FOOD RESEARCH INTERNATIONAL
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2024
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IF 7
Jiawen Li,Yuanhao Zheng,Peng Wang,Hui Zhang
In this study, electrospun zein/alginate dialdehyde (AD) nanofibers were prepared by green crosslinking. The degree of crosslinking could reach 50.72 %, and the diameter of electrospun fibers ranged from 446.2 to 541.8 nm. The generation of AD and the bonding of crosslinking were further confirmed by the changes on characteristic peaks and conformational ratios in the infrared spectroscopy and secondary structure analysis. High concentrations of AD led to improved thermal stabilities, mechanical properties, and hydrophobicity. And the highly crosslinked nanofibers (Z-8) owned the highest elastic modulus (24.92 MPa), tensile strength (0.28 MPa), and elongation at break (8.14 %) among five samples. Moreover, Z-8 possessed a high swelling ratio of 5.45 g/g, and a low weight loss of 6.09 %. The samples could encapsulate curcumin efficiently and show controllable release behaviors based on different AD addition. And the oxidation resistance of nanofibers gradually improved, consistent with the release performances. This study indicated AD crosslinking favored the preparation and application of zein nanofibers, and the oxidized polysaccharide acted as the green crosslinking agent, which provided reference value for the application of polysaccharides in food-related electrospun materials.
研究领域:
材料科学
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纳米技术
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药学
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食品科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Hong Xiang,Yu Zhang,Jiaming Li,Li Li,Ziwei Li,Rui Ni,Dan Peng,Lining Jiang,Jianhong Chen,Yao Liu
Ethnopharmacological relevance Terminalia bellirica (Gaertn.) Roxb. (TBR) , a popular herbal remedy in India and Southeast Asia, has been demonstrated to possess multiple pharmacological activities. However, systematic studies on the medicinal effects and mechanism of TBR for the androgenetic alopecia (AGA) treatment are deficient. Materials and methods Human Umbilical Vein Endothelial Cells (HUVECs) and testosterone-induced AGA mice were used to evaluate the hair regrowth activity of TBR extracts. Chemical constituents and potential active components of TBR extracts were analyed by UPLC-Q-TOF-MS in vitro / vivo . The hair regrowth mechanisms of TBR were elucidated through network pharmacology and experimental validation. Results Totally 28 chemical constituents in TBR were identified, of which 15 were predicted as potential active components for AGA therapy. TBR could significantly scavenge ROS, promote VEGF level/cell migration of HUVECs, and inhibiting type II 5α-reductase activity (the inhibit rate: 82.35 ± 1.02 %). Pharmacodynamic evaluation suggested that TBR effectively led to hair regrowth in C57BL6 mice compared to minoxidil. TBR promoted the hair follicle (HF) transition from the telogen phase to anagen phase by decreasing MDA levels, increasing VEFG expression and up-regulating phosphorylated P38/ERK protein levels in the MAPK signalling pathway. Conclusions TBR reversed AGA via inhibiting SRD5A2 activity and stimulating the MAPK pathway. Meantime, TBR could remodel the follicle microenvironment by reducing oxidative stress and increasing angiogenesis.
研究领域:
药理学
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民族药理学
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分子生物学
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细胞生物学
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皮肤科
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2025
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IF 8.2
Zhenzhen Jin,Xiangjing Cao,Qinglong Guo,Cong Zhang,Qingrong Li,Wenqi Wang,Yong Lv,Yan Ma,Xianwen Wang
As one of the most common inflammatory bowel diseases (IBDs), ulcerative colitis (UC) has become a rising global health issue that affects people’s quality of life. Conventional therapeutic drugs have low bioavailability and may cause serious side effects due to their lack of acidic resistance and lesion-targeting capabilities. The development of novel nanomedicines to overcome these problems is urgently needed. Nanozymes have attracted attention because of their excellent catalytic efficiency in various harsh environments. In this study, tannic acid-vanadium (TA-V) nanozymes with multienzymatic and excellent antioxidant abilities, which exhibit acidic resistance and a negative surface charge, were successfully developed. All these characteristics make it possible that these nanozymes are not easily decomposed by gastric acid and can effectively accumulate in colitis lesions with a positive charge through oral delivery. In vitro and in vivo experiments further demonstrated the excellent prophylactic and therapeutic value of these compounds in the treatment of UC by scavenging reactive oxygen/nitrogen species (ROS/RNS) and mitigating the oxidative stress environment, thus downregulating the levels of the proinflammatory cytokines IL-1β, IL-6, and TNF-α. Furthermore, TA-V also showed excellent biosafety and biocompatibility without causing obvious damage to the main organs. This work provides novel preventative and therapeutic TA-V nanozymes that might have potential clinical applications in UC treatment.
研究领域:
医学
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生物化学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
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2024
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IF 4.4
Zhongwang Li,Wurikaixi Aiyiti,Cijun Shuai,Lanlan Dong
Three-dimensional bioprinting has emerged as a promising technique for creating personalized scaffolds. However, traditional extrusion-based methods face challenges with resolution and structural fidelity. This study aims to introduce a hybrid bioink, combining N-acryloylglycinamide (NAGA) with a rheology modifier to enhance both the stability and precision of printed designs. Additionally, we implemented a controlled immersion shrinkage process to further enhance the resolution. Immersing the printed structures in a 55% w/v tannic acid (TA) solution, the average grid area was reduced to 35.21% of its original size, significantly improving resolution. This treatment also boosted the antioxidant properties of the hydrogel, achieving a 90.5% ABTS removal rate. The hydrogel demonstrated excellent cytocompatibility, enhanced cell proliferation, and maintained high-resolution printability and antioxidant properties, making it a promising biomaterial for soft tissue regeneration.
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
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2024
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IF 8.5
Linze Liu,Yajie Hu,Le Du,Jiahui Du,Jian Hu,Tao Sun,Tungalag Dong,Xueyan Yun
Antimicrobial packaging can prolong the shelf life of fresh food, but those active antimicrobial substances may leach into the food and affect its quality. To avoid this phenome, the C C double bond was first incorporated into the chemical structure of polylactic acid (PLLA) and tannic acid (TA) to prepare poly(L-LA- co -butyrate itaconate) (PLBI) and photoactive tannic acid (pTA). Then pTA-grafted PLBI (pTA-g-PLBI) films were fabricated using UV curing technology. Results showed that pTA was successfully grafted onto the surface of PLBI film and formed a uniform layer. The pTA-g-PLBI films exhibited good bacteriostatic effects of 86 %, 90 %, and 96 % on E. coli, P. fluorescens, and S. aureus , respectively. Additionally, pTA-g-PLBI packaging reduced the relative abundance of Shewanella , Psychrobacter, and Pseudomonas in chilled pork and delayed the deterioration of pork for more than 5 days.
研究领域:
材料科学
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食品科学
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生物技术
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化学工程
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Yiting Ye,Jiaqi Liu,Tingzi Yan,Yujia Yan,Jiangkai Fan,Xiao Zhang,Li Gan,Hui Chai,Guoying Zhou
Due to the huge waste caused by fruit mildew during transportation and storage, there is an urgent need to develop novel packing materials with antibacterial and degradable properties. Herein, poly(lactic-co-caprolactone)/Gelatin/Tannic acid (PLCL/GEL/TA) membranes were fabricated by electrospinning of PLCL and GEL to obtain PLCL/GEL membranes, followed by cross-linking with TA. The microstructures of PLCL/GEL/TA membranes were characterized by scanning electron microscope (SEM). The mechanical and wetting properties were evaluated by Instron universal material testing and Drop shape analysis system, respectively. The antibacterial and antioxidant properties were determined. The preservation properties of the membranes were evaluated using blueberry as a model fruit. The results showed that smooth and uniform microstructure was formed on all electrospun membranes. The PLCL/GEL/TA membranes exhibited enhanced mechanical property, wettability, biodegradability, antioxidant and antibacterial properties, when compared to PLCL/GEL membranes without TA treatment. In addition, these increased properties showed positive correlation with TA content. Besides, TA was slowly released from the PLCL/GEL/TA membranes, in a controlled and sustained manner. Moreover, the cytotoxicity assays confirmed the non-toxic nature of these membranes. Finally, the PLCL/GEL/TA membranes effectively inhibited decay degree, weight loss, and extended the shelf life of blueberries. Overall, the antioxidant, antibacterial, biodegradable and biocompatible PLCL/GEL/TA membranes exhibited remarkable preservation performance, demonstrating significant potential as novel packing materials.
研究领域:
食品科学
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材料科学
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生物学
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产品关联
DOI
高影响因子
Acta Biomaterialia
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2024
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IF 9.4
Cong Zhang,Qingrong Li,Jianghao Xing,Yan Yang,Mengmei Zhu,Liting Lin,Yue Yu,Xiaojun Cai,Xianwen Wang
Colon mucosal overexpression of reactive oxygen and nitrogen species (RONS) accelerates the development of inflammatory bowel disease (IBD) and destroys the mucosa and its barrier. IBD can be alleviated by removing RONS from the inflamed colon. The preparation of strong and efficient nanoantioxidants remains a challenge despite the development of numerous nanoantioxidants. In this paper, Zn-TA nanoparticles with fine hollow microstructure (HZn-TA) were successfully prepared and could be effectively used to treat IBD. In the first step, ZIF-8 nanoparticles were synthesized by a one-pot method. On this basis, HZn-TA nanoparticles were etched by TA, and a multifunctional nanase was developed for the treatment of IBD. RONS, including reactive oxygen species (ROS) and nitric oxide (NO), can be eliminated to increase cell survival following Hydrogen peroxide (H 2 O 2) stimulation, including reactive oxygen species (ROS) and nitric oxide (NO with hydrogen peroxide (H 2 O 2 ). In a model for preventing and delaying acute colitis, clearance of RONS has been shown to reduce intestinal inflammation in mice by reducing colon damage, proinflammatory cytokine levels, the spleen index, and body weight. Intestinal mucosal healing can be promoted by HZn-TA nanoparticles, which can upregulate zonula occludens protein 1 (ZO-1) and claudin-1 expression. Based on the results of this study, HZn-TA nanoparticles were able to effectively treat IBD with minimal adverse effects by being biocompatible, multienzyme active, and capable of scavenging RONS. Therefore, we pioneered the application of HZn-TA nanoparticles for the treatment of IBD, which are capable of clearing RONS without significant adverse effects. Statement of significance ➢ HZn-TA nanoparticles were successfully prepared and could be effectively used to treat IBD. ➢ Intestinal mucosal healing can be promoted by HZn-TA nanoparticles, which can upregulate ZO-1 and claudin-1 expression. ➢ HZn-TA nanoparticles were able to effectively treat IBD with minimal adverse effects by being biocompatible, multienzyme active, and capable of scavenging RONS.
研究领域:
医学
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生物化学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
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2024
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IF 5.6
Diao Zhentian,Li Longkang,Zhou Huan,Yang Lei
Healing of chronic diabetic wounds is challenging due to complications of severe inflammatory microenvironment, bacterial infection and poor vascular formation. Herein, a novel injectable polyvinyl alcohol–hyaluronic acid-based composite hydrogel was developed, with tannic acid (TA) and silicate functionalization to fabricate an ‘all-in-one’ hydrogel PTKH. On one hand, after being locally injected into the wound site, the hydrogel underwent a gradual sol–gel transition in situ, forming an adhesive and protective dressing for the wound. Manipulations of rheological characteristics, mechanical properties and swelling ability of PTKH could be performed via regulating TA and silicate content in hydrogel. On the other hand, PTKH was capable of eliminating reactive oxygen species overexpression, combating infection and generating a cell-favored microenvironment for wound healing acceleration in vitro. Subsequent animal studies demonstrated that PTKH could greatly stimulate angiogenesis and epithelization, accompanied with inflammation and infection risk reduction. Therefore, in consideration of its impressive in vitro and in vivo outcomes, this ‘all-in-one’ multifunctional hydrogel may hold promise for chronic diabetic wound treatment.
研究领域:
生物材料
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医学工程
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再生医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Duo Yu,Somia Yassin Hussain Abdalkarim,Meijin Jin,Yuanhua Zhang,Hou-Yong Yu
Both nanocellulose and graphene nanosheets serve as exceptional fillers for biopolymers. However, there are limited materials that effectively combine the properties of these two fillers in Poly (propylene carbonate) (PPC) to enhance their overall properties. This study presents a meticulous approach to producing graphitized nanocellulose (GCNC) with tailored rod-like (R-GCNC) and spheres-like (S-GCNC) under low-temperature and ambient-pressure conditions. The formation and integration of the reinforcement network within the PPC matrix were compared by modulating these morphologies. The R-GC 3% , with its stronger hydrogen bonding interactions, achieved a more optimal combination of properties than S-GC 3% . Significantly, R-GCNC and PPC formed a robust reinforcement network, resulting in remarkable reductions of approximately 153 % in water absorption and 1669 % in water vapor permeability. Significantly, the mechanical properties of PPC were improved by 95 % in tensile strength and 1038 % in Young's modulus due to improved dispersion of R-GCNC with higher aspect ratio. In addition, R-GC 3% had the highest glass transition temperature of 35.1 °C, and a maximum degradation temperature increased by 16.5 °C. The PPC/GCNC composites exhibited outstanding UV shielding, antioxidant properties, and rapid degradation rates. This study introduces a practical method for choosing suitable GCNCs as reinforcing agents to produce innovative green materials for the active packaging.
研究领域:
材料科学
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纳米技术
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环境科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Qing Huang,Fei Jiang,Li Shuai,Chengke Zhao
Conventional lignin, a dehydrogenated polymer derived primarily from hydroxycinnamic alcohol monomers, exhibits relatively low antioxidant and ultraviolet (UV)-blocking activities due to its structural imperfection. Herein, we demonstrated that the dehydrogenated polymer of ferulic acid (an unconventional lignin precursor) (FAL) had excellent antioxidant and UV-blocking properties. Structural characterization showed that FAL contains abundant dihydrobenzofuran and butyrolactone structures, free phenolic hydroxyl groups, and cinnamic acid end groups. Such structural characteristics endow FAL with much higher antioxidant activity and broader and stronger UV absorptivity (especially UVA) than conventional lignins. Our investigation showed that FAL could significantly improve the UV-blocking property of commercial SPF30 and SPF50 and render a relatively light color. These versatile properties make the FAL a potential ingredient for application in sunscreen products. This work is enlightening not only for exploring better antioxidant and UV-blocking polymers from the dehydrogenated polymers of phenolic compounds but also for biosynthesizing more advantageous lignin in plants.
研究领域:
材料科学
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生物学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Arabian Journal of Chemistry
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2024
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IF 5.3
Zhiwen Qi,Pujun Xie,Zhihong Wang,Hao Zhou,Ran Tao,Sergey A. Popov,Guliang Yang,Elvira E. Shults,Chengzhang Wang
Excessive oxidation can lead to inflammation and affect health. Studies have shown that ursolic acid (UA) and gallic acid are widely employed in medicine and cosmetics owing to their obvious antioxidant and anti-inflammatory properties. In this study, a series of 16 novel UA hybrids tethered via 1,2,3-triazole to the modified gallate moieties were synthesized via CuAAC 1,3-cycloaddition reactions. In vitro , all derivatives were proved to be effective in antioxidation and anti-inflammation activities. Interestingly, compound 20 significantly inhibited the expression of pro-inflammatory cytokines including mRNA of inducible nitric oxide synthase (iNOS) ( p < 0.05) and cyclooxygenase-2 (COX-2) ( p < 0.01) in lipopolysaccharide (LPS)-induced RAW264.7 cells in a dose-dependent manner. The inhibitory effect of compound 20 on pro-inflammatory cytokines was closely associated with suppression of the LPS-activated PI 3 K/Akt signal pathway. Compound 20 significantly alleviated inflammation in the gastrointestinal tract of zebrafish in vivo . In addition, compound 20 showed good biosafety in cytotoxicity evaluation. This study provides a novel reference for the development of treatments for health problems related to anti-oxidation and anti-inflammation properties.
研究领域:
药理学
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有机化学
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炎症研究
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Minggang Hu,Xiaochen Wang,Can Wang,Hongtao Chu,Xinfeng Song,Guohua Dong,Jiyuan Zhang,Jin Xing
In this study, a new and simple method for synthesizing boron complexes was presented. The boron complexes with C 2 -symmetric ligands were prepared from in situ generated tertiary amine by the reaction of salicylaldehyde with primary amine in the presence of sodium borohydride. The boron complexes were characterized by 1 H and 13 C NMR spectroscopy, elemental analysis, and mass spectrometry. The crystal structures of complexes 1 and 2 were determined by single crystal X-ray diffraction method. The complex is a mononuclear boron complex with a tertiary amine ligand. The boron center is tetracoordinated with a distorted tetrahedral geometry. Catalytic activities of the boron complexes in the reduction of dyes, was investigated using sodium borohydride as a reducing agent. Complexes 1 and 2 were effective catalysts for degradation of dyes. Kinetic studies reveal that the reduction of methylene blue is of the first order. Free radical scavenging activities of the boron complexes have been tested using DPPH, ABTS and hydroxyl radicals, respectively. The result shows that the boron complexes have effective antioxidant activity.
研究领域:
化学
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材料科学
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环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）