collagen deposition. The increasing prevalence of soft tissue fillers has given rise to a concern regarding the occurrence of local sterile inflammation induced by the filler material. This study proposes the use of Poly(D,L-lactic acid) (PDLLA) microspheres composite with D-α-Tocopherol acetate (α-TA) and Hydroxyapatite (HAp) to eliminate aseptic inflammation caused by PDLLA degradation. The reduction of aseptic inflammation is achieved by prolonging degradation time, modulating the local microenvironment, and suppressing inflammatory mediators. HAp and α-TA were evenly distributed in PDLLA/HAp(α-TA) microspheres, and those microspheres have a particle size suitable for soft tissue filling (30–70 µm). Utilizing a conventional commercial formulation, PDLLA/HAp(α-TA) is uniformly amalgamated with carboxymethyl cellulose (CMC) to formulate CMC@PDLLA/HAp(α-TA) gel. CMC@PDLLA/HAp(α-TA) exhibits sustained release properties for at least 6 weeks and possesses excellent injectability. Meanwhile, CMC@PDLLA/HAp(α-TA) exhibits excellent biocompatibility and the ability to promote cell migration. Specifically, CMC@PDLLA/HAp(α-TA) significantly reduces inflammatory mediators and reactive ROS levels, while exhibiting prolonged and orderly collagen deposition. In summary, as an injectable soft tissue filler, CMC@PDLLA/HAp(α-TA) offers a novel strategy for the long-term suppression of sterile inflammation. Download: Download high-res image (287KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Junjie Huang,Jiahao Zhu,Huijun Zheng,Enhui Zhu,Chenqi Yang,Liqin Ying,Yucong Zhou,Hao Liu
The neuroprotective effect of DAAOi is associated with increased levels of its substrate, D-Serine. • D-Serine can ameliorate cognitive and behavioral deficits in MCAO rats. • D-Serine may exert its neuroprotective effect by promoting the D-Serine/GluN2A/BDNF signaling pathway. To investigate the mechanisms of D-Amino acid oxidase inhibitor (DAAOi) in ameliorating cerebral ischemia-reperfusion (I/R) injury and the underlying neuroprotective effect of substrate D-Serine. A middle cerebral artery occlusion (MCAO) rat model and an oxygen-glucose deprivation (OGD)-induced HT22 cell model were used to mimic ischemic stroke. The modified Neurological Severity Scores (mNSS) and 2, 3, 5-triphenyltetrazolium chloride staining were applied to assess neurological behavioral scores and cerebral infarct area, respectively. The effects of DAAOi 4H-Furo[3,2-b]pyrrole-5- carboxylic acid (SUN) and D-Serine intervention on cognitive and behavioral functions in MCAO rats were evaluated by using the Y-maze and Novel Object Recognition Test (NORT). Intracerebral stereotaxic injection of Compound SUN and D-Serine (0.21 mg, 1.05 mg, 2.1 mg) significantly reduced cerebral infarct area, indicating that DAAOi might improve cerebral I/R injury by elevating D-Serine levels. Similarly, D-Serine significantly enhanced cognitive and behavioral performance in MCAO rats (mNSS: improved by 2.3 scores; Y-maze: spontaneous alternation rate increased by 14.76%; NORT: recognition index improved by 12.28%). D-Serine pretreatment (10 μM-10 mM) dose-dependently increased the viability of HT22 cells subjected to OGD. In both in vitro and in vivo models, D-Serine significantly increased the protein level of N-methyl-D-aspartate receptor subunit 2A (GluN2A). Additionally, D-Serine promoted the expression of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein-95 but inhibited the apoptosis-related p38 MAPK phosphorylation. This study demonstrated that the neuroprotective effect of DAAOi was at least partly mediated by elevating cerebral D-Serine levels, which regulated the GluN2A/BDNF axis to enhance synaptic plasticity and cognitive function. Download: Download high-res image (323KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2022
·
IF 3.318
Hua Li,Yang Wang,Ru Ding,Chen Chen,Zhixuan Tian,Hongnan Yin,Lieming Ding
A sensitive and reliable method was developed to determine befotertinib (D-0316) and its metabolite D-0865 from human plasma by LC-MS/MS. The samples were prepared by simple protein precipitation and 2 µL of the supernatant were chromatographed on a C18 analytical column (ACE Excel 2 Super C 18 , 50 × 2.1 mm). Elution was performed with mobile phase A (10 mM ammonium acetate in water containing 1 % formic acid) and mobile phase B (acetonitrile containing 1 % formic acid) under a gradient program in a total run time of 4 min. Triple Quadruple 5500 equipped with Turbo Ion Spray source and multiple reaction monitoring (MRM) were used for the analysis detection. The transitions were m / z 568.3 → 72.1 m / z (befotertinib), m / z 554.2 → 497.2 (D-0865), and m / z 455.2 → 164.9 (verapamil, internal standard). According to the Chinese Pharmacopeia Commission and ICH Harmonised Guideline for Bioanalytical Method Validation, this method was validated within the spectrum of its accuracy, precision, selectivity, linearity, recovery, matrix effect, and stability. This LC-MS/MS method was successfully applied for the quantitation of befotertinib and its metabolite D-0865 in human plasma during the pharmacokinetics study of befotertinib in non-small cell lung cancer (NSCLC) patients.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2016
·
IF 4.052
Baogang Xie,Yalan Liu,Huiqin Zou,Yong Son,Huiyun Wang,Haipeng Wang,Jianghua Shao
d -Glucaric acid (GA) derivatives exhibit anti-cancerogenic properties in vivo in apples, but quantitative information about these derivatives is limited. Hydrophilic interaction-based HPLC with ultraviolet detection or mass spectrometry was developed to quantify GA and/or d -glucaro-1,4-lacton (1,4-GL) in apples. Although the formation of 1,4-GL from GA could be the prerequisite to exert biological effects in vivo , only a small portion of GA (<5%) was identified and converted to 1,4-GL in the rat stomach. The 1,4-GL content in apples ranged from 0.3 mg/g to 0.9 mg/g, and this amount can substantiate health claims associated with apples. The amount of 1,4-GL was 1.5 times higher in Gala and the ratio of 1,4-GL to GA was lower in Green Delicious apples than those in the other varieties. Our findings suggested that the variety and maturity of apples at harvest are factors that determine 1,4-GL content.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2021
·
IF 4.24
Jiao Yuan,Yuvaraj Ravikumar,Guoyan Zhang,Junhua Yun,Yufei Zhang,Hossain M. Zabed,Xianghui Qi
l -arabinose isomerases (L-AIS) are enzymes that mediate the conversion of l -arabinose into l -ribulose and D-galactose into D-tagatose. The potential of L-AI from Lactobacillus parabuchneri CICC 6004 (LPAI) in D-galactose biotransformation using E. coli whole-cells was studied. The parameters investigated in this study were 1) the optimum pH, temperature, and cofactor specificity for maximum enzyme activity ; 2) the D-tagatose biosynthesis from D-galactose using whole-cells containing LPAI. The results showed that with D-galactose, the purified LPAI showed the highest activity, 15.52 U/mg at pH 6.7, 45 °C, and necessitates 3 mM Ca 2+ as its cofactor. The K m , V max and K cat /K m values of LPAI for D-galactose were 5.4 mM, 35.5 U/mg and 2.8 mM −1 min −1 , respectively, while the respective values for l -arabinose were found to be 4.3 mM, 63.1 U/mg and 5.9 mM −1 min −1 .The applicability of LPAI for D-tagatose synthesis was shown by using whole-cell biocatalyst approach. Under the optimum conditions, during one-stage biotransformation of D-galactose by E. coli whole cells, 39.0 g/L of D-tagatose was produced from 140 g/L of D-galactose after 50 h, which corresponded to the yield and productivity of 0.28 g/g and 0.78 g/L/h, respectively. Further addition of new cells into the reaction mixture in the second stage produced 54.0 g/L of D-tagatose after 100 h. The D-tagatose total yield and productivity were 0.39 g/g and 0.54 g/L/h, respectively. The results attained in this study showed LPAI as a potential candidate for the industrial production of D-tagatose.
✓ 已验证
DOI
高影响因子
Foods
·
2022
·Vol. 11
·期 20
·3225
·
IF 5.561
Xinrui Tang,Yingfeng An,Muhammad Waheed Iqbal,Hongri Cong,Guoyan Zhang,Yufei Zhang,Yuvaraj Ravikumar,Hossain M. Zabed,Mei Zhao,Haixing Zhou,Xianghui Qi
D-allulose is a natural rare sugar with important physiological properties that is used in food, health care items, and even the pharmaceutical industry. In the current study, a novel D-allulose 3-epimerase gene (Bp-DAE) from the probiotic strainBlautia producawas discovered for the production and characterization of an enzyme known as Bp-DAE that can epimerize D-fructose into D-allulose. Bp-DAE was strictly dependent on metals (Mn2+and Co2+), and the addition of 1 mM of Mn2+could enhance the half-life of Bp-DAE at 55 °C from 60 to 180 min. It exhibited optimal activity in a pH of 8 and 55 °C, and theKmvalues of Bp-DAE for the different substrates D-fructose and D-allulose were 235.7 and 150.7 mM, respectively. Bp-DAE was used for the transformation from 500 g/L D-fructose to 150 g/L D-allulose and exhibited a 30% of conversion yield during biotransformation. Furthermore, it was possible to employ the food-grade microbial speciesBacillus subtilisfor the production of D-allulose using a technique of whole-cell catalysis to circumvent the laborious process of enzyme purification and to obtain a more stable biocatalyst. This method also yields a 30% conversion yield.Keywords:D-allulose 3-epimerase;D-allulose;Blautia produca;probiotics;biochemical characterization;biotransformation
✓ 已验证
DOI
PubMed
高影响因子
CATALYSIS TODAY
·
2014
·
IF 3.309
Senlin Wang,Wei Wei,Yu Zhao,Hexing Li,Hui Li
In this paper, highly ordered mesoporous silica nanospheres externally covered by methyl groups ( CH 3 ) but internally grafted by aminopropyl groups ( NH 2 ) were used as host matrix for loading Ru–B amorphous alloy nanoparticles (NPs). The NH 2 and the CH 3 groups served synergistically as effective functionalities for highly dispersing Ru–B NPs within the pore channels of the mesoporous host. Such catalyst was used in the liquid-phase d -glucose hydrogenation and delivered much higher activity than industrial Raney Ni and the commercial Ru/C catalysts. Meanwhile, it could be used repetitively for more than 9 times, showing a good potential in practical applications. This work demonstrated that the surface properties of mesoporous materials can be modified through region-selective immobilization of diverse organic groups, which is essential to optimize the catalysis for some reactions.
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Yulin Fan,Fang Fu,Langqiu Chen,Jiping Li,Jing Zhang,Guochao Zhang,Jingyi Liao
Based on reconstructing conventional alkyl β - d -glucopyranosides, alkyltri(oxyethyl) β - d -glucopyranosides ( 4a ~ 4h , n = 6 ~ 16) were prepared by introducing a tri(oxyethyl) group ((–OCH 2 CH 2 –) 3 ) as a hydrophilic spacer to improve effectively the related water solubility. Their foaming performance, emulsifying property, hygroscopicity, solubility, and thermotropic phase transitions were further investigated. The experimental results showed that the phase transition temperature (T iso ) increased with increasing their alkyl chain length. Such β - d -glucopyranosides ( 4b ~ 4h , n = 7 ~ 16) showed a smectic focal conic-shaped texture. Their water solubility, surface tension, CMC value, and hygroscopicity decreased with increasing their alkyl chain length. Meanwhile, 4e (n = 10) had the best foamability. In the rapeseed oil/water system, 4f (n = 12) had excellent emulsifying property. Furthermore, 4 (n = 8, 10, 12) and SDS or CTAC had the synergistic effect because their experimental CMC value was smaller than their ideal CMC value (CMC id ).
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2026
·
IF 12.8
Jiajun Lu,Rongjie Jiang,Defang Ma,Baoyu Gao,Shuang Zhao,Yan Wang
Oxidative polymerization driven by direct electron transfer (DET) demonstrates superior selectivity and strong anti-interference capability in water purification. However, its practical application is constrained by inherent limitations, including inadequate polymerization efficiency and extent, as well as catalytic site deactivation. To address these challenges, we propose a catalytic pathway engineering strategy through d-band broadening. Building upon this principle, a cobalt-manganese oxide-modified graphite felt (Co‑MnO 2 @GF) catalyst was developed and integrated into a dual-chamber reaction system. Facilitated by a downward shift of the d-band peak, surface-confined oxidative polymerization converted >94% of model pollutants into separable, potentially recoverable polymers. This yielded an effluent free of detectable intermediates and achieved near-complete removal of total organic carbon (TOC). More importantly, the electron delocalization induced by broadened d-band enables electrons derived from pollutants to migrate rapidly toward the oxidant instead of being trapped in Mn d-orbitals. This mitigates the deep reduction of Mn(IV) caused by excessive electron accumulation on Co‑MnO 2 @GF, thereby stabilizing high-valence Mn species during operation and underpinning the superior long-term stability of the catalyst in oxidative polymerization. Our work demonstrates that rational electronic structure design can effectively overcome the intrinsic barriers of DET-driven oxidative polymerization, establishing a scalable purification strategy for sustainable water treatment.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 44
·20641-20653
·
IF 4.682
Ren Meiqi,Dong Xiaoli,Wang Yu,Zheng Nan,Ma Hongchao,Zhang Xiufang
Conjugated microporous polymers have attracted significant attention in recent years due to their high porosity, broad functionality and excellent chemical stability. In this work, the small-sized layered structure of poly(phenylenethiazolo[5,4-d]thiazole) (p-PhTT) copolymer was achieved by a facile solvothermal-assisted exfoliation process in a polar organic solvent. Owing to the shorter diffusion length, the layered structure could enhance carrier diffusion from the interior to the surface, as well as provide more active sites in photocatalytic reaction. The obtained exfoliated p-PhTT copolymers show good dispersion and stability in aqueous solution and exhibit efficiently photocatalytic activity for degrading rhodamine B dye under visible-light irradiation. This effective method offers a promising strategy for exfoliating other organic porous polymers. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2022
·
IF 7.305
Dongya Li,Hong Zhong
Solar driven steam generation is a typical application of solar energy harvesting for clean water production, which has undergone a long-term development. Up to now, a desirable evaporation efficiency has been achieved in lab-scale via advanced materials and structural design However, to maintain a stable performance for long-term practical application, the simplicity of fabrication process, the cost of the raw material and the salt accumulation issue have to be taken into consideration. Here, this research proposed an efficient solar evaporator based on laser induced graphene (LIG) and the commercialized nickel foam. The nickel foam was preferred as the skeleton of the evaporator coupling with hydrophilic polyvinyl alcohol (PVA) to provide sufficient water pathways with reduced water vaporization enthalpy in the bottom layer of the solar evaporator. In addition, plasmonic antimony doped tin oxide (ATO) nanoparticles were introduced into the porous graphene to further enhance the solar absorption and photothermal conversion. Thus, the 3D evaporator exhibits a high evaporation efficiency of 2.21 kg m −2 h −1 in salt water (20 wt% NaCl) under 1 solar irradiation (1 kw m −2 ). Moreover, the evaporator enables a stable evaporation performance upon the saline water during a 120 h test, with no salt crystals accumulated on the surface of evaporator. It is believed that this work presents a potential simple pathway to design and fabricate a portable and efficient evaporator equipped with efficient LIG nanocomposite as an efficient solar absorber .
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）